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박승택,윤향석,형근영,조정구,이강창,김원신,김형민,전병훈,윤용갑,Park Seung-Taeck,Yoon Hyang-Suk,Hyoung Keon-Young,Cho Chung-Gu,Lee Kang-Chang,Kim Won-Shin,Kim Hyung-Min,Jeon Byung-Hoon,Yun Young-Gap 대한한의학방제학회 1999 大韓韓醫學方劑學會誌 Vol.7 No.1
In order to eludidate the mechanism of oxidative stress in cultured spinal motor neurons damaged by oxygen free radicals, cytoxicity was assesed by MTT assay and NR assay after spinal motor neurons from mouse were cultured in media containing various concentrations of xanthine oxidase(XO) and hypoxanthine(HX) for 3 hours. In addition, neuroprotective effects of several herb extracts on oxidant-induced neurotoxicity were examined in these cultures, compared with nerve growth factors such as basic fibroblast growth factor(bFGF). XO/HX decreased cell viability in dose- and time dependent manners on cultured mouse spinal motor neurons, and MTT50 and NR50 values were measured at 20mU/ml XO and 0.1mM HX for 3 hours in these cultures. bFGF significantlt increased cell viability. In neuroprotective of herb extracts, Epimedium Koreanum Nakai(EK) and Alpinia oxphylla Mig(IJI) was very effective in the prevention of the neurotoxicity induced by XO/HX in cultured mouse spinal motor neurons. From the above results, it is suggested that XO/HX shows toxic effect in cultured mouse spinal motor neurons and selective herb extracts such as Epimedium Koreanum Nakai(EK) and Alpinia oxphylla Mig(IJI) were very effective in the increase of cell viability against the neurotoxicity induced by oxygen radicals in these cultures.
급성기 항염치료에 반응하지 않은 가와사끼병의 임상양상과 검사소견
김은정,홍명은,이창우,오연균,김종덕,윤향석,Kim, Eun-Jung,Hong, Myung-Eun,Lee, Chang-Woo,Oh, Yeon-Geun,Kim, Jong-Duk,Yoon, Hyang-Suk 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.5
목 적: 소아의 가와사끼병에서 급성기 항염치료는 고용량의 IVIG와 경구용 아스피린의 병합투여가 일반적으로 사용되고 있다. 이러한 초기 항염치료에 반응을 보이지 않은 경우에는 IVIG의 추가투여나 스테로이드가 사용될 수 있으며 발열기간과 입원기간이 길어질 수 있다. 관련인자로서 환자의 나이, 성별, 발열-치료 간격과 백혈구수, CRP 등이 연관될 수 있다는 보고가 있었다. 저자들은 이러한 초기 치료실패에 임상적 또는 검사소견상의 관련인자가 있는가를 알아보기 위해 본 연구를 시행하였다. 방 법 : 1997년 6월부터 2002년 6월까지 만 5년간 원광대학교병원 소아과에서 가와사끼병으로 입원하여 치료받았던 177명의 환자를 대상으로 후향적으로 조사하였다. 1회의 투여로 반응을 보이지 않은 군(A군, n=19)과 반응을 보였던 대조군(B군, n=158)에서 나이와 성별, 발열에서 입원까지의 기간(hr)을 비교하였다. 입원 당시와 발병 6주째에 백혈구수와 혈소판, ESR, CRP, AST/ALT, ASO치, 소변검사, 관상동맥 심초음파 검사를 시행하여 비교하였다. 통계적 비교는 chi-square와 t-test를 이용하였다. 결 과 : 초기치료에 반응하지 않은 환아는 177례 중 19례(10.7%)였다. 나이와 성별, 백혈구수, 농뇨, 관상동맥의 이상에서는 두 군간에 유의한 차이가 없었다. 재치료군에서는 발열-입원 기간(hr)이 유의하게 짧았으며(P=0.041), AST/ALT치의 동반 상승(P=0.011), ASO치의 상승(P=0.000)이 관찰되었다. 결 론 : 백혈구수와 ESR, CRP의 증가나 AST, ALT가 따로 상승한 경우, 농뇨의 존재 여부에서는 재치료율과 관계가 없었다. 반면에, 발열-입원 기간이 짧았던 경우와 AST/ALT의 동시상승, ASO치 상승군에서 재치료율이 유의하게 높았다. 향후, AST/ALT치와 ASO치의 관련성에 대한 추가적인 연구가 더 필요할 것으로 사료된다. Purpose : To assess the clinical features and laboratory findings in Kawasaki patients with nonresponsibility to the acute antiinflammatory treatment, and identify the risk factors for the nonresponsibility, we reviewed the medical records of patients with Kawasaki disease. Methods : A retrospective study of 177 patients with Kawasaki disease at Wonkwang University Medical Center from June, 1997 to June, 2002, was performed. High dose intravenous immune globulin(IVIG) and aspirin were all used for the initial acute antiinflammatory treatment. Two groups, group A(n=19) of initial nonresponders and group B(n=158) of initial responders were compared clinically and laboratorically. Results : Nineteen(10.7%) of 177 patients hardly responded to the initial antiinflammatory treatment. Patients with failure to respond to initial treatment(group A) did not differ from the control group in terms of age, sex, WBC count, coronary abnormalities, and evidence of pyuria. Compared with initial responders(group B), the patients who were retreated(group A) had a significantly shorter feveradmission interval(P=0.041), and a higher level of both AST/ALT(P=0.011) and ASO titier(P=0.000). Conclusion : Among Kawasaki disease patients studied, retreatment group with initial nonresponders had significantly shorter fever-admission interval, and higher both AST/ALT level and ASO titer, than the initial response group.
회소돌기아교세포에 있어서 메틸수은에 의해 유도된 신경독성에 대한 glutathione의 영향
박승택(Seung Taeck Park),오재민(Jae Mm Oh),최민규(Mm Kyo ChOl),김정중(Jung Joong KIm),윤향석(Hyang Suk Yoon),정진원(Hyang Suk Yoon),박옥규(Jm Won Chung),전병훈(Ick Kyu Park),김원신(Byung Hun Jeon),정연태(Won SIn KIm) 대한체질인류학회 1997 해부·생물인류학 (Anat Biol Anthropol) Vol.10 No.1
에틸수은 (methylmecury, MM) 이 소의 배양 희소돌기아교세포에 미치는 신경독성효과를 규명하기 위하여 여러 농도의 methylmercuric chloride (MMC)가 들어있는 배양액에서 신경세포를 24시간 동안 배양한 다음 이에 대한 신경특성을 MTT 분석법에 의하여 조사하였으며 또한 MMC에 의한 옥성효과에 대하여 항산화제의 방어효과를 분석 하였다. MMC는 처리한 농도와 시간에 비례하여 소의 배양 희소돌기아교세포의 생존율을 강소시켰으며 glutathione이 MMC에 의해 유도된 신경독성을 방어하였다. 이상의 경파로 부터 MM은 소의 배양 희소돌기아교세포에 독성을 나타냈으며 glutathione과 같은 선택적인 항산화제가 MM에 의한 신경독성을 방어하는데 매우 효과적인 것으로 나타났다.
최근 10년간 원광의대병원에서 시행한 소아 심장혈관 수술의 임상적 고찰
윤향석,정수미,최두영,오광수,오연균,김종덕,양현웅,이삼윤,김형곤,최종범,최순호,노병석 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.2
We reviewed 10 years experiences of the clinical aspects and early postoperative results in 544 pediatric patients(age less than 16 years old). Among them. 529 cases had the congenital heart diseases, and 15 had the acquired diseases. Open heart surgery was performed in 413 patients. 115 cases were treated with non-open heart surgery. 16 with interventional catheterization. Annual increase of the cardiac patients was not significant in recent 10 years, except slight increase in 1994. The mean age of the study patients had been evidently changed to younger year by year. Total mortality rate of the open heart surgery was 6.4%. The cyanotic congenital heart diseases were high in early postoperative mortality by 25.7%, whereas 4% in acyanotic group. The age group less than one month was most highest in surgical mortality(66.7%). There were no deaths in patients with patent ductus arteriosus(103 cases), atrial septal defect(83 cases) or pulmonary stenosis(17 cases). Among 220 patients with ventricular septal defects(VSD). 10(4.5%) were died early postoperatively. In cyanotic group, the patients with pulmonary atresia with ventricular septal defects(PAVSD), transposition of the great arteries(TGA), interrupted aortic arch(IAA), complex cardiac anomalies with isomerism seemed to be most susceptible to an early death.
영아의 선천성심질환에 대한 개심술후의 집중치료에서 복막투석용 도관삽입의 의의
오재화,윤향석 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.2
Background: We reviewed 5 years' experience with peritoneal drainage(PDr) in infants who underwent open heart surgery. The aim of this study was to investigate the effect of PDr on fluid balance and several parameters of intensive care. We hypothesized that PDr is safe and effective in infants with low-output cardiac failure after cardiac operations. Methods: Six(3.3%) of 60 consecutive infants who underwent open heart surgery required peritoneal dialysis(PD) during the PDr. Simple PDr was performed in remaining 54 infants. The silicone rubber PD catheter was inserted into the center of abdominal cavity just after the operation, and the subsequent PDr was maintained during the intensive care. Results: Early postoperative mortality in all in infants with congenital heart disease was 1.6%. Total amount of intake was 6.30±1.59 ㎖/㎏/hr, and total output was 6.95±2.32 ㎖/㎏/hr, urine output was 5.08±2.55 ㎖/㎏/hr, pleural fluid 0.78±0.52 ㎖/㎏/hr, peritoneal fluid 1.20±0.90 ㎖/㎏/hr. The ratio of the output to the intake(O/I) was 1.1. None of the complications required early termination of the drainage. Hemodynamics and pulmonary function were maintained steadily during the postoperative intensive care. Conclusions: The early institution of peritoneal drainage(PDr) in infants with congenital heart disease after cardiac operations not only removes fluid, thus easing fluid restriction, but may also improve cardiopulmonary function.
Duct-Occlud를 이용한 동맥관개존의 비수술적 폐쇄
오만택,오재화,윤향석 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.2
Background: We tried to occlude the duct with retrievable coil device(Duct-Occlud) in 6 children with patent ductus arteriosus(PDA). And, we reviewed the technical aspects and the short-term results. Methods: PDA occlusion with "Duct-Occlud" system was attempted in 6 patients with small to moderate size PDA from January 1999 to November 1999. Mean age of the patients was 6.56 (1.33 to 14)year. After estimation of the size of PDA, retrievable coil device(Duct-Occlud) was inserted through the femoral vein route. The angiocardiography was performed 10 minutes after the procedure. On next day and one week later, the follow-up echocardiogaphy was checked. And then, it repeated at 3 months, 6 months later. The follow-up duration was 5.5(1 to 11) months. Results: The Qp/Qs was 1.44(1.25 to 1.63), Rp/Rs 0.09(0.03 to 0.15), size of pulmonary end 2.73(2.1 to 3.5)㎜, aortic end 4.58(2.8 to 5.5)㎜, length 5.83(3.8 to 8)㎜. The complication of the procedure occurred in one patient by uneventful earlier detatchment. Flow disturbance was not developed. Conclusions: Coil occlusion with the Duct-Occlud system is a safe and effective method for percutaneous closure of small to moderate-size PDAs. Larger numbers of treated patients and longer follow-up period would be necessary to more precisely define the efficacy, and most appropriate indications for this system.