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부영민 ( Yung Min Bu ),백선경 ( Sun Kyung Baek ),김진화 ( Zhen Hua Jin ),강동호 ( Tong Ho Kang ),노승주 ( Seung Ju Rho ),김호철 ( Ho Cheol Kim ) 대한본초학회 2004 大韓本草學會誌 Vol.19 No.2
N/A Objectives: The root of Rhodiola sachalinensis A. bor (RS), which has been used to strengthen qi(補氣), reduce heat of lung (淸縮), nourish heart (養心), stop bleeding (止血), reduce edema(消腫) for the treatment of fatigue, amnesia, bleeding and edema. It`s flavour and channel tropism is sweet (甘), acting on the lung (肺). The purpose of the study we report here was to determine the neuroprotective effect of the roots of RS on transient focal cerebral ischemia in SD rats. Methods: The root of RS was lyophilized after extraction with 85% methanol. We occluded middle cerebral artery for 90 minutes and reperfused for 24 hours. The brain slices were stained by 2 % 2, 3, 5-triphenyltetrazolium chloride and the infarct volume was measured by graphic analyzer. Results: The root extracts of RS showed significant neuroprotective effects (100 mg/kg, p〈0.05) compared with control group. The neuroprotective efficacy was about 35%. Immunohistochemical data explained the protective effects of RS via attenuation of COX-2 induction in neocortex and inhibition of microglia activation in the penumbral region. Conclusions: The root of RS has neuroprotective effects on transient focal cerebral ischemia in Spargue-Dawley rats and the mechanism might be the attenuation of COX-2 induction and microglial activation.
한방병원에 내원한 특발성 폐섬유화증 환자 82명에 대한 임상적 특징 분석; 후향적 차트 리뷰
홍성은,강성우,박지원,장권준,박수현,김관일,부영민,정희재,이범준,Hong, Sung-eun,Kang, Sung-woo,Park, Ji-won,Jang, Kwon-jun,Park, Su-hyeon,Kim, Kwan-il,Bu, Yung-min,Jung, Hee-jae,Lee, Beom-joon 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.3
Objective: This study was designed to analyze the clinical features of idiopathic pulmonary fibrosis patients who attended a Korean medicine hospital and the treatment effects through retrospective chart reviews. Methods: The medical records of 82 outpatients who had been diagnosed with idiopathic pulmonary fibrosis and visited the Allergy, Immune, and Respiratory System Department of Kyung Hee Korean Medicine Hospital from 8 January 2015 to 8 January 2021 were retrospectively reviewed. To assess the treatment outcomes, we used the FVC (Forced Vital Capacity), DLCO (Diffusing capacity of the Lung for CO), 6-minute walk test, and HRCT (High Resolution Computed Tomography). Results: The study group consisted of 28 females and 54 males. The median age of the patients was 67.98±11.44 years. The chief complaints were cough (n=51) and dyspnea (n=49). Other frequent symptoms were general weakness (n=8), weight loss (n=4), and a fever (n=2). A total of 77 (93.90%) patients were prescribed Korean herbal medicine, and 52 (63.41%) patients were treated with acupuncture, moxibustion, cupping therapy, ICT, or pharmacopuncture. After treatments, FVC, DLCO, the 6-minute walk test, and HRCT were maintained or worsened slightly. Conclusions: This study presented the characteristics of idiopathic pulmonary fibrosis patients treated by Korean medical therapies, and further studies of Korean medical treatments for idiopathic pulmonary fibrosis patients would be valuable.