반세기 한국경제의 산 증인-최호진 박사

윤기중,Yun, Gi-Jung 한국대학교육협의회 2000 大學敎育 Vol.106 No.-

악하선의 석회화를 동반한 타액선 관암종의 세침흡인 세포학적 소견 - 1예 보고 -

윤기중,한원철,조향정,이광만,Yun, Ki-Jung,Han, Weon-Cheol,Jo, Hyang-Jeong,Lee, Kwang-Man 대한세포병리학회 2001 대한세포병리학회지 Vol.12 No.1

Salivary duct carcinoma is an uncommon aggressive malignant epithelial neoplasm with similarity to intraductal carcinoma of the breast. This neoplasm occurs most often in the parotid gland of middle-aged and older males. About 7% of reported tumors occured in the submandibular gland. The report of salivary duct carcinoma with calcification is rare. We report a case of salivary duct carcinoma with calcification in the submandibular gland. The patient was a 73-year-old male with a mass of the right submandibular gland for 1 year. On the fine needle aspiration cytology, the aspirate showed scant cellularity, small clusters of tumor cells, and scattered small calcifications. Nuclei of the tumor cells showed mild pleomorphism and round to oval in shape, and cytoplasm was abundant and finely granular. Nucleoli were indistinct and necrosis was not noted. There were no cribriform or papillary arrangements of tumor cells. Cytologlc findings of salivary duct carcinoma are variable depending on histologic findings, and calcifications could be an additional cytologic findings.

위장판 : 허혈 대장염에서 Heme Oxygenase-1 발현

윤기중 ( Ki Jung Yun ),최석채 ( Suck Chei Choi ),오재민 ( Jay Min Oh ) 대한소화기학회 2005 대한소화기학회지 Vol.45 No.5

위장관 34 : 만성 궤양성 대장염에서 Ki - 67 및 Apoptosis 발현

윤기중(K . J . Yun),최석채(S . C . Choi),나용호(Y . H . Nah) 대한소화기학회 1998 대한소화기학회 추계학술대회 Vol.1998 No.-

Heme Oxygenase-1 is Involved in the Down-regulation of Nuclear Transcription Factor κB Activation in the Colonic Epithelium During Inflammation

윤기중(Ki Jung Yun),김유림(Yu Rim Kim),이홍재(Heung Jae Lee),김경숙(Kyoung Suk Kim),권영미(Young-Mi Kwon),최민규(Min Kyu Choi),오재민(JaeMin Oh),정연태(Yeun Tai Chung) 대한해부학회 2004 Anatomy & Cell Biology Vol.37 No.6

HO-1은 스트레스에 의해 유도되는 효소로 그 항염증작용에 대한 기전은 거의 밝혀지지 않고 있다. NF-κB 활성은 만성 염증성 대장염을 일으키는데 관여하는 매우 중요한 인자이다. 우리는 대장염에서 NF-κB 활성과 HO-1 사이의 관계에 대하여 조사하였다. 정상인에 비하여 염증성 대장염이나 acute pesudomembranous colitis를 가진 환자에서 대장의 상피조직의 HO-1의 발현이 현저히 감소하였다. 또한 사람 대장상피세포주인 HT-29세포에서 TNF-α와 IL-1β 등의 사이토카인들은 HO-1의 발현을 억제하였다. HO-1의 유도제인 CoPPIX는 TNF-α에 의한 NF-κB 활성을 억제하였다. 또한 HO-1의 대사물질인 일산화탄소와 빌리루빈 역시 TNF-α에 의한 NF-κB 활성을 억제하였다. 그러나 다른 대사물질인 철은 TNF-α에 의한 NF-κB 활성을 억제하는데 아무런 효과가 없었다. 재미있게도 CoPPIX는 TNBS에 의해 유도된 만성 대장염을 현저히 개선하였고 궤양성 대장염의 동물모델에서도 NF-κB 활성을 억제하였다. 이상의 결과로 CoPPIX는 NF-κB 활성의 억제를 통해서 TNBS에 의해 유도된 만성 대장염의 증상들을 개선시킨다고 생각되었고 HO-1은 만성 염증성 대장염을 치료하는데 중요한 타겟물질이라고 생각하였다. Heme oxygenase-1 (HO-1) is a stress-inducible enzyme with anti-inflammatory activity, but the mechanisms underlying this activity are incompletely understood. Nuclear transcription factor κB (NF-κB) activation is an important factor in the pathogenesis of inflammatory bowel disease (IBD). We investigated the suppressive effects of HO-1 on the activation of NF-κB by pro-inflammatory cytokines in cultured colonic epithelial cells and by trinitrobenzene sulfonic acid (TNBS) in the colon of mice. The expression level of HO-1 in the colonic epithelium of a patient with inflammatory bowel disease and pseudomembranous colitis was lower than that in a healthy control subject. In cultured human colonic epithelial HT-29 cells, pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and IL-1β down-regulate HO-1 expression. The HO-1 inducer, cobalt protoporphyrin IX (CoPPIX), dramatically down-regulated NF-κB activation in HT-29 cells by TNF-α. In addition, bilirubin-a product of heme catabolism by HO-1-and the carbon monoxide donor tricarbonyldichlororuthenium (II) dimer also suppressed NF-κB activation by TNF-α. However, iron, another heme metabolite, did not suppress NF-κB activation by TNF-α. Furthermore, CoPPIX diminished the macroscopic and histopathological symptoms of TNBS-induced colitis and down-regulated NF-κB activation in mice. In conclusion, this study suggests that HO-1 plays an important role in the down-regulation of NF-κB activation, which is a key factor in the pathogenesis of IBD and is thus an excellent therapeutic target for the treatment of IBD.

IEEE - 1394 네트웍 기반 분산형 로봇 제어기의 소프트웨어 구조에 관한 연구

윤기중(Gi-Jung Yun),박재현(Jae-Hyun Park),김홍석(Hong-seok Kim) 한국정보과학회 2003 한국정보과학회 학술발표논문집 Vol.30 No.2Ⅲ

현재 대부분의 로봇 제어용 네트웍으로는 FieldBus 등이 사용되고 있다. 그러나 로봇 시스템의 고성능화와 다양한 기능으로 인하여 기존의 FieldBus가 제공하던 기능으로는 대역폭에서나 성능면에서 부족한 점이 나타나고 있다. IEEE1394는 이러한 로봇 제어용 네트웍에 매우 적합한 특성을 갖고 있다. 본 논문에서는 IEEE1394가 로봇 제어용 네트웍에 사용될 때 가질 수 있는 실시간성과 신뢰성 특징에 대해 분석해보고, IEEE1394의 특성을 잘 살릴 수 있는 제어용 소프트웨어 구조에 대해 연구하고 이를 구현한다. 실시간성 데이터를 위해서는 우선순위 큐를 이용한 패킷 전송방법을, 주기적 데이터를 위해서 동시성 전송방법을 이용한다.

일본의 신고제도

윤기중(Yun, Ki-Jung) 경희법학연구소 2017 경희법학 Vol.52 No.2

신고는신청과함께행정법상대표적인사인의공법행위이다. 이러한신고는공행정분야에서 사인이 행위주체로 등장하는 대표적인 예라는 점에서 결코 간과할 수 없는 주제이다. 그간 신고와 관련해 꾸준한 연구가 진행되어 왔고 소기의 성과도 있었다. 그러나 아직도신고와 관련해서는 해결해야 할 여러 문제가 남아있다. 이러한 문제 해결의 일환으로 우리나라와유사한 법체계를갖고 있고신고와 관련해서도일부같은 문제를안고 있는일본의예를 살펴보았다. 신고제도에관한논의에있어서는분쟁발생이후의쟁송법상논의못지않게, 분쟁발생이전신고자에게는 신고처리절차에 대한예측가능성을, 공무원에게는 그처리방향을, 입법자에게는 다른 규제 수단과 구분되는 입법의 기준을 제시해주는 것 역시 중요하다. 따라서쟁송법상 수리(거부)의 처분성 논의뿐만 아니라 절차상 문제, 신고의 요건과 심사, 수리의요부 등 쟁송전후의 문제를 균형감 있게 다루고자 하였다. 이러한목표로살펴본결과, 신고의종류에관한논의에있어서는우리와큰차이는없었다. 다만, 우리에게는 없는 일본의 명령 권고유보부 신고의 분류가 있어 이에 관해 좀 더살펴보았다. 일본 역시 적법한 신고여부에 대한 신고자와 행정청간의 판단의 차이로 인한 분쟁, 허가제가 신고제로 규제완화 되었음에도 불구하고 실무상 여전히 허가제처럼 운용되는문제가있었다. 신고의요건과심사와관련해서는일본의경우는관련용어와간단한개념 설명 정도의 논의만 있을 뿐 구체적으로 다룬 글은 발견하지 못했다. 수리 개념의 요부문제는 신고와 행정구제의 문제로까지 이어지는데, 이는 곧 행정절차법상의 신고에 대한수리(접수)거부의 처분성 및 소송형태와 관련된다. 일본과 달리 우리는 아직 소송형태에 관한 한 항고소송만을 전제로 하고 있을 뿐 공법상 당사자소송으로서의 신고의무이행확인소송과 같은 소송형태는 인정하지 않고 있다. 그러나 당사자소송의 대상 확대나 활성화 차원 에서라도 이를 고려해봄 직하다. Reporting system is typical individual public law act in administrative law with the application. It is a subject that can not be ignored in public administration in terms of a few cases in which individual appears as actors. In the meantime, steady research has been conducted in relation to the reporting system and there have been some achievements. However, there are still many problems to be solved. In this regard, I have examined the case of Japan which has a legal system similar to our country and is also concerned with reporting. As a result of the comparative legal research, I confirmed that ours are discussed at a more specific classification stage. In Japan also various types of disputes are occurring in the reporting process, such as the dispute between the reporter and the administrative office about the legality of the report. Regarding the requirements for the report and the judging in Japan, there is only a discussion about the terms and a brief description of the concept, but there are no articles dealing specifically with it. The problem of the concept of reception also leads to the problem of report and administrative relief, which is related to the disposition nature of the denial of reception in the administrative procedure law and the form of litigation. In this regard, we are still presupposing only an appeal litigation in respect of the form of litigation, and we have not yet considered a form of litigation such as a confirmation litigation about the fulfillment of reporting duty. However, I think it is meaningful to take this into consideration in terms of expanding or revitalizing the party litigation.

Polystyrene Latex Bead에 의한 뇌혈관연축 모델에서 K⁺ 통로활성제의 전신투여

장성조,강성돈,윤기중,Jang, Sung Jo,Kang, Sung Don,Yun, Ki Jung 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.6

Objectives : It has been reported that the presence of a pharmacologically inactive foreign substance, polystyrene latex bead, in subarachnoid space activates a non-specific immunological response and elicits arterial narrowing. Recently the activation of potassium($K^+$) channels may be of benefit in relieving cerebral vasospasm. The present study examined the effects of systemic administration of a ATP-sensitive $K^+$ channel activator, cromakalim, on the polystyrene latex bead-induced cerebral vasospasm. Methods : The spasm models similar to that caused by subarachnoid blood injection were created by injection of bead into rabbit cisterna magna. Intravenous injections of cromakalim were administered twice daily(bid) 30 minutes after induction of vasospasm. Animals were killed by perfusion-fixation 2 days after vasospasm. Basilar arteries were removed and sectioned, and the luminal cross-sectional areas were measured. Results : Injection of bead elicited an arterial constriction, reducing arterial diameter to 33.3% of resting tone. Cromakalim inhibited bead-induced constriction at a dose of 0.3mg/kg(Mann-Whitney test, p<0.01). Conclusion : These results support the concept that the cellular events triggered by inactivation of ATP-sensitive $K^+$ channels are responsible for the pathogenesis of vasospasm. The findings also indicate that cromakalim represents a potential therapeutic agents for the treatment of cerebral vasospasm.

아래눈꺼풀에 발생한 원발성 반지세포암종 1예

신선애,김상덕,윤기중,Seon Ae Shin,Sang Duck Kim,Ki Jung Yun 대한안과학회 2014 대한안과학회지 Vol.55 No.4

Purpose: To report a rare case of a painless mass on the lower lid, histologically diagnosed as primary signet ring cell carcinoma of the eyelid. Case summary: A 74-year-old male presented with a painless mass on the right lower lid which had developed seven months prior to presentation. Incisional biopsy of the mass and attached lower lid skin was performed, revealing signet ring cell carcinoma. A systemic evaluation, including whole body positron emission tomography-computed tomography (PET-CT), chest CT, abdomen and pelvis CT, gastrointestinal endoscopy, and colonoscopy, revealed no other abnormal lesions. Therefore, the eyelid lesion was considered primary signet ring cell carcinoma of the skin and was treated with radiotherapy of 6600 cGy in 33 fractions over 7 weeks. Conclusions: Herein, the authors report a rare case of primary signet ring cell carcinoma of the eyelid with no evidence of tumor recurrence or metastasis for 5 years after radiotherapy. J Korean Ophthalmol Soc 2014;55(4):611-615

세침흡인 세포검사로 진단된 인두주위에 발생한 신경절 신경종 - 1예 보고 -

이지신,조향정,윤기중,문형배,Lee, Ji-Shin,Cho, Hyang-Jeong,Yun, Ki-Jung,Moon, Hyung-Bae 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.2

Ganglioneuromas are a fully differentiated tumor that contains no immature elements. The majority of sanglioneuromas are diagnosed in patients older than 10 years and are most often located in the posterior mediastinum, followed by the retroperitoneum. The location of these tumors in the parapharyngeal region is extremely uncommon and there are only a few reports on the cytologic appearance of the tumor. We report a case of ganglioneuroma presenting in a parapharyngeal location in a 4 year-old boy, diagnosed by fine needle aspiration cytology. The smears revealed scattered large oval to polygonal cells with voluminous, granular cytoplasms. The nuclei were one to two in number and had a prominent nucleolus. Clusters of benign spindle-shaped cells were also present.