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식물생리활성물질과 과일류 추출물이 MCF-7 유방암 세포에서 H₂O₂로 유도된 Poly(ADP-ribose) Polymerase (PARP) 활성도에 미치는 영향
윤현근(Hyungeun Yoon) 한국식품과학회 2019 한국식품과학회지 Vol.51 No.5
사과 추출물(AE), 크랜베리 추출물(CE), 포도 추출물(CE), EGCG는 hydrogen peroxide에 의하여 유발된 MCF-7 인간 유방암 세포의 PARP 활성을 유의하게 억제하였다. GE는 본 연구에서 다른 과일류 추출물보다 우수한 PARP 활성 억제능을 나타내었다. 식품 성분으로서 안전성을 갖춘 우수한 PARP 활성 억제소재를 발굴하여 PARP 활성 억제 기전을 구명하고 PARP 활성억제제 효능 향상을 방안을 제시하는 연구가 필요하다. Poly(ADP-ribose) polymerase (PARP) is a nuclear enzyme which is activated in response to DNA damage, and which mediates DNA repair. PARP inhibitors can be used to reduce resistance of cancer cells to anticancer treatments. The objective of this study was to investigate the effects of selected phytochemicals and fruit extracts on PARP activation in MCF-7 breast cancer cells subjected to oxidative stress. Pre-incubation with epigallocatechin gallate (EGCG), apple extract (AE), cranberry extract (CE), or grape extract (GE) for 2 hours at test concentrations reduced PARP activity induced upon treatment with hydrogen peroxide in a dose-dependent manner (p<0.05). GE was found to be the most efficient PARP inhibitor among the fruit extracts examined. These results suggest that phytochemicals of fruit extracts might be used as PARP inhibitors in order to assist anticancer agents.
렌즈콩(Lens culinaris) 추출물이 HepG2 인간 간암 세포에서 Proteasome 활성과 Nuclear Factor κB 활성화에 미치는 영향
민수영,윤현근,Min, Sooyeong,Yoon, Hyungeun 한국식품영양학회 2019 韓國食品營養學會誌 Vol.32 No.5
Proteasome inhibitors can improve the efficiency of cancer treatments by inhibiting nuclear factor ${\kappa}B$($NF-{\kappa}B$) activation in cancer cells. Lentils are a type of beans of which consumption of such beans is increasing. The purpose of this study was to investigate the effects of lentils extract (LE) on the proteasomal activities, $NF-{\kappa}B$ activation, and cell cycle in HepG2 human liver cancer cells. LE treatments inhibited proteasomal activities at concentrations of 10, 50, and $100{\mu}g/mL$ respectively, and repressed $NF-{\kappa}B$ activation at concentrations of 1, 10, and $100{\mu}g/mL$ respectively, in HepG2 cells. LE treatments at concentrations of 1, 10, and $100{\mu}g/mL$ respectively, increased sub-G1 cell population in HepG2 cells, which may be the result of apoptosis. The results suggest that LE inhibited $NF-{\kappa}B$ activation partially with its proteasome inhibitory activities, and the increase of sub-G1 cell population was induced partially, by inhibition of $NF-{\kappa}B$ activation in HepG2 cells.
전통발효유 타락의 면역세포 증식 및 멜라닌 생성에의 효과
김소영(Soyoung Kim),최유미(Yumi Choi),이희라(Heera Lee),박지수(Jisoo Park),한영숙(Young-Sook Han),고성희(Seong-Hee Ko),장성식(Sung-Sik Jang),김수아(Soo-A Kim),심재헌(Jae-Hun Shim),윤현근(Hyungeun Yoon) 한국식품영양과학회 2015 한국식품영양과학회지 Vol.44 No.11
시판 막걸리에서 분리한 균주(Lactobacillus paracasei ssp. paracasei M13-65-3)로 타락을 제조하였다. M13-65-3 균주를 이용하여 제조한 타락 추출물에 의하여 T lymphocyte인 Jurkat 세포의 증식이 촉진되었고 피부세포의 멜라닌 생성이 억제되었다. 본 연구의 결과는 타락이 면역 증강 기능성과 피부색소 조절 기능성을 보유할 가능성을 제시하고 있다. Tarak is a Korean traditional fermented milk product that is fermented by adding rice wine to milk. Tarak was produced with Lactobacillus paracasei ssp. paracasei M13-65-3 isolated from rice wine, and its effects on immune cell proliferation and melanin biosynthesis were investigated. Tarak extract significantly increased proliferation of T lymphocyte Jurkat clone E6-1 cells at concentrations from 10 to 100 μg/mL. Tarak inhibited activities of tyrosinase and α-melanocyte-stimulating hormone-induced melanin biosynthesis in mouse skin B16-F10 cells at a concentration of 100 μg/mL. These results suggest that tarak might have functionalities for enhancing the immune system by increasing immune cell proliferation and regulating melanin biosynthesis.