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CDCA와 UDCA의 복합제제인 빌레놀(Bilenol)의 방사선 투과성 담석 용해능에 관한 연구 : 제1보
신우원 대한소화기학회 1992 대한소화기학회지 Vol.24 No.6
To see if a combination of chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA) is effective and well tolerated, 32 patients with radiolucent gallstones were treated with a combination of CDCA and UDCA (10 ㎎/㎏/day) for 6 months. Eleven had stones ≤5 ㎜, 9 had stones $gt;5 ㎜ but ≤10 ㎜, twelve had stones $gt;10 ㎜. Patients with stones $gt; 10 ㎜ received oral dissolution therapy of gallstone fragments after extracorporeal shock wave lithotripsy. The effects of treatment on stone dissolution evaluated by cholecystography and ultrasonography at 3 and 6 mo, Complete dissolution of gallstones occured in 9 patients (28%) and partial dissolution occured in 13 patients (41%). In the patients with stones ≤5 ㎜, rates of complete and partial dissolutions were higher than in the patients with stones $gt;5 ㎜ but ≤ 10 ㎜ (74% vs. 55%). In patients with stones $gt; 10 ㎜ after lithotripsy, total dissolution was 75%. There was a statistically significant different dissolution rate by size of gallstones. We concluded that CDCA plus UDCA dissolves radiolucent. stones quickly, with a rare adverse effects and also after lithotripsy.