열충격 단백질의 신경정신의학적 의의와 중요성

오동훈,양병환,최준호,Oh, Dong-Hoon,Yang, Byung-Hwan,Choi, Joonho 대한생물정신의학회 2007 생물정신의학 Vol.14 No.4

Recent researches have shown that important cellular-based autoprotective mechanisms are mediated by heat-shock proteins(HSPs), also called 'molecular chaperones'. HSPs as molecular chaperones are the primary cellular defense mechanism against damage to the proteome, initiating refolding of denatured proteins and regulating degradation after severe protein damage. HSPs also modulate multiple events within apoptotic pathways to help sustain cell survival following damaging stimuli. HSPs are induced by almost every type of stresses including physical and psychological stresses. Our nervous system in the brain are more vulnerable to stress and damage than any other tissues due to HSPs insufficiency. The normal function of HSPs is a key factor for endogenous stress adaptation of neural tissues. HSPs play an important role in the process of neurodevelopment, neurodegeneration, and neuroendocrine regulation. The altered function of HSPs would be associated with the development of several neuropsychiatric disorders. Therefore, an understanding of HSPs activities could help to improve autoprotective mechanism of our neural system. This paper will review the literature related to the significance of HSPs in neuropsychiatric field.

안구운동 민감 소실 및 재처리 요법(Eye Movement Desensitization and Reprocessing) 치료 후 국소 뇌 혈류 변화:두 증례의 SPECT 연구

오동훈,최준호,Oh, Dong-Hoon,Choi, Joonho 대한생물정신의학회 2004 생물정신의학 Vol.11 No.2

Over the last decade, EMDR(Eye Movement Desensitization and Reprocessing) has emerged as a promising new treatment for trauma and other anxiety-based disorders. However, neurobiological mechanism of EMDR has not been well understood. Authors report SPECT findings of two patients of PTSD before and after EMDR. Brain 99mTc-ECD-SPECT was performed before and after EMDR treatment. To evaluate the significance of changes in the regional cerebral perfusion, t-test was conducted on the resulting images using SPM99. In addition, clinical scales(CAPS, CGI, STAI) were employed to asses the changes in the clinical symptoms of the patients. After EMDR treatment, each showed significant improvement in clinical symptoms. The cerebral perfusion increased in bilateral dorsolateral prefrontal cortex, and decreased in the temporal association cortex. The differences in the cerebral perfusion between patients after treatment and normal controls decreased. These changes appeared mainly in the limbic area the and the prefrontal cortex. These results suggest that EMDR may show the therapeutic effect through 1) improvement in the emotional control by increased activity in the prefrontal cortex, 2) inhibited hyperstimuli on amygdala by deactivation of the association cortex, 3) inhibition on past trauma related memory, and 4) keeping the functional balance between the limbic area and the prefrontal cortex. This case report needs further replication from studies with larger sample.

부산북항 재개발에 따른 유동장 및 해수교환 변화 모의

오동훈,이중우,금동호,전성환,김강민,Oh, Dong-Hoon,Lee, Joong-Woo,Keum, Dong-Ho,Jun, Sung-Hwan,Kim, Kang-Min 한국항해항만학회 2006 한국항해항만학회지 Vol.30 No.10

부산항(북항) 재개발사업은 노후화된 북항 일반부두를 해양관광의 중심지역 그리고 부산시민을 위한 친수공간으로 개발하기 위해 그동안 많은 연구와 노력이 진행되어 왔으며, 현재 구체적인 방안이 모색되는 실행단계로 진입하였다. 한편, 재개발로 인한 유동장 및 해수교환의 변화는 환경적인 측면에서 중요한 검토사항 중 하나이다. 본 연구에서는 북항 재개발에 따른 일반적인 자료를 수집 분석하고, 이를 바탕으로 하여 재개발에 따른 유동장의 변화와 만 내 해수교환을 수치실험으로 검토하였다. 실험결과, 조류속 변화는 북항 및 내항에서 감소가 나타나고 주수로상에서 증가가 나타나고 있다. 해수교환 변화는 15일이 지난 준 정상상태에서 재개발 전후 공히 약 77% 내외에 달하는 것으로 나타났다. In connection with redevelopment of Busan North Port, there has been lots of studies and efforts for the development of superannuated North general piers into a center of marine tourism and waterfront for the citizens of Busan. Recently it has moved to the stage of execution, after several trials to find concrete solutions. On the other hand, the change of flow field and tidal exchange cuased by redevelopment is one of the important investigation subjects. This study deals with the change of flow field and water exchange after redevelopment using numerical simulation technique, based on the general data which were collected and analyzed. As a result of simulation, the speed of tidal currents are tended to decrease near the North and inner-port and increase at the main waterway. Furthermore, the tidal exchange had a tendency to be small both before and after redevelopment by about 77% in a quasi steady state, which is about 15 days after.

단일벽 탄소나노튜브 필름의 전기적 및 광학적 특성

오동훈,강영진,정혁,송혜진,조유석,김도진,Oh, Dong-Hoon,Kang, Young-Jin,Jung, Hyuck,Song, Hye-Jin,Cho, You-Suk,Kim, Do-Jin 한국재료학회 2009 한국재료학회지 Vol.19 No.9

Thin films of single-wall carbon nanotubes (SWNT) with various thicknesses were fabricated, and their optical and electrical properties were investigated. The SWNTs of various thicknesses were directly coated in the arc-discharge chamber during the synthesis and then thermally and chemically purified. The crystalline quality of the SWNTs was improved by the purification processes as determined by Raman spectroscopy measurements. The resistance of the film is the lowest for the chemically purified SWNTs. The resistance vs. thickness measurements reveal the percolation thickness of the SWNT film to be $\sim$50 nm. Optical absorption coefficient due to Beer-Lambert is estimated to be $7.1{\times}10^{-2}nm^{-1}$. The film thickness for 80% transparency is about 32 nm, and the sheet resistance is 242$\Omega$/sq. The authors also confirmed the relation between electrical conductance and optical conductance with very good reliability by measuring the resistance and transparency measurements.

정신분열병의 시각자극 사건유발전위 P300에 대한 연구

오동훈,남정현,안동현,김석현,최준호,Oh, Dong-Hoon,Nam, Jung-Hyun,Ahn, Dong-Hyun,Kim, Seok-Hyun,Choi, Joon-Ho 대한생물정신의학회 2004 생물정신의학 Vol.11 No.1

Objective:Event-related potentials(ERPs) are electrical changes recorded at the surface of the scalp in response to stimulus presentation, and their latency and amplitude change according to cognitive processes. Through past studies of the auditory ERP in schizophrenia, the P300 has been reported to be statistically smaller and delayed in schizophrenia than comparison groups. However, studies of the visual ERP have not been systematically examined. The present study was designed to investigate the visual P300 in patients with schizophrenia and normal controls and to compare the pattern of P300 between them. Methods:The subjects were composed of patients(N=22) with schizophrenia by DSM-IV and normal controls(N=22). The visual ERPs were measured by the visual continuous performance test. P300 amplitude and latency measured on 5 scalp electrodes(Fz, Cz, Pz, $T_7$, $T_8$) were compared between patients and controls. Results:The P300 latencies measured on Fz, Cz, Pz, and $T_7$ electrodes were significantly longer in patients than controls(p<0.05). The P300 amplitudes in patients were smaller than controls. However, the difference between them was not statistically significant. Conclusion:Analysis of the visual ERPs showed that the P300 latency is significantly delayed and the P300 amplitude is slightly smaller in patients than controls. These results are similar to established studies of the auditory P300 in schizophrenia.

삼극 진공관의 기원과 드 포리스트 ( Lee de Forest )

오동훈 ( Dong Hoon Oh ) 한국과학사학회 1996 한국과학사학회지 Vol.18 No.1

수도권 북부 신도시개발의 필요성과 개발방향에 관한 연구

오동훈(Oh. Dong-Hoon),허재완(Hur. Jae-Wan),이재순(Lee. Jae-Soon) 한국지역개발학회 2008 韓國地域開發學會誌 Vol.20 No.2

As South Korea’s economic and urban growth have been continued, the development has been concentrated in Southern Seoul Metropolitan area. As a result, a demand for development has been growing in Northern Seoul Metropolitan area where the development has been relatively neglected. The purpose of this study is to find the necessity and desirable direction of Newtown Development in Northern Seoul Metropolitan Area, so this paper indicates 1) the ba1anced development in Seoul Metropolitan Area to solve the severe imbalance between Southern and Northern area, 2) solutions of housing problems, 3)the growth management, 4) a high-tech industria1 complex development in Northern GyeongGiDo area, and 5) a developing key position city for 1nter- Korean cooperation programs in terms of the future growth potentialities in Northern Seoul Metropolitan area. 1n addition, this study a1so suggests three different kinds of urban development which can help newtown in Northern Seoul Metropolitan Area to be a distinctive and competitive city in the future First of all, we need to develop an attractive city through reflecting consumer preferences, for example, the insurance of an accessibility to relieve the concentration phenomenon in Seoul area, building the excellent educational and residentia1 environment, and the waterfront development. Secondly, the newtown development needs to be linked with neighbor cities to buiJd a key position having the sufficient population (over one million people) to be the driving force of urban growth in Northern Seoul Metropolitan Area. Fina11y, including Ha11yu-wood which is a project to make a Korean cultura1 tourism c1uster in GyeongGi- Do, culture-oriented urban development linked with the accumulated infrastructures of cultural production in Northern Seoul Metropolitan Area is suggested.

[論文]주택건설업의 중장기 경쟁력 제고를 위한 개발금융기법 비교

오동훈(Dong-Hoon Oh),송승호(Sang-Ho Song) 한국주택학회 2005 주택연구 Vol.13 No.2

본 연구는 선분양에서 후분양으로 주택분양제도가 전환되어 갈 것에 대비하여 국가 경제의 중요한 축인 주택건설업계 입장에서 자금조달기법이 가자는 장단점을 검토하고 적정한 개발금융기법을 선택·활용할 수 있는 기준을 제시하며 동 기준으로 개발금융 가합들을 비교 · 분석하는 것을 목적으로 한다. 연구의 주요결과를 통해 주택건설업계에 서는 개발금융의 비교기준인 자금조달의 용이성, 자금조달원의 안정성, 프로젝트의 성 공가능성, 금융비용, 프로젝트의 종류, 프로젝트의 규모에 따라 각 개발금융기법을 활용 하는 때에, 자사의 상황과 또한 프로젝트의 상황별로 각 개발금융을 이용해야 한다. 특히 개발금융을 실제로 활용하여 사업을 진행시키는 주택건설업계의 업장에서 자금조달 기법을 비교하고, 주택건설업계가 선택·활용할 수 있는 개발금융기법을 제시하여 정부 가 개발금융을 도입할 때도 활용주체인 주택건설업계의 입장을 고려해야 함을 보여주었다. This study aims on finding a way for housing construction industry, which is an important circle of national economy, to get ready for the future through examining strength and weakness development financing technique has from the view of housing construction industry preparing for a change from pre-sale to post-sale on housing development finance system. Also, it proposes standards to choose and utilize a suitable raising fund technique. Through main results of the study, housing construction industry should use each development financing by condition of a company and a project at the time each development financing technique is utilized according to comparing standards of development financing, which are easiness of raising fund, stability of funding source, possibility to succeed on a project, financing cost, project type, and project size. Especially, it showed that standpoint of housing construction industry, which is the subject of utilization, should be considered even on induction of development financing by government while examining strength and weakness of development financing technique from the standpoint of housing construction industry, which utilizes development financing practically to proceed its business, and showing a development financing technique, which housing construction industry can choose and utilize.

연구노트 : 「부동산학연구」 게재논문의 연구경향 분석: 1995~2014

오동훈 ( Dong Hoon Oh ),이용만 ( Yong Man Lee ),이재순 ( Jae Soon Lee ) 한국부동산분석학회 2015 不動産學硏究 Vol.21 No.2

「주택연구」 게재논문의 연구경향 분석 - 1993년부터 2004년까지 12년간의 기고논문을 중심으로

오동훈(Oh Dong-Hoon),이재순(Lee Jae Soon) 한국주택학회 2006 주택연구 Vol.14 No.1

  본 연구의 목적은 1993년부터 2004년까지 「주택연구」에 기고된 논문을 중심으로 12년 동안 주택분야 연구의 경향을 분석하는 것이다. 연구 주제의 분류는 「주택정책론」(하성규, 2004)과 「주택백서」(건설교통부, 2002)를 근거로 연구주제를 ① 거시주택시장분석 ② 미시주택시장분석 ③ 주택관련제도 ④ 주택환경정비 ⑤ 임대주택제도 ⑥ 주택건설기술산업 ⑦ 주택산업지원 ⑧ 주택금융투자 ⑨ 기타 등 9개로 분류하였다. 연구의 결과는 다음과 같다. 첫째, 연구주제로는 ‘미시주택시장분석’, ‘거시주택시장분석’, 그리고 ‘주택관련제도’에 관한 논문이 많은 것으로 나타났다. 둘째, 연구의도 및 목적은 설명적 연구가 가장 많았으며, 그 다음으로 처방적 연구가 많은 것으로 나타났다. 셋째, 연구에 사용된 자료수집방법 및 이용을 보면 1차 자료(42.9%)보다 2차 자료(57.1%)의 이용비율이 다소 높았다. 넷째, 다른 학문 분야에 비해 공동연구의 비중이 높게 나타났으며, 저자의 소속기관에 있어서도 대학 이외의 기관에 소속되어 있는 종사가 상대적으로 많았다. 전반적으로「주택연구」에 기고된 연구논문의 연구경향은 일반 순수학문분야와는 달리 주택이라는 실제적인 분야로서의 특성을 잘 보여주고 있었다.   The purpose of this paper is to analyze the research tendency of Housing Studies by reviewing the papers published at 「Housing Studies Review」 for 12 years from 1993 to 2004. Based on both a textbook, "Housing Policy" authored by Prof. Ha, Sung-kyu in 2004 and "Housing white paper" published by the Ministry of Construction and Transportation in 2002, the authors classified research topics into 9 areas such as ① Housing Price and Market, ② Behavior and Situation related to Housing, ③ Housing Related System, ④ Maintenance for Housing Environment, ⑤ Rental Housing System, ⑥ Industry of Housing Construction and its Technology, ⑦ Supporting Area for Housing Industry, ⑧ Finance and Investment for Housing, ⑨ Others. The results of this study are as follows; First, research topics dealt with ② Behavior and Situation related to Housing, ① Housing Price and Market, and ③ Housing Related System were of main stream in Housing Studies Review. Second, concerning research intention and purpose, explanatory research ranked 1 and prescriptive research ranked 2. Third, primary data and secondary data used in the papers showed 42.9% and 57.1%, respectively. Fourth, at Housing Studies Review, joint researches (co-work) were more than those of other field of studies. In terms of authors" job, the ratio of paper written by professors was relatively small when comparing other field of studies. In general, the research tendency of papers published at「Housing Studies Review」had shown well the characteristics of Housing as a practical field.