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L-carnitine 투여가 최대하 운동시 혈중 지질성분과호흡교환율에 미치는 영향
성동준,차광석 한국생활환경학회 2007 한국생활환경학회지 Vol.14 No.3
The aim of this study was to investigate the effect of carnitine supplementation on blood lipid profiles and respiratory exchange ratio. Each subject performed maximal exercise testing on a treadmill and the exercise intensity was determined based on the testing. All subjects were orally ingested both placebo and carnitine (3.3 g) at an interval of 1 week. Carnitine treatment group showed a significant change in serum FFA and lipase compared to pre carnitine treatment group. However, other variables showed no differences. Also, the RER was reduced by an average 0.02 and it was notably reduced by 0.05 at 10 min after exercise. These results indicate that acute supplementation of L-carnitine had the effect on an increase of FFA and activation of lipase. But the supplementation of L-carnitine had no effect on the other lipid metabolic indices in the serum and glycogen sparing effect.
성동준,전용균,최재일,김보경,Shadi Golpasandi,박상웅,오승범,배영민 대한약리학회 2022 The Korean Journal of Physiology & Pharmacology Vol.26 No.5
Atrial fibrillation (AF) is the most common supraventricular arrhythmia, and it corresponds highly with exercise intensity. Here, we induced AF in mice using acetylcholine (ACh)-CaCl2 for 7 days and aimed to determine the appropriate exercise intensity (no, low, moderate, high) to protect against AF by running the mice at different intensities for 4 weeks before the AF induction by ACh-CaCl2. We examined the AF-induced atrial remodeling using electrocardiogram, patch-clamp, and immunohistochemistry. After the AF induction, heart rate, % increase of heart rate, and heart weight/body weight ratio were significantly higher in all the four AF groups than in the normal control; highest in the high-ex AF and lowest in the low-ex (lower than the no-ex AF), which indicates that low-ex treated the AF. Consistent with these changes, G protein-gated inwardly rectifying K+ currents, which were induced by ACh, increased in an exercise intensity-dependent manner and were lower in the low-ex AF than the no-ex AF. The peak level of Ca2+ current (at 0 mV) increased also in an exercise intensity-dependent manner and the inactivation time constants were shorter in all AF groups except for the low-ex AF group, in which the time constant was similar to that of the control. Finally, action potential duration was shorter in all the four AF groups than in the normal control; shortest in the high-ex AF and longest in the low-ex AF. Taken together, we conclude that low-intensity exercise protects the heart from AF, whereas high-intensity exercise might exacerbate AF.
성동준,노현주,김재곤,박상웅,김보경,조하나,배영민 생화학분자생물학회 2013 Experimental and molecular medicine Vol.45 No.12
Serotonin (5-hydroxytryptamine (5-HT)) is a neurotransmitter that regulates a variety of functions in the nervous,gastrointestinal and cardiovascular systems. Despite such importance, 5-HT signaling pathways are not entirely clear. We demonstrated previously that 4-aminopyridine (4-AP)-sensitive voltage-gated Kþ (Kv) channels determine the resting membrane potential of arterial smooth muscle cells and that the Kv channels are inhibited by 5-HT, which depolarizes the membranes. Therefore, we hypothesized that 5-HT contracts arteries by inhibiting Kv channels. Here we studied 5-HT signaling and the detailed role of Kv currents in rat mesenteric arteries using patch-clamp and isometric tension measurements. Our data showed that inhibiting 4-AP-sensitive Kv channels contracted arterial rings, whereas inhibiting Ca2þ-activated Kþ, inward rectifier Kþ and ATP-sensitive Kþ channels had little effect on arterial contraction, indicating a central role of Kv channels in the regulation of resting arterial tone. 5-HT-induced arterial contraction decreased significantly in the presence of high KCl or the voltage-gated Ca2þ channel (VGCC) inhibitor nifedipine, indicating that membrane depolarization and the consequent activation of VGCCs mediate the 5-HT-induced vasoconstriction. The effects of 5-HT on Kv currents and arterial contraction were markedly prevented by the 5-HT2A receptor antagonists ketanserin and spiperone. Consistently, a-methyl 5-HT, a 5-HT2receptor agonist, mimicked the 5-HT action on Kv channels. Pretreatment with a Src tyrosine kinase inhibitor, 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine, prevented both the 5-HT-mediated vasoconstriction and Kv current inhibition. Our data suggest that 4-AP-sensitive Kv channels are the primary regulator of the resting tone in rat mesenteric arteries. 5-HT constricts the arteries by inhibiting Kv channels via the 5-HT2A receptor and Src tyrosine kinase pathway.
성동준(Sung Dong Jun),이윤모(Lee Yun Mo),최원호(Choi Won Ho),박주양(Park Joo Yang) 대한토목학회 2008 대한토목학회논문집 B Vol.28 No.1B
철의 환원 특성에 관한 연구는 이미 널리 수행되었으며 특히 미네랄과 2가철의 반응 메커니즘은 2가철의 흡착이나 바운드를 통해 Fe(Ⅱ)-Fe(Ⅲ) (hydr)oxides를 생성하여 2가철이 3가철로 산화됨으로써 물질을 환원시키는 것으로 받아들여지고 있다. 그러나 2가철로 개질된 재강슬래그를 이용한 DS/S 실험과정에서 이러한 메커니즘으로 설명하기 힘든 현상을 발견하였다. 재강슬래그의 주요 성분중의 하나인 FeO와 Fe(Ⅱ)만을 이용하여 TCE의 분해과정을 실험해 본 결과 초기 TCE의 분해가 이루어지지 않다가 급속히 분해되는 현상을 보였으며 이러한 시스템에서 TCE의 분해는 예상치 못한 결과였다. FeO/Fe(Ⅱ) 시스템은 3가철이 존재하지 않기 때문에 기존의 Fe(Ⅱ)-Fe(Ⅲ) (hydr)oxides를 형성하는 환원 메커니즘으로는 설명할 수 없었다. 따라서 본 연구에서는 TCE의 분해실험과 분해 부산물의 측정, 2가철과 3가철을 확인함으로써 FeO/Fe(Ⅱ) 시스템의 환원특성을 확인해 보고자 하였다. 실험 결과 2가철이 FeO에 홉착 또는 바운드 되는 것을 확인 할 수 는 있었으나 기존의 메커니즘으로 설명하기에는 부족한 부분이 있었다. 분해부산물들을 통해 환원으로 인한 TCE의 분해는 의심의 여지가 없었으나 FeO/Fe(Ⅱ) 시스템이 새로운 species를 형성하는지 , 혹은 FeO에 Fe(Ⅱ)가 흡착 또는 바운드 되어 이제껏 알려지지 않은 형태의 새로운 미네랄 상을 형성하는지는 좀 더 상세한 연구가 필요하다. The reaction between iron oxide and ferrous iron is known to be the adsorption of ferrous iron onto the oxide surfaces that produces Fe(Ⅱ)-Fe(Ⅲ) (hydr)oxides and ferrous oxide oxidized to ferric ion which is the reducing agent of the target compounds. In our investigations on DS/S using ferrous modified steel slag, the results did not follow the trends. FeO and Fe(Ⅱ), the major component of steel slag, were used to investigate the degradation of TCE. Degradation did not take place for the first and suddenly degraded after awhile. Degradation of TCE in this system was unexpected because Fe(Ⅱ)-Fe(Ⅲ) (hydr)oxides could not be produced in absence of ferric oxide. In this study, the characteristics of FeO/Fe(Ⅱ) system as a reducing agent were observed through the degradation of TCE, measuring byproducts of TCE and the concentration of Fe(Ⅱ) and Fe(Ⅲ). Adsorption of ferrous ion on FeO was observed and the generation of byproducts of TCE showed the degradation of TCE by reduction in the system is obvious. However it did not correspond with the typical reducing mechanisms. Future research on this system needs to be continued to find out whether new species are generated or any unknown mineral oxides are produced in the system that acted in the degradation of TCE.
운동과 고혈압 : 운동에 의한 산화질소 생성과 혈관확장에 대한 종설
성동준(Dong-Jun Sung),소위영(Wi-Young So),박혜미(Hye-Mi Park),차광석(Kwang-Suk Cha) 한국생활환경학회 2010 한국생활환경학회지 Vol.17 No.2
Hypertension is an independent risk factor for coronary artery disease and associated with endothelial dysfunction. Endothelium-derived relaxation factors (EDRF) including nitric oxide (NO) are reduced bioavailability in hypertension and cause increased agonist-induced vasoconstriction. Recently studies, regular exercise has been shown to improve endothelium function via various mechanical change as a shear stress and cell signal transduction in hypertensive animal model and in patients with hypertension. In addition, hydrogen peroxide (H₂O₂) and adiponectin independently lead to vasodilation and increasing endothelium nitric oxide synthase. H₂O₂ activates K? channel either by direct regulation of the channels or increase of endothelial nitric oxide synthease (eNOS). Hypodiponectinemia is associated with impaired endothelium-dependent vasodilation, which indicate reduced vasodilation. This review summarizes the current information on the improvement of NO bioavailability by regular exercise in hypertensive animal models and hypertensive patient.
L-carnitine 투여가 최대하 운동시 혈중 지질성분과 호흡교환율에 미치는 영향
성동준(Dong-Jun Sung),차광석(Kwang-Suk Cha) 한국생활환경학회 2007 한국생활환경학회지 Vol.14 No.3
The aim of this study was to investigate the effect of carnitine supplementation on blood lipid profiles and respiratory exchange ratio. Each subject performed maximal exercise testing on a treadmill and the exercise intensity was determined based on the testing. All subjects were orally ingested both placebo and carnitine (3.3 g) at an interval of 1 week. Carnitine treatment group showed a significant change in serum FFA and lipase compared to pre carnitine treatment group. However, other variables showed no differences. Also, the RER was reduced by an average 0.02 and it was notably reduced by 0.05 at 10 min after exercise. These results indicate that acute supplementation of L-carnitine had the effect on an increase of FFA and activation of lipase. But the supplementation of L-carnitine had no effect on the other lipid metabolic indices in the serum and glycogen sparing effect.
교양체육 수업이 대학생의 신체조성과 신체효율지수에 미치는 영향
성동준(Sung, Dong-Jun),임영태(Lim, Young-Tae),소위영(So, Wi-Young),이용식(Lee, Young-Sik),차광석(Cha, Kwang-Suk) 한국체육과학회 2014 한국체육과학회지 Vol.23 No.2
The study examined the effect of participation in cultural physical education on the body composition and physical efficiency index in college students. 164 male and 89 female healthy students were participated in this lecture. The subjects were performed resistance training for 8 weeks. The results were analyzed by paired t-test using SPSS 12.0 program. In male subjects, LBM, muscle mass, % fat, WHR, and basal metabolic rate were significantly changed by resistance training. In female subjects, FBM, % fat and WHR were significantly decreased by resistance training. Also, PEI was enhanced via resistance training in male and female subjects. These results indicate that cultural physical education class in this study is very effective tool for controlling body composition and improving PEI in college students. Also, we suggest that participation of cultural physical education lead to improve health status and fitness level in college students.