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이승호,이두진,이태형,이영기,배철준,곽양수,이용훈,김미진 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.7
Gonadal tumors occur in a small percentage of patients who are diagnosed as having gonadal dysgenesis. Most of the tumors were gonadoblastomas and dysgerminomas. We present here with brief review of literature one case of mixed germ cell tumor of phenotycally typical female without sexual ambiguity who presented with primary amenorrhea, short stature and minimal abnormal somatic features, whose chromosome analysis showed 45,X/ 46,X, +mar karyotype.
백서에서 비스테로이드성 항염증약물 , Heparin , Hyskon , TC-7의 술후 유착형성 억제효과에 관한 비교
고민환,이태형,박윤기,이영기,배철준,곽양수,이경아 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.7
The purpose of this study was to evaluate and compare the effect of inhibition of postsurgical adhesion formation in the rat model by meclofenamate, tolmetin, TC-7, Hyskon, and heparin. Laparotomies were performed on grossly healthy, mature nonpregnant female rats, and proximal 1 cm of each uterine horn was traumatized with unipolar electrocautery. Each rat was randomly assigned to one of six different groups(control, meclofenamate, tolmetin, heparin, TC-7, and Hyskon group), and different solutions or an adhesion barrier were placed into traumatized uterine horn before closure. One week later adhesion formation was scored according to percent involvement of each traumatized uterine horn(0 to 4), and adhesion density(0 to 2), and compared using one-way analysis of variance and Fishers exact test. Compared with the control group, postsurgical adhesion formation was significantly decreased in the TC-7 group(average adhesion score, 1.72), the meclofenamate group(2.19), the Hyskon group(2.53), and the tolmetin group(2.93). The TC-7 group was also significantly decreased in adhesion formation compared with the Hyskon, tolmetin, heparin groups, and meclofenamate group was significantly decreased in adhesion formation compared with tolmetin and heparin groups. There were no significant differences between groups in adhesion density. So we suggest that meclofenamate is a cost-effective agent in inhibition of postsurgical adhesion formation.
Magnesium Sulfate치료가 중증 자간전증 임산부의 혈장 Endothelin치에 미치는 영향
이승호,이두진,이태형,이재열,김종호,배철준 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.10
정상 임산부군과 자간전증 임산부군에서의 모체혈장 endothelin치의 차이와 자간전증 임산부군에서 황산 마그네슘 치료에 따른 모체 혈장 endothelin치의 동태를 관찰하기 위하여, 1993년 1월 1일부터 12월 31일까지 12개월간 영남대학교 의과대학 부속병원 산부인과에 유도분만을 위해 입원한 정상 임산부 20명과 황산 마그네슘 치료를 시행한 중증 자간전증 임산부 26명을 대상으로 모체 혈장 endothelin치와 간 및 신장기능검사를 시행하여 다음과 같은 성적을 얻었다. 정상 임산부군과 중증 자간전증 임산부군의 평균 모체 혈장 endothelin치의 차이는 없었다(10.02+-3.21 pg/ml vs. 11.78+-3.52 pg/ml). 중증 자간전증 임산부군에서 황산 마그네슘 치료전후의 평균 모체 혈장 endothelin치는 각각 77.78+-3.52 pg/ml와 6.64+-2.96 pg/ml로 황상 마그네슘 치료후의혈장 endothelin치가 통계적으로 유의하게 낮았다(p$lt;0.01). 중증 자간전증 임산부군에서 평균 수축기 및 이완기 혈압은 황산 마그네슘 치료전이 각각 172+-14.50 mmHg와 116+-14.50 mmHg, 치료후가 각각 160+-8.41 mmHg, 105.779 mmHg으로 치료후 각각 통계적으로 유의하게 저하하였다(p$lt;0.01). 중증 자간전증 임산부군에서 황산 마그네슘 치료전과치료후의 혈청 GOT, GPT, LDH, BUN, 뇨산 및 Creatinine치는 각각 차이가 없었다. 이상의 연구성적으로 미루어 통상적으로 황산 마그네슘 치료가 시행되지 않고 있는 제왕절개 분만중증 자간전증 임산부에서도 수술전 황산마그네슘 치료를 시행하여 혈정 endothelin치의 저하를 유도함으로써 자궁-태반의 혈류량 증대와 태아 및 신생아의 상태개선에 유리한 영향을 기대할 수도 있을 것으로 추정된다. To evaluate the clinical efficacy of measurement of maternal plasma endothelin level in preeclampsia, maternal plasma endothelin levels and blood chemistry for liver and renal function were analysed in 20 women with normotensive term pregnancies and 26 women with severe preeclampsia, who were admitted to induce labor at the Department of Obstetrics and Gynecology, Yeungnam University Hospital from January 1st, 1993 to December 31st, 1993. The mean plasma endothelin levels of normotensive pregnant women, before and after magneisum sulfate therapy in severe preeclamptic women were 10.02+-3.21 pg/ml, 11.78+-3.52 pg/ml and 6.64+-2.96 pg/ml, respectively. There was no statistical difference between normotensive pregnant women and preeclamptic women in the mean plasma endothelin levels. However, in the preeclamptic women, mean palsma endothelin levels of before magnesium sulfate therapy was statistically higher than those of after magnesium sulfate therapy(P$lt;0.01). In severe preeclamptic women, the mean blood systolic and diastolic blood pressure before magnesium sulfate therapy were 172+-14.50 mmHg and 116+-14.50 mmHg, respectively, and those of after magnesium therapy were 160+-8.41 mmHg and 105+-7.79 mmHg, respectively. Systolic and diastolic blood pressure were statistically lowered after magnesium therapy(p$lt;0.01). In severe preeclamptic women, mean serum lever enzymes, uric acid, BUN, creatinine levels before magnesium sulfate therapy were not statistically different from those of after magnesium therapy. Above results and review of literatures may suggest that better neonatal outcome would be anticipated with magnesium sulfate therapy prior to cesarean section in preeclamptic women, buty further studies should be necessitate to confirm above results.