악교정 수술 환자에서 발관 후 발생된 급성 호흡곤란 증후군 : 증례보고

박지영,이정아,윤성훈,박민규,김창현,박재억,Park, Ji-Young,Lee, Jung-A,Yun, Sung-Hun,Park, Min-Kyou,Kim, Chang-Hyun,Park, Je-Uk 대한악안면성형재건외과학회 2007 Maxillofacial Plastic Reconstructive Surgery Vol.29 No.1

급성호흡곤란 증후군은 드물게 발생되나 환자의 생명을 위협할 수 있는 응급 합병증이다. 본 증례는 내과적 기왕력이 없는 건강한 악교정 수술 환자에서 발관 후 지연 발생된 급성호흡곤란 증후군의 치험례로서, 즉각적인 진단 및 응급처치로 타 장기로의 합병증 없이 24시간 내에 빠르게 호전되었다. 구강외과의사는 전신마취 수술 중 혹은 수술 후 발생될 수 있는 다양한 응급상황에 대해 정확히 이해하고, 즉각적인 처치를 시행할 수 있어야 하며, 이로 인한 합병증을 줄이는 노력을 계속 하여야 할 것이다. Acute respiratory distress syndrome(ARDS) is severe acute hypoxic respiratory failure state with dynamic impairment in oxygen and carbon dioxide transfer with the need for high levels of supplementary oxygen and a high minute ventilation. This syndrome is caused by pulmonary edema due to increased permeability of the alveolar capillary barrier by various factors. ARDS is an uncommon, but a potentially life-threatening complication. Therefore, immediate diagnosis and appropriate therapy must be performed. The present case is post-extubation ARDS immediately occurred in an orthognathic surgery patient who are healthy 19-year-old man. He rapidly recovered from ARDS without complication by early diagnosis and proper treatment. This case report was aimed to describe the process of the development, possible causes and the management of ARDS occurred in an orthognathic surgery patient

방사성 노블가스 측정을 위한 최소검출방사능 산출의 조절인자

박지영,고영건,김현철,임종명,이완로,Park, Ji-young,Ko, Young Gun,Kim, Hyuncheol,Lim, Jong-Myoung,Lee, Wanno 한국방사성폐기물학회 2018 방사성폐기물학회지 Vol.16 No.3

Anthropogenic radioactive noble gases formed by nuclear fission are significant indicators used to monitor the nuclear activity of neighboring countries. In particular, radioactive xenon, owing to its abundant generation and short half-life, can be used to detect nuclear testing, and radioactive krypton has been used as a tracer to monitor the reprocessing of nuclear fuels. Released radioactive noble gases are in the atmosphere at infinitesimal amounts due to their dilution in the air and their short half-life decay. Therefore, to obtain reliable and significant data when performing measurement of noble gases in the atmosphere, the minimum detectable activity (MDA) for noble gases should be defined as low as possible. In this study, the MDA values for radioactive xenon and krypton were theoretically obtained based on the BfS-IAR system by collecting both noble gases simultaneously. In addition, various MDA methods, confidence level and analysis conditions were suggested to reduce and optimize MDA with an assessment of the factors affecting MDA. The current investigation indicated that maximizing the pretreatment efficiency and performance maintenance of the counter were the most important aspects for Xe. In the case of Kr, since sample activities are much higher than those of Xe, it is possible to change the target MDA or to simplification of the analysis system.

정오 "슬라임(액체괴물) 중 붕소 함량과 어린이의 붕소 노출량 추정"

박지영,임미영,이기영,Park, Ji Young,Lim, Miyoung,Lee, Kiyoung 한국환경보건학회 2019 한국환경보건학회지 Vol.45 No.1

비-혈관평활근에서 새로운 $K^+$ 통로 개방제인 SKP-450의 약리학적 작용의 특성-Levcromakalim의 작용과 비교

박지영,김현희,유성은,홍기환,Park, Ji-Young,Kim, Hyun-Hee,Yoo, Sung-Eun,Hong, Ki-Whan 대한약리학회 1997 The Korean Journal of Physiology & Pharmacology Vol.1 No.6

In the present study, we characterized the non-vascular smooth muscle relaxant effects of a novel benzoyran derivative ,SKP-450 (2-[2'(1',3'-dioxolone)-2-methyl-4- (2'-oxo-1'-pyrrolidinyl) -6-nitro-2H-1- benzopyran) and its metabolite, SKP-310, in comparison with levcromakalim (LCRK). In the rat stomach fundus, the spontaneous motility stimulated by $10^{-6.5}\;M$ bethanechol was completely eliminated not only by $10^{-7}\;M$ SKP-450 but also by $10^{-6}\;M$ LCRK, which were blocked by $10^{-6}\;M$ glibenclamide. The inhibitory effect of SKP-450 $pD_2,\;3.94{\pm}0.66)$ was much less than LCRK $(pD2,\;5.73{\pm}0.38,\;p<0.05)$. In the bethanechol $(10{-6.5 }\;M)-stimulated$ urinary bladder, the tonus was decreased in association with elimination of spontaneous motility by $10^{-7}\;M$ M SKP-450 and $10^{-6}\;M\;LCRK\;(pD2,\;6.77{\pm}0.06)\;(P<0.05)$, which were inhibitable by $10^{-6}\;M$ glibenclamide. The inhibitory effect of SKP-450 $(pD2,\;7.66{\pm}0.05)$ was significantly more potent than that of LCRK $(pD2,\;6.77{\pm}0.06,\;p<0.05)$. In the rat uterus stimulated by $PGF_{2\alpha}\;(10^{-7}\;M)$, both increased tonus and spontaneous motility were eliminated by $10^{-6}\;M$ LCRK with slight depression of the tonus, but not by SKP-450 $(10^{-5}\;M)$. The stimulated trachea of guinea-pig by $10^{-6.5}\;M$ bethanechol was moderately suppressed by SKP-450 $(10^{-6}{sim}10^{-5}\;M)$ but little by SKP-310. In association with the relaxant effects, SKP-450 $(10^{-6}\;M)$ and LCRK $(10^{-5}\;M)$ caused a significant stimulation of the $^{86}Rb$ efflux from rat urinary bladder and stomach fundus, which were antagonized by $10^{-5}\;M$ glibenclamide, whereas the $K^+$ channel openers could not exert a stimulation of the $^{86}Rb$ efflux from rat uterus. In conclusion, it is suggested that SKP-450 exerts potent relaxant effects on the urinary bladder detrusor muscle and duodenum, whereas it shows much less effect on stomach fundus and uterus as contrasted to LCRK.

ERRATUM ANNOUNCEMENT

박지영,박영숙,이정은,김수빈,Park, Jiyoung,Park, Yeong-Suk,Lee, Jeong-Eun,Kim, Su-Bin 한국아동간호학회 2017 Child Health Nursing Research Vol.23 No.3

아메리카동애등에 발육에 미치는 스트레스 음파 효과

박지영,이상훈,이한웅,김용균,Park, Jiyeong,Lee, Sanghoon,Lee, Hanwoong,Kim, Yonggyun 한국응용곤충학회 2013 한국응용곤충학회지 Vol.52 No.3

잡식성인 아메리카동애등에(Hermetia illucens)는 최근 음식물 쓰레기를 처리하는 환경 정화용 곤충으로 알려져 있을 뿐만 아니라 항생물질을 분비하여 여러 방면에 산업적으로 이용될 가능성이 보이고 있다. 또한 대량적으로 사육이 가능하여 전 사육과정을 자동화하는 기반에서 생산화가 진행되고 있는데 이때 가동되는 기계에서 소음이 발생하게 된다. 곤충에게 소리는 주로 짝짓기나 보호를 위해 사용되기 때문에 이러한 소음은 곤충에게 스트레스로 작용될 수 있다. 본 실험은 동애등에 발육에 미치는 음파의 영향 평가는 최적의 발육 조건인 $25^{\circ}C$와 광조건 8:16 h(L:D)에 실시되었다. 분석된 음파는 95 dB 조건에서 상이한 주파수(0-5,000 Hz)를 유충에 처리하였다. 주파수가 증가함에 따라 용화율과 우화율이 현격하게 낮아졌다. 다음으로 동일한 주파수(5,000 Hz)에서 소리세기(0-105 dB)를 다양하게 처리한 경우 85 dB 이상의 음파가 동애등에의 발육을 억제하는 것으로 나타났다. 본 연구는 또한 동애등에 발육에 영향을 주는 음파 조건(5,000 Hz, 95 dB)이 일부 면역 및 소화 유전자들의 발현을 교란시켰다. 이상의 결과는 85 dB 이상 고주파 음파 처리가 동애등에의 발육에 영향을 주는 것으로 나타났다. The black soldier fly (BSF), Hermetia illucens, is a generalist detritivore that is usually exploited for recycling environmental wastes, including food remnants. These insects can also be used to produce antibiotics for medical applications. For this purpose, flies need to be mass-reared using an automatic rearing system that generates various sounds. Insects use sound as a means of communication for mating or warning against predators. Thus, extrinsic sounds may interrupt the normal physiological processes of insects. In this study, we analyzed the physiological changes due to various sound treatments at $25^{\circ}C$ and 8:16 h (L:D) photoperiod. At 95 dB, larvae were exposed to different sound frequencies (0-5,000 Hz). The treated larvae were adversely affected by the high-frequency sounds and showed significant reduction in pupation and adult emergence. Different sound intensities (0-105 dB) at 5,000 Hz caused significant changes in the pupation and survival of the adults at 85 dB or above. Under a stress sound condition (5,000 Hz, 95 dB), the BSF larvae exhibited aberrations in the expression of genes related to the immune system and digestion. These results indicate that high-frequency sound treatments at or above 85 dB act as a stress sound to BSF development.

문화유산 자원 통합 활용을 위한 CRM 기반 FRBR 응용 온톨로지 적용에 관한 연구 - FRBRoo를 중심으로(object-oriented FRBR) -

박지영,Park, Zi-Young 한국비블리아학회 2008 한국비블리아학회지 Vol.19 No.2

A reference ontology for cultural heritage information, CIDOC Conceptual Reference Model (CRM), has promoted cooperation among memory institutions and FRBRoo, re-constructed version of FRBR based on CRM, was developed. In this study, the harmonized ontology version of FRBR, FRBRoo, was analysed and, as a results, the followings are suggested: empowered interoperability for information exchange and integration among cultural institutions and designing more comprehensible inference rules than original FRBR model. Moreover, the by-products of harmonization gave opportunity to recognize internal inconsistencies of the FRBR model and CRM itself and refine them.

용인시 생태발자국 지수의 분석과 고찰 - 음식, 건조환경, 산림, 에너지 부문을 중심으로 -

박지영,김진오,Park, Ji Young,Kim, Jin-Oh 한국조경학회 2016 韓國造景學會誌 Vol.44 No.2

본 연구의 목적은 용인시에 대한 생태발자국 지수 산정 및 변화분석을 통해 용인시의 환경용량 추이를 분석하고, 이를 바탕으로 용인시의 도시개발 및 계획의 방향을 제언하는 것이다. 이를 위하여 용인시를 대상으로 1993년, 2003년, 2013년에 걸친 생태발자국 지수 분석을 실시하였으며, 지수분석 결과를 바탕으로 용인시의 토지이용 변화와 개발패턴의 문제점에 대하여 분석하였다. 또한 GIS(Geographic Information System)를 기반으로 한 토지피복도와 생태발자국 지수의 비교를 통해 용인시 토지이용의 변화를 환경적 측면에서 분석하였다. 본 연구 결과는 다음의 세 가지로 요약될 수 있다. 첫째, 용인시의 총 생태발자국 지수는 1993년 3.20(gha), 2003년 6.50(gha), 2013년 11.15(gha)로 산정되었으며, 이는 용인시의 생태발자국이 세계적으로 요구되는 1인당 생태발자국 1.8(gha)는 물론, 한국 전체의 1인당 평균 생태발자국인 3.56(gha)을 훨씬 상회하는 수준으로, 지역 환경용량에 비해 과도한 자원소비가 이루어지고 있다는 것을 보여주고 있다. 둘째, 1993년부터 20여 년간 용인시의 생태발자국을 부문별로 분석한 결과, 산림부문의 생태발자국이 가장 크게 증가하였으며, 다음으로 에너지 부문, 음식 부문, 건조환경부문으로 순으로 나타났다. 특히, 산림 생태발자국의 경우 1993년에는 가장 낮은 0.002(gha)였으나, 2013년에는 7.32(gha)로 급증했으며, 에너지의 경우도 0.87(gha)에서 2.38(gha)로 비교적 높은 증가율을 보였다. 이는 급격한 도시개발로 인한 목재수요와 목재생산력의 지나친 불균형 및 주거와 상업용지 개발에 따른 에너지 수요의 급격한 증가에 기인하는 것으로 분석된다. 셋째, 지난 10여 년간 생태발자국과 산림 및 건조환경 토지피복의 변화를 관찰한 결과, 산림부문의 생태발자국이 가장 크게 확대되었으며, 실제 훼손된 산림면적 또한 증가된 건조환경 면적에 집중되어 있음을 알 수 있었다. 에너지 부문의 생태발자국 또한 급격한 증가를 보여주고 있는데, 이는 토지피복도 분석에서 알 수 있듯 건조환경부문, 특히 상업시설과 도로 및 철도용지의 급증에 크게 기인하는 것으로 분석되었다. 이는 향후 용인시가 개발 시 산림의 훼손을 최소화하고, 녹지면적을 확대해야 할 필요성을 제기하고 있으며, LPG 등 화석연료의 소비를 줄이는 대신 신재생에너지의 확대를 적극적으로 추진해야 한다는 근거를 제공할 수 있다. The purpose of this study is to analyze the change of environmental capacity in Yong-in City, Gyeonggi-do, South Korea through calculation of ecological footprint indices and analysis of their changes, and to suggest implications for urban development and planning. In this study, we analyzed ecological footprints of 1993, 2003, and 2013 to understand the patterns of land use changes and development in Yong-in City. We also compared the GIS land cover maps and ecological footprint indices to figure out land cover changes associated with resource consumption in Yong-in City. As a result, we found the following three lessons. First, the ecological footprint indices of Yong-in City are 3.20(gha) in 1993, 6.50(gha) in 2003, and 11.15(gha) in 2013. This implies that the ecological footprint of Yong-in City is much larger than 1.80(gha), the globally required ecological footprint per capita and 3.56(gha), the average ecological footprint of South Korea. Second, the forest ecological footprint of Yong-in City was calculated as the largest, followed by the ecological footprints of energy, food, and built environment. In particular, the forest ecological footprint was the most rapidly increased from 0.002(gha) in 1993 to 7.32(gha) in 2013, followed by energy ecological footprint from 0.87(gha) to 2.38(gha). This implies that the provision and consumption of timber are seriously unbalanced, and energy consumption is unsustainable because of the rapid increase of residential and commercial land development in the city. Third, our analysis of the rapid increase of forest ecological footprint indicates that the disturbed forest areas are concentrated in the increased built environment areas. We also observed that the increase of energy ecological footprint indices was caused largely by the increase of the commercial and road areas. This implies that Yong-in City should minimize forest disturbance and expand green areas for future in the city. In addition, this may provide a reasonable ground that the city should reduce the use of fossil fuels and facilitate the use of renewable energy.

서지레코드의 주제전거를 위한 FRSAD 모형 연구

박지영,Park, Zi-Young 한국과학기술정보연구원 과학기술정보센터 2011 Journal of Information Science Theory and Practice Vol.42 No.1

2010년 6월에는 IFLA에서 FRBR 시리즈의 세 번째 보고서인 '주제전거레코드의 기능상의 요건'(FRSAD)이 발표되었다. 이 개념모형은 최근의 주제전거 동향을 나타낼 뿐 아니라, FRBR 체제에 적합한 주제전거레코드를 위한 밑거름이 될 것이다. 이에 본 연구에서는 FRBR 시리즈의 맥락 안에서 FRSAD 모형을 분석하고, 이 모형을 우리나라의 주제명표와 서지레코드에 시범적으로 적용하였다. 이를 위해 개체와 속성, 관계를 중심으로 FRSAD 모형을 분석하였는데, 그 결과 FRSAD는 개체의 범주를 미리 규정하지 않은 개방성을 가지고 있으며, 테마와 노멘을 구분함으로써 주제명의 형식 측면 뿐아니라 개념 측면까지 강조하고 있음을 알 수 있었다. 그리고 이 개념모형을 FAST의 패싯과 연계하여 NLSH에 속한 일부 주제명의 개념구조와 주제전거와 관련된 서지레코드의 필드로 표현한 사례를 함께 제시하였다. 단, 본 연구에서는 인명과 단체명, 표제를 제외한 추가적인 개체로서의 주제전거 데이터만을 분석대상으로 하였다. 그 결과 FRSAD에서 별도로 정의하지 않은 제3집단 개체의 유형을 선정하는 기준과 그 기준을 주제명표에 일관되게 적용하는 방안이 필요함을 알 수 있었다. 앞으로는 보다 더욱 구체적인 적용 사례와 그 결과를 분석한 후속연구가 필요할 것이다. The final report of the Functional Requirement of Subject Authority Data(FRSAD), the 3rd report of the FRBR family model, is announced by IFLA in June, 2010. This model represents the international trends of subject authority control and suggests a direction to the future subject authority record suitable for the FRBR system. Therefore aims of this study are to analysis the FRSAD model in context of the FRBR family and apply the model to the subject headings and bibliographic records of Korean National Library. For these aims, we analyse the model focused on the entities, attributes, and relationships between entities. From this analysis, we have found the openness of the FRSAD, which does not force a certain entity types and has focus on the conceptual aspects of the entity not only the form of the headings. Moreover, we suggest examples by applying the FRSAD frame and facets of the FAST to the Headings of the NLSH and related KORMARC fields. The scope of this study is the additional entities of the FRBR groups, so personal names, corporate names, family names and titles are not included. As a result, it is necessary to determine the criteria for the types of thema and to apply the types consistently in bibliographic records. A follow up research will be needed to suggest more detailed examples.

Ketoprofen 전신투여후 활액내로의 분포 약동학 : 집단약동학적 분석

박지영,손정환,윤영란,손지홍,차인준,서승석,최장석,신재국,Park, Ji-Young,Sohn, Jeong-Hwan,Yoon, Young-Ran,Shon, Ji-Hong,Cha, In-June,Seo, Seung-Suk,Choi, Jang-Suk,Shin, Jae-Gook 대한임상약리학회 2001 臨床藥理學會誌 Vol.9 No.1

Background : The disposition kinetics of ketoprofen into synovial fluid was estimated to predict the time course of ketoprofen concentration in synovial fluid in patients with arthritis. Methods : After repeated oral doses of ketoprofen 100 mg twice daily, ketoprofen concentrations of plasma and synovial fluid were determined at steady-state by high performance liquid chromatography(HPLC) in 17 arthritic patients. Plasma pharmacokinetic parameters were estimated from one compartmental open model and the penetration pharmacokinetic parameters into synovial fluid were estimated from nonlinear fitting to the effect compartment model using $NONMEM^{\circledR}$. Results: At steady-state, the observed peak concentrations of plasma and synovial fluid were $4.6{\pm}3.2{\mu}g/ml\;and\;2.4{\pm}1.9{\mu}g/ml$ at 2 hours and 5 hours after the last dose, respectively. Plots of plasma ketoprofen concentration against synovial concentration showed anticlockwise hysteresis, suggesting the time delay in the distribution of ketoprofen into synovial fluid from plasma. The estimated average rate constant for the ketoprofen loss from synovial $fluid({\kappa}_{co})$ was $0.16\;h^{-1}$. From the simulation of ketoprofen concentration curves, the predicted $C_{max}$ of synovial fluid was corresponded to 76.6 % of the plasma $concentration(1.44\;{\mu}g/ml\;vs\;1.881{\mu}g/ml)$ and time lag of $T_{max}$ between both fluid spaces was estimated to 3.1 hours. Conclusions : These results suggest that the time course of ketoprofen concentration in synovial fluid is different from plasma concentration-time profile after systemic administration of ketoprofen. The effect compartment model approach appears to be useful to predict the kinetics of ketoprofen in synovial fluid from the plasma data.