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송윤규,Song, Yoon-Kyu 대한전자공학회 2013 전자공학회논문지 Vol.50 No.6
In this paper, we investigate several important issues on the implementation of a totally implantable microsystem for brain-machine interface that has been attracting a lot of attention recently. So far most of the scientific research has been focused on the high performance, low power electronics or systems such as neural signal amplifiers and wireless signal transmitters, but the real application of the implantable microsystem is affected significantly by a number of factors, ranging from design of the encapsulation structure to physiological and anatomical characteristics of the brain. In this work, we discuss on the thermal effect of the system, the detecting volume of the neural probes, wireless data transmission and power delivery, and physiological and anatomical factors that are critically important for the actual implementation of a totally brain implantable neural interface microsystem. 본 논문은 최근 활발하게 연구되고 있는 뇌-기계 접속을 위한 완전 삽입형 마이크로 시스템의 구현에 있어서 중요한 이슈들을 고찰한다. 현재까지의 과학 기술적 연구는 신경 신호 증폭기, 무선 신호 전송 등 주로 고성능 저전력 전자기기 및 시스템을 구현하는데 집중되어 왔으나, 마이크로 시스템의 실제적인 응용은 전자 기기의 특성뿐만 아니라 밀봉 구조의 디자인에서 뇌의 생리 해부학적 특성에 이르기까지 여러 가지 요인에 의해 영향을 받게 된다. 본 논문은 특히 뇌 삽입형 마이크로 시스템의 실질적인 구현에 결정적인 영향을 주는 시스템 발열의 영향, 신경 프로브의 감지 부피, 무선 데이터 전송 및 전력 전달, 그리고 뇌의 생리 해부학적인 고려 요인에 대해 논의한다.
전자선 묘화를 이용한 장파장 DFB-LD용 격자 구조의 제작 및 특성 분석
송윤규,김성준,윤의준 대한전자공학회 1995 전자공학회논문지-A Vol.32 No.1
The 1st and 2nd-order grating structure for long wavelength DFB(Distributed FeedBack) laser diodes are successfully fabricated on InP substrates by using electron beam lithography and reactive ion etch techniques, and also characterized non-destructively by diffraction analysis without removal of photo-resis layer. A new composite layer made by lifted-off Cr layer on thin SiO2 film is developed and used as an etch mask, because PMMA, the e-beamresist, is unsuitable for reactive ion etch of InP. In addition, it is experimentally confiremed that diffraction analysis makes it possible to predict the grating parameters, and the analysis can be used as a non-destructive on-line test to prevent incomplete gratings from being successively processed.
Profiling of the Bacteria Responsible for Pyogenic Liver Abscess by 16S rRNA Gene Pyrosequencing
송윤규,심상군,김광민,이동해,김대수,최상행,송재영,강형련,백승철,이우곤,조명제,이광호 한국미생물학회 2014 The journal of microbiology Vol.52 No.6
Pyogenic liver abscess (PLA) is a severe disease with considerablemortality and is often polymicrobial. Understandingthe pathogens that cause PLA is the basis for PLA treatment. Here, we profiled the bacterial composition in PLA fluid bypyrosequencing the 16S ribosomal RNA (rRNA) gene basedon next-generation sequencing (NGS) technology to identifyetiological agents of PLA and to provide information oftheir 16S rRNA sequences for application to DNA-basedtechniques in the hospital. Twenty patients with PLA whounderwent percutaneous catheter drainage, abscess culture,and blood culture for isolates were included. Genomic DNAsfrom abscess fluids were subjected to polymerase chain reactionand pyrosequencing of the 16S rRNA gene with a454 GS Junior System. The abscess and blood cultures werepositive in nine (45%) and four (20%) patients, respectively. Pyrosequencing of 16S rRNA gene showed that 90% of thePLA fluid samples contained single or multiple genera ofknown bacteria such as Klebsiella, Fusobacterium, Streptococcus,Bacteroides, Prevotella, Peptostreptococcus, unassignedEnterobacteriaceae, and Dialister. Klebsiella was predominantlyfound in the PLA fluid samples. All samples thatcarried unassigned bacteria had 26.8% reads on average. We demonstrated that the occurrence of PLA was associatedwith eight known bacterial genera as well as unassignedbacteria and that 16S rRNA gene sequencing was more usefulthan conventional culture methods for accurate identificationof bacterial pathogens from PLA.