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HaCaT 각질형성세포에서 자외선 B에 대한 세포자멸사 및 자가포식현상 유도
윤상돈 ( Sang Don Yoon ),백원기 ( Won Ki Baek ),김상표 ( Sang Pyo Kim ),이규석 ( Kyu Suk Lee ),조재위 ( Jae We Cho ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.8
Background: UVB irradiation induces apoptosis or/and autophagy through several molecular pathways in keratinocytes. However, the precise molecular mechanism of UVB-induced autophagy is largely unknown in keratinocytes. Objective: The purpose of this study was to investigate the molecular mechanisms of UVB-induced apoptosis and autophagy in HaCaT cell lines. Methods: Cells were irradiated by UVB (Westinghouse FS-40 sunlamps) with various doses (0, 30, 60, 120, 240 mJ/cm2). The expression levels of caspase-3, Bax, Bcl2, Bcl-XL and LC3 were confirmed by Western blot analysis in UVB-irradiated HaCaT cell lines. Apoptotic cells were analyzed by PI staining, and autophagy cells were analyzed by immunofluorescent staining. Results: The expression of Bcl-XL decreased from UVB 60 mJ/cm2 and Bcl2 decreased from UVB 240 mJ/cm2. The expression of caspase-3 was increased from UVB 120 mJ/cm2. These data showed that UVB-induced apoptosis is mediated by up-regulation of caspase-3 and down-regulation of Bcl2 and Bcl-XL. Furthermore, the expression of LC3 increased from UVB 120 mJ/cm2. In addition, autophagy formation was observed in few fractions of apoptotic HaCaT cells in immunofluorescent staining; most apoptotic cells did not show autophagy formation. Moreover, autophagy formation inhibitor treatment induced a slight increment of apoptotic cell population under UVB irradiation. Conclusion: UVB irradiation induces not only apoptotic cell death but also autophagy formations; these events may create a defense mechanism for the prevention of apoptosis in UVB-treated HaCaT cells. (Korean J Dermatol 2013; 51(8):600∼607)
상보적 교수법이 중,고등학생의 문식성 향상에 미치는 효과
윤상돈 ( Sang Don Yoon ) 한국현대영어영문학회 2014 현대영어영문학 Vol.58 No.4
The purpose of this study is to examine the effect of reciprocal teaching method on improving the literacy of middle school and high school students in Korea. For this study, 118 students were selected as subjects. The middle school students were divided into two groups (20 students for each group) and so were the high school students (34 students for each group). Reciprocal teaching was adapted to the experimental groups while teacher guided teaching was adopted to the controlled ones. To verify the effectiveness of the present study, 4 reading ability tests and 8 writing ability tests were designed and they were administered before and after the experiment respectively. The result of the study revealed the followings: 1) Reciprocal teaching is effective for the improvement of reading ability. 2) Reciprocal teaching is also effective for the improvement of writing ability. 3) Reciprocal teaching is significantly effective for the improvement of literacy. These results offer EFL teachers insights into utilizing reciprocal teaching method for English literacy education in secondary level in Korea.
쓰기 지도 방법의 차이가 중학생의 영어 쓰기능력 및 영어 쓰기에 대한 태도에 미치는 영향 분석
윤상돈 ( Sang Don Yoon ) 한국현대언어학회 2012 언어연구 Vol.28 No.1
This study investigated the effect of process-oriented approach on improving middle school students` writing ability and attitude toward English writing. For this study, 18 students in the third year of a middle school were selected as subjects. They were divided into two groups. Process-oriented writing activities were adapted to the experimental group while product-oriented writing activities were adapted to the controlled one. To verify the effectiveness of process-oriented writing activities for improvement of writing competence, four types of test were administered before and after the experiment. The result of the questionnaire survey and analysis of the administered tests suggested that the effect of process-oriented writing activities on middle school students` writing competence and attitude toward English writing be proved to be significantly positive. (Chungnam Institute of Foreign Language Education)
윤상돈 ( Sang Don Yoon ),이규석 ( Kyu Suk Lee ),조재위 ( Jae We Cho ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.11
Glufosinate ammonium herbicide is a nonselective herbicide used worldwide because it is less toxic than paraquat. Acute glufosinate ammonium intoxications manifest as injuries of the intestinal mucosa, abdominal pain, vomiting, diarrhea, convulsions, respiratory distress, and death resulting from human abuse. We present a case of irritant contact dermatitis on the back caused by accidental exposure to glufosinate ammonium and followed by erythema multiforme-like eruptions without systemic intoxication, which has not been documented previously in Korea. (Korean J Dermatol 2014;52(11):809∼812)
윤상돈 ( Sang Don Yoon ),권준일 ( Jun Il Kwon ),이규석 ( Kyu Suk Lee ),조재위 ( Jae We Cho ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.3
Reactive perforating collagenosis (RPC) is one of a range of essential perforating disorders. Two types have been recognized: the childhood or inherited form, and the adult or acquired form. Acquired RPC is usually associated with systemic disease, especially diabetes mellitus and/or renal failure. Lesions of acquired perforating collagenosis are usually smaller than 1 cm, but lesions of the giant variant of acquired perforating collagenosis are larger than 2 cm. We present a case of the giant variant of acquired perforating collagenosis, which has not previously been documented in Korea. (Korean J Dermatol 2012;50(3):248~251)
윤상돈 ( Sang Don Yoon ),김성애 ( Sung Ae Kim ),이규석 ( Kyu Suk Lee ),조재위 ( Jae We Cho ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.4
Halo nevus is a pigmented nevus surrounded by acquired round depigmentation. Depigmentation appears mostly around several types of pigmented lesions, such as acquired nevus, congenital nevus, blue nevus and Spitz nevus. In contrast, it is rare that depigmentation develops around a congenital nevus. While the precise etiology of halo nevus and vitiligo remains uncertain, several theories suggest that both phenomena result from an immunologic reaction to melanocytes by CD8 + T cell. We report a case of halo congenital nevus in the arm, which is followed by periocular vitiligo. This is the third case in Korean dermatological literature. (Korean J Dermatol 2013;51(4):280∼283).
인플루엔자 예방접종 후 발생한 Stevens-Johnson Syndrome
윤상돈 ( Sang Don Yoon ),이규석 ( Kyu Suk Lee ),조재위 ( Jae We Cho ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.7
Stevens-Johnson syndrome (SJS) is a rare, severe and immune-mediated cutaneous reaction usually secondary to the idiosyncratic reaction of medication, such as sulfonamide, anti-convulsant, NSAIDs and so on. The infection with Mycoplasma pneumoniae is also a well-documented cause. Influenza vaccination is relatively safe and increases with pandemic advance. Mild adverse reactions of influenza vaccination are relatively frequent, such as erythema, pains, fevers, myalgia, headaches and so on. But, severe skin adverse reactions are also very rare. We present a case of seasonal influenza vaccination induced Stevens-Johnson syndrome which has not previously been documented in Korea. (Korean J Dermatol 2013;51(7):560∼564)
자막의 종류에 대한 학습자의 선험 학습 경험이 영어 읽기 및 듣기 능력에 미치는 영향
윤상돈(Yoon Sang don) 영상영어교육학회 2018 영상영어교육 (STEM journal) Vol.19 No.3
The purpose of the present study is to verify the effect of learners’ prior learning experience of subtitles and its effect on their reading competence and listening competence in an EFL learning context in Korea. A total of 119 Korean high school students participated in this study. They were divided into two groups in accordance with the subtitles (Korean, English) that they were exposed to. (58 for Korean subtitles and 61 for English). Each group was divided again into two smaller groups in accordance with the learner’s prior experience of using subtitles (Korean, English) in learning English. An American TV series The Newsroom, season 1 (10 episodes, Sorkin, 2012) was adapted to each group with two different types of subtitles (Korean, English). The experiment operated for 15 weeks (2 hours every week, 30 hours in total). To verify the effectiveness of the present study, 2 reading comprehension tests and 2 listening comprehension tests were administered before and after the experiment. The results of the study revealed that the learners who participated in the class which corresponded to their prior learning experience showed a significant improvement in both reading and listening competence.