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유창훈,오충렬,김승태,배우균,최혜진,오도연,이명아,류백렬 대한암학회 2021 Cancer Research and Treatment Vol.53 No.2
Neuroendocrine tumors (NETs) are a group of malignancies arising from neuroendocrine cells and frequently originate in the gastrointestinal tract and pancreas. Although curative resection is the main treatment for localized disease, systemic therapy is needed for relapsed or metastatic/unresectable gastroenteropancreatic NETs (GEP-NETs). Although there are several NET treatment guidelines from various countries, the geographical discrepancies between patient clinical characteristics, the regulatory approval status for therapeutic agents, and medical practices necessitate specific guidelines for Korean patients. We here provide a consensus review of the diagnosis, staging and systemic treatment of Korean GEP-NET patients. Systemic therapy options and the current Korean expert consensus on these treatments, including somatostatin analogs, targeted therapies such as everolimus and sunitinib, peptide receptor radionuclide treatments, and cytotoxic chemotherapies are addressed.
유창훈,문종필,이현철,이상진,양기은,박기득,이성재 대한인간공학회 2009 대한인간공학회 학술대회논문집 Vol.2009 No.5
최근 국내에서 개발되고 있는 고령친화용 컴포트화 시제품들의 생체역학적 기능성 분석의 일환으로 34명의 남녀노인을 대상으로 족저압 (plantar pressure)을 측정하여 유명 수입제품과 상대적 비교분석을 수행하였다. F-Scan을 이용하여 족저부를 8개의 planter region으로 나누어 피검자 보행시 Peak Contact Pressure를 분석한 결과, 국산 시제품이 전반적으로 수입 완제품에 비해 전 구역에서 족저압 pattern의 차이를 보였고, VAS를 이용한 착용감 점수도 상대적으로 낮은 것으로 파악되어 디자인 및 재질 개선의 필요성을 확인할 수 있었다.
혈역학적 삼첨판 협착증을 동반한 간세포 암종의 심장내 전이와 동시에 발생한 간폐증후군 1예
유창훈,김수홍,김경찬,김재균,김일수,강욱 대한노인병학회 2008 Annals of geriatric medicine and research Vol.12 No.4
Intracardiac m etastasis of hepatocellular carcinom a w ith functional tricuspid valve stenosis is not com m on. Furtherm ore, hepatopulm onary syndrom e associated w ith hepatocellular carcinom a is rarely encountered. W e present a case of intracardiac m etastasis of hepatocellular carcinom a presenting w ith functional tricuspid valve stenosis accom panied w ith hepatopulm onary syndrom e.
Serum beta-2 microglobulin in malignant lymphomas: an old but powerful prognostic factor
유창훈,윤덕현,서철원 대한혈액학회 2014 Blood Research Vol.49 No.3
Beta-2 microglobulin is synthesized in all nucleated cells and forms the light chain subunit of the major histocompatibility complex class I antigen. Despite its potential role as a con-venient and non-invasive prognostic indicator in malignant lymphomas, the influence of serum β2 microglobulin is currently underestimated, and therapeutic decision making is rarely affected by this marker. Recent studies that included relatively large numbers of patients with specific histologic subtypes showed that serum β2 microglobulin is a po-tent prognostic marker in malignant lymphomas. In follicular lymphoma, this effort led to the incorporation of serum β2 microglobulin as an indicator in a new prognostic model. In this review, we summarize the current evidence supporting the role of serum β2 micro-globulin as a prognostic factor in patients with malignant lymphoma and discuss per-spectives for future investigations.
Relationship between Dietary Mercury Intake and Blood Mercury Level in Korea
유창훈,김병권,김유미,이상아,김록범,서정욱,홍영섭 대한의학회 2014 Journal of Korean medical science Vol.29 No.2
This study was performed to evaluate the effect of dietary factors for mercury exposure by comparing with blood mercury concentration. Study population consisted of 1,866 adults (839 men and 1,027 women) in randomly-selected 30 districts in southeast Korea. Dietary mercury intake was calculated from food frequency questionnaire (FFQ) on seafood items and 24 hr recall record. Blood mercury concentration was measured with atomic absorption spectrometry. Mean age of the subjects was 43.5±14.6 yr. The FFQ showed that mercury-laden fish (tuna, shark) and frequently-eating fish (squid, belt fish, mackerel) were important in mercury intake from fish species. The recall record suggested that fish and shellfish was a highest group (63.1%) of mercury intake and had a wide distribution in the food groups. In comparison with the blood mercury concentration, age group, sex, household income, education, drinking status and coastal area were statistically significant (P<0.001). In multiple regression analysis, coefficient from the FFQ (β=0.003) had greater effect on the blood mercury than the recall record (β=0.002), but the effect was restricted (adjusted R2=0.234). Further studies with more precise estimation of dietary mercury intake were required to evaluate the risk for mercury exposure by foods and assure risk communication with heavily-exposed group.
유창훈,김성배,노정실,임석아,임영혁,김지현,안진희,정경해,송홍석,강석윤,박희숙,정현철 대한암학회 2016 Cancer Research and Treatment Vol.48 No.2
Purpose This study analyzed the role of plasma biomarkers for TSU-68 in a previous phase II trial comparing TSU-68 plus docetaxel and docetaxel alone in patients with metastatic breast cancer. Materials and Methods A total of 77 patients were eligible for this study (38!in the TSU-68 plus docetaxel arm and 39 in the docetaxel alone arm). Blood samples were collected prior to the start of each cycle, and vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF)- AA, -AB, -BB, fibroblast growth factor, M30, C-reactive protein (CRP), and interleukin 6 (IL-6) levels were measured using enzyme linked immunosorbent assay. The primary endpoint was progression-free survival (PFS). Results In patients with baseline PDGF-AA " median, median PFS was significantly worse in the TSU- 68 plus docetaxel group than in the docetaxel alone group (5.4 months vs. 13.7 months, p=0.049), while a trend toward a PFS benefit was observed in those with baseline PDGFAA < median (9.7 months vs. 4.0 months, p=0.18; p for interaction=0.03). In the TSU-68 plus docetaxel group, PFS showed significant association with fold changes in CRP (p=0.001), IL-6 (p < .001), PDGF-BB (p=0.02), and VEGF (p=0.047) following the first treatment cycle. Conclusion Baseline PDGF-AA levels and dynamics of VEGF, PDGF-BB, CRP, and IL-6 levels were predictive for the efficacy of TSU-68.
유창훈,김성배,안진희,김정은,정경해,공경엽,손병호,안세현,안승도,김학희,신희정,김우건 대한암학회 2015 Cancer Research and Treatment Vol.47 No.3
Purpose Given the promising activity of capecitabine and vinorelbine in metastatic breast cancer, this randomized phase II trial evaluated the efficacy and safety of this combination as neoadjuvant chemotherapy in breast cancer. Materials and Methods Patients with operable breast cancer (n=75) were randomly assigned to receive either four cycles of adriamycin 60 mg/m2 plus cyclophosphamide 600 mg/m2 every 3 weeks followed by four cycles of docetaxel 75 mg/m2 every 3 weeks (AC-D) or four cycles of capecitabine 2,000 mg/m2 (day 1-14) plus vinorelbine 25 mg/m2 (days 1 and 8) every 3 weeks followed by four cycles of docetaxel 75 mg/m2 (CV-D). The primary endpoint was pathologic complete response (pCR) in the primary breast (ypT0/is). Results Most patients (84%) had locally advanced (n=41) or inflammatory breast cancer (n=22). pCR rates in the primary breast were 15% (95% confidence interval [CI], 7% to 30%) and 11% (95% CI, 4% to 26%) in the AC-D and CV-D groups, respectively. The overall response rates and 5-year progression-free survival rates in the AC-D and CV-D groups were 62% and 64%, and 51.3% (95% CI, 34.6% to 68.0%) and 30.2% (95% CI, 13.3% to 47.1%), respectively. Although both regimens were well tolerated, CV-D showed less frequent grade 3-4 neutropenia and vomiting than AC-D, whereas manageable diarrhea and hand-foot syndrome were more common in the CV-D group. Conclusion CV-D is a feasible and active non-anthracycline–based neoadjuvant chemotherapy regimen for breast cancer.