강단 (講壇) : 학불자일람 (學佛者一覽) / 이제 (伊齊) 유경종 (劉敬鍾)

유경종 조선불교월보사 1912 朝鮮佛敎月報 Vol.9 No.-

사자후 (獅子吼) : 변사집현정리설 (辨邪執顯正理說) 속 (續)

유경종 조선불교월보사 1915 朝鮮佛敎月報 Vol.15 No.-

Smooth Muscle Cells Transplantation is better than Heart Cells Transplantation for Improvement of Heart Function in Dilated Cardiomyopathy

유경종,Ren-Ke Li,Richard D. Weisel,Donald A.G. Mickle,Shinji Tomita,Nobu Ohno,Takeshiro Fujii 연세대학교의과대학 2002 Yonsei medical journal Vol.43 No.3

Muscle cell transplantation may delay or prevent cardiac dilation in dilated cardiomyopathy. The present study was designed to compare the effects of the heart function of smooth muscle cell (SMCs) auto-transplantation and heart cell (CMs) allo-transplantation in dilated cardiomyopathic hamsters, and to determine which cells are better for cell transplantation. CMs and SMCs were isolated from BIO 53.58 hamsters, and cultured for transplantation. CMs, SMCs (4×106 cells each) or culture medium were transplanted into 17 weeks old BIO 53.58 hamsters to achieve CM transplantation (CMTx), SMC transplantation (SMCTx), and controls (Con) (N=10 each). Cyclosporine (5mg/Kg) was administered subcutaneously to CMTx. Healthy hamsters (sham, N=6) were used to compare heart functions. Four weeks after transplantation, heart function was evaluated in all groups using a Langendorff perfusion apparatus. Histology demonstrated severe focal myocardial necrosis in the dilated cardiomyopathic hearts. CMTx and SMCTx formed huge muscle tissue in the dilated myocardium. Sham, SMCTx, and CMTx had a better heart function than Con (p<0.01), and SMCTx had a better peak systolic pressure (p<0.05) and developed pressure (p<0.05) than CMTx at any balloon volume. However, sham and SMCTx were not statistically different. SMCTx and CMTx formed muscle tissue and produced better heart function in the cardiomyopathic hearts, and SMCTx showed better systolic and developed pressures than CMTx, even though they were similar in other functions. Significantly, SMCTx had heart functions, which were similar to those of healthy hamster's hearts.

Autologous Bone Marrow Cell Transplantation Combined with Off-Pump Coronary Artery Bypass Grafting in Human Ischemic Myocardium

유경종,김현옥,곽영란,강석민,장양수,임상현,안지영,Ren-Ke Li 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.SUP

Recently, autologous bone marrow cell transplantation (CTx) for angiogenesis and myogenesis in ischemic myocardium has been extensively investigated to improve heart function. This study was designed to evaluate the effects of CTx with off-pump coronary artery bypass grafting (OPCAB) in patients who were not feasible for complete revascularization. Seven male patients underwent CTx combined with OPCAB in 5, CTx only in 1, and mitral valve repair in 1 patient simultaneously. Bone marrow was aspirated from iliac bone. Mean 1.5×109 mononuclear cells including mean 7.3×106 CD34+ cells and 2.4×106 AC133+ cells were obtained and concentrated with 10cc. These cells were transplanted into non-graftable ischemic myocardium. Heart function was evaluated in all patients using MIBI scan, echocardiogram and heart magnetic resonance imaging (MRI) preoperatively. The effect of CTx was evaluated using MIBI scan, echocardiogram, and MRI postoperatively. An average of 2 grafts were bypassed. Other territories were transplanted with isolated mononuclear cell. All patients had an uncomplicated postoperative course. After 2 to 7 months follow-up, there was improvement in symptom, ejection fraction (from 43% to 47%) on echocardiogram and myocardial perfusion on MIBI scan and MRI in all patients. These preliminary data showed improvement of heart function and myocardial perfusion and also showed the feasibility and safety of combined therapy with OPCAB and CTx in ischemic myocardium. However, the effectiveness of CTx alone cannot be readily assessed. Further randomized, controlled studies are required to evaluate the effectiveness of CTx alone.

동면심근을 가진 관상동맥 환자의 수술 후 기능회복의 예측에 대한 임상적 고찰 - Dobutamine 심초음파의 역할 -

유경종,강면식,이교준,김대준,임세중,정남식 대한흉부심장혈관외과학회 1998 Journal of Chest Surgery (J Chest Surg) Vol.31 No.8

배경: 심각한 국소적 심실 운동장애를 동반한 관상동맥질환 환자에서 관상동맥 우회로술을 계획할 때 수술 후 심실 운동장애가 동반된 부위의 운동회복 가능성 여부가 심실 운동장애를 일으킨 관상동맥에 혈관이식 여부를 결정하는 중요한 요소가 된다. 수술 후 회복될 수 있는 동면심근을 알아보기 위한 방법으로 Stress Thallium-201 Single Photon Emission Computed Tomography가 있으며, 최근에 들어 Positron Emission Tomography 및 도부타민 심초음파 등이 이용되고 있다. 저자들은 검사방법이 비교적 간단하고 빠르며, 경제적으로도 비교적 저렴한 도부타민 심초음파를 이용하여 이를 예측할 수 있는지 알아보고자 하였다. 대상 및 방법: 연구방법은 1995년 10월부터 1997년 5월까지 연세대학교 심장혈관센터에서 관상동맥 우회로 술을 시행받았던 환자중 심각한 국소적 심실벽 운동장애의 수술 후 회복여부를 도부타민 심초음파로 예측하였던 16명의 환자를 대상으로 하였으며, 1개월이내의 급성심근경색증을 가진 환자는 제외하였다. 결과: 16명 모두 남자였으며, 연령은 42세에서 73세 사이로 평균 58.4$\pm$9.5세 였다. 수술전 심근경색증의 기왕력이 12례에서 있었고, 좌심실박출계수는 19%에서 55% 사이로 평균 41.8$\pm$11.1%였다. 수술시 사용한 이식편수는 평균 3.2$\pm$0.8개였다. 도부타민 심초음파(baseline, 5, 10, 20 g/kg/min) 는 수술전 1일에서 33일 사이에 시행하고 (평균 13$\pm$10.5일), 수술 후 2개월에서 21개월 사이에(평균 9.6$\pm$5.9 개월) 추적 심초음파를 시행하여 심실운동의 변화를 관찰하였다. 좌심실을 16개 분절로 나누어 각각의 분절에 대하여 semiquantitative scoring system(1: normal , 2: mild to moderate hypokinesia, 3: severe hypokinesia, 4: akinesia, 5: dyskinesia) 으로 분석하였으며, 심실운동의 호전은 2개 이상의 인접한 분절에서 동시에 wall motion score 1 이상의 호전이 관찰되는 경우로 정의하 였다. 결과를 보면 수술전 도부타민 심초음파에서 국소적 심실운동의 호전을 보인 환자는 8명이었으며, 이중 추적 심초음파에서 6명이 심실운동의 회복을 보였고 수술전 도부타민 심초음파에서 심실운동의 호전을 보이지 않았던 환자 8명중 3명에서 추적 심초음파에서 심실운동의 회복을 보였다. 안정시 severe hypokinesia, akinesia, dyskinesia 의 심실운동을 보이는 분절은 총 84개였으며 수술전 도부타민 심초음파에서 호전되었던 31개 분절중 23개 분절에서, 호전 되지 않았던 53개 분절중 12개 분절에서 추적 심초음파에서 회복됨을 관찰하여 관상동맥우회로술 후 심실운동 회복의 예측에 있어 도부타민 심초음파의 민감도는 66%, 특이도는 84% 였으며, positive predictive value는 74%, negative predictive value는 77%였다. 결론: 결론적으로 수술전 도부타민 심초음파는 관상동맥우회로술 후 동면심근의 기능회복에 대한 예측에 도움이 되리라 생각된다. Background: In patients with coronary artery disease, dysfunctional hypoperfused myocardium at rest may represent either nonviable or viable hibernating myocardium. Two-dimensional echocardiography can detect regional wall motion abnormalities resulting from myocardial ischemia by dobutamine infusion. The purpose of the present study was to identify the prediction of improvement of regional left ventricular(LV) function after surgical revascularization. Materials and methods: Sixteen patients with chronic regional LV dysfunction underwent dobutamine stress echocardiography(DSE) (dobutamine: baseline, 5, 10, 20$\mu$g/kg/min) before coronary artery bypass grafting(CABG) and underwent echocardiography at least 2 months after CABG. Results: All patients were male with mean age of 58 years ranging from 42 to 73 years. The mean LV ejection fraction was 41.8% with a range from 19% to 55%. During DSE, there were no complications, also, there were no operative morbidities or mortalities. Improvement of wall motion within the dysfunctional myocardium was found in 8(50%) of 16 patients in DSE. Among them, 6 patients(75%) showed functional recovery after CABG. Another 8 patients did not show improvement of wall motion in DSE. But among them, 3 patients(38%) showed functional recovery after CABG. 84 dysfunctional segments were found in 256 segments of 16 patients. Improvement of wall motion was found in 34 of 84 segments in DSE. Among them, 23 segments(74%) showed functional recovery after CABG. Another 53 segments did not show improvement of wall motion in DSE. But among them, 12 segments(23%) showed functional recovery after CABG. The sensitivity and specificity of DSE for the prediction of postoperative improvement of segmental wall motion were 66% and 84%, respectively. The positive and negative predictive value of DSE were 74% and 77%, respectively. In patients with chronic regional LV dysfunction, think that DSE is a good predictor of the improvement of dysfunctional segments after CABG.

적응잡음 제거기에서 퍼지 논리를 이용한 수렴율에 관한 연구 ( A Study of the Convergence Rate Using Fuzzy Logic in an Adaptive Noise Canceller )

유경종,채창현,김학성,최한고 대한전자공학회 1995 대한전자공학회 학술대회 Vol.1995 No.1

기능적 삼첨판 폐쇄부전증 환자에서 판막륜 성형술의 효과

유경종 대한흉부심장혈관외과학회 1995 Journal of Chest Surgery (J Chest Surg) Vol.28 No.9

Ninety-one adult patients underwent three different methods of annuloplasty and compared them by the amount of tricuspid regurgitation. Group I [n=17 is Kay method, Group II [n=46 is modified Kay method and Group III [n=28 is De Vega and modified De Vega method. Preoperative and postopeative size of the liver and its function, the cardiothoracic ratio, EKG and echocardiogram were analyzed. The follow up was done for all the patients [mean 20.0$\pm$ 8.5 months . The postoperative size of the liver, the postoperative cardiothoracic ratio and the postoperative systolic pressure of the right ventricle decreased significantly compared to preoperative size, ratio and pressure [p=0.0001, p=0.0001, p=0.0001 . But there were no differences between the groups. The results of annuloplasty revealed that tricuspid regurgitation improved postoperatively [p=0.0001 even though there was no statistically significant differences in relation to the methods of annuloplasty. The right ventricular systolic pressure and the amount of regurgitation decreased significantly during the postoperative period by performing 3 different methods of annuloplasty, although we could not find the differences between the three different methods.

On Pump-CABG와 Off Pump-CABG의 임상적 고찰에 관한 비교연구

유경종,임상현,송석원,김치영,홍유선,장병철 대한흉부외과학회 2002 Journal of Chest Surgery (J Chest Surg) Vol.35 No.4

=The Comparison of Clinical Study of Off Pump and On Pump CABG

대학도서관 이용조사를 통한 경영개선 연구

유경종,박일종 한국정보관리학회 2007 정보관리학회지 Vol.24 No.3

The books and circulation-related data in the Library Automation System(LAS) of C-academic library were collected and analyzed, and also the method which may be applied to the Customer Relationship Management (CRM) based on the results was suggested in this paper. Collected data were 269,387 bibliographic data of books, 12,281 patron data, and 39,269 circulation records. User identity, circulation frequencies, total number of circulated books, and publication year as relation factor from the analyzed data of circulation records were extracted. They were also analyzed, and verified by correlation coefficient. 본 논문은 C대학도서관의 학술정보시스템(LAS)에 구축되어 있는 장서와 대출기록 및 고객관련 데이터를 수집하여 이를 분석하고 그 결과를 고객관계관리(CRM)에 적용할 수 있는 방안을 제시하였다. 수집된 자료는 C 대학도서관에서 소장하고 있는 대출이 가능한 단행본 총 269,387책의서지데이타와고객 12,281명의 데이터, 이용자 대출기록 39,269건이었다. 대출기록 분석 데이터에서 관계변수로 이용자 신분, 대출빈도, 대출책수와 대출횟수, 출판년도를 추출하여 데이터 마이닝 기법으로 분석하고, 상관계수로 검증하였다.

강단 (講壇) : 변사집현정리설 (辨邪執顯正理說) ( 속 (續) )

유경종 조선불교월보사 1913 朝鮮佛敎月報 Vol.12 No.-