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연구논문초록(’81-’90) : 니켈 - 알루미나합금의 복합전착에 관한 연구
박성국,김대용,윤병하 한국부식학회 1991 Corrosion Science and Technology Vol.20 No.1
Electro-codeposition of nicke-alumina composite from a modified Watt's bath containning fine alumina partic-les has been studied and mechanical properties and oxidation resistance of deposit have been examined. The pH value and temperature of electrolyte appeared to have no influence on AI₂O₃ content in the deposit m the range of pH 2∼5 and 20℃-90℃. With increasing alumina content in electrolyte up to 140g/ℓ at a constant current density, the amount of alumina dispersed in the deposit increased linearly up to about 12 volume percent. But with increasing current density at a constant alumina content in electrolyte, alumina content in the deposit decreased. The Guglielmi's model for the mechanism of electro-codeposition was found to valid and the value of absorption constant κ showed about 0.72. The higher content of alumina in the deposit, the higher was the value of hardness of deposit, but tensile strength of deposits decreased with increasing of alumina content. Nickel-alumina composites showed a higher oxidation resistance comparing with pure electrodeposited nickel, and the higher the content of alumina in the deposit, the better showed the oxidation resistance of the deposit.
비용 조직에서 Hypoxia-Inducible Factor 1α의 발현 및 Vascular Endothelial Growth Factor와의 상관관계
박성국,정천규,허경욱,최정배,양영일,장원희 대한이비인후과학회 2004 대한이비인후과학회지 두경부외과학 Vol.47 No.6
Background and Objectives:The function of hypoxia-inducible factors (HIFs) in the hypoxic environment is to orchestrate -dothelial growth factors (VEGF). It has been suggested that VEGF is involved in the pathogenesis of nasal polyp. The purpose of this study is to determine and correlate concentrations of HIF-1α and VEGF in nasal polyps. Materials and Method:Twenty-five nasal polyps were colected at the time of endoscopic sinus surgery. The production of HIF-1α and VEGF mesenger RNA (mRNA) was measured by reverse transcriptase polymerase chain reaction (RT-PCR) and HIF-1α and VEGF proteins were Results:The expresions of HIF-1, VEGF mRNA and proteins were detected in nasal polyps. RT-PCR demonstrated that the level of mRNA expression of HIF-1α and VEGF were 1.12± 0.33 and 1.1± 0.42, respectively. A positive correlation was observed betwen HIF-1α and VEGF mRNA (correlation coeficient [r]= 0.49, p<0.05). The imunohistochemical studies revealed that HIF-1α was predominantly expressed in surface epithelial cels, submucosal glan-landular epithelial cells, vascular endothelial cells, and inflamatory cels than in surface epithelial cels. The expressions of HIF-1α and VEGF proteins were 3.24± 1.80 and 3.52± 1.89, respectively. A positive corelation was observed betwen HIF-1α and VEGF proteins (r= 0.76, p<0.05). Conclusion:We sugest that HIF-1α has a role in inducing VEGF in nasal polyps, and hypoxia is an important factor in the growth of nasal polyps.