백서 치주인대세포에서 Doxycycline의 Mefenamic Acid 병용사용 시 MMP-13mRNA 발현 억제 효과

서진희,최득철,김영준,Seo, Jin-Hee,Ciu, De-Zhe,Kim, Young-Joon 대한치주과학회 2005 Journal of Periodontal & Implant Science Vol.35 No.1

It has been focused on the importance of the host inflammatory response in periodontal pathogenesis and progression, treatment has been introduced to control the host response and the method, which diminishes production and activity of MMP by doxycycline, has been used in periodontal field. MMP is a proteolytic enzyme which plays a major role in tissue destruction and MMP-1 is secreted in the periodontally healthy tissue, while MMP-8, 9, 13, etc in the inflammatory state. Among these, MMP-13 has been discovered lately and reported to degrade primarily type II collagen. Periodontal ligament (PDL) cell plays a role in destruction of periodontal tissue. This study was to evaluate the effect of doxycycline and mefenamic acid, non-steroidal antiinflammatory drug on MMP-13 mRNA expression in the rat PDL cell. Doxycycline concentration of $1{\sim}100\;{\mu}g/ml$ was added rat PDL cell and cell activity was measured by MIT assay at day 1 and 3. MMP-13 gene expression was evaluated by RT-PCR after PDL cells were pre-treated for 1hour with doxycycline (50 ${\mu}g/ml$) alone or with mefenamic acid ($10^{-6}M$), then added $IL-1{\beta}$(1.0 ng/ml) and incubated for 16-18 hours. The results are as follows: 1. Cell activity decreased Significantly at 24 and 72 hours in 100 ${\mu}g/ml$ (p<0.05). 2. Level of MMP-13 mRNA was in 20.2% increase by $IL-1{\beta}$ and in pre-treating doxycycline group, expression of $IL-1{\beta}$ induced MMP-13 mRNA was inhibited by 31% than $IL-1{\beta}$ treated only. 3. Mefenamic acid did not inhibit on the expression of $IL-1{\beta}$ induced MMP-13 mRNA, while mefenamic acid in combination with doxycycline inhibited the expression by 41% compared to only $IL-1{\beta}$ stimulation. These results suggest that doxycycline synergistically inhibit the expression of $IL-1{\beta}$ induced MMP-13 mRNA in combination with mefenamic acid.

커피전문점의 평면형태에 따른 실내공간분석 -스타벅스 매장사례중심으로-

서진희,구자준 한국기초조형학회 2023 기초조형학연구 Vol.24 No.5

Recently, the number of brand coffee shops has increased rapidly, and each brand coffee shop is making continuous attempts to express its identity in order to differentiate itself from other shops. Interior space design, one of the various differentiation strategies, can give the identity of the brand to the interior space within the limits of the architecturally predetermined space. This study selects examples of brand coffee shops that have recently opened, to analyze the space composition according to the interior design process and check the characteristics and effects of the space composition. The subjects of this study were selected from three types of planes: horizontal, vertical, and square among Starbucks shops opened after 2020, and the floor plan of each shop was used to analyze the characteristics of the space composition in each design process. In the coffee shop, the location of the order counter was determined according to the location of the main entrance without being affected by connectivity to the outdoors, wall finishing materials, and shapes of floor plan. In addition, the staff space and the customer space are divided based on the location of the order counter, and the circulations of the employees are based on work efficiency, and the circulations of the customers are planned considering the return to the seat after ordering and pickup. Furniture and seats are arranged according to the circulations. In order to differentiate each shop, the physical elements of the interior are used to create the shop's own characteristics, however, the staff space and customer space are maintained in a consistent area and ratio, even if the shape of the shop is different. This method is consequentially effective to show the diversity of shops by maintaining not only consistent spatial composition, but also the identity of the brand, and effectively creates various differentiations for each shop. The results of detailed analysis of the interior space by type of this study can be used as basic data that can be referred to when planning the floor plan by the type of coffee shops in the future.

LED 광원 사용 시 line beam 형성을 위한 자유 곡면 bar type의 TIR lens 설계

서진희,이정수,김서영,정유진,박혜진,남득영,정미숙 한국광학회 2017 한국광학회지 Vol.28 No.6

In this paper, we have studied a method of forming a line beam using a UV LED. The existing linear-type UV LED curingoptical system is composed of several cylindrical lenses, but problems such as optical system alignment, enlargement of themodule, efficiency, etc. may arise in the future. As an alternative to these problems, a bar-type TIR lens having a freeform surfaceonly in the y-axis direction is designed, to verify that it shows advantages in maximum illuminance, uniformity of illuminance,and flux efficiency.

The Interaction of Quantifier Scope in the Agree system: Going back to QR?

서진희 사단법인 한국언어학회 2002 언어학 Vol.0 No.34

Hornstein (1995, 1999) has shown that Quantifier Raising (QR) as a rule of Universal Grammar can be eliminated. He argues that it is supported not only by the theory-internal reasons in the Minimalist Program (MP), but also by empirical motivations. His system which exploits Case chain structure or other A-chains crucially relies on movement with copying and deletion whether it is feature movement (Attract) or phrasal movement. The recent version of MP, however, suggests that we dispense with Attract, together with complications it produces and Checking reduces to deletion under matching (Agree) with a local goal activated by the uninterpretable feature without movement. The purpose of this paper is, therefore, to show that non-QR approach to the relative scope of quantifiers still works in the new system of MP. It is argued that the EPP effect by the functional category (T and v in particular) is responsible for the explanation rather than Case driven A-movement. Some apparent problems presented for the support of the existence of QR are also discussed and it is shown that there is no empirical loss regarding them.

The Linguistic Patterns in the Naming of Brands in Korean: The Case of Drinks

서진희 한국응용언어학회 2002 응용 언어학 Vol.18 No.2

Lentivirus-mediated shRNA targeting of cyclin D1 inhibits chemoresistance of human gastric cancer to 5-fluorouracil

서진희,정의숙,최양규 한국실험동물학회 2013 한국실험동물학회 학술발표대회 논문집 Vol.2013 No.8

Complete Mitochondrial Genome Sequences of Korean Phytophthora infestans Isolates and Comparative Analysis of Mitochondrial Haplotypes

서진희,최장규,Hyun-Jin Park,조지홍,박영은,임주성,홍수영,조광수 한국식물병리학회 2022 Plant Pathology Journal Vol.38 No.5

Potato late blight caused by Phytophthora infestans is a destructive disease in Korea. To elucidate the genomic variation of the mitochondrial (mt) genome, we assembled its complete mt genome and compared its sequence among different haplotypes. The mt genome sequences of four Korean P. infestans isolates were revealed by Illumina HiSeq. The size of the circular mt genome of the four major genotypes, KR_1_A1, KR_2_A2, SIB-1, and US-11, was 39,872, 39,836, 39,872, and 39,840 bp, respectively. All genotypes contained the same 61 genes in the same order, comprising two RNA-encoding genes, 16 ribosomal genes, 25 transfer RNA, 17 genes encoding electron transport and ATP synthesis, 11 open reading frames of unknown function, and one protein import-related gene, tatC. The coding region comprised 91% of the genome, and GC content was 22.3%. The haplotypes were further analyzed based on sequence polymorphism at two hypervariable regions (HVRi), carrying a 2 kb insertion/deletion sequence, and HVRii, carrying 36 bp variable number tandem repeats (VNTRs). All four genotypes carried the 2 kb insertion/deletion sequence in HVRi, whereas HVRii had two VNTRs in KR_1_A1 and SIB-1 but three VNTRs in US-11 and KR_2_A2. Minimal spanning network and phylogenetic analysis based on 5,814 bp of mtDNA sequences from five loci, KR_1_A1 and SIB-1 were classified as IIa-6 haplotype, and isolates KR_1_A2 and US-11 as haplotypes IIa-5 and IIb-2, respectively. mtDNA sequences of KR_1_A1 and SIB-1 shared 100% sequence identity, and both were 99.9% similar to those of KR_2_A2 and US-11.

부모진로행동이 중학생자녀의 진로결정 자기효능감과 진로성숙에 미치는 영향

서진희,이제경 한국상담학회 2009 상담학연구 Vol.10 No.4

This study aims at inspecting Parent Career Behavior of performance of the middle school student's career decision-making self-efficacy and career maturity and providing useful information on Young Adolescents's Career Development. As measurement tools for this study, 28 questions from the Parent Career Behavior Checklist, developed by Keller & Whiston in 2008, 12 questions Career Decision-Making Self-Efficacy among Middle School Self-Efficacy Scale developed by Fouad, Smith and Enoch(1997), and the modified scale for middle and high school students, colleges and universities students by E. K. Lee(2001) from the Career Attitude Maturity Inventory were used. Such as the social-economy level of parents and scholarly attainment were included as background variables. The total number of students involved as subjects were 367, consisting of 183 male students (49.9%) and 184 female students (50.1%). Among 421 questionnaires collected, 367 copies of the final effective ones were statistically analyzed using SPSS Win 17.0 Program. As for the testing methods used for the statistical analysis, descriptive analysis was used to calculate frequency & percentage, and related samples paired t-test, Decision trees were conducted to find parent career behavior for estimating level of middle school student's career decision-making self-efficacy and career maturity. Therefore, this study has proven that parent career behavior have an impact on career decision-making self-efficacy and career maturity in third-year middle school students. Based on such study results, it is meaningful to provide educational direction for parent career behavior for the enhancement of career decision-making self-efficacy and career maturity which is to be a motive of career development for middle school students and to provide an efficient method and educational implication for career related parent behavior. 본 연구는 중학교 3학년 학생들을 대상으로 이들이 지각하고 있는 부모진로행동이 진로결정 자기효능감과 진로성숙에 미치는 영향력을 알아보고, 중학생의 진로결정 자기효능감과 진로성숙에 중요한 역할을 하는 구체적인 부모의 진로행동을 확인함으로써 청소년들의 진로발달을 촉진하는데 유용한 정보를 제공하고자 하였다. 서울, 경기도에 소재하고 있는 중학교 3학년 학생 367명과 그들의 동일 부모를 대상으로 하였으며 조사기간은 2009년 5월 1일부터 5월 6일까지였다. 부모진로행동에 대한 부모-자녀간 평균차이를 알아보기 위한 방법으로 대응표본 t-test를 사용하고 중학생자녀의 진로결정 자기효능감과 진로성숙을 예측할 수 있는 부모의 진로행동을 알아보기 위해 의사결정나무분석법을 사용하였다. 부모진로행동에 대하여 자녀 보다는 부모가 긍정적으로 지각하고 있었는데 부모를 대상으로 하는 교육현장에서 부모-자녀간 지각차이에 대한 인식이 필요함을 알 수 있었다. 또한, 중학생 자녀의 진로결정 자기효능감과 진로성숙을 예측하는데 부모의 진로정보제공보다는 심리적지지가 예측력이 우위에 있었다. 부모진로행동 요인 중 심리적지지가 큰 영향을 미치는 바, 가정에서 진로관련 자녀교육을 할 때 구체적인 진로정보제공보다는 심리적지지가 더 효과적임을 입증하고 있다. 이러한 연구결과에 기초하여 중학생의 진로발달에 원동력이 되는 진로결정 자기효능감과 진로성숙 증진을 위한 부모진로행동의 교육적 방향을 제시하고 합리적인 부모교육 방안을 제공하는 데 본 연구의 의의가 있다.

[동화 당선작] 딱 한 가지 질문

서진희,김병규,임정진 샘터사 2010 월간 샘터 Vol.483 No.-

초등학교 고학년 아동의 신체증상 및 생활습관이 자살생각에 미치는 영향

서진희,김가은 한국아동간호학회 2019 Child Health Nursing Research Vol.25 No.2

Purpose: This study was conducted to analyze physical symptom-related and life-style factors affecting suicidal ideation of senior grade students in elementary school. Methods: Physical symptom-related and life-style factors were used to investigate suicidal ideation among 663 elementary school students. From February 11 to 15, 2018, data were collected using a structured questionnaire and analyzed using the x2 test, Pearson correlation analysis, and logistic regression analysis in SPSS for Windows version 22.0. Results: The factors affecting suicidal ideation were gender, family structure, economic status, academic performance, exposure to school violence during the past year, physical symptoms, drinking experience, smoking experience, sleeping time, and ramen noodle consumption. The regression analysis showed that exposure to school violence during the past year (odds ratio [OR]: 102.99, 95% confidence interval [CI]: 51.19~207.19, p=.001), number of physical symptoms (OR: 1.25, 95% CI: 1.12~1.41, p=.001), drinking experience (OR: 3.17, 95% CI: 1.66~6.06, p=.001), and game and internet usage time (OR: 2.08, 95% CI: 1.08~4.01, p=.029) affected suicidal ideation. Conclusion: This study revealed that physical symptoms and life-style significantly influenced suicidal ideation. Therefore, interventions to reduce suicidal ideation in children must focus on improving children’s physical symptoms and life-style.