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류마티스 관절염에서 Glutathione S-transferase 유전자 다형성에 관한 연구
윤보라,AhmedEl-Sohemy,MarilynC.Cornelis,곽은주,강태영,정청일,이혜순,엄완식,김태환,전재범,유대현,배상철 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.3
Association of Polymorphism in Glutathione S-transferase Gene with Susceptibility and Severity of Rheumatoid ArthritisBo-Ra Yun, M.D., Ahmed El-Sohemy, Ph.D.*, Marilyn C. Cornelis, M.S.*,Eun-Joo Kwak, M.S., Tae-Young Kang, M.D., Chung-Il Joung, M.D.,Hye-Soon Lee, M.D., Wan-Sik Uhm, M.D., Tae-Hwan Kim, M.D.,Jae-Bum Jun, M.D., Dae-Hyun Yoo, M.D., Sang-Cheol Bae, M.D.Center, Seoul, Korea,
열 태양광 발전을 위한 원형 홀 패턴의 Metal-Dielectric-Metal 선택형 방사체
윤보람(Boram Yoon),이남규(Namkyu Lee),배지열(Ji-Yeul Bae),Fakadu Tolessa,조형희(Hyung Hee Cho) 대한기계학회 2018 大韓機械學會論文集B Vol.42 No.5
본 연구에서는 열 태양광 발전을 위한 원형 홀 패턴의 Metal-Dielectric-Metal 선택형 방사체를 제안한다. 텅스텐과 산화 알루미늄을 구조체 전체적으로 사용하여 내열성을 확보하였다. 설계 변수의 변화에 따른 흡수/방사 특성을 분석하였고, 이를 통해 InGaAs 셀의 높은 변환 효율을 갖는 파장 대역에서 선택적으로 높은 방사율을 갖는 구조체를 형성하였다. 높은 흡수/방사의 파장 대역에서 텅스텐 원형 홀패턴의 가장자리 주변에서 국부적으로 발생하는 표면 플라즈몬 공명이 발생하였다. 이러한 공명은 루프형태의 유도 전류를 형성함으로써 자기장을 유전체 층에 가두는 효과가 있다. 본 연구에서 제안하는 선택형 방사체의 스펙트럼 효율은 1000K에서 41.0%, 1300K에서 63.7 %였다. 이는 동일한 온도의 흑체보다 각각 5배, 3배 높은 효율을 보였다. In this study, we propose a thermophotovoltaic circular hole pattern Metal-Dielectric-Metal selective emitter. Tungsten and aluminum oxides are used to ensure heat resistance. By analyzing the absorption/emission characteristics per the change of design parameters, we obtain optimal design values that secure selectively high emissivity. Localized surface plasmon resonance occurs at the edge of the tungsten circular hole pattern in the high absorption/emission band. This resonance has the effect of confining the magnetic field to the dielectric layer by forming induced loop-like currents. The spectral efficiency of the proposed emitter is 41.0% at 1,000K and 63.7% at 1,300K. It showed five- and three-times higher efficiency, respectively, than the black-body of the same temperature.
윤보라,류선영,윤수진 대한치매학회 2018 Dementia and Neurocognitive Disorders Vol.17 No.3
Background and Purpose: Prospective memory (PM) has a known relationship with frontal function, and PM decline has been observed in amnestic mild cognitive impairment (aMCI). Cerebral small vessel disease, as evidenced by white matter hyperintensities (WMHs), is linked to frontal dysfunction. This study was undertaken to evaluate the relationship between PM decline and WMHs in patients with aMCI. Methods: Of 74 enrollees with aMCI, 69 completed this prospective study. We compared total scores and sub-scores of the Prospective and Retrospective Memory Questionnaire (PRMQ) administered at baseline and 3 months later, stratifying patients by degree of WMHs. Results: A significant decline was seen in PRMQ total scores and PM scores at the 3-month mark in patients with moderate (vs. mild) degrees of WMHs (−2.8±7.2 vs. 0.2±7.1; p =0.032). In addition, patients with moderate (vs. mild) degrees of deep WMHs (DWMHs) showed greater PM decline, whereas PM loss in patients with mild, moderate, or severe degrees of periventricular WMHs (PVWMHs) did not differ significantly. Conclusions: Findings of this study indicate that the burden of WMHs is consistently implicated in PM deterioration experienced by patients with aMCI, and signifies greater PM decline, especially in instances of extensive DWMHs. Greater attention to the change of PM is therefore needed in aMCI patients with WMHs.
윤보라 ( Bo Ra Yun ),이명호 ( Myung Ho Lee ),이혜순 ( Hye Sun Lee ),최윤영 ( Yoon Young Choi ),김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),배상철 ( Sang Cheol Bae ),유대현 ( Dae Hyun Yoo ) 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.4
Objective: Insufficiency fracture (IF) occurs when normal or physiological muscular activity stresses a bone that is deficient in mineral or elastic resistance. We studied clinical characteristics of IF in patients with chronic inflammatory joint diseases in Korea. Methods: Between Aug. 1997 and Feb. 2003, thirty five patients with 77 fractures were studied at the authors` institution when they were being treated for their rheumatic diseases. The clinical and laboratory data were collected by review of medical record retrospectively. Results: All patients except four were postmenopausal women (mean age 63.0±10.0 years) with long disease duration (mean 14.2±11.6 years). Thirty three patients had rheumatoid arthritis, 1 ankylosing spondylitis and 1 systemic lupus erythematosus. Twenty nine patients (85.7%) were receiving regular steroid treatment (mean dose 4.0±2.3 mg/day, mean duration 6.1±4.2 years). Twenty four patients were treated with methotrexate. The significant reduction in their bone mineral density was found 27 patients based on BMD or QCT. Eight patients without osteoporosis were treated with steroid or MTX. Twenty three patients were ever used for osteoporosis treatment. Most patients except four presented with pain in the low back, groin, hip, pelvic, leg and knee. Initial simple radiography was positive in only 7 patients, with vertebral compression fracture in 11 patients and no effect on mobility except ten. Diagnosis was delayed (mean duration of symptom until diagnosis was 45.6±64.5 days). IF was confirmed using the bone scan. Sacrum and pelvic bone was most frequently affected site. The other sites were SI joint, iliac wing, symphysis pubis, acetabulum and femur neck. Twenty nine patients required in-patient stay (mean 17.4 days). All but one patient showed an uneventful recovery with conservative treatment. Conclusion: The low grade nature of symptoms, minimal effect on mobility, absence of significant trauma and missed on initial plain radiography make diagnosis difficult and delayed. IF should be suspected in cases of unexplained pain with local tenderness in patients of chronic inflammatory joint diseases. The technetium-99m diphosphonate bone scintigraphy was valuable diagnostic tool in the early recognition of IF.