http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
한국형 중독 치료지침서(Ⅲ) : 알코올 사용장애의 정신사회 치료
오승헌,이계성,한창우,서정석,조근호,이해국,윤홍균,최삼욱,김현수,이보혜 대한신경정신의학회 2014 신경정신의학 Vol.53 No.4
Objectives The aim of this study is to develop guidelines for psychosocial treatment of alcoholuse disorder. Methods According to the ADAPTE manual, the Korean alcohol use disorder treatment guidelineswere developed by the guideline development committee. Recommendations from foreignguidelines were evaluated regarding the applicability and acceptability to domestic circumstances. In addition, a survey from experts was conducted, along with a review of Korean literature. By these means, recommendations of psychosocial treatment for alcohol use disorder were established. Results The main findings of the survey were as follows : 1) Although Group therapy was notrecommended by foreign clinical guidelines, it was considered as a first-line treatment by Koreanexperts. 2) Among many psychosocial treatment programs, cognitive behavior therapy (CBT),coping skills training, 12-step facilitation, and Group therapy were commonly used programs inKorea. Finally, the following treatment methods were selected for recommendations : Grouptherapy, motivational enhancement treatment, CBT, behavioral self-management, alcoholicanonymous, 12-step facilitation, psychodynamic psychotherapy, psychoeducational intervention,continuous case management, and community residential rehabilitation program. Conclusion Just as in treatment of chronic diseases such as hypertension, continuity is importantfor management of alcohol use disorder. Therefore, not only pharmacological treatment butalso psychosocial treatment should be provided comprehensively after treatment of acute withdrawalsymptoms.
미요시근병증에서 Dysferlin의 면역세포화학검사와 Western Blot의 분석
오승헌,김승민,선우일남,김태승,최영철 대한신경과학회 2005 대한신경과학회지 Vol.23 No.4
Background: Recent genetic analyses have shown that Miyoshi myopathy (MM) is caused by a mutation in the DYSF, which induces the dysfunction of dysferlin. We identified the deficiency of dysferlin by immunohistochemistry and Western blot in four patients with clinically diagnosed MM, and investigated the clinical and pathological characteristics of MM. Methods: A muscle biopsy was performed in four patients who were diagnosed with MM by clinical and electrophysiological study. Immunostaining of muscle specimens for dyferlin, dystrophin, α, β, γ, δ-sarcoglycan, β-dystroglycan, and caveolin-3 were performed in all four patients. We analyzed the quantitative analysis for dysferlin by Western blot in three of four patients. Results: All four patients showed clinical onset during adolescence or early adulthood (15-26 year old), a slowly progressive course, and a relatively high serum creatine kinase level (2240-6400 IU/L). Routine pathological studies showed non-specific myopathic changes. On immunocytochemistry, there was negative immunoreacticity for dysferlin on muscle specimens in all patients. The immunoreactivities for dystrophin, α, β, γ, δ-sarcoglycan, β-dystroglycan, and caveolin-3 were normal. On Western blotting, complete loss of dysferlin was noted in all three patients with MM Conclusions: Identification of isolated deficiency of dysferlin on immunocytochemistry or Western blot is important for the confirmative diagnosis of MM.
모델기반 강화학습을 활용한 Flexible Jobshop 스케줄링 연구
오승헌,송준호,우종훈 대한산업공학회 2021 대한산업공학회 춘계학술대회논문집 Vol.2021 No.6
기존의 휴리스틱 기반 최적화 방법들은 데이터의 변동성이 크고 규모가 큰 문제에 대해서 수렴하지 못하거나 계산 시간이 오래 걸리는 단점이 존재한다. 본 연구에서는 메타 휴리스틱과 규칙 기반 휴리스틱의 한계점 개선을 위한 강화학습 연구를 수행하였다. 하지만 최근 연구되고 있는 강화학습 스케줄링 방법은 대부분 모델 프리 (model free) 환경을 기반으로 하고 있어 학습을 통한 인공신경망의 성과 지표가 기존의 휴리스틱 방법을 극복하지 못하는 경우가 많다. 특히, 다른 에이전트의 영향에 의한 전이 의존성 (transition dependency)을 고려해야 하는 멀티 에이전트 환경에서 모델 프리 강화학습은 한계가 있다. 따라서, 본 연구에서는 모델 기반의 에이전트 간의 영향관계를 파악하여 학습에 도움을 줄 수 있는 모델 기반 강화학습을 수행하였다. 개발된 모델 기반 강화학습을 통해 훈련된 인공 신경망은 FJSP (flexible job shop problem) 문제에 대해 기존의 휴리스틱 방법과 비교하여 우수한 성능을 보임을 확인하였다.
오승헌,이진구,나상준,박지형,김원주 연세대학교의과대학 2002 Yonsei medical journal Vol.43 No.3
The prediction of functional outcome in patients with acute cerebral infarction depends on many factors. Various techniques have been applied to predict severity and outcome after cerebral infarction. Neuron-specific enolase (NSE) is a component of a specific brain enzyme and a useful marker of brain injury. We evaluated the relation between initial serum NSE level and short- and long-term clinical outcome in 59 patients with acute cerebral infarction and in 38 age-matched healthy controls. Serum NSE levels were determined in patients with carotid artery (CA) territory cerebral infarction within 24 hours of onset. Brain MRI was performed four to seven days after stroke. Patients were divided into two groups: large CA territory infarction with a lesion extending cortex (cortex group), and small subcortical CA territory infarction (subcortical group) with a lesion confined to the subcortical white matter. We compared the initial serum NSE levels of the two groups. National Institute of Health Stroke Scale (NIHSS) was determined at admission and seven days after onset and the modified Rankin's scale was used at the 3 months follow-up after onset. Serum NSE levels were significantly elevated in patients with acute cerebral infarction compared with the normal controls (13.88 ± 5.47ng/dl vs. 8.15 ± 1.53ng/dl, p<0.05). The initial (<24h) serum NSE level was higher in the cortical group than in the subcortical group (16.68 ± 5.70ng/dl vs. 10.98 ± 3.34ng/dl, p<0.05). NIHSS on admission and on the 7th day correlated with the initial serum NSE level (p<0.05), as were more severe functional outcomes, as determined 3 months after onset (p<0.05). This study shows that initial serum NSE level may be a useful marker for severity in acute ischemic stroke, and that it may be well correlated with short-term and long-term functional outcomes.
오승헌,최청갑,노정은,이나연,정용우,전익수,신정민,김지혜,김호진,이지민,김현숙,김옥준,송지환 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
The human umbilical cord is a promising source of mesenchymal stromal cells (MSCs). Intravenous administration of human umbilical cord-derived MSCs (IV-hUMSCs) showed a favorable effect in a rodent stroke model by a paracrine mechanism. However, its underlying therapeutic mechanisms must be determined for clinical application. We investigated the therapeutic effects and mechanisms of our good manufacturing practice (GMP)-manufactured hUMSCs using various cell doses and delivery time points in a rodent model of stroke. IV-hUMSCs at a dose of 1 × 106 cells at 24 h after stroke improved functional deficits and reduced neuronal damage by attenuation of post-ischemic inflammation. Transcriptome and immunohistochemical analyses showed that interleukin-1 receptor antagonist (IL-1ra) was highly upregulated in ED-1-positive inflammatory cells in rats treated with IV-hUMSCs. Treatment with conditioned medium of hUMSCs increased the expression of IL-1ra in a macrophage cell line via activation of cAMPresponse element-binding protein (CREB). These results strongly suggest that the attenuation of neuroinflammation mediated by endogenous IL-1ra is an important therapeutic mechanism of IV-hUMSCs for the treatment of stroke.
오승헌,강성웅,이진구,나상준,김태성,최영철 대한의학회 2004 Journal of Korean medical science Vol.19 No.3
Limb-girdle muscular dystrophy type 2B (LGMD2B), a subtype of autosomal recessive limb-girdle muscular dystrophy (ARLGMD), is characterized by a relatively late onset and slow progressive course. LGMD2B is known to be caused by the loss of the dysferlin protein at sarcolemma in muscle fibers. In this study, the clinical and pathological characteristics of Korean LGMD2B patients were investigated. Seventeen patients with ARLGMD underwent muscle biopsy and the histochemical examination was performed. For the immunocytochemistry, a set of antibodies against dystrophin, , , , -sarcoglycans, dysferlin, caveolin-3, and -dystroglycan was used. Four patients (24%) showed selective loss of immunoreactivity against dysfer-lin at the sarcolemma on the muscle specimens. Therefore, they were classified into the LGMD2B category. The age at the onset of disease ranged from 9 yr to 33 yr, and none of the patients was wheelchair bound at the neurological examination. The serum creatine kinase (CK) was high in all the patients (4010-5310 IU/L). The patho-logic examination showed mild to moderate dystrophic features. These are the first Korean LGMD2B cases with a dysferlin deficiency confirmed by immunocytochemistry. The clinical, pathological, and immunocytochemical findings of the patients with LGMD2B in this study were in accordance with those of other previous reports.