액체구조에 관한 천이상태이론의 물에 대한 적용

박형석,장세현,Pak, Hyung-Suk,Chang, Sei-Hun 대한화학회 1966 대한화학회지 Vol.10 No.2

The partition function for liquid water is developed according to the transient state theory of significant liquid structure proposed by Pak, Ahn and Chang. This theory assumes that the molecules may possess solid-like, transient and gas-like degrees of freedom in liquid state. Although liquid water has several special properties, for example, minimum molar volume at 4^{\circ}C$, the general theory of liquid can be applied successfully. The theoretically calculated values for thermodynamic properties at the liquid temperature range and for the critical properties are in good agreement with the observed values. 박형석, 안운선과 장세헌이 제안한 액체구조에 관한 천이상태이론을 물에 적용시켜 액체상태에 있는 물의 상태합을 구했다. 이 이론은 액체의 분자가 고체와 같은 자유도, 천이상태의 자유도 및 기체와 같은 자유도를 갖는다는 것이다. 물은 4^{\circ}C$에서 그의 부피가 최소로 되는 등 특유한 성질들을 가졌지만 이 액체이론이 잘 적용된다. 이 이론을 써서 계산한 물의 몰부피, 증가압, 엔트로피, 증발열 및 일정한 압력에서의 비열 그리고 임계점에서의 성질 등은 실측치와의 좋은 일치를 보여준다.

보일러의 열효율 산정 방법

박형석,Park, Hyeong-Seok 한국설비기술협회 1989 설비 : 공조ㆍ냉동ㆍ위생 Vol.6 No.12

야누스적 두 얼굴

朴炯錫 세계평화교수협의회 1983 廣場 Vol.120 No.-

펄스 레이저 증착법(PLD)으로 제조된 LiCoO₂ 박막의 특성

박형석,최규하,이원준 한국진공학회 2010 한국진공학회 학술발표회초록집 Vol.38 No.-

Detection of Circulating Tumor Cells in Breast Cancer Patients Using Cytokeratin-19 Real-Time RT-PCR

박형석,김승일,한현주,이수현,김건민,박세호,최연아,이정동,김기문,손주혁 연세대학교의과대학 2017 Yonsei medical journal Vol.58 No.1

Purpose: The roles of circulating tumor cells (CTCs) as predictive and prognostic factors, as well as key mediators in the metastatic cascade, have been investigated. This study aimed to validate a method to quantify CTCs in peripheral blood using a real-time reversetranscriptase polymerase chain reaction (RT-PCR) assay for cytokeratin (CK)-19 and to evaluate the utility of this assay in detecting CTCs in breast cancer patients. Materials and Methods: Real-time monitoring PCR of fluorescently labeled specific hybridization probes for CK-19 mRNA was established. Peripheral blood samples from 30 healthy donors, 69 patients with early breast cancer, 47 patients with locally advanced breast cancer, and 126 patients with metastatic breast cancer were prospectively obtained and analyzed for CTC detection. Results: CK-19 mRNA was not detectable in healthy subjects using the real-time RT-PCR method. The detection rates of CK-19 mRNA in breast cancer patients were 47.8% for early breast cancer (33/69), 46.8% for locally advanced breast cancer (22/47), and 61.1% for metastatic breast cancer (77/129). The detection rate of CK-19-positive CTCs in metastatic disease was slightly higher than early or locally advanced breast cancer; however, the detection rate according to disease burden was not statistically different(p=0.097). The detection rate was higher in patients with pleural metastasis (p=0.045). CTC detection was associated with poor survival (p=0.014). Conclusion: A highly specific and sensitive CK-19 mRNA-based method to detect CTCs in peripheral blood in breast cancer patientscan be used in further prospective studies to evaluate the predictive and prognostic importance of CTCs.

Characteristics and Treatment of Temporomandibular Disorder in Children and Adolescents: An Analytic Review

박형석,안용우,정성희,전혜미,옥수민 대한안면통증∙구강내과학회 2017 Journal of Oral Medicine and Pain Vol.42 No.4

Purpose: The purpose of this study is to investigate the prevalence of temporomandibular disorders(TMDs) in children and adolescents, their characteristic contributing factors, the characteristicfeatures of symptoms and symptoms, and the response to treatment. Methods: We studied the researches, that were the results of the searches for words such astemporomandibular disorder, TMD, children, adolescents, and juvenile through PubMed andDBpia. Results: According to a study conducted in Busan, the ratio of adolescents increased from18.3% to 21% in 2008 compared to 2000, and the proportion of boys increased from 38.58% to45.38%. One of the characteristic contributing factors for adolescents is the macrotrauma suchas jaw trauma, vehicle accidents, sports, physical abuse, forceful intubation, and third molarextraction. The second is a microtrauma from parafunctional habit such as bruxism, clenching,hyperextension, wind instrument, and fingernail biting that can cause joint overload, cartilagebreakdown, synovial fluid alterations, and other changes within the joint. The diagnosis ofTMDs in juvenile adolescents is not significantly different from that of adults. Medical history,clinical examination and radiological examinations are required. Conclusions: In the temporomandibular joint history and assessment, all comprehensive dentalhistory examination is required, including head and neck pain, mandibular dysfunction,previous orofacial trauma, history of present illness with an account of current symptoms. For the treatment and management of temporomandibular arthritis in juvenile adolescents,understanding the characteristics of TMDs in juvenile adolescents and thoroughly analyzingappropriate diagnosis and possible contributing factors through comprehensive history taking& examination, conservative treatment, including fast and active cautions education, will beessential.

The Statistical Thermodynamic Approach to the Liquid-Vapor Interface of Binary Solution

박형석,Hyungsuk Park Korean Chemical Society 1971 대한화학회지 Vol.15 No.3

액체구조의 천이상태이론을 이성분용액의 액체-증기 계면에 적용하여, $C_6H_{12}-C_6H_6$ $CCI_4-C_6H_6$, $CHCl_3-C_6H_6$, $CHCl_3-CCl_4$, $CCl_4-CS_2$계의 표면장력, 표면흡착량, 표면에서의 활동도 계수들을 계산하였다. A method of theoretical calculation of the thermodynamic properties for liquid-vapor interface of binary solution is developed according to the transient state theory of significant liquid structure. The surface tensions, the adsorbed amounts at the liquid-vapor interface and the activity coefficients of the components for the solutions of $C_6H_{12}-C_6H_6$ $CCI_4-C_6H_6$, $CHCl_3-C_6H_6$, $CHCl_3-CCl_4$, $CCl_4-CS_2$ are calculated through the full ranges of the compositions.

티타늄 임플란트와 수산화아파타이트 사이의 접착력 향상을 위한 Yttria-stabilized Zirconia Buffer Layer에 관한 연구

박형석,강성근,이원준 한국진공학회 2010 한국진공학회 학술발표회초록집 Vol.38 No.-

소옥천 유역의 오염제어 대책에 따른 대청호 조류저감 효과 분석

박형석,정세웅,윤성완,황현식 한국환경영향평가학회 2016 환경영향평가 Vol.25 No.4

This study was aimed to assess the effect of diverse pollutants control measures suggested in the Chuso basin and its upstream of So-oak stream watershed where are the most concerned areas on the control of algal bloom occurring in Daecheong Reservoir. The control measures were classified as watershed measures and in-reservoir measures, and their effects were simulated using a two-dimensional hydrodynamic and water quality model. The watershed measures were made up of 1) point sources control, non-point sources control, and their combinations. The in-reservoir measures were supposed to treat sediment at Chuso basin and to install a phosphorus elimination plant (PEP) at the end of So-oak stream. The results showed that the effect of each measure was influenced by the hydrological condition of the year. In wet year, as the contribution of non-point sources increased, the non-point source control measures (NPS1~NPS4) showed more effective compared to other measures, while, the PEP system to eliminate phosphorus from So-oak stream showed better performance in dry year. In particular, the scenario of NPS1, in which all livestock manures were collected and treated but only chemical fertilizers (NPS1) were used for agriculture fields, showed the best performance for the control of algal bloom in Chuso basin among the watershed measures. 본 연구의 목적은 대청호의 녹조발생 저감을 위해 우심지역인 추소수역과 그 상류 소옥천 유역에서의 다양한 수질개선 대책들을 제시하고, 대책 시행 시 저수지 수질개선 효과를 평가하는데 있다. 대책별 모의 시나리오는 유역대책과 저수지 내 대책으로 분류하였으며, 시나리오별 녹조저감 효과는 2차원 수리·수질모델을 적용하여 모의하였다. 유역 대책은 점오염원, 비점오염원, 복합 대책으로 시나리오를 구성하였으며, 호내 대책은 추소수역의 퇴적물 처리 및 소옥천 유입수의 인 처리시설 설치를 고려하였다. 연구결과, 개별 대책의 녹조저감 효과는 수문상황에 따라 다르게 나타났으며, 강우가 많은 해에는 비점오염부하량이 증가하여 비점오염원 저감대책(NPS1∼NPS4)이 효과적인 것으로 평가되었으며, 강우가 적은해에는 평상시 호 내로 유입하는 인의 유입부하를 저감하는 화학적 인처리시설 설치(LS2)가 효과적인 것으로 평가되었다. 특히, 유역에서 발생되는 축산 분뇨를 전량 수거·처리하고 농경지에는 표준시비량만을적용한 방안(NPS1)이 수질개선에 가장 효과적인 것으로 나타났다.

Association between Genetic Polymorphisms of CYP2D6 and Outcomes in Breast Cancer Patients with Tamoxifen Treatment

박형석,최지엽,이미정,박세호,여창우,이상섭,신재국,박병우 대한의학회 2011 Journal of Korean medical science Vol.26 No.8

The aim of the study was to evaluate the association between genetic polymorphisms of CYP2D6 and outcomes in breast cancer patients with tamoxifen treatment. We evaluated the CYP2D6 genetic polymorphisms in 766 breast cancer patients. Among them, 110patients whose samples were prospectively collected before surgery and treated with tamoxifen were included to evaluate the association between CYP2D6 and outcomes. The genotypes of CYP2D6 were categorized as extensive metabolizer (EM), intermediate metabolizer (IM), and poor metabolizer (PM) according to the activity score. The clinicopathologic features of 110 patients were not significantly different among the three groups except for the T-stage and nodal status. The high T-stage and axillary metastasis were more frequent in the PM group. While recurrence-free and overall survival in the PM group was poorer than the other groups, there was no significant difference between the EM and the IM group. The difference between the PM and the other groups on univariate analysis disappeared on multivariate analysis. These conflicting results suggest that the clinical value of CYP2D6 polymorphisms is still unclear and more large-sized and comprehensively designed trials are necessary.