발기부전 처방에 사용되는 쇄양(鎖陽)이 음경해면체 이완에 미치는 영향

신선미,박선영,Shin, Seon-mi,Park, Sun-young 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.4

Objective: This study aimed to examine the relaxation effects and underlying mechanisms of Cynomorii herba (CH) extract in isolated rabbit corpus cavernous tissues.Methods: We experimented with CH extract (0.01-3.0 mg/mL). Nω-nitro-L-arginine (L-NNA) was experimented before the CH extract to contracted strips induced by phenylephrine (PE, 1 μM)and compared with nonexperimented. In addition, we experimented with calcium chloride (Ca²⁺, 1 mM) after pretreatment of the CH extract in Ca²⁺-free Krebs-Ringer solution to contracted strips induced by PE. The cell viability and nitric oxide (NO) concentration of human umbilical vein endothelial cells (HUVECs) were measured by an methylthiazol-2-yl-2, 5-diphenyl tetrazoliumbromide (MTT) assay and Griess reagent system. The ratio of smooth muscles to collagen fibers, in addition to eNOS- and PDE-5-positive reactions, was examined by histochemical and immunohistochemical staining.Results: The CH extract significantly induced the relaxation of the cavernous strips, and the pretreatment with L-NNA inhibited CH extract-induced relaxation. The L-NNA pretreatment reduced the increased contraction induced by the addition of Ca²⁺in Ca²⁺-free solution. Furthermore, the NO concentration of the HUVECs increased. When the CH extract was applied to the corpus cavernosum of the penis (CCP) of Sprague Dawley rats, the ratio of smooth muscles to collagen fibers by PE and the formation of eNOS around the helicine artery increased. However, the CH extract treatment decreased PDE-5 positive reactions.Conclusions: These results show that the relaxation effects induced by the CH extract are associated with the suppression of the influx of extracellular Ca²⁺ via the production of NO and eNOS and inhibition of PDE-5.

SM-2015의 혈중 알코올 분해 및 숙취 개선 효과

신선미,박선영,김태연,Shin, Seon-mi,Park, Sun-young,Kim, Tae-yeon 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.1

Objectives: This study investigated the effect of SM-2015 on blood alcohol clearance and hangover. We undertook this study to test whether SM-2015 is effective in decreasing blood alcohol concentration and preventing the symptoms of alcohol-induced hangover. Methods: Twenty healthy volunteers participated in this randomized crossover study. All participants were classified between an SM-2015 intake group (test group) and a non-intake group (control group). The primary outcome measure was the difference in blood alcohol concentration and hangover severity scores between the test and control groups. The secondary outcome measure was the difference in a liver function test (LFT) between the test and control groups. Results: After alcohol exposure, the sensitivity scores of blood alcohol concentration and hangover symptoms (sleepiness, dizziness, nausea, weakness, stomach pain, diarrhea, and concentration disorder) were significantly decreased in the SM-2015 intake group compared with the non-intake group. There were no differences in the LFT results between the SM-2015 intake group and the non-intake group. Conclusions: SM-2015 is effective in decreasing blood alcohol concentration and preventing the symptoms of alcohol-induced hangover. Larger studies are required to confirm these findings.

골다공증 다빈도 처방과 구성 약물의 네트워크 분석 - 오아시스 검색을 중심으로

신선미,고흥,Shin, Seon-mi,Ko, Heung 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.4

Objectives: This study analyzed, through network analysis and data mining analysis, the relationship between herbs used in osteoporosis prescriptions, diversified the analysis of osteoporosis-related prescriptions, and analyzed the combination of herbs used in osteoporosis-related prescriptions. Methods: The prescriptions used in osteoporosis treatment and experiments were established by conducting a full survey of the papers published by the OASIS site. A database for osteoporosis-related prescriptions was established, herbs were extracted, and the frequency of frequent herbs and prescriptions were investigated using Excel (MS offices ver. 2013). Using the freeware R version 4.0.3 (2020-10-10), igraph, and arules package, network analysis was performed in the first second of prescription composition. Results: Among the osteoporosis-related prescriptions, the most studied prescriptions are as follows.: Yukmijihwang-tang (六味地黃湯) and Samul-tang (四物湯). In the osteoporosis prescription network, herbs with connection centrality, proximity centrality, mediation centrality, and eigenvector centrality appeared in the order of Rehmanniae Radix Preparata, Angelicae Gigantis Radix, Poria Sclerotium, Paeoniae Radix, and Glycyrrhizae Radix et Rhizoma. After extracting the herbal combination network, including the corresponding herbs, and clustering it, it can be divided into drugs of the Yukmijihwang-tang (六味地黃湯) series and the Samul-tang (四物湯). Conclusions: This study could assist researchers in diversifyingy formula analysis in future studies. Moreover, the herbal combination used in osteoporosis prescriptions could be used to search for osteoporosis prescriptions in other databases or to create a new prescription.

SM-2000의 항피로 효과에 대한 임상적 연구

신선미,고흥,Shin, Seon-Mi,Ko, Heung 대한한방내과학회 2011 大韓韓方內科學會誌 Vol.32 No.3

Objectives : This study was performed to investigate the antifatigue effect of SM-2000 on fatigued and stressed people. Methods : This study was carried out on 23 healthy people who have fatigue and stress. 11 people as the mentally-stressed group were examined by subjective symptoms of fatigue and blood cortisol test. They drank SM-2000 for seven days. SM-2000 was made up herbs which were used for fatigue. After that they were again examined by subjective symptoms of fatigue and blood cortisol test. 12 people as the physically-fatigued group were examined with fatigue biomarkers and exercise test. They also drank SM-2000 for seven days. After that they were again examined with fatigue biomarkers and exercise test. Results : Cortisol level, subjective symptoms of fatigue scores and physical, mental, and neuro-sensory symptoms of fatigue scores after drinking SM-2000 were not significantly increased compared with before drinking SM-2000 in the mental stressed group. SM-2000 significantly decreased lactate, glucose, and phosphorous levels, and running time after drinking SM-2000 was significantly suppressed compared with before drinking SM-2000 in the physically-fatigued group. Conclusions : On the basis of these results, SM-2000 had a clinical antifatigue effect in physically-fatigued people.

의료급여 장기이용 수급권자의 잉여약물 실태와 관련요인

신선미,김의숙,이희우,Shin, Sun-Mi,Kim, Eui-Sook,Lee, Hee-Woo 대한예방의학회 2009 예방의학회지 Vol.42 No.6

Objectives : The amount of medical utilization by Medical Aid recipients was 3.7 times that of patients with Korean Medical Insurance. This study aims to describe the surplus medicine and the medication-related utilization, and to determine factors contributing to surplus medicine. Methods : Among those who used copayment-free Class I Medical Aid in 2005, 146,880 subjects who were $\geq19$ year-old and received >365 days medical treatment per year were studied with their case managers by conducting face-to-face interviews. The analytic methods were description, chi-square, t-tests, ANCOVA and multiple logistic regressions. Results : Most subjects were female (68.6%), the elderly (62.5%), and the separated (61.6%), had an elementary graduation or less (74.8%), and had disabilities (33.2%). The percentage of subjects with surplus medicine was 18.5%. However, the percentage of females, the elderly, those with non-disabilities, the separated, the uneducated, those with a very poor perceived health status and those with an economical burden for medical treatment was 19.3%, 18.9%, 19.0%, 19.3%, 19.0%, 20.2% and 24.3%, respectively. For subjects with surplus medicine, averages for the number of used pharmacies, the pharmacy-visit days and the medication costs were 4.6 drugstores, 34.9 days and approximately 1,124 thousand Won(￦). These values were higher than those without surplus medicine (4.4 drugstores, 33.8 days, and ￦1,110 thousand, respectively). The odds ratios of the contributing factors to surplus medicine were female 1.11 (95% CI=1.07-1.14), the elderly 1.06 (95% CI=1.02-1.10), those with non-disabilities 1.08 (95% CI=1.05-1.12), the separated 1.14 (95% CI=1.10-1.18), the unmarried 1.12 (95% CI=1.07-1.18), the uneducated 1.03 (95% CI=1.01-1.08), those with a very poor perceived health status 1.04 (95% CI=1.01-1.08) and experiencing an economical burden for medical treatment 2.33 (95% CI=2.26-2.40). Conclusions : 18.5% of subjects had surplus medicine with a higher mean of medication cost. Therefore, health education and health promotion programs to prevent surplus medicine and to improve the appropriate usage of medication are necessary.

학생 건강에 대한 OECD와 한국의 통계지표

신선미,Shin, Sun-Mi 한국학교보건학회 2012 韓國學校保健學會誌 Vol.25 No.1

Purpose: The purpose of this study was to identify the statistical indicators of OECD and Korea for student health among Korea's approval statistics. Methods: Searching for health indicators by using Health at a Glance 2009, Society at a Glance 2009, and Education at a Glance 2009 through the formal OECD web site in 2010, and investigating the approval statistics through the Korean formal organizational web sites and published data in 2012. Results: Among OECD indicators, indicators for adolescent health were smoking and alcohol consumption, nutrition, physical activity, overweight and obesity, bullying, risk behaviors, and poverty children. However, most of Korea student health indicators were missing except poverty children and life satisfaction, because OECD has taken chiefly data from Health Behavior in School-aged Children survey (HBSC), international study, which has not been carried out in Korea. The Ministry Of Education, Science And Technology (MEST) and the Ministry of Health and Welfare, and National Youth Policy Institute in Korea have produced the major statistics for student health which was only 11 (1.3%) among 858 approval statistics. Conclusion: Identifying a current Korea school health is essential through participating actively to OECD whose statistic indicators are internationally comparable with Students Physical Development Survey, MEST's approval statistics, using Korea Student Health Examination. It was also suggested that quantitative and qualitative expansions for Korea student health statistics by the activation of approval statistics including processed statistics, and by researchers' easy expanded access to a raw data.

WeXGene: 웹 기반 XML 데이터 생성기

신선미,정회진,이상호,Shin Sun Mi,Jeong Hoe Jin,Lee Sang Ho 한국정보처리학회 2005 정보처리학회논문지D Vol.12 No.2

XML 데이터베이스 시스템 성능 평가를 수행하기 위해서는 다양한 형태의 XML 데이터 생성을 필요로 한다. 기존 XML 데이터 생성기들은 특정 성능 평가에 적용 가능한 데이터만을 생성하고, 그 기능 또한 매우 제한적이다. 본 논문에서는 기존 XML 데이터 생성기들의 제한된 기능을 보완하고 동시에 새로운 기능들을 추가한 새로운 XML 데이터 생성기인 "WeXGene"을 제안한다. WeXGene은 열 단위 또는 행 단위의 데이터를 포함하는 사용자 데이터 화일 및 "SDTD(Symbolic DTD)" 또는 입력 파라미터를 명시한 구조 정의 화일을 이용하여 XML 데이터를 생성한다. 또한 사용자 데이터 화일 없이도 임의의 데이터론 포함하는 XML 데이터 생성이 가능하다. 본 논문은 WeXGene의 구체적인 설계 내용, 구조, 데이터 생성과정 등을 기술한다. 또한 타 XML 데이터 생성기와 기능을 비교 분석하였다. We need XML generate various kinds of XML data to evaluate XML database systems. Existing XML data generators are developed to generate XML data that are suitable for particular evaluation methods, and their functionalities are limited in terms of generating XML data This paper introduces a new XML data generator, WeXGene, that not only improves the drawbacks of existing data generators but also adds new data generation functionalities. For generating XML data WeXGene uses the user data files and the structure definition files, which specify SDTD(Symbolic DTD) or input parameters. The user data file is a text data file that has column data or row data. It is also possible that WeXGene generates XML data without accessing the user data file. This paper presents the design details, overall system architecture, and data generation process of WeXGene. An analytic comparison with other XML data generators is also presented.

의료급여 과다 이용 수급권자 중 장애인의 의료이용

신선미,김의숙,박창기,이희우,Shin, Sun-Mi,Kim, Eui-Sook,Park, Chang-Ki,Lee, Hee-Woo 대한예방의학회 2010 예방의학회지 Vol.43 No.1

Objectives: In Korea, the top 10% of Medical Aid recipients represent nearly 60% of total payment, with the costs for those disabled for over 365 days representing approximately 30% of total payment. The purpose of this study was to compare Medical Aid use of the disabled with non-disabled recipients, and to identify contributing factors to the total payment in the top 2% of recipients identified as Medical Aid overusers. Methods: Subjects (n=2,211) selected were ${\geq}18$-years-of-age and received >1000 days of co-payment-free type I Medical Aid. Case managers (n=200) conducted interviews in December 2006, and collected data from Health Insurance Review & Assessment Service. Amounts over the 9 months from January September 2006 were analyzed descriptively and using Chi-square, ANCOVA, and robust multiple linear regression. Results: Disabled individuals (mean age 61.3 years) composed 36.6% of subjects; 44.8% of the disabled were male. On a monthly basis per capita, the disabled group averaged 10.5 outpatient days, total payment of 523,000 Korean Won(￦), inpatient payment of ￦359,000, and outpatient payment of ￦183,000. All values exceeded the monthly average for non-disabled individuals. Contributing factors were identified as male gender (￦82,000), elementary school or lower educational level (￦64,000), residence in a small city (￦82,000), lack of family support (￦61,000), kidney disability (￦673,000), intellectual disability (￦151,000), and multiple disabilities (￦119,000). Conclusions: The identification of contributing factors to Medical Aid use by those defined as disabled supports the adoption of comprehensive alternative policies such as strengthening of education and consultation services, provision of alternative facilities, and promotion of self-care.

컴퓨터과학 : 정보공시 자료를 이용한 교육/연구성과 영향요인 추출 및 대학의 군집 분석

신선미 ( Sun Mi Shin ),김현철 ( Hyeon Cheol Kim ) 한국컴퓨터교육학회 2014 컴퓨터교육학회 논문지 Vol.17 No.1

본 연구의 목적은 통계 분석과 데이터마이닝 기법을 이용하여 대학정보공시 자료 속의 새로운 패턴이나 의미 있는 결과를 도출함으로써 대학의 교육역량 및 경쟁력을 나타내는 지표 개선에 유용한 지식을 제공하는 것이다. 이를 위해 교육/연구성과를 나타내는 취업률, 기술이전건수, 전임교원 1인당 논문수 지표의 영향요인 탐색 및 의사결정나무 모형 도출과 대학평가 관련지표를 이용한 대학의 군집분석을 실시하였다. 연구 결과, 대학 교육/연구성과 지표의 공통 영향요인은 신입생충원율, 재학생충원율,전임교원 1인당 학생수로 나타났다. 군집분석에서는 전체 대학, 대학규모별, 소재지별로 각각 실시하였을 때 유명대학, 예체능ㆍ비이공계ㆍ종교지도자양성 대학, 그 외 대학으로 군집이 형성되는 양상을 보였고, 그 주요 영향요인으로는 대학 교육/연구성과 지표인 취업률, 기술이전건수 등으로 나타났다. The purpose of this study is to provide useful knowledge for improving indicators that represent competitiveness and educational competency of the university by deriving a new pattern or the meaningful results from the data of information disclosure of universities using statistical analysis and data mining techniques. To achieve this, a model of decision tree was made and various factors that affect education/research performance such as employment rate, the number of technology transfer and papers per full-time faculty were explored. In addition to this, the cluster analysis of universities was conducted using attributes related to evaluation of university. According to the analysis, common factors affecting higher education/research performance are following indicators ; incoming student recruitment rate, enrollment rate, and the number of students per full-time faculty. In the cluster analysis, when performed by the entire university, the size, location of the university respectively, clusters are mainly ormed by well-known universities, art·physical·non-science and engineering·religious leaders training universities, and others. The main influencing factors of this cluster are higher education/research performance indicators such as employment rate and the number of technology transfer.

침몰선박 주변 해양 특성 및 위해도 분석 연구

신선미(Sunmi Shin),정자헌(Jahun Jung),서영교(Youngkyo Seo),강태원(Taewon Kang),정철교(Cheolgyo Jung),범주원(Juwon Beom),김세훈(Sehun Kim),노재환(Jaehwan No) 한국해양환경·에너지학회 2023 한국해양환경·에너지학회 학술대회논문집 Vol.2023 No.05