경기육괴 중앙부에 위치하는 양구 지역의 변성암석학적연구

서지은,권용완,최선규 한국암석학회 2002 한국암석학회 학술발표회 논문집 Vol.- No.-

한방의료보험약 12종의 세포 독성 및 항산화 활성 스크리닝

서지은,김희영,배창환,이한울,김승태 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

중뇌의 도파민 신경세포가 사멸하면서 생기는 신경퇴행성질환인 파킨슨병은 활성 산소종의 생성 증가로 인한 산화적 스트레스, 미토콘드리아 기능장애 등이 병의 요인으로 알려져 있다. 56종의 한방의료보험약 중 전문가 자문을 통해 파킨슨병의 치료가 있을 것으로 기대되는 12종의 한약을 선정하고, 항산화 효과 및 신경 세포 독성 효과를 스크리닝하였다. 한약 0.001-2.5 mg/mL의 농도에서 2,2-diphenyl-1-picrylhydrazyl(DPPH) assay와 SH-SY5Y human neuroblastoma cells을 이용해 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT) assay를 수행하였다. 한약 농도와 DPPH radical 소거율과의 관계식을 이용하여 소거율이 50%에 해당하는 시료 농도(IC50)를 계산하였을 때 12종의 한약이 0.7–2.5 mg/mL 농도 내에서 항산화 효과를 보였고, 농도의존적으로 항산화 활성이 높았다. MTT assay 결과 연구에 쓰인 대부분의 한약이 0.01-0.001 mg/mL 농도에서 세포 생존율이 80% 이상이었다. 세포 생존율과 DPPH 라디칼 소거 활성을 고려할 때, 시호소간탕, 시호청간탕, 청상견통탕이 항산화 활성 기전을 통해 신경보호효과를 가지는 것으로 보인다.

거실공간에서 공간지각을 유도하기 위한 조명계획에 관한 연구

서지은,이정호 대한건축학회 2006 대한건축학회논문집 Vol.22 No.10

The purpose of this study is to grope for a method planning of lighting to derive space perception that effects on users' availability and behavior in living room space. The result of this study is as follows : First, we could branch from space perception to be derived by 'human work light' of 6 kinds that 'extension', 'deeply', 'boundary', 'reiteration', 'center' and 'modeling'. Second, we know that space perception effects on users' utilize degree and utilize degree at living room space. so lighting is important factor to derive space perception. Third, it is need to derive space perception that 1 kind of 'architectural lighting' and 2 kinds of 'appliance of lighting'. Fourth, we proposed a method planning of lighting by collected kinds and position of lighting in <table 30>. Though <table 30>, we know that we should differently use kinds of 'architectural lighting' and 'appliance of lighting' to derive for space perception through arrangement of lighting to be selected. so we need to grope a technique of planning of lighting to enhance users' satisfaction and affordance.

환경시?환경음 인자가 어린이놀이터의 행태지원에 미치는 영향에 관한 기초연구

서지은,이정호 대한건축학회 2006 대한건축학회논문집 Vol.22 No.8

The purpose of this study is to evaluate factors of 'Ambient Vision' and 'Ambient Sound' at surrounding playground in housing complex and to extract the affirmative affected factors to user in playground and to understand characteristics of factors.The results of this study is as following : First, one of component parts in playground, 'Nature' was not affecting in availability. Through analysis result about 'a Person' and 'Vehicles', we could know that users are preferring more to look at factors which have no motion than suspending factors. Second, I extracted cause that a clearly shadow view have affected affirmative effect in playground and then it was that user felt a different perception according to change of shadow each other. therefore, even if factors have not motions, it is effective to recognize that arranged considering brightness contrast. Third, as the result analysis 'Ambient Sound', we could know that irregular living environment sound to feeling activity is causing affirmative effect in utilization. Finally, this study is processing and the result is going to utilize to basic data in study about user's affordance reaction and space perception by 'Ambient Vision' and 'Ambient Sound'.

놀이공간의 주변 환경자극에 대한 이용자의 행태반응 및 공간지각 연구

서지은,이정호 대한건축학회 2006 대한건축학회논문집 Vol.22 No.5

The purpose of this study is to analyze users' behavioral response and spatial perception which result from environmental stimuli of play ground surrounding.The result of this study is as following :First, we could know that users are preferring environment factors which give 'Activeness' us visually or aurally. but, even if factors have 'Activeness' factors that have visual without sound were not influencing in users' activity. Second, the moving of user was receiving much effects to 'Transfer' of 'flow factors' in playing space. we could know that user' availability is high because they could feel 'Change' though feeling this factors. Third, it is though about 14 seconds that users recognize children's play action. the time that user move users' gaze to other place is about 5 seconds. Fourth, the strong factor of environment factors was 'Road traffic noise'. because those were acted by affirmative factor in using playing space when user can percept noise factors visually. Finally, users who use the playing space have various behavioral response by environmental stimuli. they have felt to space that is extended than actuality space' size through these behavioral response.

거실공간에서 거주자 행태와 공간지각을 고려한 조명(照明)위치 연구

서지은,정지석,이정호 대한건축학회 2006 대한건축학회논문집 Vol.22 No.12

This study is to analyze the lighting position preference in spatial perception and effect affected residents' behavior in spatial perception by lighting.The results is as following :First, we could classify spatial perception by lighting in 6 types, residents' behavior in a livingroom space. Each spatial perception can be classed by positive and negative meaning. Second, we know that spatial perception as influence in residents' behavior is different particularly appearance of behavior's type, and lighting could support residents' behavior. we could know that negative meaning as well as positive meaning about spatial perception affects affirmative residents' behavior. It is necessary that negative meaning of the class of variables about space perception is analyzed to evaluate psychological environment of residents. Third, according to results that analyzed lighting position, we could know that lighting position appeared a different according to the number of family participant, behavior and it's characteristic. Finally, we can show that residents prefer lighting position differently by residents' sex, age, and house scale.

고려시대 사찰 주불전의 건축 특성 연구

서지은,홍승재 대한건축학회 2004 대한건축학회논문집 Vol.20 No.12

This study is the architectural characteristics of main Buddhist sanctum in Koryeo period. The study regarding to the Temples built in the age of Koryeo Dynasty of which most part in the research for Buddhist architectural history is yet remained left behind as a vacant period due to limitation of the relevant materials thereof. Recently, as being carried out the excavation on those relics of Koryeo temples, the architectural features for Koryeo temples are also being clarified. The plan style of main Buddhist sanctum founded in the Koryeo Period and the composition of the Buddhist sanctum are relatively various. The plane style was examined in regard to the religious contents and Buddhist consciousness at that time. Also, based on the plane structure, it was estimated whether they were single-storied or multiple-storied. For this, they were analyzed by comparing with the existing buildings of the Choseon Period.

한방건강보험약 12종의 항산화 활성 및 신경세포 독성 스크리닝 연구

서지은,이한울,배창환,윤동학,김희영,김승태,Seo, Ji Eun,Lee, Hanul,Bae, Chang-Hwan,Yoon, Dong Hak,Kim, Hee-Young,Kim, Seungtae 경락경혈학회 2022 Korean Journal of Acupuncture Vol.39 No.2

Objectives : Parkinson's disease (PD) is a neurodegenerative disease caused by dopaminergic neuronal death in the substantia nigra pars compacta. PD is known to be linked with mitochondrial dysfunction and increased oxidative stress. In this study, anti-cytotoxic and anti-oxidative effect of 12 herbal formulae were compared. Methods : According to experts' advice, 12 types of herbal formulae (Gamisoyosan, Galgeuntang, Galgeunhaegitang, Banhabaekchoolcheonmatang, Bojungikgitang, Boheotang, Sihogyejitang, Sihosogantang, Sihocheonggantang, Ojeoksan, Cheongsanggyeontongtang and Palmultang) were selected from 56 types of herbal formulae covered by the National Health Insurance Service in Korea. To detect anti-oxidative effect, 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay was performed, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed to detect anti-cytotoxic effect of 12 herbal formulae using SH-SY5Y human neuroblastoma cells. Results : In DPPH assay, anti-oxidant activity was increased in a dose-dependent manner and half maximal inhibitory concentration was highest in the order of Galgeuntang, Gamisoyosan, Galgeunhaegitang, Ojeoksan, Palmultang, Sihogyejitang, Sihosogantang, Cheongsanggyeontongtang, Sihocheonggantang, Bojungikgitang, Boheotang and Banhabaekchoolcheonmatang. In MTT assay, concentration of 80% cell survival was highest in the order of Sihosogantang, Cheongsanggyeontongtang, Sihocheonggantang, Sihogyejitang, Bojungikgitang, Galgeuntang, Ojeoksan, Boheotang, Palmultang, Galgeunhaegitang, Banhabaekchoolcheonmatang and Gamisoyosan. Formulae with more than 50% DPPH radical scavenging activity at concentrations for 80% cell survival were Sihosogantang, Cheongsanggyeontongtang, Sihogyejitang, Galgeuntang and Sihocheonggantang. Conclusions : Sihosogantang, Cheongsanggyeontongtang, Sihogyejitang, Galgeuntang and Sihocheonggantang extracts can be candidate medicines for PD, but the effect should be validated in PD models.

조선시대 주거지의 연구 -경기지역에서 확인된 유적을 중심으로-

서지은,홍승재 한국건축역사학회 2013 한국건축역사학회 학술발표대회논문집 Vol.2013 No.춘계

특수학교 교사의 직무스트레스와 스트레스 대처전략: 부산광역시를 중심으로

서지은,박재국,김은라 한국지체.중복.건강장애교육학회 2018 지체.중복.건강장애연구 Vol.61 No.1

Purpose: The purpose of this study was to investigate perception on the job stress and coping strategies of special education teachers. Method: 161 special education teachers were surveyed by using job stress and coping strategy scale. The collected data were analyzed by using descriptive statistics, independent sample t-test, one way ANOVA, and correlation analysis. Results: First, the overall level of job stress of special education teachers was normal. There were statistically significant differences between the groups according to age, career, kind of school, school grade, Second, the level of coping strategy for job stress of special education teachers was normal, and particularly, the problem-oriented coping strategy was on the highest level. As well, there was a significant difference in coping strategies according to the gender of special education teachers. Third, the relationship between job stress and coping strategy was statistically different. Conclusion: Based on these results, it was suggested that positive stress coping strategies should be implemented to reduce negative stressors and to develop strategies and programs for teachers' healthy restraint by identifying job stress variables affecting special education teachers. 연구목적: 본 연구는 특수학교 교사의 직무스트레스와 스트레스 대처전략 간의 관계를 탐색함으로써 특수학교 교사의 스트레스 수준을 감소시킬 수 있는 방안을 살피고자 하였다. 연구방법: 이를 위하여 특수교육기관에 재직 중인 교사 161명을 대상으로 직무스트레스와 대처전략에 대한 설문조사를 실시하였으며, 수집된 자료는 연구문제에 따라 통계처리 하였다. 연구결과: 첫째, 특수학교 교사의 직무스트레스 수준을 보통인 것으로 나타났다. 특수학교 교사의 성별, 연령, 경력, 학교종류, 학교 급, 담임여부, 담당 학생 수에 따라 집단 간 유의미한 차이가 확인되었다. 둘째, 특수학교 교사의 스트레스 대처전략에 대한 인식은 보통인 것으로 나타났다. 또한 특수학교 교사의 성별에 따라 집단 간 유의미한 차이가 확인되었다. 셋째, 특수학교 교사의 직무스트레스와 스트레스 대처전략 간에 통계적으로 유의미한 관계가 확인되었다. 결론: 본 연구의 결과를 토대로 특수학교 교사의 스트레스에 대한 대처전략을 개발하고 함양시킴으로써 직무스트레스를 감소시킬 수 있는 방안을 제시하였다.