위암 환자에서 위전절제술시 비절제술이 예후에 미치는 영향

신용섭,하우송,박순태,권수인,이영준,이영재 대한외과학회 1997 대한외과학회 학술대회 초록집 Vol.1997 No.11

모래/폴리스티렌 유동층에서 입자 혼합에 관한 연구

신용섭 경성대학교 환경문제연구소 2000 環境硏報 Vol.10 No.1

The minimum fluidization velocities of sand/polystryrene mixture in a fluidized bed were measured according to variation of mixing ratio. Particle concentration distributions in the bed were also measured with mixing ratio and superficial air velocity. The mixing index was defined and calculated from the measured particle concentration distribution. As mixing ratio of the sand was increased, voidage of the fixed bed showed trend of concave curve and voidages at minimum fluidization conditions also behaved as those of fixed bed. Based on the measured results, it could be concluded that the minimum fluidization velocities were determined by the components which had high mixing ratio. It was also evident that sand particle took a role of jetsam and polystyrene particle took a role of floatsam and their behavior were independent of mixing ratio and superficial air velocity. As mixing ratio and superficial air velocity were increased, particle concentration distribution in the middle section of the bed was improved. However, particle concentration distributions near the bottom of the bed and especially, near the top section were not improved. The mixing index of the bed was increased with the excess air velocity.

불균일상 촉매를 이용한 대두유의 에스테르화 반응

신용섭 한국생명과학회 2004 생명과학회지 Vol.14 No.2

불균일상 촉매를 이용한 대두유와 메탄올간의 에스테르화 반응에 대하여 조사하였다. 온도 40∼$65^{\circ}C$에서 대두유와 메탄올 혼합물 내 성분 분배를 측정하였다. NaOH, CaO, Ca(OH)$_2$, MgO, Mg(OH)$_2$, and Ba(OH)$_2$과 같은 촉매에 대하여 반응 혼합물의 글리세린 함량을 측정하였다. 측정된 글리세린 농도로부터 반응 혼합물의 전화율을 계산하였다. 촉매 투여량, 보조용매 그리고 반응온도의 최종전화율에 대한 영향을 조사하였다. 대두유에 대한 메탄올의 용해도는 메탄올에 대한 대두유의 용해도보다 월등히 컸다. 대두유의 에스테르화 반응에 불균일상 촉매를 사용한 경우 최종전화율은 불균일상 촉매의 염기도에 크게 의존하였고, 촉매 금속의 염기도 증가에 따라 증가하였다. 알칼리 금속의 수산화물이 산화물 보다 효과적이었으며, 산화물은 촉매효과를 보이지 않았다. Ca(OH)$_2$를 에스테르화 반응의 촉매로 사용한 경우, 최종전화율의 최대값이 촉매 투여량 4%일 때 측정되었다. 최종전화율과 반응속도는 온도증가에 따라 증가하였으며 5$0^{\circ}C$에서 급격한 증가를 보였다. Ba(OH)$_2$를 촉매로 사용한 경우 보조용매로 HCl$_2$를 투여하면, 투여량 3%일 때 최종전화율의 최대값이 측정되었다. Using heterogeneous catalyst, esterification reaction of soybean oil (SBO) with methanol was investigated. Distributions of components in mixtures of soybean oil and methanol were measured at temperatures ranging from 40 to $65^{\circ}C$. Glycerine contents of reaction mixtures were measured for the different kinds of catalysts, such as NaOH, CaO, Ca(OH)$_2$, MgO, Mg(OH)$_2$, and Ba(OH)$_2$. Based on the measured glycerine concentrations, conversions of the reaction mixtures were calculated. The effects of dose of catalyst, cosolvent and reaction temperature on final conversion were examined. Solubility of methanol in soybean oil was substantially greater than that of soybean oil in methanol. When the esterification reaction of soybean oil was catalyzed by heterogeneous catalyst, final conversion was strongly dependent on the alkalinity of the heterogeneous catalyst, and increased with the alkalinity of the catalyst material. Hydroxides from the alkali metals were more effective than oxides, which actually had no catalytic effects. When Ca(OH)$_2$ was used for the esterification catalyst, maximum value of final conversion was measured at dose of 4%. The final conversion and reaction rate increased with reaction temperature, and showed substantial increment at reaction temperature of 5$0^{\circ}C$. When cosolvent, CHCl$_3$, was added into the reaction mixture of soybean oil which catalyzed by Ba(OH)$_2$, maximum value of final conversion was appeared at dose of 3%.

노인 환자에서 경막외 마취전 수액제제의 투여에 따른 저혈압 발생에 대한 비교 연구 : Comparison between Preanesthetic Administration of Crystalloid, Colloid and No Prehydration

신용섭 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

This study was designed to compare the incidence and frequency of hypotension and vasopressor therapy after epidural anesthesia and crystalloid, colloid and no prehydration in the elderly patents. Forty-five ASA GRADE 1 or 2 patients, aged 60 years of over, scheduled for orthopedic surgery under epidural anesthesia were randomized to one of three groups. Group 1 received 500 ml crystalloid solution(lactated Ringer's solution), group 2 received 500 ml colloid(6% hydroxyethyl starch) and group 3 received no prehydration over 15 minute prior to epidural anesthesia. Hypotension was defined as 30% decreased form baseline systolic blood pressure of systolic less than 90 mmHg, and was treated with ephedrine 5 mg boluses. The incidence of hypotension was not significantly different between the groups. The incidence of ephdrine use, incidence of nausea/vomiting and median total dose of ephedrine were not significantly different between the groups. The study has demonstrated that, in elderly patients, administration of crystalloid or colloid before epidural anesthesia did not decrease the incidence of degree of hypotension of need for vasopressor therapy compared with withholding prehydration.

Midazolam의 투여가 전신마취시 혈중 Glucose 측정치에 미치는 영향

신용섭 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.2

This study examined the effects of midazolam on circulating concentrations of blood glucose and cardiovascular response and compaired with a comparable group of patients receiving thiopental as induction agent only. Twenty patients of ASA class 1 were randomly allocated to Control or Midazolam group. Blood glucose level in reponse to anesthesia and surgery were comparable in the two groups of patients. The use of midazolam as premedicant (0.05 mg/kg, intramuscularly) and intravenous induction agent (0.3 mg/kg) was not associated with significant increase in blood glucose and mean arterial pressure.

Morphine투여시 Fentanyl, Clonidine과의 병용과 투여시기가 수술 후 통증에 미치는 영향

신용섭 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

The spinal surgical patients were randomly assigned to two groups. One group received fentanyl(3㎍/kg) intravenously during general anesthetic induction, continuous morphine(l.0mg/hr) infusion through the patient-controlled analgesia(PCA) infusion system and a bolus dose of clonidine(3㎍/kg). Another group received a bolus intravenous morphine O.lmg/kg at immediately before the skin closure. Anesthesia was maintained with 50% of nitrous oxide and enflurane or isoflurane in oxygen. Both group received continuous intravenous morphine through the PCA infusion pump(infusion rate 0.5mg/hour, bolus dose 1.0mg) in the postoperative period for 48 hours after operation. Pain scores on Visual Analogue Scale were assessed 1, 2, 6, 24 and 48hour after surgery. There was significant difference between the two groups in VAS at only 1 hour after surgery. In conclusion, intravenous fentanyl administration during tie induction, intraoperative continuous intravenous morphine infusion and sngle dose of intravenous clonidine were effective in reducing postoperative pair immediately after surgery. However, further investigations with regard to of optimization of the agents used, their combination and timing of administration will be necessary.

전분과 탄산칼슘을 포함한 HDPE 복합필름의 인장특성

신용섭,신부영,이훈복 한국화학공학회 1995 NICE Vol.13 No.5

부산시의 자동차 배출가스 저감사업 추진에 따른 온실가스 및 대기오염물질 저감효과 산출

신용섭,정장표,양희원,이성희 한국대기환경학회 2011 한국대기환경학회 학술대회논문집 Vol.2011 No.10

전신마취에서 각성과 회복시 혈압 상승에 대한 Urapidil과 Labetalol의 효과

신용섭 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

The effects of urapidil on increase in blood pressure, heart rate and rate-pressure product(RPP) during emergence and recovery from general anesthesia were compared to that of labetalol. Urapidil 0.2 mg/kg(urapidil group) or labetalol 0.2 mg/kg(labetalol group) were injected before emergence from general anesthesia. The systolic, diastolic and mean arterial pressure and heart rate were measured continuously before giving the test drug, 1, 3, 5 minute after administration and just prior to endotracheal extubation. Also, the hemodynamic responses during recovery were measured at 1, 3, 5, 10, 15, 20, 25, and 30 minute after extubation. The blood pressure peak during emergence and recovery occurred significantly(p<0.05) just before the extubation in the both group. The significant increases (p<0.05) of systolic arterial pressure were measured at 1, 5, and 15 min after extubation in the urapidil group. The changes of diastolic and mean arterial pressure were not significant in the both group during recovery. The heart rates were significantly(p<0.05) increased just prior to extubation, 1 minute and 5 minute after extubation in urapidil group. The changes of heart rate were not significant in the labetalol group. There was not prolonged tachycardia in both group. The peak rate-pressure products were measured just prior to extubation in both group. However, increases in RPP were significantly more frequent in patients given urapidil. There were no significant differences in arterial pressure and heart rate between the two groups. The hemodynamic effects of relatively small dose of urapidil and labetalol appeared to be beneficial during emergence and recovery period in patients undergoing general anesthesia.

Urapidil, Labetalol의 투여가 기관내 삽관시 심혈관계에 미치는 영향

신용섭,윤석화,손수창,이원형,이정은,황원재,김만수,김영주,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

We have examined the comparative efficacy of small doses of intravenous urapidil and labetalol in blunting hemodynamic response to endotracheal intubation and surgical incision in 30 patients without cardiovascular diseases. After intravenous urapidil 0.2 mg/kg or labetalol 0.2 mg/kg anesthesia was induced with thiopental 5mg/kg. Endotracheal intubation was facilitated by vecuronium 0.15 mg/kg with priming principle and anesthesia was maintained with enflurane and nitrous oxide in oxygen. Systolic, diastolic and mean arterial pressure and heart rate were measured before administration of the drugs, 5 minute after administration, just prior to endotracheal intubation and 1, 3, 5, 10 minute after intubatin. Also the peak blood pressures and heart rate within 10 minutes after surgical incision were measured. Endotracheal intubation and surgical stimulation were associated with significant increases in blood pressures and heart rate in both urapidil and labetalol group. Comparison of the changes in systolic, diastolic, and mean artrial pressures and heart rate between urapidil and labetalol group showed no significant difference except peak systolic pressure after surgical incision. It is concluded that the pressor response to endotracheal intubation and surgical stimulation are not influenced significantly by urapidil 0.2 mg/kg or labetalol 0.2 mg/kg. However, urapidil and labetalol preloading may be similarly effective in the blunting of the increases in blood pressures with larger doses of the durgs during anesthetic induction.