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응급실에서 소아환자의 진정제로서 케타민(Ketamine)의 사용
서정필,박준석,황태식,장석준,김승호 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3
Background: Ketamine use in emergency room has been increased. It has rapid onset of action and appropriate duration of action. It does not need endotracheal intubation and produces potent analgesia, sedation, and amnesia. The object of this study is to determine the safety and the degree of physician's satisfaction in relation to ketamine use. Materials and Methods: This is a prospective study using protocol. Pediatric trauma patients who need sedation were given IM ketamine(4 ㎎/㎏) and atropine(0.01 ㎎/㎏) in a same syringe. Monitoring of patients was done by EM residents and complications of ketamine use were recorded. Physician's satisfaction was also recorded after the procedure. Results: Intramuscular ketamine was administered 54 times, mainly for laceration repair. Physicians completed protocol for 51 of treated children. The median time for onset of sedation was 6.5±2.4 min, and duration of action was 32.4±10.8 min. Hypersalivation occurred in 9.8%(n=5); random movement 3.9%(n=2), emesis during procedure(n=1), emesis at home(n=1), and transient oxygen desaturation(n=1). All were quickly identified and treated without specific airway management and sequelae. Of 84% of physicians was satisfied with ketamine use for pediatric sedation. Conclusion: Intramuscular ketamine can be administered safely and satisfactorily in emergency room to facilitate pediatric procedures in conjunction with a defined protocol and appropriate monitoring.
장폐쇄가 동반된 대장암에 대한 초기치료로서 수술 전 자가팽창성 금속스텐트 삽입술과 응급 수술의 비교
서정필,김상우,백창렬,박재명,조유경,이인석,최명규,최규용,정인식,강원경,오승택 대한소화기내시경학회 2007 Clinical Endoscopy Vol.35 No.5
Background/Aims: Emergency surgery for obstructive colorectal cancer is associated with a high rate of postoperative complications. The objective of this study is to investigate the clinical difference between the use of elective surgery after stent insertion, and the performance of emergency surgery as an initial treatment for colorectal cancer with an intestinal obstruction. Methods: For patients that were admitted from February 2004 to June 2006 for obstructive colorectal cancer, a retrospective analysis on the clinical outcome was performed for a group of patients that received a stent as an initial treatment (stent group) and a group of patients that received emergency surgery as an initial treatment (emergency operation group). Results: Postoperative complications in the stent group included pneumonia and wound infection (9.5%). For the emergency operation group, postoperative complications included sepsis, deep vein thrombosis, wound infection, anastomosis leakage and postoperative bleeding (38.9%). The number of postoperative complications were significantly less in patients in the stent group than for patients in the emergency operation group (p=0.032). The number of a one-staged operation was significantly higher in the stent group compared with the emergency operation group (85.7% vs 55.6%; p=0.039). The number of a stoma created at least once was significantly lower in the stent group (14.3% vs 50%; p=0.017) than in the emergency operation group. Conclusions: As an initial treatment for an obstructive colorectal cancer, the use of stent insertion for primary management should be considered since it can reduce the degree of postoperative complications and the necessity for multi-staged operations. (Korean J Gastrointest Endosc 2007;35:321-327) 목적: 급성 장폐쇄에 대한 응급 수술은 불량한 대장 정결상태 등으로 인해 수술 후 합병증의 빈도가 높다. 본 연구의 목적은 장폐쇄가 동반된 대장암에 대한 초기치료로서 자가팽창성 금속스텐트 삽입 후 수술을 시행했을 때와 일차적으로 응급 수술을 시행했을 때의 임상적 차이점을 알아보고자 하였다. 대상 및 방법: 2004년 2월부터 2006년 6월까지 대장암에 의한 장폐쇄로 입원한 환자 중 절제 가능한 병변에 대하여 스텐트 삽입 후 예정 수술을 받은 환자 21명과 스텐트 삽입 없이 응급 절제술을 받은 환자 18명의 수술 후 합병증 및 임상적 결과를 후향적으로 비교 분석하였다. 결과: 수술 후 합병증은 수술 전 스텐트 삽입군에서 폐렴 1명, 창상감염 1명으로 2예(9.5%)가 있었고 응급 절제술군에서는 패혈증 1명, 심부정맥 혈전증 1명, 창상감염 3명, 문합부 누출 1명, 수술 후 출혈 1명으로 7예(38.9%)가 있어 수술 전 스텐트 삽입군에서 유의하게 수술 후 합병증 발생이 적었다(p=0.032). 응급 절제술군에 비해 단단계 수술을 받은 비율이 수술 전 스텐트 삽입군에서 유의하게 높았고 (85.7% vs 55.6%, p=0.039) 치료과정 중에 한 번이라도 장루를 경험했던 비율도 수술 전 스텐트 삽입군에서 유의하게 적었다(14.3% vs 50%, p=0.017). 결론: 장폐쇄가 동반된 대장암에 대한 초기치료로 수술 전 자가팽창성 금속스텐트 삽입술은 응급 절제술보다 수술 후 합병증 및 여러 번의 단계적 수술을 줄일 수 있다는 점에서 일차적으로 고려해야 할 치료법이다.
Visualization of the inverse layer-plus-island growth in Fe islands on W(110) substrate
서정필,김태환,국양 한국물리학회 2015 Current Applied Physics Vol.15 No.9
Many experiments have been conducted so far to control the growth mode in heterostructures, but success has only been restricted to strain-controlled growth systems. In this study, using the shadow mask deposition technique, we have changed the growth mode in the Fe/W heterostructures from the layer-plus-island growth mode to island-plus-layer growth mode. From this, we have ignited the competing growth between forming the islands and wetting the first layer, and have directly visualized the island-plus-layer growth by controlling the annealing temperature of the system. This unconventional growth mode may play an important role in studying the hidden boundaries of hetero-interfaces.
간이식 후 담관 협착과 화농성 담관염이 동반된 담관 원주 증후군 1예
서정필,이인석,장재혁,권정현,허원행,배시현,최명규,정인식,김동구 대한소화기내시경학회 2007 Clinical Endoscopy Vol.35 No.4
Biliary complications after liver transplantation occur in 13∼35% of patients. Biliary cast syndrome, cast formation of biliary sludge along the bile duct, can develop in 4∼18% of liver transplant recipients, although the incidence rate is significantly decreasing due to the improvement of graft harvesting and preservation. It is very important that early diagnosis and effective management of biliary cast syndrome be performed when there is a bile duct stricture or dilatation associated with jaundice and cholangitis in the recipient after liver transplantation, due to the possibility of retransplantation and death of the patient from graft loss. We report a case of a biliary cast formed with suppurative cholangitis and extracted incidentally with a plastic biliary stent during an endoscopic procedure after cadaveric liver transplantation, in which the ERCP findings revealed a stricture at the anastomosis site of the common bile duct and cholangitis. (Korean J Gastrointest Endosc 2007;35:281-286) 간이식 후 담관계 합병증은 13∼35%의 환자에서 발생하는 것으로 알려져 있다. 이중 담관 원주 증후군(biliary cast syndrome)은 담관의 슬러지가 담관의 형태를 따라 종괴를 형성하는 것으로 간이식 환자의 4∼18%에서 발생하며 간이식 도입 초기에 비해 장기적출 및 보관기술 등의 발전으로 최근 발생빈도는 감소하고 있지만 발생 시 경우에 따라 이식편의 손실 및 재이식이 필요하거나 환자의 사망으로까지 이어질 수 있으므로 조기 진단 및 효과적인 치료가 필요하다. 저자들은 사체 간이식 후 황달과 담관염이 발생하여 시행한 내시경 역행 담췌관 조영술에서 문합부 담관 협착 및 담관염의 소견을 보였으며 화농성 담관염과 동반하여 생성된 담관 원주가 내시경시술로 플라스틱 담관 스텐트와 함께 배출된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.