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말기 신부전 환자에서 신 이식후 혈중 Homocysteine 농도의 변동
양동호,전진호,홍세용 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.3
A prospective study of vitamin B6, B12, folate, and homocysteine levels was carried out in 7 kidney transplant(KT) recipients. The first sample for the basal level was drawn on the morning of the KT day before the start of cyclosporine injection. Thereafter, serial blood samples were taken every day until the serum creatinine level decreased below 1.5 mg/dl and then every 2 or 3days until discharge. The serum creatinine level decreased to below 1.5 mg/dl within 3days except for cases 4 and 6. The homocysteine levels decreased markedly in synchronisation with serum creatinine levels increased during the first 7days and then declined together with serum creatinine levels but went up again after a few days. The levels of B6, and vitamin B12 do not continue to decrease after the levels of serum creatinine have decreased to 1.5mg/dl, while homocysteine levels go up progressively. In conclusion, contrary to our expectation, the level of homocysteine rebounds a few days after KT following a transient decline. A deficiency of folic acid, vitamin B6 and vitamin B12 does not seem to cause hyperhomocysteinemia in KT recipients. It is necessary to pay attention to hyperhomocysteinemia in KT recipients, especially when the recipients have an atherosclerosis-related complication.
양동호,오명진,김재한,윤병옥,서기현,홍세용,김의한 대한신장학회 1999 Kidney Research and Clinical Practice Vol.18 No.6
Spontaneous renal allograft rupture is an uncommon complication of renal transplantation, but it represents a life-threatening emergency that requires prompt recognition and treatment. The incidence of spontaneous renal allograft rupture is variable and range between 3.6 and 9.6 percent of all transplants. In the majority of cases the rupture is associated with acute rejection episodes and with renal vein thrombosis. Most frequently, the allograft rupture occurs within the first 2 weeks of transplantation. in addition, most ruptures reported have occurred in cadaveric renal allograft. Debate on the management of such allograft salvage versus transplant nephrectomy. It appears that the recent trend is toward performing surgical repair of the graft if the rupture is secondary to rejection and oo evidence of renal vein thrombosis ; otherwise, graft nephrectomy be done. We report a case of spontaneous renal allograft rupture due to renal vein thrombosis occurred in a 21-year-old woman 6 days after transplantation. Unusual severe localized pain, swelling over at allograft site, and hypotension, a triad frequently seen in renal allograft rupture, were present. Management by graft nephrectomy was inevitable because of the patient's downhill course.
양동호,이소영 대한의사협회 2020 대한의사협회지 Vol.63 No.1
Diabetic kidney disease is a microvascular complication of diabetes mellitus and the leading cause of end-stage renal disease resulting in renal replacement therapy. Approximately 30% to 40% of diabetic patients have diabetic kidney disease, which contributes to a significant increase in morbidity and mortality. Microalbuminuria is considered the gold standard for diabetic kidney disease diagnosis; however, its predictive value is restricted. Although blood glucose control, blood pressure control, and angiotensin converting enzyme inhibitors have been the primary treatment strategies, there are no definitive treatment modalities capable of inhibiting the progression of kidney dysfunction in these patients. This study was undertaken to answer seven questions regarding the various aspects of diabetic kidney disease. Why does it develop? what kind of factors affect its development? How is it diagnosed? What are its possible biomarkers? When is a kidney biopsy necessary? What are the preventive and therapeutic options? And what are the novel treatments?
Paraquat 중독환자에서 Free Radical Scavenger 를 이용한 치료경험
양동호,홍세용,김영통 대한내과학회 1996 대한내과학회지 Vol.51 No.1
The purpose of this paper is to report three cases of severe paraquat intoxication treated successfully with multiple antioxidants combination therapy of superoxide dismutase inhalation by nebulizer, intravenous administration of aminoacids, vitamin C and E. Three cases of the patients with paraquat intoxication were treated with Superoxide dismutase inhalation by nebulizer, packed RBC transfusion, intravenous injection of aminoacids, Vitamin C and Vitamin E. Case-1 was a 35 year old woman, swallowed 6 mouthfuls of 20% paraquat for the purpose of suicide. The plasma paraquat concentrations were 2133 ng/ml at 2 hours retrospectively. Case-2 was a 50 year old woman, swallowed two mouthful of 20ra paraquat. The plasma paraquat concentrations were 3522 ng/ml at 6 hours, 1358 ng/ml at 12 hours, 85 ng at 18 hours, and 8 ng/ml at 24 hours retrospectively. Case-3 was a 55 year old man who drank 2 mouthfuls of 20% paraquat. The plasma paraquat concentrations were 1172 ng/ml at 10 hours, 189 ng/ml at 16 hours, and 16 ng/ml at 22 hours retrospectively. All of the three cases were treated successfully and discharged without specific complication except exertional dyspnea in case. We found that the mortality of paraquat intoxication could he decreased by various efforts to improve free radical scavenger which are easily available in clinic. Further controlled study is necessary to prove it.
양동호,이상협,차승환,이종찬,Yang, Dong-Ho,Lee, Sang-Hyeop,Cha, Seung-Hwan,Lee, Jong-Chan 한국기계가공학회 2022 한국기계가공학회지 Vol.21 No.6
Automobile brake discs are a major part of automobiles that are directly related to driver safety, and prevention of judder and squall noise is very important. This phenomenon occurs for complex reasons such as the precision and assembly of the brake module, and the material of the brake disc. The purpose of this study is to analyze the effect of the grinding wheel's grain size on the grinding conditions when machining cast iron, the material of the brake disc, and to derive the optimal grinding conditions through this.