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      • KCI등재

        고령의 만성 C형 간염 환자에서 Daclatasvir와 Asunaprevir 병용 요법의 유효성 및 안전성 평가

        박유경,신수진,최유옥,최혜정,강진숙,황보신이 한국병원약사회 2018 病院藥師會誌 Vol.35 No.4

        Background : The prevalence of chronic hepatitis C virus (HCV) tends to be higher in the elderly. Pegylated interferon and ribavirin therapy (Peg-IFN/RBV) was recommended as the first-line treatment in the past decades, but this regimen showed unsatisfactory results in terms of safety and efficacy especially in elderly patients. Recently, it was demonstrated that dual therapy with daclatasvir and asunaprevir was well tolerated and led to high sustained virological response (SVR) rates, irrespective of age. We conducted a study to evaluate the efficacy and safety of daclatasvir plus asunaprevir by involving elderly patients aged above 65 years. Methods : We retrospectively analyzed clinical data from chronic hepatitis C virus (HCV) genotype 1b patients treated with daclatasvir plus asunaprevir from September 2015 to December 2016 at Seoul St. Mary’s hospital. The patients were divided into two groups as elderly patients (older than 65 years) and non-elderly patients (younger than 65 years) and compared the efficacy and safety. Results : A total of 112 patients were treated with daclatasvir plus asunaprevir for chronic hepatitis C. Among them, 101 patients completed the whole treatment, and in 88 patients the amount of HCV RNA was measured after 12 weeks of treatment. There was no significant difference in SVR at 12 weeks between both the groups (p=0.68). Typically, 91.4%(32/35) of elderly patients and 94.3%(50/53) of nonelderly patients achieved SVR12. Common adverse events included elevation in transaminase level, headache, and gastrointestinal disorders. There was no statistical difference in the symptoms between the two groups. Conclusions : The combination therapy with daclatasvir plus asunaprevir exhibited similar rates of SVR12 in HCV elderly patients without leading to further adverse events compared to non-elderly patients. Therefore, it is proposed that daclatasvir plus asunaprevir therapy could be considered as an effective and safe treatment, even in patients aged over 65 years.

      • KCI등재

        조건 연결어미 ‘-다면’의 용법

        박유경 한국어의미학회 2015 한국어 의미학 Vol.50 No.-

        Yugyeong Park. 2015. The usage of the Korean conditional connective ‘-tamyen’. Korean Semantics, 50. This paper aims to examine the conditional connective –tamyen ‘if’ by comparing with another conditional connective –myen. I show that a tamyen-clause morphologically includes hypothetical meaning, and so it can only be used in conditionals involving a temporary context update. Since generic, temporal, and deictic conditionals do not involve a supposition in their interpretations, -tamyen is not permitted in those conditionals. By contrast, a myen-clause can be used either in a hypothetical conditional or in a non-hypothetical conditional in which the if-clause functions as a simple domain restrictor. I also suggest that -tamyen can be used in anaphoric conditionals, a new type of conditionals, when there’s a need to explicitly express that the speaker’s public belief has been updated with the previous utterance. I further claim that the suppositional meaning of tamyen-clauses is due to the meaning of the declarative -ta. Formally, -ta expresses that its proposition is updated to the speaker’s public belief. By embedding the declarative marked phrase under the conditional, the antecedent clause of tamyen-conditional conveys the implied message that the speaker’s public belief is temporarily updated with the proposition of the antecedent clause. As a result, the tamyen-clause can convey the message that the speaker is assuming its proposition.

      • KCI등재

        Growth and Early Yield of Stenting-Propagated Domestic Roses Are Not Affected by Cytokinins Applied at Transplanting

        박유경,정병룡 한국화훼학회 2012 화훼연구 Vol.20 No.2

        This study was conducted to investigate the effect of cytokinins, known to have an effect on the delay of senescence in the plant, applied either to the shoot or the roots at transplanting on growth and early yield of stenting-propagated spray cut rose (Rosa hybrida Hort.) ‘New Man’ and ‘New Lady’ bred in Korea. Rooted plants, either not treated (control) or treated by foliar-spray (shoot treatment) or drench (root treatment)with 10 mg·L^-1 kinetin or 50 mg·L^-1 BA, were transplanted to rockwool slabs at 0 or 7 days after the treatment. Shoot length at the early stage of cultivation of ‘New Man’ but not ‘New Lady’ which was transplanted either at 0 or 7 days after treatment was slightly promoted in both foliar-spray and drench treatments of kinetin or BA. However, total cut flower yield in the first three harvests of both cultivars were not affected by either foliar-spray or drench treatment of either kinetin or BA. In the control treatment, total cut flower yield in the first three harvests of the plants transplanted at 0 day was greater than those transplanted at 7 days. These results suggested that stenting-propagated ‘New Man’ and ‘New Lady’ do not need any exogenous application of cytokinins. It is rather recommended that propagated plants are transplanted as soon as possible to avoid any senescence of the root.

      • KCI등재

        우울증을 동반한 소양인(少陽人) 파킨슨병 환자 치험 1례

        박유경,이미숙,배나영,Park, Yu-Gyeong,Lee, Mi-Suk,Bae, Na-Young 사상체질의학회 2015 사상체질의학회지 Vol.27 No.3

        Objectives The aim of this study was to examine significant improvement of motor and non-motor symptoms after treatment with Sasang constitutional medicine treatment on a Soyangin patient with Parkinson disease having depression. Methods The patient was treated with Soyangin's constitutional medications treatment(herb and acupuncture) and scalp acupuncture. The progress was evaluated using the Global Assessment Scale (GAS scale), Hoehn and Yahr scale (H&Y scale) and Unified Parkinson disease rating scale (UPDRS) before and after treatment. These scales were used to assess the overall function of patient. Result We observed a significant improvement in patient's motor and non-motor symptoms using GAS scale, H&Y scale and UPDRS. The UPDRS scores decreased in Part I, Part II, Part III and Part IV. Conclusion This study shows that Sasang constitutional medicine treatment can be effective for Soyangin patient with Parkinson disease having depression.

      • KCI등재

        A Facial Chuna Manual Therapy for Peripheral Facial Nerve Palsy

        박유경,이초인,이정희,이현종,이윤규,서정철,김재수 대한침구의학회 2019 대한침구의학회지 Vol.25 No.3

        The purpose of this study was to investigate useful manual therapy techniques for peripheral facial nerve palsy and to propose guidelines to be applied for current manual therapy techniques. Several databases were searched to find manual therapies for facial palsy. These therapies included cervical, and temporomandibular joint chuna manual therapy, proprioceptive neuromuscular facilitation, neuromuscular re-education, facial exercise, and mime therapy. Both cervical, and temporomandibular joint chuna manual therapy release nerve compression, helping blood circulation and nerve conduction. Proprioceptive neuromuscular facilitation uses irradiation, bilateral activation, and eccentric facilitation to improve muscle power and symmetry. Neuromuscular re-education, as a retraining tool for facial movement patterns, enhances neuromuscular feedback. Facial exercise helps the patient continuously move and massage facial muscle themselves. Mime therapy aims to develop a conscious connection between the use of certain muscles and facial expressions. The use of facial chuna manual therapy for peripheral facial nerve palsy can stimulate the proprioceptive neuromuscular receptors in the face. Peripheral facial nerve palsy has 4 phases; progress phase, plateau phase, recovery phase, and sequelae phase. Each phase needs different treatments which include relaxation, assistance, resistance, origin-insertion extension, and nerve pathway expansion.

      • KCI등재

        학령 후기 아동의 행동습관에 대한 잠재프로파일 분류와 영향요인 검증: 신체적 자아상과 부모요인을 중심으로

        박유경,이금규,김유정,김민정,이강이 육아정책연구소 2023 육아정책연구 Vol.17 No.1

        학령 후기 아동의 행동습관을 신체활동, 스크린타임, 수면을 기준으로 유형화하고, 영향요인을 검증하였다. 한국아동패널조사 13차년도 데이터의 1,397가구 자료를 잠재프로파일 분석한 결과, 행동습관 유형은 ‘행동습관 균형형(77.7)’, ‘신체활동 선호형(4.1)’, ‘스크린타임 과잉형(18.3)’으로 분류되었으며. 아동요인(신체적 자아상)과 부모요인(부모의 학습참여, 성인 없이 보내는 시간)이 유형을 예측하였다. 표준화된 가이드라인에서 나아간 개별화된 개입 정책 및 자녀의 행동습관에 기여하는 부모의 역할과 아동의 경험에 대한 전문적인 정보 제공의 필요성을 논의하였다. 구체적으로 마을교육공동체와 청소년방과후아카데미 사업을 언급하고 아동의 신체활동을 장려할 수 있는 시설 마련과 부모교육 실시를 제언하였다. This study categorized movement behavior in late childhood and verified the factors affecting it according to a daily time index. Therefore, a latent profile analysis was conducted using data from 1,397 participants in the 13th wave of the Panel Study on Korean Children conducted by the Korea Institute of Child Care and Education. The results are as follows: First, the movement behavior types of the children were “movement behavior balanced type”, “physical activity preferred type”, and “screen time excessive type”. Second, children’s physical self-image, parental involvement in children’s learning, and time spent without adults predicted children’s movement behavior types. This is the result of confirming individual differences in movement behaviors in late childhood after the outbreak of Coronavirus Disease 2019, and it suggests the necessity and direction for preparing supporting measures according to the movement behavior types.

      • KCI등재

        Soft X-ray spectroscopic study on the electronic structure of WO3 thin films fabricated under various annealing temperature and gas flow conditions

        박유경,임창진,임영지,조수행,조상완,이현복,Ogasawara Hirohito 한국물리학회 2021 Current Applied Physics Vol.21 No.-

        The electrical properties of WO3 thin films vary significantly depending on the growth conditions. In this work, the influence of O2 gas on the band gap of WO3 thin films during growth was investigated via electronic structure characterization using X-ray photoelectron spectroscopy (XPS), X-ray absorption spectroscopy (XAS), and X-ray emission spectroscopy (XES). A substantial decrease in the electrical conductivity of the WO3 films was observed with an increase in the O2 partial pressure during growth. Spectral differences in the peak energy and intensity were apparent for WO3 films grown under only Ar and those grown in Ar:O2. It is difficult to explain the acquired spectrum of WO3 with oxygen defects through the rigid-band model in terms of the simple addition of electrons to the conduction band of WO3. Our results show that an oxygen deficiency in WO3 moves the conduction band to the Fermi edge.

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