The Efficacy and Safety of Tadalafil 5 mg Once Daily in the Treatment of Erectile Dysfunction After Robot-Assisted Laparoscopic Radical Prostatectomy: 1-Year Follow-up

서영은,김수동,김태효,성경탁 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.2

Purpose: To evaluate the efficacy and safety of tadalafil 5 mg once daily use in the treatment of erectile dysfunction (ED) after robot-assisted laparoscopic radical prostatectomy (RALP). Materials and Methods: The study retrospectively evaluated 92 patients who underwent RALP at Dong-A University Hospital. The patients were surveyed by use of the abridged five-item version of the International Index of Erectile Function (IIEF-5) questionnaire, which was self-administered before surgery and at 6 months and 1 year after surgery. The 92 patients were classified into the tadalafil group (n=47) and the non-tadalafil group (n=45). Each group was then classified depending on the nerve-sparing (NS) procedure used: bilateral NS or unilateral NS. Results: At 6 months, the total IIEF-5 scores of the tadalafil group and the non-tadalafil group were 10.0±3.4 and 7.0±4.0, respectively. At 1 year, the total IIEF-5 score in the tadalafil group was significantly greater than that in the non-tadalafil group (13.2±5.6 vs. 7.7±4.8, p<0.0001). Statistically significant improvements (p<0.05) were observed in the tadalafil group for all 5 domains of the IIEF-5 score, whereas in the non-tadalafil group there was no significant improvement in any of the domains at 1 year. The reported side effects were flushing (8.5%, n=4), headache (4.3%, n=2), and dizziness (2.1%, n=1). Conclusions: In ED patients after NS RALP, a once-daily dose of tadalafil 5 mg was well tolerated and significantly improved EF compared with that in the non-tadalafil group.

액체배양에 의한 홍국색소 생산의 최적배양조건

서영은,정혁준,홍순명,유대식,Seo, Young-Eun,Jung, Hyuck-Jun,Hong, Soon-Myung,Yu, Tae-Shick 한국미생물학회 2007 미생물학회지 Vol.43 No.1

홍국 색소의 액체배양에 의한 대량생산조건을 개발하기 위하여 Monascus sp. KM 1001 변이주를 대상으로 균체생산 및 색소생성에 미치는 최적배양조건을 비교 검토하였다. 실험균주의 색소생성을 위한 액체배지의 최적화학적 조성은 4% rice powder, 0.15% Bacto-peptone, 0.1% glycine, 0.01% $FeSO_{4}{\cdot}7H_{2}O,\;0.1%\;MgSO_{4}{\cdot}7H_{2}O,\;0.25%\;KH_{2}PO_{4},\;pH4.5$였다. 실험균주의 $2.0{\times}10^{6}\;spores/ml$의 포자현탁액을 액체배지 50 ml에 접종하여 배양온도 $30^{\circ}C$에서 150 rpm으로 5일간 배양하였을 때, 10.00 g/L의 균체생산과 세포외 황색색소 오렌지색소와 적색색소는 각각 3.25 unit, 1.59 unit, 0.88 unit를 생성하였으며, 세포내 황색색소 오렌지색소와 적색색소는 84.96 unit, 78.84 unit, 91.80 unit의 색소를 생산할 수 있었다. The optimal conditions for Monascus pigments production of Monascus sp. KM 1001, pigment overproducing mutant, in submerged culture was investigated. The optimal medium for the production of pigment from KM 1001 mutant is determined to be composed of 4% rice powder, 0.15% Bacto-peptone, 0.1% glycine, 0.01% $FeSO_{4}{\cdot}7H_{2}O,\;0.1%\;MgSO_{4}{\cdot}7H_{2}O,\;0.25%\;KH_{2}PO_{4},\;pH4.5$. On optimal conditions,10.0 g/L of the cell mass was obtained at $30^{\circ}C$ for 5 days. Yellow, orange and red pigment of Monascus sp. KM 1001 were produced 3.25 units, 1.59 units and 0.88 units in extracellular part, and 84.96 units, 78.84 units and 91.80 units in intracellular part, respectively.

특수아동을 위한 놀이치료 연구 분석: 1997-2009년까지의 국내 연구를 중심으로

서영은,이영선 한국자폐학회 2009 자폐성 장애연구 Vol.9 No.2

In recent years a growing number of studies employing play therapies for children with special needs were conducted and previous research shows that play therapies were successfully utilized for multiple mental health and concerns as well as psychosocial and behavior supports for children with various disabilities. This study reviewed a body of research using play therapy as a primary intervention, focusing on 34 studies which had been published in Korean journals between 1997 to 2009. The synthesis was conducted in the following categories: research participants, research design, interventions and their effects. The types of intervention were structured group play therapy and non-directive play, therapy and some of interventions included subject's parents or their peers without disabilities. Most of interventions were provided in segregated play therapy room by play therapists. Play therapy was effective for promoting verbal language and social and cognitive development as well as decreasing behavior problems and anxiety level. Based on results from this synthesis, further discussion on the results and implications for further research and practice were entailed. 최근 국내외에서 놀이치료의 수요가 증가하면서 다양한 환경에서 놀이치료가 실시되고 있으며 특수아동들을 대상으로 한 놀이치료 역시 늘어나고 있다. 본 연구는 장애 및 장애 위험 아동들을 대상으로 하는 놀이치료를 다룬 연구들을 종합 분석하여 현재까지의 연구를 정리하고 앞으로의 연구 방향을 제시하고자 하였다. 이를 위하여 놀이치료가 국내에 도입되어 활발하게 시작되어 온 1997년부터 2009년까지 지난 13년간 국내 학술지에 게재된 34편의 논문들을 분석 자료로 활용하여 연구 대상자, 연구 설계, 놀이치료, 중재의 효과를 중심으로 분석되었다. 놀이치료는 구조화된 집단놀이치료와 비지시적 놀이치료로 나누어서 분석이 이루어졌으며, 대부분의 중재들은 부모 참여 및 지원을 제공하고 있었다(부모-아동을 대상으로 한 연구, 부모 상담, 부모 놀이치료 등). 또한 놀이치료는 교실이나 가정보다는 분리된 치료실에서 놀이치료사에 의해서 이루어지는 경우가 대부분이었으며, 놀이치료의 효과는 언어표현 향상, 사회성 향상, 과잉행동 및 부주의 행동 감소, 불안심리 감소, 인지 향상 등으로 나타났다. 분석 결과를 바탕으로 국내 놀이치료 연구 및 현장에서의 특수아동에게 적용을 위한 논의 및 제언이 제시되었다.

Interfraction Prostate Movement in Bone Alignment After Rectal Enema for Radiotherapy

서영은,김태효,이기수,조원열,이형식,허원주,최영민 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.1

Purpose: To assess the effect of a rectal enema on interfraction prostate movement inbone alignment (BA) for prostate radiotherapy (RT), we analyzed the spatial differencein prostates in a bone-matched setup. Materials and Methods: We performed BA retrospectively with data from prostate cancerpatients who underwent image-guided RT (IGRT). The prostate was identified withimplanted fiducial markers. The setup for the IGRT was conducted with the matchingof three fiducial markers on RT planning computed tomography images and those ontwo oblique kV x-ray images. Offline BA was performed at the same position. The coordinatesof a virtual prostate in BA and a real prostate were obtained by use of theExaxTrac/NovalisBody system, and the distance between them was calculated as thespatial difference. Interfraction prostate displacement was drawn from the comparisonof the spatial differences. Results: A total of 15 patients with localized prostate cancer treated with curative hypofractionatedIGRT were enrolled. A total of 420 fractions were analyzed. The mean ofthe interfraction prostate displacements after BA was 3.12±2.00 mm (range, 0.20–10.53mm). The directional difference was profound in the anterior-posterior and supero-inferiordirections (2.14±1.73 mm and 1.97±1.44 mm, respectively) compared with theright-left direction (0.26±0.22 mm, p<0.05). The required margin around the clinicaltarget volume was 4.97 mm with the formula of van Herk et al. Conclusions: The interfraction prostate displacement was less frequent when a rectalenema was performed before the procedure. A rectal enema can be used to reduce interfractionprostate displacement and resulting clinical target volume-to-planning targetvolume margin.

성공적인 색전술로 치료된 복수천자 후 발생한 간경화 환자의 좌측 심부장골회선동맥 출혈에 의한 복벽 혈종: 증례보고 및 문헌 고찰

서영은,임채준,임재웅,김제성,오형훈,마건영,류가람,임찬묵,이병찬,주영은 대한소화기학회 2024 대한소화기학회지 Vol.83 No.4

The occurrence of an abdominal wall hematoma caused by abdominal paracentesis in patients with liver cirrhosis is rare. This paper presents a case of an abdominal wall hematoma caused by abdominal paracentesis in a 67-year-old woman with liver cirrhosis with a review of the relevant literature. Two days prior, the patient underwent abdominal paracentesis for symptom relief for refractory ascites at a local clinic. Upon admission, a physical examination revealed purpuric patches with swelling and mild tenderness in the left lower quadrant of the abdominal wall. Abdominal computed tomography revealed advanced liver cirrhosis with splenomegaly, tortuous dilatation of the para-umbilical vein, a large volume of ascites, and a large acute hematoma at the left lower quadrant of the abdominal wall. An external iliac artery angiogram showed the extravasation of contrast media from the left deep circumflex iliac artery. Embolization of the target arterial branches using N-butyl-2-cyanoacrylate was then performed, and the bleeding was stopped. The final diagnosis was an abdominal wall hematoma from the left deep circumflex iliac artery after abdominal paracentesis in a patient with liver cirrhosis.

섬망 심각도와 관련된 위험 요인

서영은,김태석,원왕연,이창욱,이철 대한신경정신의학회 2010 신경정신의학 Vol.49 No.6

ObjectivesZZThe purpose of this study was to investigate the relationship between the sum of the risk factors for delirium and the severity of delirium and to identify those risk factors which increase the severity of delirium. MethodsZZThe participants were 151 patients who were consulted with a consultation-liaison psychiatrist and diagnosed using DSM-IV criteria as suffering from delirium. Sociodemographic and clinical characteristics were obtained through structured interviews and medical chart reviews. The severity of delirium symptoms was measured by the Korean version of the Delirium Rating Scale-Revised 98 (K-DRS-R98). Patients were divided into two groups : a ‘mild delirium group (MDG)’, whose total scores on the K-DRS-R98 were below 16, and a ‘severe delirium group (SDG)’ with the scores above 16. ResultsZZThere was a positive correlation between the sum of known risk factors for delirium and total scores on the K-DRS-R98 (p=0.009). The SDG showed a significantly higher incidence of abnormal potassium levels, abnormal sodium levels, old age, and polypharmacy than the MDG (p=0.010, p=0.046, p=0.042, and p=0.033 respectively). In a logistic regression model, old age, abnormal sodium and potassium levels, and polypharmacy were found to predict increased severity of the delirium (p=0.001, p=0.007, p=0.019, and p=0.005 respectively). ConclusionZZThe present findings suggested that there are certain factors which not only affect the occurrence of delirium, but also severity of delirium symptoms. ObjectivesZZThe purpose of this study was to investigate the relationship between the sum of the risk factors for delirium and the severity of delirium and to identify those risk factors which increase the severity of delirium. MethodsZZThe participants were 151 patients who were consulted with a consultation-liaison psychiatrist and diagnosed using DSM-IV criteria as suffering from delirium. Sociodemographic and clinical characteristics were obtained through structured interviews and medical chart reviews. The severity of delirium symptoms was measured by the Korean version of the Delirium Rating Scale-Revised 98 (K-DRS-R98). Patients were divided into two groups : a ‘mild delirium group (MDG)’, whose total scores on the K-DRS-R98 were below 16, and a ‘severe delirium group (SDG)’ with the scores above 16. ResultsZZThere was a positive correlation between the sum of known risk factors for delirium and total scores on the K-DRS-R98 (p=0.009). The SDG showed a significantly higher incidence of abnormal potassium levels, abnormal sodium levels, old age, and polypharmacy than the MDG (p=0.010, p=0.046, p=0.042, and p=0.033 respectively). In a logistic regression model, old age, abnormal sodium and potassium levels, and polypharmacy were found to predict increased severity of the delirium (p=0.001, p=0.007, p=0.019, and p=0.005 respectively). ConclusionZZThe present findings suggested that there are certain factors which not only affect the occurrence of delirium, but also severity of delirium symptoms.

오는 봄 누가 막으리

서영은 샘터사 1990 월간 샘터 Vol.21 No.4

Plychlorinated biphenyl ( PCB ) 분해균주의 분리·동정 및 특성에 관한 연구

서영은,조홍범,최영길 ( Young Eun Suh,Hong Bum Cho,Yong Keel Choi ) 한국하천호수학회 1991 생태와 환경 Vol.24 No.2

The ratios of PCB degrading bacteria to heterotrophic bacteria were about 0.035%∼0.444% in Han River and Anyang stream. The highest ratio was found at Gunpo bridge in Anyang stream into which plants` effluents has been directly releasing. The two isolates capable of degradading Aroclor 1254, one of the PCB mixtures, were identified as Pseudomonas sp.. GS5, one of the two isolates, in the ability of biodegradation of Aroclor 1254 shown the degradation rate of 18%, 34%, 68% and GS6, the other isolate 2%, 28% 56% during 3, 6, 9 days, respectively. While the mixed culture of isolates had not influenced the ability of degradading Aroclor 1254, the isolates showed two times of degradading ability when biphenyl was added to it. The genes encoding enzymes of Aroclor 1254 degradation were located at plasmid and chromosome in the case of GS5 and GS6, respectively.

조기수술이 필요한 폐 선천성 낭포성 샘 모양 기형아의 특성과 수술 전 중재적 시술

서영은,김현경,최용성,이병섭,김기수,원혜성,이필량,심재윤,김암,윤종현,김동관,김애란 대한신생아학회 2013 Neonatal medicine Vol.20 No.1

Purpose: To identify neonatal characteristics associated with congenital cystic adenomatoid malformation (CCAM) who required early operations and to introduce preoperative interventions to delay definitive operations until stabilized. Methods: A retrospective review of dataset was performed from January 2000 to December 2011 for neonates admitted to NICU at Asan Medical Center with prenatally diagnosed CCAM. Variable prenatal and postnatal factors were compared for those who required early operations to those asymptomatic neonates who required elective operations at later age. Results: A total of 60 patients were enrolled and patients were divided into 2 groups according to time of operation. Median time of surgery for group 1 (n=12, 20%) and group 2 (n=48, 80%) was 5.5 days and 504 days, respectively. Maternal characteristics including age, parity, preterm labor, oligohydramnios were similar in between two groups. Factors associated with early operation included prenatal history of polyhydramnios (OR 23, P=0.001), who had undergone fetal interventions (OR 47, P=0.001), low 1 and 5 minute Apgar scores and increasing fetal fluid-filled cystic sizes (OR 26, P=0.013). Of those 3 neonates who required preoperative interventions to decrease air-filled cysts to relieve initial respiratory symptoms were successful and all underwent for definitive operations during NICU hospitalizations. All survived. Conclusion: Most neonates with CCAM undergo elective operations during infancy. However, about 20% neonates with polyhydramnios, fetal intervention, increasing fetal cystic mass and born with low Apgar scores required early operations for whom prenatal and postnatal interventions prior to definitive surgery can improve survival rate. 목적: 폐 선천성 낭포성 샘 모양 기형(congenital cystic adenomatoid malformation, CCAM)에서 출생 후 증상을 보여 조기수술을 하게 되는 환자와 연관된 인자를 알아보고, 수술 전 호흡 기능의 안정화를 위한 중재적 시술 방법에 대해 소개하고자 하였다. 방법: 서울 아산병원 소아청소년병원 신생아중환자실 혹은 신생아실로 2001년 1월부터 2011년 12월까지 지난 11년간 본원에서 산전초음파로 CCAM 진단받고 입원 후 폐 절제 수술을 받은 환아들을 대상으로 후향적 연구를 하였다. 출생 직후 증상을 보인 조기수술군과 증상이 없었던 계획수술 군으로 나누어 환아와 산모의 특성, 조기수술과 연관된 인자를 조사하여 통계학적 방법으로 비교하였다. 아울러 산전 중재적 시술과 출생 후 수술 전 중재적 시술을 받았던 환아들의 임상 경과도 살펴보았다. 결과: 총 60명의 환자들이 등록되었고 수술 시기에 따라 조기수술 군과 계획수술 군으로 나누었다. 수술 시기는 조기수술군(n=12, 20%) 이 중간값 5.5일, 계획수술군(n=48, 80%)이 504일이었다. 나이, 조산, 양수과소증을 포함한 산모의 특성은 두 군간 비슷하였다. 양수과다증이 있었거나(OR 23, P=0.001), 산전 중재적 시술을 받았거나(OR 47,P=0.001),, 산전 CCAM의 크기 증가를 보이면서 출생 시 낮은 아프가 점수를 보였던 환아가 조기수술과 연관된 인자들로 조사되었다. 출생 후 호흡기증상이 발생하고 생체징후가 불안전하여 응급수술을 시행하지 못한 3명의 환아가 수술 전 중재적 시술을 받았고 이후 성공적으로 폐 절제수술 시행이 가능하였다. 결론: 대부분의 CCAM을 지닌 신생아는 증상이 없어 계획적 수술이 가능하였지만 신생아 시기에 조기수술이 약 20%에서필요하였다. 조기수술과 관련된 인자로 양수과다증, 산전 중재적 시술, 산전 CCAM의 크기 증가, 낮은 아프가 점수를 보인 신생아로 조사되었고 이들에게 적극적인 산전 중재적 시술, 수술 전 중재적 시술과 궁극적으로 폐 절제 조기수술을 시행함으로써 단 한 건의 사망 없이 생존율을 향상시킬 수 있었다.

프로바이오틱스의 기능성과 안전성

서영은,윤요한,김세정 한국낙농식품응용생물학회 2019 Journal of Dairy Science and Biotechnology (JMSB) Vol.37 No.2

Probiotics stabilize intestinal microflora, reduce constipation, reduce decay by inhibiting harmful bacteria, and prevent diseases. Probiotics have also been studied for their possible roles in immune activation, treatment of cancer, remediation of cholesterol, treatment of diabetes, alleviation of allergies, and relief of lactose intolerance. However, recent data concerning the side effects of probiotics have prompted debate regarding their efficacy and safety. Major adverse events associated with probiotics are gastrointestinal symptoms, such as diarrhea, gastrointestinal disorders, and vomiting, along with skin rash and urticaria. Probiotics occasionally cause sepsis in infants with poor immunity and elderly people with severe diseases. In contrast to previous studies that described the efficacy of probiotics in intestinal regulation, some recent studies have reported that the activity of intestinal microbes becomes weak as a result of the influx of probiotics. The data indicate that the safety of probiotics is not guaranteed and that further investigations are needed.