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호산구증가증 환자에서 Toxocara canis에 대한 특이 IgE 항체의 진단적 의의
박한정 ( Han Jung Park ),최성진 ( Sung Jin Choi ),김현미 ( Hyun Mi Kim ),최길순 ( Gil Soon Choi ),성준모 ( Jun Mo Sung ),이진우 ( Jin Woo Lee ),예영민 ( Young Min Ye ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2009 천식 및 알레르기 Vol.29 No.2
Background: Toxocariasis is one of the major causes of peripheral eosinophilia and it provokes eosinophilic infiltration in the internal organs. Diagnosis of toxocariasis has relied mainly on the immunological methods including measurement of serum specific IgG to Toxocara canis excretory-secretory antigen (TES-Ag) in which the detection rate by ELISA was 68% in patients with eosinophilia. Objective: The aim of this study is to measure serum specific antibodies to TES-Ag in patients with peripheral eosinophilia in order to evaluate the clinical significance. Method: Twenty-one patients with peripheral eosinohilia (>500 cells/uL or >10% of total white blood cell count), who have no identifiable cause of eosinophilia such as drugs, well known parasite infection, malignancy or allergic diseases, were enrolled. Serum specific IgE, IgG1 and IgG4 antibodies to TES-Ag were determined by ELISA (Phadia, Uppsala, Sweden) which were compared to those of specific IgE by immunoCAP system (Phadia), and specific IgG to TES-Ag by ELISA (Bordier). Serum total IgE and ECP levels were measured by immunoCAP system. Result: The detection rate of serum specific IgE by ELISA was the highest (90.5%) followed by serum specific IgG1 (65%) and IgG4 (75%). Concordance rate of specific IgE by ELISA and immunoCAP was 100%, while that between specific IgE by ELISA (home-made) and specific IgG by ELISA (Bordier) was 60%. The most commonly involved organ was liver (57.1%). Serum total IgE level in patients with liver involvement was significantly higher than those without it (P<0.01). Conclusion: Toxocariasis should be considered as one of the major causes of the patients with eosinophilia in this country. Measurement of serum specific IgE to TES-Ag may be useful to evaluate the Toxocara canis infection. (Korean J Asthma Allergy Clin Immunol 2009;29:105-111)
박한정 ( Han Jung Park ),성준모 ( Jun Mo Sung ),김무정 ( Moo Jung Kim ),최길순 ( Gil Soon Choi ),신유섭 ( Yoo Seob Shin ),예영민 ( Young Min Ye ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2008 천식 및 알레르기 Vol.28 No.2
Immediate hypersensitivity to raw potato has been presented as one or a combination of wheezing, rhinorrhea, sneezing, contact urticaria and contact dermatitis. We experienced a case of contact urticaria caused by raw potato in a 25-year-old female patient with allergic rhinitis and conjunctivitis. She had experienced itching and generalized urticaria after application of raw potato on her face 10 years earlier. Allergy skin tests showed positive results to common inhalant allergens, including D. pteronyssinus, D. farina, ragweed pollen, mugwort pollen and several kinds of grass pollens, but showed a negative result to raw potato e×tract. However, the provocation test by applying raw potato on her forearm produced an immediate onset of contact urticaria with itching sensation. High serum-specific IgE to raw potato compared to normal healthy controls was detected by ELISA. We first report here in a case of raw potato-induced contact urticaria in Korea, which suggested an IgE-mediated mechanism. (Korean J Asthma Allergy Clin Immunol 2008;28:148-151)
박한정 ( Han Jung Park ),성준모 ( Jun Mo Sung ),김무정 ( Moo Jung Kim ),최길순 ( Gil Soon Choi ),예영민 ( Young Min Ye ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2009 천식 및 알레르기 Vol.29 No.1
Heparin is used for thromboprophylaxis in patients on hemodialysis, hemofiltration or continuous renal replacement therapies. Heparin-related immediate-type hypersensitivity reactions such as urticaria, angioedema or bronchospasm are very rare, and only a few cases of anaphylaxis-like responses have been described. We experienced the case of a 67-year-old female patient with an end-stage renal disease who presented generalized urticaria induced by heparin during hemodialysis. She began to experience recurrent itching and generalized urticaria after 2 weeks of the initiation of hemodialysis. The episodes started within 30 minutes of hemodialysis with heparin infusion; either sodium heparin or dalteparin (low molecular weight heparin) was used. Utilization of different dialyzers was unable to avoid the episodes, and these symptoms could be reduced when she was treated with heparin-free hemodialysis. She had no previous history of allergic diseases. In order to confirm the causative agent, we measured serum specific IgE antibodies against ethylene oxide, latex and formaldehyde using immunoCAP (Phadia, Sweden) and obtained negative results. Although skin prick tests and intradermal tests to the used heparin showed negative results, the intravenous provocation test using 1,500 U of heparin (with a bolus-loading dose of 1,000 U and a continuous intravenous infusion of 500 U for 3 hours) reproduced an immediate-onset generalized urticaria with itching sensation. We report herein a case of heparin-induced urticaria during hemodialysis in Korea. Because of increasing use of heparin in medical practice, physicians should be aware of possible immediate hypersensitivity reactions to this medication. (Korean J Asthma Allergy Clin Immunol 2009;29:69-73)
Isocyanate 에 의한 직업성천식 환자에서 흡입성 항원에 대한 신감작의 발생률 및 예후에 미치는 영향
박한정 ( Han Jung Park ),김현아 ( Hyun Ah Kim ),허규영 ( Gyu Young Hur ),예영민 ( Young Min Ye ),서창희 ( Chang Hee Suh ),남동호 ( Dong Ho Nahm ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2006 천식 및 알레르기 Vol.26 No.3
Background: It has been reported that half of toluene diisocyanate (TDI)-induced asthma patients had persistent asthmatic symptoms even after complete avoidance. We hypothesized that new sensitization to common inhalant allergens may contribute to persistent and aggravation of asthmatic symptoms. Objective: The aim of this study is to investigate the prevalence and clinical significance of new sensitization to common inhalant allergens in patients with TDI-induced asthma. Method: Thirty-six TDI-induced asthma patients who had been followed up for more than three years were enrolled. They were classified into two groups, newly-sensitized and not-sensitized groups, according to the results of the skin-prick test and serum specific IgE antibodies to common inhalant allergens monitored every year. The clinical features, drug requirements for systemic steroids, and airway hyper responsiveness were compared between the two groups. Result: Thirteen (36.1%) of 36 patients with TDI-asthma developed new sensitization to common inhalant allergens during the follow-up periods. The mean onset time were 4.93±2.49 years. The prevalence of atopic status and allergic rhinitis tended to be higher in the newly sensitized group. The duration of asthmatic symptoms before the diagnosis was significantly longer in the newly sensitized group (P<0.05). The drug requirements for systemic steroids tended to increase after the new sensitization in the newly sensitized group. Conclusion: The development of new sensitization to common inhalant allergen in TDI-asthma may be associated with chronic persistent asthmatic symptoms. New sensitization to common inhalant allergens should be monitored regularly in TDI-induced asthmatic patients. (Korean J Asthma Allergy Clin Immunol 2006;26:213-218)
박한정 ( Han Jung Park ),허규영 ( Gyu Young Hur ),김현아 ( Hyun Ah Kim ),예영민 ( Young Min Ye ),서창희 ( Chang Hee Suh ),남동호 ( Dong Ho Nahm ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.1
We report a case of a 54-year-old woman with atopy who showed a severe anaphylactic reaction after the ingestion of bee pollens. A few minutes after the ingestion, generalized pruritus, urticaria, periorbital and perioral angioedema, and dyspnea developed, and thus the emergency care including subcutaneous epinephrine and intravenous methylprednisolone was performed. She suffered from seasonal allergic rhinitis for 10 years. Microscopic examination of the bee pollen ingested showed mostly mugwort and ragweed pollen, and several kinds of tree pollens. In vivo and in vitro studies demonstrated that the patient had allergic rhinitis sensitive to mugwort and ragweed pollens and sensitized to some tree pollens as well. This case demonstrated that a severe systemic allergic reaction could occur in a pollen-sensitized patient after the ingestion of bee pollens. (Korean J Asthma Allergy Clin Immunol 2007;27:57-60)
아목시실린에 의한 약물 과민반응 16예의 임상적 특성과 혈청학적 검사의 의의
박한정 ( Han Jung Park ),허규영 ( Gyu Young Hur ),김현아 ( Hyoun Ah Kim ),최길순 ( Gil Soon Choi ),최성진 ( Sung Jin Choi ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.3
Background: Amoxicillin is one of the broad spectrum antibiotics and is widely used in the treatment of various infective diseases. There are various forms of amoxicillin-induced hypersensitivity reactions including urticaria/angioedema, erythema multiforme and anaphylaxis. Objective: To observe the clinical features and evaluate the significance of in vitro testing of amoxicilin-induced hypersensitivity reactions. Method: We retrospectively reviewed medical records of patients diagnosed as having amoxicillin-induced hypersensitivity reactions from January 2002 to February 2007. Serum-specifc IgE antiboides to ampicilloyl (AMP) and amoxicilloyl (AXO) were determined using the immunoCAP Result: Sixteen subjects were enrolled in this study. Clinical features of amoxicillin-induced hypersensitivity reactions included erythema multiforme (n=6, 37.5%), urticaria/angioedema (n=4, 25.0%), anaphylaxis (n=3, 18.8%), maculopapular skin eruption (n=2, 12.5%) and fixed-drug eruptions (n=1, 6.3%). Six subjects had a high serum specific IgE to AMP and all anaphylaxis patients had a high serum specific IgE to AXO and/or AMP. Conclusion: These findings suggest that amoxicillin could induce various cutaneous manifestations in which the most common ones are erythema multiforme and urticaria/ angioedema. The serious reactions of anaphylaxis were noted in 18.8% of subjects in which IgE mediated responses to 2 antigenic determinants were involved. (Korean J Asthma Allergy Clin Immunol 2007;27:162-167)
Moxifloxacin에 의한 급성전신발진 농포증(Acute Generalized Exanthematous Pustulosis)
정윤정 ( Yun Jung Jung ),김주희 ( Joo Hee Kim ),박한정 ( Han Jung Park ),성준모 ( Jun Mo Sung ),이진우 ( Jin Woo Lee ),최길순 ( Gil Soon Choi ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2010 천식 및 알레르기 Vol.30 No.1
Acute generalized exanthematous pustulosis (AGEP) is an uncommon skin disease characterized by acute development of numerous, nonfollicular, sterile pustules on an erythematous background combined with fever and peripheral blood leukocytosis. It is caused by drugs in more than 90% of cases. We report the case of a 46-year-old woman with AGEP induced by moxifloxacin who underwent kidney transplantation. She developed a generalized pustular lesion with high fever and leukocytosis 1 month after daily taking 400 mg of moxifloxacin. After discontinuation of moxifloxacin, her skin lesion gradually improved, and the same symptoms recurred after the challenge of moxifloxacin. To our knowledge, this is the first report of moxifloxacin-induced AGEP in Korea. (Korean J Asthma Allergy Clin Immunol 2010;30:59-62)
박원경(Won Kyeong Park),이수진(Su Jin Lee),박용수(Yong Su Park),송한정(Han Jung Song) 대한전자공학회 2013 전자공학회논문지 Vol.50 No.10
본 논문에서는 고속 PMIC(Power Management Integrated Circuit) 회로를 위한 저전압 입력 보호기능을 가지는 UVLO(Under Voltage Lock Out) 기능이 탑재된 LDO(Low Drop-Out) 레귤레이터를 설계하였다. 설계된 LDO 레귤레이터는 밴드갭 기준전압 회로, 오차 증폭회로, 파워 트랜지스터 등으로 이루어지진다. LDO 레귤레이터는 5 V 전원전압으로부터 3.3V 출력을 갖도록 설계되었으며, 저전압 입력보호 기능을 하는 UVLO 회로는 전원부와 파워 트랜지스터 사이에 삽입된다. 또한 UVLO는 5 V 구동전압에서, 하강 시 2.7 V 에서 LDO 레귤레이터 동작을 멈추게 하고, 구동전압 상승 시 4.0 V 에서 LDO 레귤레이터가 정상 동작한다. 1 ㎛ 20 V 고전압 CMOS 공정을 사용하여 모의실험 한 결과, 설계한 LDO 레귤레이터는 5.88 mV/V의 라인레귤레이션을 가지고, 부하전류가 0 mA에서 200 mA로 변할 때 27.5 uV/mA의 로드레귤레이션을 보였다. This paper presents a design of the CMOS LDO regulator with a UVLO protection function for a high speed PMIC. Proposed LDO regulator circuit consists of a BGR reference circuit, an error amplifier and a power transistor and so on. UVLO block between the power transistor and the power supply is added for a low input protection function. Also, UVLO block showed normal operation with turn-off voltage of 2.7V and turn-on voltage of 4 V in condition of 5 V power supply. Proposed circuit generated fixed 3.3 V from a supply of 5V. From SPICE simulation results using a 1 ㎛ high voltage CMOS technology, simulation results were 5.88 mV/V line regulation and 27.5 uV/mA load regulation with load current 0 mA to 200 mA.
LED 구동 IC를 위한 레벨 시프터 방식의 전하펌프 회로 설계
박원경,박용수,송한정,Park, Won-Kyeong,Park, Yong-Su,Song, Han-Jung 한국전기전자재료학회 2013 전기전자재료학회논문지 Vol.26 No.1
In this paper, we designed a charge pump circuit using level shifter for LED driver IC. The designed circuit makes the 15 V output voltage from the 5 V input in condition of 50 kHz switching frequency. The prototype chip which include the proposed charge pump circuit and its several internal sub-blocks such as oscillator, level shifter was fabricated using a 0.35 um 20 V BCD process technology. The size of the fabricated prototype chip is 2,350 um ${\times}$ 2,350 um. We examined performances of the fabricated chip and compared its measured results with SPICE simulation data.
극 배치 기법을 이용한 표면 부착형 영구자석 동기 전동기의 고속 토크 제어
박효성(Hyo-Seong Park),임재식(Jae-Sik Lim),한정호(Jung-ho Han),송중호(Joong-Ho Song),이영일(Young-Il Lee) 제어로봇시스템학회 2013 제어·로봇·시스템학회 논문지 Vol.19 No.12
In this paper we propose a novel torque control method for permanent magnet synchronous motors using the SVPWM (Space Vector PWM). The control law is described in the rotating d-q frame and is devised to track a given reference flux with which the reference torque is generated. The key feature of the proposed control is that it provides uniform dynamics with desired closed-loop poles independent of the rotating speed and the desired poles can be selected to yield a fast response with only a small amount of torque ripple.