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고본양정방 투여가 TCDD 유도 랫드의 항산화 변화에 미치는 영향
양동현,오지혜,박운규,조충식,황석연 한국산학기술학회 2020 한국산학기술학회논문지 Vol.21 No.10
본 연구의 목적은 TCDD로 인해 발생하는 산화적 스트레스에 대한 GYB의 내분비 기능 및 항산화 효능에 미치는 영향을 평가하기 위한 것이다. 2017년도에, 산화적 스트레스에 대한 GYB의 효능을 평가하기 위해 35마리의 수컷 SD 랫드를 5개의 그룹으로 나누어 실험하였다. 정상 대조군은 vehicle 및 saline을 투여하였으며, TCDD 단독투여그룹은 TCDD(2 μg/kg, weeks) 및 생리식염수를 복강 내 투여하였으며, 시험 군은 6주 동안 GYB (75, 150, 300 mg/kg)를 3가지 농도로 나누어 경구로 투여하였다. 체중은 NC 그룹의 랫드와 비교하였을 때 TCDD 노출 후 6주 후에 유의하게 감소하였다(p<0.001). 그러나 TCDD에 의한 체중 감소는 GYB 300 mg/kg 투여에 의해 현저하게 보호되었다(p<0.01). TCDD로 유도된 랫드의 간은 세포질의 공포 변성이 나타났으며, 간의 동양 혈관과 중량의 증가를 나타냈다. MDA, SOD를 측정한 결과, TCDD 투여에 의하여 두 항목 모두 감소하는 경향이 나타났다. 반면, GYB 투여에 의한 변화는 나타나지 않았고, SOD 결과에서 GYB 300군에서 NC군 대비 유의성이 관찰(p<0.05) 되었다. 이러한 발견은 GYB가 랫드에서 TCDD 유도 간 독성에 대해 보호 효과를 가질 수 있음을 증명하였다. The purpose of this study was to evaluate the effects of gobonyangjeonbang (GYB) on the endocrine function and the antioxidant efficacy of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative stress in rats. In 2017, to evaluate the efficacy of GYB on oxidative stress, 35 male SD rats were divided into five groups and tested. The normal control group was administered saline as a vehicle, while the TCDD-alone group was administered TCDD (2 μg/kg per week) intraperitoneally and with physiological saline, and the test group was administered GYB orally by dividing it into three concentrations (75, 150, and 300 mg/kg) for six weeks. Bodyweight decreased significantly after six weeks of TCDD exposure, when compared to rats in the NC group (p<0.001). However, weight loss from TCDD was significantly protected by administration of GYB at 300 mg/kg (p<0.01). The rat liver induced by TCDD showed cytoplasmic vacuole degeneration, and the hepatic sinusoid and weight increased. As a result of measuring MDA and SOD, both items tended to decrease under TCDD administration. On the other hand, there was no change due to GYB administration, and significance was observed in the GYB 300 mg/kg group compared to the NC group in the SOD result (p<0.05). These findings demonstrated that GYB may have a protective effect against TCDD-induced liver toxicity in rats.
양동현,김형준,남웅,이두영,김진 대한구강악안면병리학회 2014 대한구강악안면병리학회지 Vol.38 No.2
Primary oral squamous cell carcinoma (OSCC) associated with dental osseointegrated implants is very rare. We experienced twopatients who had received dental implant surgery before they were diagnosed with OSCC. We report these cases to emphasize theimportance of differential diagnosis of malignant lesions associated with dental implants. Additionally, we also suggest that bone graftmaterials around implants can serve as a potential inducer of invasiveness in cancer cells.
양동현,구현우,윤종현 대한영상의학회 2003 대한영상의학회지 Vol.49 No.1
마제부신은 양측 부신의 내측 변연이 융합되어 있는 드문 선천성 기형으로, 흔히 심혈관계, 신경계, 비뇨생식기계 기형을 동반하는 것으로 보고 되었다. 저자들은 마제부신과 잘 동반되는 심혈관계 기형 중 하나인 우이성체가 있는 신생아에서 초음파로 진단된 마제부신을 경험하였기에, 이를 보고하고자 한다. Horseshoe adrenal gland is a rare congenital abnormality associated with multiple congenital anomalies that may involve the cardiovascular, central nervous, and genitourinary systems. In this report, we describe the sonographic findings of horseshoe adrenal gland in a newborn with right isomerism a frequently associated cardiovascular anomaly.
Data Envelopment Analysis/Window 모형과 Global Malmquist 생산성지수 모형을 이용한 지방의료원의 효율성과 생산성 변화 분석
양동현 한국보건행정학회 2013 보건행정학회지 Vol.23 No.1
This study empirically analyze efficiency and productivity changes of public hospitals of Korea using data envelopment analysis/Window model and global Malmquist indices model. We use the ten-year data from 2001 to 2010 of 30 regional public hospitals listed database from the Association of Korean Regional Public Hospitals. The main focuses are to reveal whether the technical inefficiency are improved as time goes by, and efficiency and productivity are affected by environmental factors. The results can be summarized as follows. First, the efficiencies of public hospitals rise in trend as time passes. Second, regional public hospitals show the different average efficiencies according to their regional type, hospital type, operational type, medicaid type, and demand and supply conditions by Mann-Whitney U-tests. Third, technical efficiency changes mainly contribute to 4.4% annual average growth rate of productivity of regional public hospitals during that period. Our findings have some policy implications. It is confirmed that there exist some environmental inefficiencies, and those inefficiencies can not be overcome through just improving the inner management system. Thus, policy and institutional changes are necessary for regional public hospitals to improve efficiency and productivity overall.
양동현,김형준,박혁,양우익,김현실 대한구강악안면병리학회 2013 대한구강악안면병리학회지 Vol.37 No.2
Small cell osteosarcoma of bone, which was first described in 1979, is an unusual variant of osteosarcoma. Osteoid production by tumor cells is frequently focal or minimal, making the differential diagnosis with other small round cell tumors of bone difficult. Here, we present a rare case of small cell osteosarcoma of the mandible appearing as bony bulging mass in 31-year-old male who has neither tenderness nor paresthesia. Histologically, the tumor contains hypercellular cartilage and abnormal osteoid associated with small round to ovoid malignant cells. Awareness of small cell osteosarcoma should be emphasized because it has worse prognosis than both other small round cell tumor and conventional osteosarcoma.
日帝下 韓國敎育政策 變遷考 : 第 1.2次 朝鮮敎育令 變改를 中心으로
梁東絢 광주대학교 민족문화예술연구소 1992 論文集 Vol.1 No.-
The Japanese impeialism declared that they should establish the educational bureau which was aimed at the colonial education to control korea eternally since the Japanese annexation of Korea. And by the name of a subject of the Crown, or the domestic equalism, they tried to stike out the character and the tradition of Korea and to japanize Korean people. And in the contents of their education they pactised the differential education devided into the primary and industrial education, which is foced to rear the low working men to be necessary for the colonial control. Though the Japanese impeialism was puzzled by the resistance of the Samil Independence Movement of Korea, they claimed to stand for the cultural reign to found a stable colonial education.