Vecuronium에 의한 기관내 삽관시 안압 및 심맥관계에 미치는 영향

신용섭,이정은,최세진 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1

The effects of muscle relaxants(vecuronium, pancuronium, d-tubocurarine, and succinylcholine) for endotracheal intubation on intraocular pressure, blood pressure, heart rate, and arrhythmia were studied in 60 patients undergoing general anesthesia, The patients were divided into 4 groups : vecuronium group (0. 1 mg/kg), pancuronium group (0.08 mg/kg), d-tubocurarine group(0.4 mg/kg), and succinylcholine group(1 mg/kg) according to be administrated. Before induction of anesthesia, initial measurement of intraocular pressure (control value) was taken with Schiotz tonometer after instilling of a 0. 5% pontocaine on conjunctival sac. Subsequent measurement were undertaken as soon as the lid reflex was lost after thiopental sodium injection and then at 75-100% depression of first twitch height of train-of-four after intravenous administration of muscle relaxants. It was measured at 1, 3, 5, 10 minutes after endotracheal intubation too. Blood pressure (systolic and diastolic), heart rate, and ECG abnormalities were observed in all cases. The results were as follows; 1. After thiopental sodium injection, intraocular pressure(IOP) decreased than the control value. 2. At 70-100% depression of first twitch height, IOP decreaeed significantly in vecuronium, pancuronium and d-tubocurarine group, but increased significantly in succinylcholine group than the control value. 3. After 1 minute of endotracheal intubation, IOP increased in all groups. There was no stastistical significance in vecuronium group compared with the control value. 4. After 3 minutes of endotracheal intubation, IOP decreased in all groups. 5. The changes of systolic and diastolic blood pressure and heart rate in vecuronium group were the smallest value among all groups. 6. There was no arrythmia in vecurouium group.

상온 2단 선회류 유동층 연소로에서 미세입자의 비산유출속도에 대한 상단 가스공탑속

신용섭 부산수산대학교 산업기술연구소 1995 産業技術硏究所 硏究報告 Vol.6 No.2

Hankel-norm 을 이용한 극점을 유지하는 모델감소방법 ( Pole Preserving Model reduction using Hankel-norm approximation )

신용섭,이주장 대한전자공학회 1997 대한전자공학회 학술대회 Vol.1997 No.01

전북지방의 북서부에 A형 간염 바이러스에 대한 항체의 양성률

신용섭,김유현 대한임상검사과학회 2013 대한임상검사과학회지(KJCLS) Vol.45 No.3

Hepatitis A (HA) is an acute infectious disease of the liver caused by the Hepatitis A virus (HAV). In acute HA, the presence of anti-HAV IgM is detectable and about 3 weeks after exposure, its titre increases over 4 to 6 weeks. Anti-HAV IgG is detectable within a few days of the onset of symptoms. IgG antibodies continue to last for years after infection and provide lifelong immunity to the host. This study was performed to investigate the current seroprevalence of anti-HAV antibodies in Jeonbuk province, South Korea. A total of 591 (male 322, female 269) serum samples were collected in July 2011 to June 2012. We tested the antibodies of anti-HAV IgG and IgM using a Modular E170 (Roche Diagnostics, Germany), and analysed the serum alanine aminotransferase (ALT) levels by HITACH 7600-100 (HITACH, Japan). The overall seroprevalence of anti-HAV IgG was 84.6% (500/591), and the rate of females (85.9%) was higher than males (83.5%). According to the decade of age, seroprevalence of anti-HAV IgG were as follows; 68.8% (11/16) in the under 10 years old category, 100% (19/19) in the 10∼19 category, 96% (48/50) in the 20∼29 category, 83.6% (56/67) in the 30∼39 category, 84.3% (123/146) in the 40∼49 category, 83.3% (135/162) in the 50∼59 category, 83.1% (54/65) in the 60∼69 category, 78.1% (32/41) in the 70 ∼79 category, and 88% (22/25) in the over 80 category. Total seroprevalence of anti-HAV IgM was 3.4% (20/591), and according to gender, the seroprevalence of male (3.1%) was very similar to that of female (3.7%). Through this study, we know that the seroprevalence of anti-HAV antibody in north-west Jeonbuk province, South Korea, was high. Only children under the age of 10 remain susceptible to HAV infection. Vaccination against HAV is not needed at the present time for the people of Jeonbuk province, South Korea, but a vaccination should be recommended and the improvement in sanitary conditions and personal hygiene should be highlighted.

정보통신 표준화정책 방향

신용섭,Sin, Yong-Seop 한국정보통신집흥협회 1998 정보화사회 Vol.125 No.-

정보통신부가 '97년에는 TTA로 표준화 추진체계를 일원화하였다면 '98년에는 이를 바탕으로 표준화 예산을 양적으로 대폭 확대하여 내실있는 표준화를 추진할 방침이다. 신규 연구개발 확대와 기존 연구개발 과제를 대폭 지원할 계획이며 표준화의 중요성을 고려하여 예산을 매년 2배씩 증액하였고 따라서 정보통신 표준화에 추진되는 소요예산은 총 23개과제 260억원이다.

불균일상 촉매를 이용한 대두유의 에스테르화 반응

신용섭 한국생명과학회 2004 생명과학회지 Vol.14 No.2

Using heterogeneous catalyst, esterification reaction of soybean oil (SBO) with methanol was investigated. Distributions of components in mixtures of soybean oil and methanol were measured at temperatures ranging from 40 to $65^{\circ}C$. Glycerine contents of reaction mixtures were measured for the different kinds of catalysts, such as NaOH, CaO, Ca(OH)$_2$, MgO, Mg(OH)$_2$, and Ba(OH)$_2$. Based on the measured glycerine concentrations, conversions of the reaction mixtures were calculated. The effects of dose of catalyst, cosolvent and reaction temperature on final conversion were examined. Solubility of methanol in soybean oil was substantially greater than that of soybean oil in methanol. When the esterification reaction of soybean oil was catalyzed by heterogeneous catalyst, final conversion was strongly dependent on the alkalinity of the heterogeneous catalyst, and increased with the alkalinity of the catalyst material. Hydroxides from the alkali metals were more effective than oxides, which actually had no catalytic effects. When Ca(OH)$_2$ was used for the esterification catalyst, maximum value of final conversion was measured at dose of 4%. The final conversion and reaction rate increased with reaction temperature, and showed substantial increment at reaction temperature of 5$0^{\circ}C$. When cosolvent, CHCl$_3$, was added into the reaction mixture of soybean oil which catalyzed by Ba(OH)$_2$, maximum value of final conversion was appeared at dose of 3%.

마취 후 잔류 근이완

신용섭 대한마취통증의학회 2015 Anesthesia and pain medicine Vol.10 No.1

Postoperative residual neuromuscular blockade or residual paralysis in the postanesthesia care unit is associated with postoperative complications such as muscle weakness, difficulty in breathing, airway obstruction, and hypoxemia. Residual paralysis can be defined by inadequate neuromuscular recovery as measured by objective neuromuscular monitoring. The train-of-four ratio threshold less than or equal to 0.9 is considered to indicate inadequate neuromuscular recovery. Careful management of residual paralysis may decrease the occurrence of adverse events associated with residual neuromuscular blockade. In this review, the clinical implications of residual neuromuscular blockade are summarized.

최근 10년간 마취에 관한 임상적 고찰

신용섭,임정혁,최세진 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1

To evaluate the specificity and the historical trends of the anesthetic agents and anesthetic methods used in Chungnam National University Hospital, anesthetic experiences of 21, 595 in total performed at Chungnam National University Hospital from January 1977 to December 1986 were analyzed stastically and clinically according to age, sex, surgical department, physical status, elective and emergency surgery, premedicants, induction agents, anesthetic methods, main anesthetic agent, anesthetic technique and muscle relaxants. The results were as follows: 1. The number of cases has been steadily increased. Considerable increase in the cases has been noted since 1985, when Chungnam National University Hospital was enlarged. 2. The distribution of the number of patients according to the age were 15, 332 cases (70. 9%) in the group of 16-60 years. 3. There were 12, 109 male (56. 1%) and 9,486 female (43.9/'0) cases. 4. 6, 128 cases (28.4%) were in general surgery, 4, 276 cases (19. 8%) in orthopedic surgery, 3, 138 cases (14.5%) in OB-GY and 1, 888 cases (8.7%) in ENT in order of numbers. 5. According to the ASA classification of physical status, most of the cases were belonged to the class 1 (33. 9%) class 2 (26.6%), class 1E (14.2%) and class 2E (12.5%). Almost cases were relatively in good physical status. 6. The rate of elective to emergency was 66. 5% (14, 370 cases) to 33. 5% (7, 225 cases). 7. As premedicants, a group of atropine, diazepam and hydroxyzine (33.4%) was given most frequently. Recently, glycopyrrolate has been used increasingly. 8. Thiopental sodium has been mainly used for intravenous induction agent. 9. General anesthesia has been used as the main method of anesthesia. 10. Halothane was the most commonly used anesthetic agent. Since 1979, the use of enflurane has been increased yearly. 11. The semiclosed circle breathing system was mainly employed. 12. Succinylcholine was given to most cases. Pancuronium was the most commonly used nondepolarizing muscle relaxant. Vecuronium has been used since 1986.

Rocuronium을 이용한 신속 마취유도시 정맥마취제의 선택이 기관내 삽관 환경에 미치는 영향

신용섭,김하진 대한마취통증의학회 2004 Korean Journal of Anesthesiology Vol.47 No.1

Background: We assessed the effect of intravenous induction agents on intubation conditions and hemodynamic changes when using rocuronium 0.7 mg/kg for rapid sequence induction. Methods: Sixty ASA class I or II patients undergoing elective surgery were divided into a thiopental group (5 mg/kg, n = 20), a propofol group (2 mg/kg, n = 20) and an etomidate group (0.2 mg/kg, n = 20). Anesthesia was induced with intravenous induction agents. After loss of consciousness, rocuronium 0.7 mg/kg was injected. Intubation was attempted at 60 seconds after rocuronium administration. Arterial blood pressure and heart rate were measured before induction, immediately after intubation, and 1, 3, 5, and 10 minutes after intubation. Intubation conditions were assessed by jaw relaxation, vocal cord movement, response to tracheal intubation, and were evaluated as excellent, good, fair, and poor. Results: Excellent intubation conditions were obtained 55% (n = 11) in the thiopental group, 60% (n = 12) in the propofol group, and 45% (n = 9) in the etomidate group. Systolic and diastolic arterial blood pressures were elevated after intubation in all three groups. But these changes were minimal in the propofol group. Conclusions: Intubation conditions were not significantly different after the intravenous injection of thiopental 5 mg/kg, propofol 2 mg/kg, or etomidate 0.2 mg/kg when using rocuronium 0.7 mg/kg for rapid sequence induction. (Korean J Anesthesiol 2004; 47: 12~16)

Glucocorticoid의 투여가 근 수축과 근이완제의 반응에 미치는 영향

신용섭,손수창,윤석화,이원형,김윤희,윤희석,유용준,이정은 대한마취통증의학회 2003 Korean Journal of Anesthesiology Vol.44 No.3

=The Neuromuscular Effects of Glucocorticoid Administration on the Skeletal Muscle of RatsYong Sup Shin, M.D., Soo Chang Son, M.D., Seok Hwa Yoon, M.D., Won Hyung Le, M.D.M.D., Hee Suk Yoon, M.D., Yong Joon Yoo, M.D., and Jung Un Lee, M.D.