[신동엽 시선] 진달래 山川 외 8편

신동엽 문예운동사 2016 문예운동 Vol.- No.131

[신동엽 산문선] 서둘고 싶지 않다 외 2편

신동엽 문예운동사 2016 문예운동 Vol.- No.131

대한갑상선학회 갑상선분화암 진료권고안; Part III. 진행성 갑상선분화암의 치료 - 제4장 진행성 방사성요오드 불응성 갑상선분화암의 전신항암치료 2024

신동엽 대한갑상선학회 2024 International Journal of Thyroidology Vol.17 No.1

The primary treatment for differentiated thyroid cancer (DTC) with distant metastasis is high-dose radioactive iodine (RAI) therapy, which can have various effects depending on the iodine uptake of thyroid cancer cells. The iodine uptake of metastatic lesions decreases over time, and approximately 40-70% of patients eventually develop RAI refractory disease. Although the prognosis of patients with RAI refractory DTC is very poor, clinical outcomes vary depending on the location and progression of metastatic lesions. Therefore, it is crucial to determine which patients should receive active systemic therapy with tyrosine kinase inhibitor (TKI) and how to apply local treatment before or during systemic therapy. This guideline covers the definition, treatment principles, systemic anticancer agents, and complications of progressive RAI-refractory DTC. RAI refractory DTC is defined as (1) the absence of RAI uptake on whole body scan, (2) presence of RAI uptake in some lesions but not in others, or (3) disease progression despite RAI uptake. Treatment options for RAI refractory DTC include surgery, external beam radiation therapy, locoregional therapies such as high-intensity focused ultrasound ablation, and systemic anticancer therapy. In patients with minimal symptoms and progression, active surveillance without specific treatment may be considered. Systemic treatment should be considered for patients with multiple progressive lesions by RECIST criteria. Furthermore, testing for cancer gene mutations, including BRAF, NTRK, and RET genes, is recommended for personalized therapy. Systemic therapy should be decided based on shared decision-making between the patient and specialist, considering anticipated benefits and risks. Regular assessment of treatment responses and evaluation of adverse events is essential, with dose adjustment based on these assessments. The optimal time of use, clinical approaches for the prevention and control of adverse events, and individualized treatment approaches based on patient characteristics will be of great help in the treatment of patients with RAI-refractory DTC.

시가상으로 본 송 면앙과 정 송강과의 관계

신동엽 한글학회 1949 한글 Vol.- No.106

무주지역에서 채취한 산삼 생육 토양미생물에 대한 동정 연구

신동엽,박용일,김홍렬,안덕균,박성규 대한본초학회 2002 大韓本草學會誌 Vol.17 No.2

objectives : Microorganisms were isolated from soils remaining attached to the roots of Wild Panax ginseng C.A. Mey. naturally grown in Moo-Ju area. methods : As a preliminary study for the establishment of wild ginseng radix discrimination system based on area of growth, these isolates were identified by using mainly API 20NE and API 50CHB kits and the microbial consortia were compared. From the sample of Moo-Ju area, 9 and 6 strains were isolated and identified after the incubation of agar plates at 30℃ and 37℃, respectively. results : The results showed that 2 strains of soil bacteria, Aeromonas hydrophilia, and Bacillus cereus commonly existed in the roots of wild ginseng of both 30℃ and 37℃. And that 6 strains, Pseudomonas putida, Stenotrophomonas maltophilia, Pseudomonas fluorescence at 30℃ and Bacillus subtilis, Empedobacter brevis, Brevi. laterosporus at 37℃, inhabited specifically in the roots of wild ginseng of Moo-Ju area. conclusion : These results suggest that comparison of microbial consortia associated with roots of wild ginseng could be used for the establishment of a naturally growing wild ginseng radix discrimination system.

High Energy Density One-Dimensional Supercapacitors Based on Metallic Cotton Threads

신동엽,조진한 한국고분자학회 2019 한국고분자학회 학술대회 연구논문 초록집 Vol.44 No.1

방사성요오드 불응성 갑상선암에서 티로신키나아제억제제 투여로 유발된 출혈 이상 반응 관리

신동엽 대한갑상선학회 2018 International Journal of Thyroidology Vol.11 No.2

Adverse events such as hemoptysis and gastrointestinal hemorrhage during tyrosine kinase inhibitor treatment are relatively rare, but the severity of the bleeding can be higher than other common adverse events. It is necessary to educate patients about its possibility so that they can be found early. In this case report of radioiodine refractory thyroid cancer patient, hemoptysis and gastrointestinal bleeding has occurred following lenvatinib administration. Drug interruption and dose modification and dose interruption were required in addition to management for bleeding itself. It is necessary to confirm the high risk of bleeding before the administration of tyrosine kinase inhibitors, and to appropriately control the follow-up interval and drug dosage accordingly.

조직학습과 다각화 : 다각화 의사결정의 동태적 분석, 1988~1997

신동엽,김선혁,정기원 한국인사조직학회 2008 인사조직연구 Vol.16 No.4

The current paper examines the question of ‘when’, rather than ‘which’, firms would diversify. Many existing studies raised research questions in a dynamic term by asking ‘when firms diversify’, but eventually ended up statically testing ‘which firms diversify’, either by relying on cross-sectional analysis or by focusing on static variables that do not vary with time. However, recent studies in strategic management have started to explore the dynamic aspects of strategic actions, which may make up for the limits of existing diversification studies in near future. Along this line of inquiry, the current study attempts to propose theoretical and methodological bases for the dynamic analysis of diversification decisions by theoretically making sense of and methodologically testing the question of ‘when firms would diversify’ directly. Since firms make strategic decisions in dynamic ways by constantly adjusting their responses according to signals from changing environments, we argue that diversification studies also must employ not only longitudinal methodologies, but also proper theories that can vividly highlight dynamic aspects of strategic processes. For a dynamic analysis of diversification in terms of theory, the current study draws on organizational learning theory which suggests that organizations dynamically adjust their decisions and behaviors by reflecting feedbacks and signals from environments. The organizational learning literature treats an organization as a dynamic and strategic actor which constantly learns and evolves through interactions with its environments. The organization learning literature maintains that when an organization faces an environment similar with earlier environments which it previously encountered, it tends to respond to it by resorting to the routines and behaviors it learned through the earlier environmental interactions. If its earlier response had received positive feedbacks from the environments, it would respond to the similar environment by reusing the same response. Otherwise, it would explore new types of responses to the environment. That is, in the organizational learning literature, an organization is assumed to be a dynamic actor which constantly responds to signals from changing environments either by exploiting previously learned behaviors or by exploring new behaviors. Since environmental feedbacks change with time, environments are likely to affect organizational choices and behaviors differently by sending varying feedback signals at each time point. In this regard, the current study focuses on effects of feedback signals that the focal firm receives from environments at each time point in explaining its strategic choice of whether or not to diversify. We examines effects of two different types of feedback signals from environments; 1) reinforcement signals that the focal firm receives through performance feedbacks from environments to its own past behaviors, 2) legitimacy signals that the focal firm receives from other firms’ diversification behaviors. The empirical part of the current study examines effects of these two types of environmental signals on the focal firm’s diversification choices at each time point. The first type of environmental signal that the focal firm receives from performance feedbacks to its own past behaviors is theoretically based on the reinforcement argument of Skinnerian behavioral psychology. Reinforcement theory submits that a certain behavior is learned and repeated only when it receives positive feedback–i.e. reinforcement–from environments. Thus, we predict that when an organization produces a high performance which can be regarded as a positive reinforcement signal, it is likely to repeat its existing behaviors and routines. In contrast, when an organization suffers from a low performance which can be regarded as a negative feedback signal, it is likely to explore new behaviors and routines. By applying th... 본 논문은 ‘기업이 언제 다각화를 할까’라는 질문과 ‘어떤 기업이 다각화를 할까’라는 두 가지 유사해 보이는 질문들의 근본적 차이에 대한 인식에서 출발한다. 이 두 질문 중, 본 논문은 전자에 초점을 맞추어 기업의 다각화 의사결정을 동태적 관점에서 분석한다. 기존의 다각화 연구들은 이론상으로 ‘기업이 언제 다각화를 할까’라는 동태적 질문을 던진 경우에도 방법론적으로 횡단 연구를 시도하거나, 또는 연구모형 설정에서 시간의 흐름에 따라 변하지 않는 정태적 변수들에 초점을 맞춤으로써 기업의 전략적 행동의 동태성에 대한 적절한 분석을 제시하지 못한 경우가 많았다. 따라서 최근 일부 다각화 연구들은 전통적 연구들의 이런 정태성의 한계를 극복하기 위해 동태적 접근법을 사용하기 시작하였다. 이런 맥락에서 본 연구는 기업이 수시로 변화하는 환경에 역동적으로 대응하여 그 행동을 수정하고 적응시켜나가는 전략적 의사결정의 프로세스를 정확하게 설명하기 위해서는 방법론적으로 동태적 현상을 계량적으로 분석해낼 수 있는 종단적 분석방법론이 사용되어야 하는 것은 물론이고, 이론적으로도 기업의 역동적 전략 프로세스를 정확하게 파악할 수 있는 논리적 기반이 필요하다고 보았다. 본 연구에서는 환경과 조직간의 역동적 상호작용 프로세스에 초점을 맞추고 있는 조직학습 이론을 적극 활용하여, 환경으로부터의 시그널이 기업의 다각화 의사결정에 미치는 영향을 실증적으로 연구한다. 본 연구모형에서는 기업 자신의 과거 행동에 대한 환경으로부터의 강화 시그널로서의 성과 피드백과 다각화 전략의 정당성에 대한 환경으로부터의 시그널이 다각화 의사결정에 미치는 영향을 분석한다. 또한 본 논문에서는 각 기업이 환경으로부터의 성과 피드백에 반응하여 다각화 여부를 결정하는 정도는 기업의 지위와 다각화 전략의 정당성 시그널에 따라 다를 것이라고 예측한다. 우리나라 30대 재벌그룹이 1988년에서 1997년까지 수행한 모든 다각화에 대한 이벤트 빈도 분석의 결과, 본 연구에서 제시한 가설들이 모두 지지되었다.

CORDIC을 이용한 저면적, 저전력 신호처리 VLSI 설계 기술 및 그 응용

신동엽,박종선 대한전자공학회 2017 전자공학회지 Vol.44 No.6

Neoliberal marketization of art worlds and status multiplexity: Price formation in a Korean art auction, 1998-2007

신동엽,김은미,이중식 ELSEVIER SCIENCE BV 2014 POETICS Vol.43 No.-