US-Guided Vacuum-Assisted Biopsy of Microcalcifications in Breast Lesions and Long-Term Follow-Up Results

김화선,김민정,김은경,곽진영,손은주,오기근 대한영상의학회 2008 Korean Journal of Radiology Vol.9 No.6

Objective: To evaluate the diagnostic accuracy of the use of an ultrasonography (US)-guided vacuum-assisted biopsy for microcalcifications of breast lesions and to evaluate the efficacy of the use of US-guided vacuum-assisted biopsy with long-term follow-up results. Materials and Methods: US-guided vacuum-assisted biopsy cases of breast lesions that were performed between 2002 and 2006 for microcalcifications were retrospectively reviewed. A total of 62 breast lesions were identified where further pathological confirmation was obtained or where at least two years of mammography follow-up was obtained. These lesions were divided into the benign and malignant lesions (benign and malignant group) and were divided into underestimated group and not-underestimated lesions (underestimated and not-underestimated group) according to the diagnosis after a vacuum-assisted biopsy. The total number of specimens that contained microcalcifications was analyzed and the total number of microcalcification flecks as depicted on specimen mammography was analyzed to determine if there was any statistical difference between the groups. Results: There were no false negative cases after more than two years of follow-up. Twenty-nine lesions were diagnosed as malignant (two invasive carcinomas and 27 carcinoma in situ lesions). Two of the 27 carcinoma in situ lesions were upgraded to invasive cancers after surgery. Among three patients diagnosed with atypical ductal hyperplasia, the diagnosis was upgraded to a ductal carcinoma in situ after surgery in one patient. There was no statistically significant difference in the number of specimens with microcalcifications and the total number of microcalcification flecks between the benign group and malignant group of patients and between the underestimated group and not-underestimated group of patients. Conclusion: US-guided vacuum-assisted biopsy can be an effective alternative to stereotactic-guided vacuum-assisted biopsy in cases where microcalcifications are visible with the use of high-resolution US. Objective: To evaluate the diagnostic accuracy of the use of an ultrasonography (US)-guided vacuum-assisted biopsy for microcalcifications of breast lesions and to evaluate the efficacy of the use of US-guided vacuum-assisted biopsy with long-term follow-up results. Materials and Methods: US-guided vacuum-assisted biopsy cases of breast lesions that were performed between 2002 and 2006 for microcalcifications were retrospectively reviewed. A total of 62 breast lesions were identified where further pathological confirmation was obtained or where at least two years of mammography follow-up was obtained. These lesions were divided into the benign and malignant lesions (benign and malignant group) and were divided into underestimated group and not-underestimated lesions (underestimated and not-underestimated group) according to the diagnosis after a vacuum-assisted biopsy. The total number of specimens that contained microcalcifications was analyzed and the total number of microcalcification flecks as depicted on specimen mammography was analyzed to determine if there was any statistical difference between the groups. Results: There were no false negative cases after more than two years of follow-up. Twenty-nine lesions were diagnosed as malignant (two invasive carcinomas and 27 carcinoma in situ lesions). Two of the 27 carcinoma in situ lesions were upgraded to invasive cancers after surgery. Among three patients diagnosed with atypical ductal hyperplasia, the diagnosis was upgraded to a ductal carcinoma in situ after surgery in one patient. There was no statistically significant difference in the number of specimens with microcalcifications and the total number of microcalcification flecks between the benign group and malignant group of patients and between the underestimated group and not-underestimated group of patients. Conclusion: US-guided vacuum-assisted biopsy can be an effective alternative to stereotactic-guided vacuum-assisted biopsy in cases where microcalcifications are visible with the use of high-resolution US.

A New Abundance Estimate for the Finless Porpoise Neophocaena asiaeorientalis on the West Coast of Korea: An Indication of Population Decline

박겸준,손화선,안용락,김현우,안두해 한국수산과학회 2015 Fisheries and Aquatic Sciences Vol.18 No.4

The west coast of Korea is the largest habitat for finless porpoises, with approximately 36,000 individuals reported in 2005 (Park et al., 2007). To date, there have been no subsequent finless porpoise population estimates. However, in recent bycatches, finless porpoises accounted for the highest proportion of all cetaceans and have been reported to be most frequently caught on the west coast of Korea (Kim et al., 2013). The present study, conducted in 2011, enumerated finless porpoises inhabiting the west coast of Korea using a line transect survey in offshore and inshore regions to assess variations in their abundance. In offshore regions we found the population density of finless porpoises to be 0.122 ind./km2, whereas it was 0.565 ind./km2 in 2004. In inshore regions, the population density of finless porpoises was 0.151 ind./km2, whereas it was 0.638 ind./km2 in 2005. Therefore, we estimate that the population densities of finless porpoises in both offshore and inshore regions of the west coast of Korea decreased by approximately 70% between 2004/2005 and 2011. It is imperative to mitigate the bycatch of finless porpoises and protective action is urgently needed in the near inshore regions.

효율적인 수술재료 관리를 위한 활동

김경화,손화선,주미자,이미라 한국의료QA학회 2005 가을학술대회 Vol.2005 No.2

Age and reproduction of the finless porpoises, Neophocaena asiaeorientalis, in the Yellow Sea, Korea

이영란,안용락,박겸준,손화선,안두해,김수암 한국통합생물학회 2013 Animal cells and systems Vol.17 No.5

A total of 116 finless porpoises, Neophocaena asiaeorientalis, were collected in the Yellow Sea off Korea. About 111 specimens were incidentally caught by stow nets on anchors from March to June 2010, and five were stranded in February 2011. Age was determined by counting dentinal growth layer groups (GLGs) in thin-sectioned teeth, and sexual maturity rating (SMR) was classified by investigating ovaries and testis macroscopically and microscopically. Immature females were ranged 1–4 years old and 92.6–141.2 cm in total body length (TBL), pubertal ones were all 5 years old and 125.4–136.0 cm, and mature ones ranged 5–19 years old and 131.6–155.2 cm. Age at attainment of sexual maturity of females was 4–5 years old. Parturition season estimated based on TBL of eight fetuses was from April to August with a peak in April to May. The first age at parturition was 5 years old. Among 62 males, immature males were 1–4 years old and 87.9–154.6 cm, pubertal ones were 3–5 years old and 121.5–134.5 cm, and mature ones were 4–19 years old and 125.3–229.0 cm. Males reached sexual maturity at 4–5 years old. Testicular mass and the diameters of seminiferous tubules were dramatically increased with SMR and regressed in testis of the individuals stranded in February. It suggested that male finless porpoises have aspermatogenic period between October and February. It is presumed that the breeding season would be May–September with a peak in May–June.

발전소 배관계통의 유동유발진동 현상에 대한 수치해석 연구

오세홍(Se-Hong Oh),한진(Jin Han),홍화선(Hwa-Sun Hong),이종일(Jong-Il Lee),손성만(Sung-Man Son),최청열(Choengryul Choi) 대한기계학회 2016 대한기계학회 춘추학술대회 Vol.2016 No.12

Numerical analysis has been conducted in order to investigate the cause of piping vibration problem in thermal power plants. Piping vibration due to instability of the fluid flow is referred to flow-induced vibration(FIV), which could inhibit the structural integrity of piping system and its supporting structures. In this work, large eddy simulation(LES) and frequency analysis have been performed to evaluate the vibrational characteristics of the pipeline behind centrifugal pump. Although flow-induced vibration can be caused by a variety of reasons, present study focused on vibration phenomena only due to unstable fluid flow such as turbulence and vortex shedding. Especially, the effects of opening ratio of the discharge valve on the vibrational characteristics was mainly evaluated.

Comparative genomic analysis of Lactobacillus plantarum GB-LP4 and identification of evolutionarily divergent genes in high-osmolarity environment

정재훈,김권도,유동안,이찬호,강정선,조경진,강대경,곽우리,윤숙희,손화선,김희발,조서애 한국유전학회 2018 Genes & Genomics Vol.40 No.2

Lactobacillus plantarum is one of the widely-used probiotics and there have been a large number of advanced researches on the effectiveness of this species. However, the difference between previously reported plantarum strains, and the source of genomic variation among the strains were not clearly specified. In order to understand further on the molecular basis of L. plantarum on Korean traditional fermentation, we isolated the L. plantarum GB-LP4 from Korean fermented vegetable and conducted whole genome assembly. With comparative genomics approach, we identified the candidate genes that are expected to have undergone evolutionary acceleration. These genes have been reported to associate with the maintaining homeostasis, which are generally known to overcome instability in external environment including low pH or high osmotic pressure. Here, our results provide an evolutionary relationship between L. plantarum species and elucidate the candidate genes that play a pivotal role in evolutionary acceleration of GB-LP4 in high osmolarity environment. This study may provide guidance for further studies on L. plantarum.