말초성 안면마비 환자의 재발에 대한 임상적 고찰

신예지,권나현,박현애,우현수,백용현,박동석,고형균,Shin, Ye-Ji,Kown, Na-Hyoun,Park, Hyun-Ae,Woo, Hyun-Su,Beak, Yong-Hyeon,Park, Dong-Suk,Koh, Hyung-Kyun 대한침구의학회 2009 대한침구의학회지 Vol.26 No.1

Objectives : This study was performed to categorize and define causes of recurrent peripheral facial nerve palsy. Methods : 54 patients was identified with recurrent peripheral facial nerve palsy among 726 patients who visited the Facial Palsy Center in East-West Neo Medical Center between May 2006 and August 2008. We reviewed the medical records including gender, age, laterality, number of recurrence, primary onset age, interval between recurrences, accompanied disease(e.g. DM, HTN), and axonal loss. Results : Patients whose primary palsy onset was before their second decade had a higher possibility of recurrence and tended to recur more than twice. Double-episode ipsilaterally recurrent group showed definitely worse result of axonal loss compared with non-recurrent group and single-episode ipsilaterally recurrent group. But There was no statistically significant difference between mean axonal loss of the non-recurrent group and single-episode ipsilaterally recurrent group. Conclusions : This study was designed for 54 patients and further studies are necessary.

건강에 좋은 슈퍼푸드로 만든 우리아이 간식, 슈퍼젤리

신예지,천경은,안인숙,이선,김미나 한국식품영양과학회 2014 한국식품영양과학회 학술대회발표집 Vol.2014 No.10

다문화청소년의 우울 및 비행의 발달궤적: 환경적 요인과 개인적 요인의 영향을 중심으로

신예지,전성은,강영신 한국다문화교육학회 2023 다문화교육연구 Vol.16 No.2

This study aims to investigate the trajectories of depression and delinquent behavior among multicultural adolescents and to identify ecological and personal factors that influence these trajectories. The data was gathered from Multicultural Adolescents Panel Survey, and the data used in this study was derived from the wave 4-9 of the survey. First, the level of depression among multicultural adolescents non-linearly and moderately increased as time went by, but the level of delinquent behavior among multicultural adolescents neither increased nor decreased over time. Second, the intercept of depression could be negatively predicted by parental support and peer support and the slope of depression could be positively predicted by parental support and peer support. Third, the intercept of depression could be negatively predicted by self-resilience and the slope of depression could be positively predicted by self-resilience. Fourth, teacher support had no significant effect on depression trajectories. Fifth, the intercept of delinquent behavior could be negatively predicted by teacher support and the slope of delinquent behavior could be positively predicted by teacher support. Based on the results of this study, implications, limitations, and the suggestions for future study were also discussed. 본 연구는 다문화청소년의 우울과 비행의 발달궤적, 그리고 환경적 요인(부모지지, 교사지지, 친구지지)과 개인적 요인(자아탄력성)이 다문화청소년의 우울과 비행의 발달궤적에 미치는 영향을 알아보는데 그 목적이 있다. 이를 위해 다문화청소년패널조사(MAPS) 1기 자료 중 4차년도 자료부터 9차년도 자료(2014년-2019년)를 분석하였다. 본 연구 결과는 다음과 같다. 첫째, 다문화청소년의 우울은 비선형적으로 증가하며, 시간이 지남에 따라 더욱 완만하게 증가하는 것으로 확인되었다. 비행은 시간의 흐름에 따라 증가하거나 감소하지 않는 것으로 나타났다. 둘째, 환경적 요인 중 부모지지와 친구지지는 다문화청소년의 우울초기치를 부적으로 예측하였고, 우울의 변화율을 정적으로 예측하는 것으로 나타났다. 셋째, 개인적 요인인 자아탄력성은 다문화청소년의 우울초기치를 부적으로 예측하였고, 우울의 변화율을 정적으로 예측하는 것으로 확인되었다. 넷째, 환경적 요인 중 교사지지는 다문화청소년의 우울 발달궤적에 유의한 영향을 미치지 않는 것으로 나타났다. 다섯째, 교사지지는 다문화청소년의 비행초기치를 부적으로 예측하였고, 비행 변화율을 정적으로 예측하였다. 이와 같은 결과를 바탕으로 연구의 의의 및 제한점, 그리고 후속연구를 위한 제언을 기술하였다.

상담 효과 및 이용편의에 관한 후기가 잠재적 내담자의 상담에 대한 태도에 미치는 영향

신예지,김계현 한국상담학회 2016 상담학연구 Vol.17 No.1

This experimental research analyzed the effect of reviews about counseling services on establishing a positive attitude toward counseling services of potential clients. Two different types of reviews were given to potential clients. Their attitudes toward counseling services were measured before and after reading the reviews about counseling services. According to the Construal Level Theory, reviews divided into the effectiveness (high-level construal) and the convenience (low-level construal) of using counseling services. 114 university students in Seoul who had no previous experience in using counseling services and did not intend to use counseling services in the near future were chosen to analyze the following research. The subjects were divided into two groups: one group received reviews about the effectiveness of counseling services, and the other group received reviews about the convenience of using counseling services. Using analysis of covariance (ANCOVA), the results showed that there was a statistically significant difference in changes of attitude towards counseling services between the two groups that read reviews of effectiveness of counseling services and the group that received online reviews of the convenience of using counseling services. This result suggests that online reviews about the effect of counseling services have a positive effect on the attitude toward counseling services. 본 연구는 상담 후기가 잠재적 내담자의 상담에 대한 호의적 태도 형성에 미치는 영향을 분석하기 위한 실험연구이다. 잠재적 내담자에게 두 종류의 상담 후기를 제시하고, 상담 후기를 읽기 전과 후에 상담에 대한 태도를 측정하였다. 상담 후기는 해석수준 이론에 따라 상담 효과에 관한 후기(상위 해석수준)와 상담 이용편의에 관한 후기(하위 해석수준)로 분류하였다. 상담 경험이 없고, 상담을 빠른 시일 내에 받을 계획이 없다고 응답한 서울 소재의 대학(원)생 114명의 자료가 분석되었다. 연구 참여자는 두 집단으로 나뉘어 각각 상담 효과에 관한 후기와 상담 이용편의에 관한 후기를 제시 받았다. 공분산분석(ANCOVA) 실시 결과, 상담 효과에 관한 후기를 읽은 집단과 상담 이용편의에 관한 후기를 읽은 집단 간 상담에 대한 태도 변화에 통계적으로 유의미한 차이가 나타났다. 이 결과는 상담 효과에 관한 후기가 잠재적 내담자의 상담에 대한 호의적 태도 형성에 보다 효과적임을 시사한다.

플라즈마 전해 산화와 실리콘 오일 담지를 이용한 알루미늄 합금의 내식성 및 내마모성 향상

신예지,윤지수,김동현,이정훈 한국표면공학회 2021 한국표면공학회 학술발표회 초록집 Vol.2021 No.6

말초성 안면마비 환자의 재발에 대한 임상적 고찰

신예지,권나현,박현애,우현수,백용현,박동석,고형균 대한침구의학회 2009 대한침구의학회지 Vol.24 No.1

Objectives : This study was performed to categorize and define causes of recurrent peripheral facial nerve palsy. Methods : 54 patients was identified with recurrent peripheral facial nerve palsy among 726 patients who visited the Facial Palsy Center in East-West Neo Medical Center between May 2006 and August 2008. We reviewed the medical records including gender, age, laterality, number of recurrence, primary onset age, interval between recurrences, accompanied disease(e.g. DM, HTN), and axonal loss. Results : Patients whose primary palsy onset was before their second decade had a higher possibility of recurrence and tended to recur more than twice. Double-episode ipsilaterally recurrent group showed definitely worse result of axonal loss compared with non-recurrent group and single-episode ipsilaterally recurrent group. But There was no statistically significant difference between mean axonal loss of the non-recurrent group and single-episode ipsilaterally recurrent group. Conclusions : This study was designed for 54 patients and further studies are necessary.

알루미늄 합금의 내식성 및 내마모성 향상을 위한 플라즈마 전해 산화 처리와 실리콘 오일 담지

신예지,나민희,김권후,김동현,이정훈 한국표면공학회 2021 한국표면공학회 학술발표회 초록집 Vol.2021 No.12

The Effect of Aralia Cordata Thunb and Cimicifuga Heracleifolia on Cartilage Protection by the Regulation of Metabolism in Human Osteoarthric Chondrocytes

신예지,백용현,박동석,김재규,고형균,Shin, Ye-Ji,Beak, Yong-Hyeon,Park, Dong-Suk,Kim, Jae-Kyu,Koh, Hyung-Kyun Korean AcupunctureMoxibustion Medicine Society 2010 대한침구의학회지 Vol.27 No.4

목적 : 퇴행성 관절염은 염증성 사이토카인인 IL-$1\beta$에 의해 연골관절이 파괴되고 이로 인해 염증성 사이토카인이 더욱 증가하는 질환이다. 퇴행성 관절염을 치료하기 위해서는 연골 파괴를 가속화시키는 catabolic cytokines의 활성을 줄이고, 성장인자인 anabolic factor의 활성을 증가시는 연골 보호 작용이 있어야 한다. 본 연구에서는 독활 승마 처방(OAH19T)이 catabolic/anabolic 대사 조절에 어떤 영향을 미치는지와 그 신호 전달 기전에 대해 연구하였다. 또한 OAH19T를 구성하는 단미재 및 임상에서 사용되는 COX-2 inhibitor인 Celebrex(CEL)와 효능을 비교 실험하였다. 방법 : 배양된 세포에 IL-$1\beta$로 자극한 후 (1) glycosaminoglycan(GAG)의 분해 억제 정도, (2) OAH19T와 CEL에 대하여 MMP-1과 MMP-3의 유전자 발현 및 활성 억제, (3) Aggrecan 및 Aggrecanases의 유전자 발현 및 활성 억제, (4) OAH19T의 growth factor의 조절 능력, (5) MAPK pathway 등을 RT-PCR(reverse transcriptase-polymerase chain reaction), ELISA(Enzyme-linked immunosorbent assay), western blot, viability 측정을 통해 검증했다. 결과 : 사람 관절 세포에서 (1) 독활 승마 각각의 단미재, 임상에서 사용중인 셀레콕시브(CEL), 조인스보다 실험 약물(OAH19T)이 저농도에서 GAG 분해 억제 효과가 우수하였고, 부탄올로 분획한 OAH19B와는 동등한 효과를 보였다. (2) OAH19T는 IL-$1\beta$에 의하여 활성화된 MMP-1과 MMP-3의 발현을 모두 억제하였으나, CEL은 MMP-1의 발현은 억제하였으나 MMP-3의 발현은 억제하지 못하였다. (3) OAH19T는 IL-$1\beta$에 의하여 손상된 Aggrecan을 회복시켰으며 이는 활성화된 Aggrecanase-1과 Aggrecanase-2를 억제시킴으로써 나타난 결과이다. 그러나 CEL의 경우, 손상된 Aggrecan을 회복시키지 못하였다. (4) 배양된 세포는 IL-$1\beta$에 의하여 TGF-$\beta$II및 TGF-$\beta$ receptor II의 발현이 억제되었으나, OAH19T는 TGF-$\beta$II및 TGF-$\beta$ receptor II의 발현을 회복시켜 OAH19T가 anabolic한 조절능력이 있음을 시사한다. 그러나 CEL의 경우 growth factor에 대한 조절 능력이 없었다. (5) 대사 조절 작용에 대한 기전으로서 MAPK pathway에 대해서 연구한 결과 IL-$1\beta$에 의하여 유도된 pERK, pp38 kinase의 활성은 억제하였고, pJNK의 활성은 변하지 않았다. 또한 OAH19T는 연골 세포에 독성이 없었으며 IL-$1\beta$에 의해 유도된 세포 증식만을 억제시켰다. 이 결과로, OAH19T가 OA chondrocyte의 탈분화 및 세포 고사를 억제하여 연골보호 및 회복 효과가 있음을 알 수 있었다. 결론 : OAH19T는 이를 구성하는 단미재 및 CEL보다 연골보호 효과가 월등하였고, 이러한 연골보호 효과는 catabolic cytokines/growth factors의 균형으로 대사조절을 통해 연골세포의 탈분화 및 세포 고사를 억제하여 연골보호 및 회복 효과가 있음을 알 수 있었다.

The Short Term Effects of Ankle Strengthening Emphasis with Jumping on Strength, Mechanical Properties, and Balance with and without Wearing High Heel in Ankle Instability

신예지,윤태림 대한물리치료학회 2019 대한물리치료학회지 Vol.31 No.4

Purpose: The purpose of this study was to investigate the short term effects of ASEJ (ankle strengthening with emphasis on jumping) for 3weeks on strength, mechanical properties, and balance and to compare the balance with and without HH(high-heel) condition. Methods: ASEJ (a combined exercise of squat, heel raise up, and jumping) were performed for the subjects in 11 female ankle instability young females (21.7±2.0 yrs Cumberland ankle instability score 19±6.5). To investigate the effect of ASEJ, investigator used dynamometer for measuring strength, MyotonPRO for measuring mechanical properties(tone, stiffness, and elasticity of the muscles), I-Balance test for static balance, and Y-balance test for dynamic balance between the condition with and without HH condition. All data were normally distributed and analyzed using the SPSS 22.0 statistical program. Comparing pre- and post-intervention and the condition with and without HH conditions data were examined using the paired t-test. The level of significance was chosen as 0.05 for all the analyses. Results: 3wks of ASEJ would strengthen leg muscles and increasing muscle tone and stiffness in most muscles however there was decreasing muscle elasticity of gastrocnemious. In addition, the ASEJ improves the static balance for ankle instability young females and increases the dynamic balance when wearing the heels especially. Conclusions: the ASEJ could recommend to improve the strength and balance for ankle instability young females. Also, measuring the balance with HH conditions well represents the risk of ankle damage in female.

관절ㆍ류마티스 질환의 한ㆍ양방 협진에 관한 임상적 고찰

신예지,김찬영,권나현,권신애,이정우,고형균,우현수,박동석,백용현 대한침구의학회 2009 대한침구의학회지 Vol.26 No.6

Objectives : To evaluate the current status of East-West combination treatment in joint disorders. Methods : The medical records of patients who visited the Joints & Rheumatism Center at the Kyung Hee East-West Neo Medical Center from April 2006 to June 2009 were evaluated. The general characteristics of patients who underwent combination treatment, trend in number of cross-system referrals, and disorders and involved body regions of patients referred to the Eastern medical hospital from the Western medical hospital were initially assessed. 6 major disorders were found from the initial scanning. The trend in number of cross-hospital referrals, number of visits to the Eastern medical hospital, current status of combination treatment, treatment modality, and reason for cross-system referral was evaluated. Results : 1. 1510 patients were referred from the Eastern medical hospital to the Western medical hospital, and 1065 patients were referred from the Western medical hospital to the Eastern medical hospital. First visit patients reached a peak at the second quarter of 2007 and fourth quarter of 2006 respectively, and have steadily decreased from then on. Referrals of female patients were twice as common as male patient referrals. Patients in their sixth or seventh decade of life were most commonly referred, and more outpatients were referred compared to inpatients. 2. Patients with knee joint disorders were most commonly referred from the Western medical hospital to the Eastern medical hospital, followed by hip, shoulder, ankle, wrist, and elbow joint disorders. The most common disorders for each of the above regions in referred patients were knee osteoarthritis, avascular necrosis of the hip, adhesive capsulitis, and ankle strain and sprain. The generalized disorders rheumatoid arthritis and ankylosing spondylitis followed. 3. Patients referred to the Eastern hospital received approximately 3 to 10 Eastern medical treatment sessions. 45 percent remained on constant combination treatment, and 98 percent of referred patients received acupuncture treatment. Conclusions : In regard to the number of patients and duration of combination treatment, combination treatment was successfully performed for knee osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis, while it was not so for avascular necrosis of the hip, adhesive capsulitis, and ankle strain and sprain. Further research on this subject is required.