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세퍼드에서 ethylene glycol 독성에 관한 연구
박현종,이오형,임채웅,Park Hyun-Jong,Lee Oh-Hyung,Lim Chae Woong 한국동물위생학회 2005 韓國家畜衛生學會誌 Vol.28 No.1
Ethylene glycol (EG) intoxication in dogs can pose a diagnostic challenge. We investigated the effect of a lethal dose of EG to the Shepherd on blood, urine test, and histopathologic observation. Shepherds were treated orally with EG at $10\;m{\ell}/kg$ body weight. Clinically, EG caused the vomition, depression of central brain. Anion gap was increased, which was decreased pH of blood, The blood osmorality was increased at 3 hours, and BUN and creatinine was increased at 24 hour significantly. The pH of urine decreased. The crystal of calcium oxalate appeared at 6 hours. The amount of crystals increased at 12 and 24 hours. Microscopically, the degeneration of proximal tubules were shown at 1 hour and finally progressed as acute tubular nephrosis at 24 hours. These results suggest that the blood and urine test accompanied with histopathological examination be helpful to investigate the EG intoxication.
세퍼드에서 ethylene glycol 독성에 관한 연구
박현종 ( Hyun Jong Park ),이오형 ( Oh Hyung Lee ),임채웅 ( Chae Woong Lim ) 한국가축위생학회 2005 韓國家畜衛生學會誌 Vol.28 No.1
Ethylene glycol(EG) intoxication in dogs can pose a diagnostic challenge. We investigated the effect of a lethal dose of EG to the Shepherd on blood, urine test, and histopathologic observation. Shepherds were treated orally with EG at 10㎖/kg body weight. Clinically, EG caused the vomition, depression of central brain. Anion gap was increased, which was decreased pH of blood. The blood osmorality was increased at 3 hours, and BUN and creatinine was increased at 24 hour significantly. The pH of urine decreased. The crystal of calcium oxalate appeared at 6 hours. The amount of crystals increased at 12 and 24 hours. Microscopically, the degeneration of proximal tubules were shown at 1 hour and finally progressed as acute tubular nephrosis at 24 hours. These results suggest that the blood and urine test accompanied with histopathological examination be helpful to investigate the EG intoxication.