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Plant factory: new resource for the productivity and diversity of human and veterinary vaccines
심병식,홍기종,Puna Maya Maharjan,최성화 대한백신학회 2019 Clinical and Experimental Vaccine Research Vol.8 No.2
Vaccination is one of the most successful strategies to prevent diseases caused by pathogens. Although various expression systems including Escherichia coli, yeast, insect, and mammalian cells are currently used for producing many of vaccines, these conventional platforms have the limitation of post-translational modification, high cost, and expensive scalability. In this respect, the plant-based expression system has been considered as an attractive platform to produce recombinant vaccines due to fast, cost-effective and scalable production as well as safety. This review discusses the development of plant-derived vaccines and the current stage of plant-based expression system.
심병식,최정아,Ho-Hyun Song,박성무,천인수,Ji-Eun Jang,Sun Je Woo,Chung Hwan Cho,송민석,김혜미,Kyung Joo Song,이재면,김성욱,송대섭,최영기,김재욱,Huan Nguyen,김동욱,Young Yil Bahk,윤철희,송만기 한국미생물학회 2013 The journal of microbiology Vol.51 No.1
Influenza viruses are respiratory pathogens that continue to pose a significantly high risk of morbidity and mortality of humans worldwide. Vaccination is one of the most effective strategies for minimizing damages by influenza outbreaks. In addition, rapid development and production of efficient vaccine with convenient administration is required in case of influenza pandemic. In this study, we generated recombinant influenza virus hemagglutinin protein 1 (sHA1) of 2009 pandemic influenza virus as a vaccine candidate using a wellestablished bacterial expression system and administered it into mice via sublingual (s.l.) route. We found that s.l. immunization with the recombinant sHA1 plus cholera toxin (CT) induced mucosal antibodies as well as systemic antibodies including neutralizing Abs and provided complete protection against infection with pandemic influenza virus A/CA/04/09 (H1N1) in mice. Indeed, the protection efficacy was comparable with that induced by intramuscular (i.m.) immunization route utilized as general administration route of influenza vaccine. These results suggest that s.l. vaccination with the recombinant non-glycosylated HA1 protein offers an alternative strategy to control influenza outbreaks including pandemics.
김혜권,김정기,송호영,최정아,심병식,강보규,문형준,염민주,김상현,송대섭,송만기 한국미생물학회 2014 The journal of microbiology Vol.52 No.9
Sublingual (SL) administration of influenza vaccine would benon-invasive and effective way to give human populationsprotective immunity against the virus, especially when pandemicinfluenza outbreaks. In this study, the efficacy of pandemicinfluenza virus-based subunit vaccines was tested aftersublingual (SL) adjuvant administration in pigs. Eight specificpathogen-free Yucatan pigs were divided into 4 groups: nonvaccinatedbut challenged (A) and vaccinated and challenged(B, C, and D). The vaccinated groups were subdivided by vaccinetype and inoculation route: SL subunit vaccine (hemagglutininantigen 1 [HA1] + wild-type cholera toxin [wtCT],B); IM subunit vaccine (HA1 + aluminum hydroxide, C); andIM inactivated vaccine (+ aluminum hydroxide, D). The vaccineswere administered twice at a 2-week interval. All pigswere challenged with pandemic influenza virus (A/swine/GCVP-KS01/2009 [H1N1]) and monitored for clinical signs,serology, viral shedding, and histopathology. After vaccination,hemagglutination inhibition titre was higher in groupD (320) than in the other vaccinated groups (40–80) at thetime of challenge. The mobility and feed intake were reducedin group C. Both viral shedding and histopathological lesionswere reduced in groups B and D. Although this study haslimitation due to the limited number of pigs (2 pigs per agroup), the preliminary data in this study provided the protectivepotential of SL administration of bacteria-expressedpandemic H1N1 influenza vaccine in pigs. There should beadditional animal studies about effective adjuvant systemand vaccine types for the use of SL influenza vaccination.
박성무,구민정,주영준,천인수,황규잠,길병철,심병식,정항진,손영민,최상호,정운희,한승현,주혁,윤철희 대한면역학회 2021 Immune Network Vol.21 No.2
Scrub typhus develops after the individual is bitten by a trombiculid mite infected with Orientia tsutsugamushi. Since it has been reported that pneumonia is frequently observed in patients with scrub typhus, we investigated whether intranasal (i.n.) vaccination with the outer membrane protein of O. tsutsugamushi (OMPOT) would induce a protective immunity against O. tsutsugamushi infection. It was particular interest that when mice were infected with O. tsutsugamushi, the bacteria disseminated into the lungs, causing pneumonia. The i.n. vaccination with OMPOT induced IgG responses in serum and bronchoalveolar lavage (BAL) fluid. The anti-O. tsutsugamushi IgA Abs in BAL fluid after the vaccination showed a high correlation of the protection against O. tsutsugamushi. The vaccination induced strong Ag-specific Th1 and Th17 responses in the both spleen and lungs. In conclusion, the current study demonstrated that i.n. vaccination with OMPOT elicited protective immunity against scrub typhus in mouse with O. tsutsugamushi infection causing subsequent pneumonia.