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HaCaT Cell에서 황기 에탄올 추출물의 Aquaporin-3 발현 효과
박현철(Hyun-Chul Park),김희택(Hee-Taek Kim),하헌용(Hun-Young Ha),이평재(Pyeong-Jae Lee),윤경섭(Kyung-Sup Yoon) 한국생물공학회 2013 KSBB Journal Vol.28 No.6
Astragalus membranaceus Bunge is used in herbal medicine in Eastern Asian countries including Korea. In this study, we assessed the effects of A. membranaceus extract (AM) on the aquaporin-3 (AQP3) protein expression in HaCaT cells. AM did not affect viability of HaCaT cells. AQP3 expression and cell migration seem to be maximal at 100 μg/mL concentration. Epidermal growth factor receptor (EGFR) kinase inhibitor, PD153035, blocked AM-induced AQP3 expression and cell migration. In addition, an 80% ethanol extracts of herbal prescription, SinhyoTakleesan (ST), which is composed of A. membranaceus, Angelicae gigantis, Glycyrrhiza glabra Linne, and Lonicera japonica Flos also induced AQP3 expression at 20 μg/mL in HaCaT cells. Collectively, these results suggest that AM induce AQP3 expression via EGFR pathway.
문성훈 ( Seong Hun Moon ),권형일 ( Hyoung Il Kwon ),박현철 ( Hyun Chul Park ),김정은 ( Jeong Eun Kim ),고주연 ( Joo Yeon Ko ),노영석 ( Young Suck Ro ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.6
Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea Background: Autoimmune blistering skin diseases such as pemphigus vulgaris, pemphigus foliaceus, bullous pemphigoid and epidermolysis bullosa acquisita substantially affect patients. daily life and psychosocial well-being. Objective: The aim of this study was to evaluate the quality of life (QOL) in patients with autoimmune blistering diseases and to identify the factors that can influence their QOL by comparing them to healthy controls. Methods: Forty patients with autoimmune blistering skin diseases and 40 healthy controls were interviewed using the Korean version of Skindex-29. The study assessed the clinical severity of the disease. Results: The total, symptom, function, and emotion scores of Skindex-29 were significantly higher in patients with autoimmune blistering skin diseases (35.28, 40.78, 30.57, and 36.67, respectively) than in the healthy controls (6.90, 9.38, 5.47, and 6.60, respectively) (p<0.001). Higher disease severity had a negative correlation with QOL in patients with blistering skin diseases, and QOL was lower when patients had low levels of satisfaction with treatment. Conclusion: The results show that autoimmune blistering skin diseases can affect patients’ QOL. In addition, disease severity and low satisfaction with treatment are important factors that reduce QOL. Development of new treatments should improve treatment efficacy and the QOL of patients with autoimmune blistering diseases. (Korean J Dermatol 2014;52(6):402∼409)
경피증양 만성 피부 이식편 대 숙주질환에서 광범위하게 발생한 근막염
문성훈 ( Seong Hun Moon ),김현우 ( Hyun Woo Kim ),박현철 ( Hyun Chul Park ),김정은 ( Jeong Eun Kim ),고주연 ( Joo Yeon Ko ),노영석 ( Young Suck Ro ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.7
Fasciitis can occur very rarely with sclerotic-type chronic cutaneous graft-versus-host disease (GVHD). A 54-year-old woman presented with painful skin tightness on upper and lower limb with limited range of movement. She was diagnosed with chronic myelocytic leukemia 5 years ago and underwent allogeneic bone marrow transplantation. Histopathologically, the interlobular septum of subcutis and fascia were remarkably thickened with fibrosis and moderate inflammatory infiltrates accompanying the dilated lymphatic channels with considerable leakage of lymph fluids. Herein, we report a case of extensive fasciitis as a manifestation of chronic GVHD associated with poor prognosis. (Korean J Dermatol 2013;51(7):544∼547)
금속판을 이용한 골절치료 후 발생한 알레르기성 접촉피부염
이성렬 ( Sung Yeul Lee ),박현철 ( Hun Chul Park ),정휘정 ( Hwee Jeong Cheong ),계영철,오칠환 ( Chil Han Oh ),신용우 ( Young Woo Cinn ),김수남 ( Su Nam Kim ),손원용 ( Won Young Son ) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.2
We present herein case of allergic contact dermatitis associated with implants. A 30 year-old male patient has had oozing, crusted, eczematous lesion on the right anterior tibia for five months after tibial osteosynthesis with plate and screw made of vitalliurn. He showed positive patch test, reaction to cobalt on second and fourth days. The skin lesion disappeared after removal of T-plate.
황기 메탄올 추출물이 HaCaT 세포에서 Hyaluronic acid 생성에 미치는 영향
이평재,김희택,윤경섭,박현철,하헌용,Lee, Pyeong-Jae,Kim, Hee-Taek,Yoon, Kyung-Sup,Park, Hyun-Chul,Ha, Hun-Yong 대한한방안이비인후피부과학회 2013 한방안이비인후피부과학회지 Vol.26 No.1
Objectives: Hyaluronic acid, high molecular glycosaminoglycan, exists in extracellular matrix of tissue, especially, in skin and has been known to be deeply involved in skin hydration. In this study, we investigated the effect of methanol extract of Hwang-gi, Astragalus membranaceus root, on hyaluronic acid production in human keratinocyte HaCaT cells. Methods: We determined hyaluronic acid synthase 2 gene expression and hyaluronic acid production in HaCaT cells by using RT-PCR and ELISA, respectively. Results: Hwang-gi extract didn't show the toxicity to HaCaT cells within the treated concentration and increased the hyaluronic acid synthase 2 gene expression and hyaluronic acid production. Conclusions: Hyaluronic acid production increased by Hwang-gi could be, partially, contribute to the moisturing effect in skin by it.
벌지 실험과 나노 압입 실험을 통한 박막의 기계적 물성 측정
정봉부(Bong-Bu Jung),이헌기(Hun-Kee Lee),박현철(Hyun-Chul Park) 대한기계학회 2012 大韓機械學會論文集B Vol.36 No.2
본 연구에서는 벌지 실험과 나노 압입 실험을 통해 박막의 기계적 물성을 측정하였다. 벌지 실험은 외적 지지구조를 가지지 않는 박막 시편의 한 면에 일정한 압력을 가하여 박막의 변위를 측정, 압력과 변위의 관계를 이용하여 박막의 기계적 물성을 측정하는 실험이다. 나노 압입 실험은 시편에 압입 방향으로의 하중과 시편의 표면으로부터 압입자의 깊이에 대한 데이터를 통하여 시편의 기계적 물성을 측정하는 실험으로 modified King’s model 을 이용하여 모재의 영향이 고려된 박막의 물성을 구할 수 있다. 두 실험은 탄성 계수와 푸아송비의 수학적 관계가 다르기 때문에 벌지 실험과 나노 압입 실험결과로부터 박막의 탄성계수와 푸아송비를 동시에 측정할 수 있다. This paper discusses two different techniques used to measure the mechanical properties of thin films: the bulge test and the nanoindentation test. In the bulge test, a uniform pressure is applied to one side of the film. Measurement of the membrane deflection as a function of the applied pressure allows one to determine the mechanical properties such as Young’s modulus, and the residual stress. A nanoindentation test is performed by pushing an indenter tip into the specimen and then withdrawing it, and then recording the indentation force as a function of the indenter position. A modified King’s model is used to estimate the mechanical properties of the thin film in order to avoid the effects of the substrate layers. A combination of both the bulge test and the nanoindentation test can determine both Young’s modulus and Poisson’s ratio simultaneously.
벌지 실험을 통한 Ti 박막의 크기 효과 관찰 및 기계적 물성 측정
정봉부(Bong-Bu Jung),이헌기(Hun-Kee Lee),황경호(Kyung-Ho Hwang),박현철(Hyun-Chul Park) 대한기계학회 2013 大韓機械學會論文集B Vol.37 No.1
본 연구에서는 벌지 실험을 이용하여 티타늄 박막의 기계적 물성을 측정하였다. 벌지 실험은 외적 지지구조를 가지지 않는 박막 시편의 한 면에 일정한 압력을 가하여 박막의 변위를 측정, 압력과 변위의 관계를 이용하여 박막의 기계적 물성을 측정하는 실험이다. 스퍼터링을 이용해 증착된 티타늄 박막의 두께는 1.0, 1.5, 2.0 ㎛ 이고, 물성의 열처리 시간에 대한 영향을 알아보기 위해 증착된 시편은 600 ℃에서 각각 150, 300, 600 초 동안 열처리 되었다. 박막의 탄성 계수, 잔류 응력, 항복 응력이 벌지 실험을 통해 측정되었고, 실험 결과 항복 응력은 열처리 시간에 의존하는 특성을 확인하였다. 또한 시편 두께가 감소할수록 강도가 증가하는 크기효과를 관찰하였다. In this study, the mechanical properties of a Ti thin film are measured by a bulge test. In the bulge test, uniform pressure is applied to one side of the film. Measurement of the membrane deflection as a function of the applied pressure allows one to determine the mechanical properties of the film. Ti thin films with thicknesses of 1.0, 1.5, and 2.0 ㎛ were deposited on a Si wafer by using an RF magnetron sputtering system. These specimens were annealed at 600 ℃ for 150, 300, and 600 s to investigate the effect of temperature on the yield stress and mechanical properties of the Ti films. The elastic modulus, residual stress, and yield stress of these membranes are measured by a bulge test. The experimental results suggest that the yield stress is sensitive to the film thickness and annealing time.
식도 궤양, 급성 담낭염 및 허혈성 대장염의 소견이 현저한 알레르기성 육아 종증(Churg-Strauss Syndrome) 1 예
김광호,박성혜,이상헌,김주현,박현철,남상민,정숙향,김호연,황일순,전형식,추현광 대한내과학회 1993 대한내과학회지 Vol.45 No.3
Churg-Strauss syndrome is a kind of rare systemic vasculitis characterized by peripheral eosinophilia, bronchial asthma and relatively specific pathological findings such as necrotizing vasculitis, eosinophilic infiltration of tissue and/or extravascular granuloma. Clinically multiple organs/systems can be involved with various manifestations of disease of lung, heart, skin, musculoskeletal system, nervous system and gastrointesinal/hepatobiliary tract. Gastrointestinal symtoms were frequently accompanied, but usually mild and easily controllable so that special study for evaluation of the symptoms hardly seemed to be needed. We experienced a case of Churg-Strauss syndrome presenting as esophageal ulcers, acute acalculous cholecystitis and treatment-resistant ischemic colitis in a 24-year-old male patient with acute upper abdominal pain and watery, often bloody diarrhea. He also showed peripheral eosinophilia, bronchial asthma, mononeuritis multiplex, skin rash and arthritis. The patient received high dose corticosteroid, cyclophosphamide and exchange plasmapheresis with resolution of almost all symptoms. But symptoms of ischemic colitis such as abdominal pain and diarrhea are not completely improved in spite of intensive therapy.
In Situ Hybridization 으로 확진된 Herpes 식도염 1예
윤성균,한인수,이상호,박영훈,백선흠,남상민,박현철,황일순,추현광,김주현,박성혜,박흠례 대한내과학회 1993 대한내과학회지 Vol.44 No.1
저자등은 만성 alcoholism 환자에서 만성 췌장염 및 췌장 가낭종에 의한 심와부와 좌상복부통으로 내원하여 우연하게 실시된 식도 내시경 및 조직 생검으로 의진되어 In situ hybridization에 의하여 확진하게된 Herpes virus에 의한 식도염 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Herpes simplex esophagitis is a rare disease. Mostly, it occurs in hospitalized, immunosuppressed, and preterminal patients with or without malignancy. It is confirmed by In situ hybridization, immunohistochemistry, or direct visualization of virus by electronmicroscopy. Among them the former is an useful technique for rapid detect viral nucleic acids in the tissue sections. We report a esophageal ulceration with pancreatic pseudocyst. Herpetic esophagitis was suggested by characteristic endoscopic and light microscopic findings, and it was confirmed by In situ hypridizaion in the tissue section. With symptomatic treatment, this patient was recovered from esophageal ulceration.