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심순섭 順天靑巖大學 1996 論文集-順天靑巖大學 Vol.20 No.2
A theoretical model has been prepared, which describes the noise generated by tire/road interaction for the tire structure-borne sound analysis. The model begins with a set of thin shell equations describing the motion of the belt of a radial ply tire, as derived by Bohm("mechanisms of the belted tire", Ingeniur-Archiv, XXXV, 1966). Structural quantities required for these equations are derived from material properties of the tire. The rolling shape of a tire is computed from the steady -state limit of these equations. Vibrational response of the tire is treated by the full dependent shell equations. The force input at the tire/road interface is calculated on the basis of tread geometry and distribution of contact patch pressure. Radiation of noise is calculated by a Kirchhoff-Helmholtz integral theorem.
심순섭 대한의학유전학회 2014 대한의학유전학회지 Vol.11 No.2
Chorionic villus sampling has gained importance as a tool for early cytogenetic diagnosis with a shift toward first trimesterscreening. First trimester screening using nuchal translucency and biomarkers is effective for screening. Chorionic villussampling generally is performed at 10-12 weeks by either the transcervical or transabdominal approach. There are twomethods of analysis; the direct method and the culture method. While the direct method may prevent maternal cellcontamination, the culture method may be more representative of the true fetal karyotype. There is a concern for mosaicismwhich occurs in approximately 1% of cases, and mosaic results require genetic counseling and follow-up amniocentesisor fetal blood sampling. In terms of complications, procedure-related pregnancy loss rates may be the same as those foramniocentesis when undertaken in experienced centers. When the procedure is performed after 9 weeks gestation, the risk oflimb reduction is not greater than the risk in the general population. At present, chorionic villus sampling is the gold standardmethod for early fetal karyotyping; however, we anticipate that improvements in noninvasive prenatal testing methods, suchas cell free fetal DNA testing, will reduce the need for invasive procedures in the near future.
제대혈 내 Matrix Metalloproteinase-9 농도와 제대염의 연관성
심순섭 ( Soon Sup Shim ),강혜심 ( Hye Sim Kang ),맹영희 ( Young Hee Maeng ),김영돈 ( Young Don Kim ) 대한주산의학회 2015 Perinatology Vol.26 No.1
Objective: Intrauterine inflammation (IUI) is a leading cause of preterm delivery. Although matrix metalloproteinase8 (MMP8) and intercellular adhesion molecule1 (ICAM1) are known to be related with IUI, it has not been fully elucidated whether MMP9 or ICAM3 is associated with IUI. We performed this study to determine whether the levels of tumor necrosis factoralpha (TNFα), MMP9 and ICAM3 in umbilical cord blood of preterm infants are associated with chorioamnionitis, funisitis or bronchopulmonary dysplasia. Methods: Eightytwo pairs of pregnant women and their preterm newborns <35 weeks gestation were enrolled. Levels of TNFα, MMP9 and ICAM3 in umbilical cord blood were measured using immunoassays and compared with results of histological examination of placenta and clinical data of the study participants. Results: The level of MMP9 in umbilical cord blood was significantly associated with the presence of funisitis (P=0.007). The level of TNFα in umbilical cord blood was significantly associated with the development of bronchopulmonary dysplasia ( P=0.030). However, presence of chorioamnionitis or funisitis was not associated with development of bronchopulmonary dysplasia. With the establishment of receiver operating characteristic (ROC) curve, the best cutoff value for umbilical blood MMP9 was 99.42 pg/mL in identification of funisitis. The area under a constructed ROC curve for prediction of funisitis was 0.847 (standard error, 0.112; 95% confidence interval, 0.7500.917). Conclusion: Measurement of MMP9 concentration in umbilical cord blood may be an alternative way to predict whether a preterm infant has been exposed to IUI. Further study with larger numbers of subjects will be necessary to elucidate the association between the presence of IUI and neonatal adverse outcome.