http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
배학연 ( Hak Yeon Bae ) 대한내과학회 2011 대한내과학회지 Vol.80 No.6
Managing type 2 diabetes has become more complex as pharmacotherapy has expanded. Therapies for type 2 diabetes can be divided into drugs facilitating supply of endogenous insulin or those enhancing insulin actions. Successful treatment of type 2 diabetes combines approaches to lifestyle modification frequently in conjunction with use of pharmacologic therapy. The dual aspects of type 2 diabetes, insulin resistance and insulin deficiency, are important factors in therapy selection and the subsequent reponse to therapy. Most patients have gradually increasing needs for additional therapy. Some patients require combination pharmacologic therapy at the time of initial treatment, especially if they have a markedly elevated HbA1c. We describes combination pharmacologic therapy in type 2 diabetes, recent evidence and opinions on sequences for type 2 diabetes. (Korean JMed 2011;80:643-648)
배학연,Bae, Hak-Yeon 사단법인 한국당뇨협회 2005 당뇨 Vol.183 No.-
당뇨병 치료 중 많은 환자들이 지나치게 혈당을 낮추는 데에만 신경을 쓰는 경우가 있다. 하지만 우리 몸의 건강유지를 위해서는 적절한 수치의 혈당유지가 중요하다. 당뇨병 치료과정에서 발생할 수 있는 저혈당과 그에 대한 처치 및 예방법의 인식은 또 다른 안전한 당뇨병 치료의 길을 알려 줄 것이다.
하시모토 갑상선염을 동반한 갑상선 결절 환자의 임상적 특징
임창록(Chang Rock Lim),배학연(Hak Yeon Bae),조현진(Hyun Jin Cho),김권천(Kweon Cheon Kim) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.75 No.3
Purpose: This study investigated the clinical features of patients with thyroid nodule combined with Hashimoto’s thyroiditis, and the latter was incidentally detected after surgery. Methods: The authors retrospectively evaluated 43 patients who were diagnosed with Hashimoto’s thyroiditis after thyroidectomy between January 2001 and December 2006 at Chosun University Hospital. Results: All patients underwent ultrasonography for the diagnosis of thyroid nodules. Ultrasonography revealed 16 calcified nodules with ill-defined margins, and these nodules were suspicious for malignancy. On performing preoperative fine needle aspiration, 37 cases were suspicious for malignancy or they were diagnosed as malignancies. All the thyroid nodules were taken for frozen section examination during surgery. On the frozen sections, 19 cases that were suspicious for malignant tumors underwent near total or total thyroidectomy along with central lymph node dissection, whereas 24 cases that were diagnosed as benign tumors underwent near total thyroidectomy or thyroid lobectomy. Based on the histopathological findings, 21 cases were diagnosed as Hashimoto’s thyroiditis associated with papillary cancer; the nodules of these 21 cases were on average 0.75 ㎝, Twenty two cases were diagnosed as Hashimoto’s thyroiditis associated with benign tumors, and the nodules of these cases measured on average 1.6 ㎝. Conclusion: Hashimoto’s thyroiditis may present with a variety of clinical features, atypical ultrasonographic findings and a high false positive rate on fine needle aspiration. For the cases where Hashimoto’s thyroiditis is suspected before surgery, serum antibody tests, ultrasonography and fine needle aspiration should be performed for making the accurate diagnosis of Hashimoto’s thyroiditis. For the cases of suspicious malignant tumors, frozen section examination should be performed during surgery to decide on the correct operative procedure.
간장질환 환자의 혈중 α₁ - Antitrypsin 과 Prealbumin 에 관한 연구
채종구(Jong Koo Chae),배학연(Hak Yeon Bae),김만우(Man Woo Kim),장경식(Kyoung Sig Chang),정춘해(Choon Hae Chung),조건국(Kun Kook Cho) 대한내과학회 1987 대한내과학회지 Vol.33 No.2
N/A The alpha-1-antitrypsin and prealbumin concentrations were measured in sera of 34 cases of liver cirrhosis, 20 cases of liver cirrhosis with hepatocellular carcinoma, 18 cases of primary hepatocellular carcinoma and 30 normal control cases in Chosun University Hospital from Jan. 1985 to July 1986. The results are follows: 1) The mean concentration of alpha-1-entitrypsin in blood of normal control group was 141±39.9mg%, in liver cirrhosis, liver cirrhosis with hepatocellular carcinoma and primary hepatocellular carcinoma concentrations were increases each 151.4±93.0, 185.8±71.8 (P<0.05) and 163.4±88.6 mg% in comparison with the mean value of normal control group. 2) The mean concentration of prealburnin in blood of normal control group was 174±65 mg9o, in liver cirrhosis, liver cirrhosis with hepatocellular carcinoma and primary hepatocellular carcinoma concentrations were significantly decreased each 101±49, 82±16 and 75±26 mg% fall P<0.01). 3) The mean concentrations of serum prealbumin in each group of liver diseases with low serum alpha-1-antitrypsin levels: liver cirrhosis (79.1±21.1), liver cirrhosis with hepatocellular carcinoma (41.0±12.0) and primary hepatacellular carcinoma (52.5±17.0 mg%) were significantly decreased (all P<0.01). Consequently, in chronic liver diseases, the serum alpha-1-antitrypsin levels were usually increases and prealbumin levels were significantly decreased in comparison with mean value of normal control group. In chronic liver diseases with low serum alpha-1-antitrypsin level, serum prealbumin concentrations were significantly decreased, This study show that patients with low serum alpha-1-antitrypsin level in chronic liver diseases have severe damage of parenchymal cells in liver.
Streptozotocin 유발성 당뇨백서에서 해당효소에 대한 Phlorizin의 효과
배학연,정회상,박유환,전용준,이승일,문철웅,양성훈,이병래 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.15 No.1
In glycolysis, the reactions catalyzed by hexokinase, Phosphofructokinase, and pyruvate kinase are lally irreversible; hence they would be expected to have regulatory as well as catalytic roles. They ilso adaptive in a number of physiological states, and although the molecular mechanisms controlling adaptations are largely unknown, dietary and hormonal stimuli serve as environmental factors lating enzyme levels in vivo. The present study was undertaken to examine the effects of phlorizin, a blocker of renal tubular ose reabsorption, on the activities of glucokinase, hexokinase, and pyruvate kinase in the liver and nrocytes of streptozotocin (STZ) diabetic rats. The levels of plasma glucose and insulin and the activities of glycolytic enzymes were measured onchird day after phlonzin treatment in normal and STZ diabetic rats and the results were as follows. 1. Plasma glucose levels were reduced by 14.35%(P<0.05) in normal rats and by 39.38% (p<0.01) in STZ diabetic rats. 2. Plasma insulin levels were reduced by 45.6% (P<0.05) in normal rats and by 58.2% (P<0.01) in STZ diabetic rats. 3. On the third day after phlorizin treatment, hepatic glucokinase and pyruvate kinase activities in normal rats were reduced by approximately 56% (P<0.01) and 43% (P<0.01) respectively, and erythrocyte hexokinase and pyruvate kinase activities were reduced by approximately 18% (P<0.05) and 22% (P<0.01) respectively, In STZ diabetic rat shepatic glucokinase and pyruvate kina activities were reduced by approximately 52% (P<0.01) and 22% (P<0.01) respectively, a erythrocyte hexokmase and pyruvate kinase activities were reduced by approximately 4% and 3 respectively. Thus the overall decreases of the levels of plasma glucose and insulin and the activity of glycoly enzymes were observed on the third day after phlorizin treatment in normal and STZ diabetic ra These alterations in the enzyme activity with phlorizin treatment were shown to be a result of reducinsulin levels, and the smaller decrease in enzyme actvity in STZ diabetic rats than in normal rats thought to be probably due to the reduced response to changes in insulin levels at near basal levels enzyme activity.