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압궤손상된 백서의 좌골신경에서 구형파 전기 자극이 기능회복에 미치는 효과
유석근 大韓成形外科學會 1997 Archives of Plastic Surgery Vol.24 No.1
Effects of square-pulse stimulation on the functional recovery following a nerve injury were examined in rats. A crush injury was made on the sciatic nerve under ketamine anesthesia and square-pulse stimulation with 5-7 V,0.2ms, 20 Hz, and 5 sec ON-OFF type was applied to the lesion site through teflon coated stainless steel wires(0.45mm in diameter) for 4 hours per day up to 2 days. Motor evoked potential(MEP) of the tibial nerve and somatosensory evoked potential (SSEP) of the T12 spinal cord were recorded. And their threshold, amplitude and latency were then analyzed. 1.Threshold off MEP was 41±5 uA, and that of SSEP was 39±13 uA. 2.MEP was composed of 3 waves, i.e.,N1,N2,N3,in which N1 was conducted by Aα fibers and the others by the synaptic fibers from the spinal cord. 3.SSEP was also composed of 3 waves, in which N1 was conducted by IA,N2 to Ⅱ, and N3 to Ⅲ fibers. 4.MEP and SSEP were abolished immediately after crush injury and SSEP was more sensitive. N1 disappeared faster than N2 and N3. 5.Evoked potentials were abolished by application of local anesthetics, in which N2 and N3 were more sensitive than N1. 6.Electrical stimulation decreased thresholds of evoked potentials down to50% in MEP, and 30% in SSEP. 7.Electrical stimulation increased amplitudes of evoked potentials and decreased latencies following an injury.