http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Non-ablative Fractional Thulium Laser Irradiation Suppresses Early Tumor Growth
유수웅,박희진,오경석,황순주,윤미선,왕태준,서영석,민정준,김기현,김응삼,Young L. Kim,정의헌 한국광학회 2017 Current Optics and Photonics Vol.1 No.1
In addition to its typical use for skin rejuvenation, fractional laser irradiation of early cancerous lesions may reduce the risk of tumor development as a byproduct of wound healing in the stroma after the controlled injury. While fractional ablative lasers are commonly used for cosmetic/aesthetic purposes (e.g., photorejuvenation, hair removal, and scar reduction), we propose a novel use of such laser treatments as a stromal treatment to delay tumorigenesis and suppress carcinogenesis. In this study, we found that non-ablative fractional laser (NAFL) irradiation may have a possible suppressive effect on early tumor growth in syngeneic mouse tumor models. We included two syngeneic mouse tumor models in irradiation groups and control groups. In the irradiation group, a thulium fiber based NAFL at 1927 nm was used to irradiate the skin area including the tumor injection region with 70 mJ/spot, while no laser irradiation was applied to the control group. Numerical simulation with the same experimental condition showed that thermal damage was confined only to the irradiation spots, sparing the adjacent tissue area. The irradiation groups of both tumor models showed smaller tumor volumes than the control group at an early tumor growth stage. We also detected elevated inflammatory cytokine levels a day after the NAFL irradiation. NAFL treatment of the stromal tissue could potentially be an alternative anticancer therapeutic modality for early tumorigenesis in a minimally invasive manner.
이광자현미경을 이용한 마우스 안구의 각막, 렌즈에 대한 ex vivo, in vivo 이미징
김기현(Ki Hean Kim),이준호(Jun Ho Lee),윤대근(Daegun Yoon),왕태준(Taejun Wang),손익부,정의헌 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.11
In vivo eye imaging at cellular levels is important to study eye diseases and laser surgery processes. We applied two-photon microscopy (TPM) to in-vivo and ex-vivo imaging of the cornea and lens of mouse eyes. TPM was used to image photodisruption spots of a femtosecond laser associated with cataract surgery and the size and shape of photodisruption spots were measured. In vivo imaging was performed by using a custom made mouse holder and cellular structures of individual corneal layers were visualized with less motion artifact.
이혜련,이재철,권정현,김관창,조민선,양윤선,오원일,최수진,서은석,이상준,왕태준,홍영미 대한의학회 2015 Journal of Korean medical science Vol.30 No.5
Pulmonary arterial hypertension (PAH) causes right ventricular failure due to a gradual increase in pulmonary vascular resistance. The purposes of this study were to confirm the engraftment of human umbilical cord blood-mesenchymal stem cells (hUCB-MSCs) placed in the correct place in the lung and research on changes of hemodynamics, pulmonary pathology, immunomodulation and several gene expressions in monocrotaline (MCT)- induced PAH rat models after hUCB-MSCs transfusion. The rats were grouped as follows: the control (C) group; the M group (MCT 60 mg/kg); the U group (hUCB-MSCs transfusion). They received transfusions via the external jugular vein a week after MCT injection. The mean right ventricular pressure (RVP) was significantly reduced in the U group after the 2 week. The indicators of RV hypertrophy were significantly reduced in the U group at week 4. Reduced medial wall thickness in the pulmonary arteriole was noted in the U group at week 4. Reduced number of intra-acinar muscular pulmonary arteries was observed in the U group after 2 week. Protein expressions such as endothelin (ET)-1, endothelin receptor A (ERA), endothelial nitric oxide synthase (eNOS) and matrix metalloproteinase (MMP)-2 significantly decreased at week 4. The decreased levels of ERA, eNOS and MMP-2 immunoreactivity were noted by immnohistochemical staining. After hUCB-MSCs were administered, there were the improvement of RVH and mean RVP. Reductions in several protein expressions and immunomodulation were also detected. It is suggested that hUCB-MSCs may be a promising therapeutic option for PAH.