빛간섭단층촬영을 이용한 정상, 녹내장의증, 초기 녹내장에서의 변수 비교분석

박수은,정진권,정지용,박성희,Su Eun Park,M,D,Jin Kwon Jung,M,D,Ji Yong Jung,M,D,Song Hee Park,M,D 대한안과학회 2007 대한안과학회지 Vol.48 No.10

Purpose: The objective of this study is to compare optic nerve head (ONH) analysis parameters and retinal nerve fiber layer (RNFL) thickness parameters as measured by optical coherence tomography (OCT) among age-matched normal eyes, glaucoma-suspect eyes, and early glaucomatous eyes; and to determine the discriminating parameter best suited to distinguish early glaucoma in age-matched normal eyes and glaucoma- suspect eyes. Methods: One hundred two normal eyes, 72 glaucoma-suspect eyes, and 85 eyes with early glaucoma that had been submitted to OCT and Humphrey field analysis were enrolled in this study. Optic nerve head analysis values and RNFL thickness values with OCT scans were compared among all groups. Sensitivity and specificity for the detection of early glaucoma were determined with a receiver operating characteristic (ROC) curve. Results: The best-suited parameters were determined to be from 0.637 to 0.753 in optic nerve head parameters and from 0.506 to 0.759 in RNFL thickness parameters calculated with the area under the ROC curve (AUROC). The average thickness for early glaucomatous eye (0.818) had the widest AUROC among all parameters. The sensitivity and specificity of RNFL thickness parameter were determined to be 49.4% and 93.1%, respectively, at the cut-off value 92.17 m. Conclusions: Optic nerve head and RNFL thickness parameters measured with OCT have relatively high sensitivity and specificity for detecting early glaucomatous eyes. Furthermore, they may provide clinically relevant information for the detection of early glaucomatous damage and for monitoring glaucomatous changes.

유리체절제술과 백내장 병합수술 중 유리체절제기로 시행한 후낭절제술

박수은,이성진,Su Eun Park,Sung Jin Lee 대한안과학회 2007 대한안과학회지 Vol.48 No.10

Purpose: To analyze the effects and the stability of a posterior capsulectomy during combined vitrectomy and cataract surgeries in patients with retinal disease. Methods: Between 2003 and 2005, the records of patients who underwent posterior capsulectomy during a combined vitrectomy and cataract surgery were followed for 12 months. Among 26 total eyes (17 were from males and nine from females), the average age was 63. An epiretinal membrane was found in 18 eyes, branch retinal vein occlusion in three eyes, diabetic macular edema and vitreous opacity in two eyes, and a macular hole in one eye. The posterior capsulotomy was made smaller than the optic using a vitrectomy cutter after insertion of a posterior chamber intraocular lens (IOL). We investigated postoperative visual acuity, inflammation, and complications. Results: There were no intraoperative complications. One month postoperatively, one eye (3.8%) showed an increase in intraocular pressure of more than 30 mmHg, one eye (3.8%) showed 2+ inflammatory cells in the anterior chamber. Visual acuity increased by 2 lines postoperatively in 13 eyes (50.0%), whereas visual acuity decreased by more than 1 line in one eye (3.8%). There was a slight decenteration of IOL within 1 mm in two eyes (7.7%) and there was no reclosure of the posterior capsulectomy one year postoperatively. Conclusions: Posterior capsulectomy during combined vitrectomy and cataract surgery in patients with retinal disease was simple, safe, and effective in preventing after cataract.

당뇨망막병증 진행의 평가를 위한 망막전위도의 유용성

박수은,선해정,이현준,박태관,온영훈,Su Eun Park,Hae Jung Sun,Hyun Joon Lee,Tae Kwann Park,Young-Hoon Ohn 대한안과학회 2010 대한안과학회지 Vol.51 No.5

Purpose: To investigate the clinical significance of electroretinographic (ERG) responses, including the photopic negative response parameter, in assessing the progression of diabetic retinopathy. Methods: Standard flash ERG was tested on 28 normal controls and 143 patients who were diagnosed with diabetes mellitus. Of those, 97 patients had diabetic retinopathy in different stages. Electroretinography was performed according to the International Society for Clinical Electrophysiology of Vision (ISCEV) standards. Amplitudes and implicit times of ERG responses, including the photopic negative response (PhNR), were compared at different stages of diabetic retinopathy. Results: Amplitudes of oscillatory potentials were significantly reduced in mild NPDR. Cone b-wave amplitude, 30--Hz flicker response, and PhNR were significantly reduced in moderate NPDR. Conclusions: These results suggest that oscillatory potentials are good indicators of retinal function change in the early stage of diabetic retinopathy, and the appropriate results of the cone b-wave, 30-Hz flicker response and PhNR tests are good indicators of moderate NPDR. J Korean Ophthalmol Soc 2010;51(5):693-699

로타바이러스 백신

박수은,김경효,김종현,신선희,오성희,이환종,조대선,최은화,허재균,홍영진,Park, Su Eun,Kim, Kyung Hyo,Kim, Jong-Hyun,Shin, Seon Hee,Oh, Sung Hee,Lee, Hoan Jong,Jo, Dae Sun,Choi, Eun Hwa,Hur, Jae Kyun,Hong, Young Jin 대한소아청소년과학회 2007 Clinical and Experimental Pediatrics (CEP) Vol.50 No.8

한국 정상인에서 명소 망막전위도의 ON 반응과 OFF 반응

박수은,장지호,최경식,이정희,온영훈,"Su-Eun Park,Jee Ho Chang,Kyung-Seek Choi,Jung-Hee Lee,Young-Hoon Ohn" 대한안과학회 2008 대한안과학회지 Vol.49 No.3

`Purpose: To explore the effects of stimulus duration, stimulus intensity, and background luminance on the amplitude and waveform of the ON- and OFF- responses of photopic ERG and to provide standard parameters of ON- and OFF- responses for normal Korean populations. Methods: Twenty normal subjects (20 eyes) were enrolled to record photopic ON-and OFF-responses using a contact lens electrode with built-in LEDs and an LED-driver. The influence of stimulus duration on wave amplitudes was studied at flash durations that varied from 5 to 200 ms. The influence of stimulus intensity was studied with 0.4, 0.7, 1.1, 1.4, 1.7, 1.9, 2.0, and 2.1 log cd/m2. In addition, the influence of background luminance was studied with 20, 30, 40, and 50 cd/m2. Result: Among 20 normal subjects, the d-waves in 16 subjects were isolated from b-waves with more than 50 ms of stimulus duration. The d-wave was observed for a 30-ms stimulus duration in 3 subjects and for a 100-ms duration in 1 subject. The amplitudes of the b-and d-waves increased as stimulus intensity was increased. The amplitudes of b-and d-waves decreased as background luminance was increased. Conclusions: Our results suggest that the clinical use of ON-and OFF-response recording can be obtained with stimulus parameters from 100 to 150 ms in duration and a 1.7-2.1 log cd/m2 intensity under 30-40 cd/m2 background luminance.`

코로나바이러스감염증-19의 바이러스 (SARS-CoV-2) 특징, 전파 및 임상 양상

박수은,Park, Su Eun 대한소아감염학회 2020 Pediatric Infection and Vaccine Vol.27 No.1

A cluster of severe pneumonia of unknown etiology in Wuhan City, Hubei province in China emerged in December 2019. A novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was isolated from lower respiratory tract sample as the causative agent. The current outbreak of infections with SARS-CoV-2 is termed coronavirus disease 2019 (COVID-19) by the World Health Organization (WHO). COVID-19 rapidly spread into at least 114 countries and killed more than 4,000 people by March 11, 2020. WHO officially declared COVID-19 a pandemic on March 11, 2020. There have been 2 novel coronavirus outbreaks in the past 2 decades. The outbreak of severe acute respiratory syndrome (SARS) in 2002-2003 caused by SARS-CoV had a case fatality rate of around 10% (8,098 confirmed cases and 774 deaths), while Middle East respiratory syndrome (MERS) caused by MERS-CoV killed 858 people out of a total 2,499 confirmed cases between 2012 and 2019. The purpose of this review is to summarize known-to-date information about SARS-CoV-2, transmission of SARS-CoV-2, and clinical features of COVID-19.

산전 진찰에서 진단된 신생아 수신증에 대한 추적 관찰

박수은,김수영,Park, Su-Eun,Kim, Su-Yung 대한소아신장학회 1998 Childhood kidney diseases Vol.2 No.2

목 적 : 산전초음파 검사의 흔한 실시로 태아의 여러 선천성 신장 질환이 조기에 많이 발견되고 있고 태아의 수신증 또한 많이 발견되고 있으나 현재까지 산전에 발견된 무증상의 신생아기 수신증의 자연 경과에 대한 이해가 부족한 실정으로, 국외에서 이에 대한 여러 임상 보고가 최근 들어 증가하고 있으나, 국내 보고는 극소수이다. 이에 향후 더 많은 환자에 대한 장기간의 추적을 통하여 수신증의 자연 경과를 살펴보고자 하였다. 방 법 : 1993년 1월부터 1995년 12원까지 산전 초음파 검사에서 수신증으로 진단받고 출생후 실시한 복부 초음파 검사에서 수신증이 확인된 22명의 환아(33 renal unit)를 대상으로 하여 수신증의 원인을 분석하고, 이중 요관신우이행부 폐색이 의심되는 신장에 대해서는 8-24개월 동안 자연 호전 유무를 신 초음파 검사와 배설성 신주사 검사로 추적 관찰하였다. 결 과 : 1) 출생후 실시한 신초음파 등의 검사로 밝혀진 신생아기 수신증의 원인으로 요관 신우이행분 폐색이 23례($69.9\%$), 방광요관역류가 5례($15.1\%$)였으며, 선천성 거대요관, 요관협착, 요관방광이행부 폐색, 요관류를 동반한 중복요관, 다낭성 이형성신 이 각각 1례씩이었다. 2) 요관신우 이행부 폐색으로 진단된 23례의 신장중 복부 종괴가 촉지되었던 4례의 신장을 제외한 19례의 신장중에서 $73.6\%$에 해당하는 14례의 신장이 추적 관찰 기간 동안 수신증의 완전 소실 혹은 호전을 보였으며 단지 2례만이 수신증이 악화되었고, 이중 1례는 신기능의 저하 소견을 보여 수술을 시행받았다. 결 론 : 산전에 발견된 신생아기 수신증의 원인으로 요관신우이행부 폐색이 의심되는 경우가 가장 많았으며 이의 대부분은 실제로 비폐색성 수신증이었고 추적 관찰 기간 동안 대부분 자연 호전되었다. 그저나 현재까지 신생아 시기에 폐색성 수신증을 정확하게 진단하기는 힘드므로 장기간에 걸쳐 주의 깊게 추적 관찰하여 수술적 치료 여부를 결정할 수 있을 것이다. Purpose : Lots of congenital anomalies of urinary tract including hydronephrosis are detected in fetus and neworn by popular use of prenatal ultrasonography. But there are little data available in Korea about natural course of hydronephrosis diagnosed antenatally by ultrasonography. So we intended to help management of these patients by analizing the follow up data of the neonates with hydronephrosis diagnosed antenatally. Methods : We evaluated 22 patients with neonatal hydronephrosis(33 renal units) who were diagnosed prenatally and confirmed postnatally. Especially patients with suspected ureteropelvic junction obstruction were followed regulary with renal ultrasonography and diuretic renography for 8-24 months. Results : 1) The etiologies of neonatal hydronephrosis diagnosed prenatally were suspected ureteropelvic junction obstruction($69.9\%$), vesicoureteral reflux($15.1\%$), primary megaureter($3.0\%$), double ureter with ureterocele($3.0\%$), ureteral stricture($3.0\%$), multicystic dysplastic kidney(3.0$\%$), and ureterovesical junction obstruction(3.0$\%$). 2) The follow up results of 23 renal units of suspected ureteropelvic junction obsruction: Except 4 renal units with palpable abdominal mass, of the remained 19 renal units, 14 units($73.6\%$) were improved spontaneously, 3 units($15.7\%$) remained stable, only2 units($10.5\%$) were aggravated. Conclusion : We concluded that in most cases of hydronephrosis there is no need for immediate surgery, and that nonoperative approach, using serial ultrasonography and diuretic renogram, is safe management of neonatal hydronephrosis diagnosed anteratally.

소아의 지역 사회 획득 폐렴

박수은,Park, Su Eun 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.6

탈저(脫疽)의 한방적 치험(治驗) 1례(例)

옥민근,박수은,김창환,임웅경,Ock, Min-Keun,Park, Su-Eun,Kim, Chang-Hwan,Lim, Woong-Kyoung 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.3

Objective: The purpose of this case study is to show a case of ulcer due to Buerger's disease improved by conservative oriental medical therapy. Method: The patient was treated from 31 March, 2004 to 1 June, 2004 by acupuncture, herb, dressing Results: We evaluated through X-ray, picture of patient's foot and measuring of infect size. Conclusion: We suggest to treat ulcer resulting from Buerger's disease with oriental medical therapy and would like to research oriental medical treatment plan for the further treatment.

장결핵과 동반된 기관지 내 및 후두 결핵 1례

김수진,박수은,이민기,김건일,이창훈,박재홍,Kim, Su Jin,Park, Su Eun,Lee, Min Gi,Kim, Gun Il,Lee, Chang Hun,Park, Jae Hong 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.7

저자들은 설사와 체중 감소, 기침과 발열을 주소로 내원한 환아에서 장결핵과 기관지 내 결핵, 후두 결핵이 동반된 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Although the incidence of tuberculosis has been reduced recently because of the advance of anti-tuberculosis chemotherapy, improvements of public health, and early diagnosis, it is still high in developing countries. Intestinal tuberculosis can occur at any age, but young adults and female are more affected. Early diagnosis of childhood intestinal tuberculosis is difficult, largely because of vague symptoms and nonspecific signs. Recently, tuberculosis of the larynx combined with pulmonary tuberculosis has become quite a rare disease since anti-tuberculous chemotherapy and preventive activities are prevalent. Laryngeal tuberculosis, while relatively well recognized in the adult population, is a rare disease in chidren and adolescents. There are few reports of intestinal tuberculosis combined with endobronchial and laryngeal tuberculosis in children. We have experienced a case of intestinal tuberculosis which concurred with endobronchial and laryngeal tuberculosis in an 18-year-old girl who presented with abdominal pain, diarrhea, weight loss, a brassy cough, and anemia, which was diagnosed by a colonoscopy and bronchoscopy with biopsy.