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ISE:Behavior 합성 환경 구현을 위한 시스템 개발
양영일 대한전자공학회 1996 CAD 및 VLSI 설계연구회지 Vol.5 No.1
In this paper, we developed the Interactive Synthesis Environment (ISE) which supports designs from behavioral level on down to the floorplan level. This paper emphasizes interactivity by illustrating the use of the different design views and quality metrics in the typical design scenario. The ISE provides highly integrated views and an environment that allows the user to work in any abstraction of the design and yet be able to relate objects in different abstractions. Finally, the ISE offers numerous quality metrics and hints that assists the user in making complex design decisions. Using the ISE, a designer can explore the design space quickly, and expect to reduce design time by 50io, and the number of iterations in the design cycle to only few.
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비가족성 산발성 결직장암에서 Microsatellite Instability 와 병리조직학적 특징 및 p53 단백질 발현과의 연관성
양영일,김미성,윤혜경,임인숙 인제대학교 1997 仁濟醫學 Vol.18 No.4
Microsatellite instability는 선천성 비용종성 결직장암의 분자생물학적 원인 인자로 규명되었으며 산발성 결직장암에서도 원인 인자로 그 중요성이 제시되었다. 가족력이 동반되지 않은 산발성 결직장암 49예를 대상으로 Microsatellite instability의 빈도를 조사하여 병리학적 특성, 세포 증식력, p53 단백질 발현과의 연관성을 연구하였다. 비가족성 산발성 결직장암에서 Microsatellite instability는 24.5%에서 검출되었고, Microsatellite instability 양성 결직장암은 점액성 분화, 종양 주위의 기질내에 림프구 집합의 형성이 빈번히 동반되는 병리조직학적 특성들을 보였다. p53 단백질 발현은 microsatellite instability 양성 결직장암에서 양성율이 16.7%인 반면 음성인 종양인 경우는 67.6%로 p53 단백질 발현과 microsatellite instability 사이에는 의의 있는 역상관 관계를 보였다. 이상의 결과로 Microsatellite instability는 결직장암의 발생 과정 및 형태학적 형성 과정에 중요한 역할을 담당할 것으로 사료된다. Microsatellites are highly polymorphic, short-tandem repeat sequences dispersed throughout the genome. Defects in DNA mismatch repair can result in an increase in DNA replication errors (RER) or microsatellite instability (MSI), which are manifested as extra, aberrant bands within multiple microsatellite loci. MSI are found in the cancers from patients with hereditary non-polyposis colorectal cancer and have been also demonstrated in sporadic colorectal carcinomas (CRC). It has been suggested that the histologic features and molecular characteristics of MSI-positive CRC are similar to those of HNPCC. In order to clarify the relationship between MSI and pathological parameters including histologic features, proliferating activity, p53 protein expression, PCNA proliferating activity and PCR for microsatellite instability was performed on a series of 49 formalin-fixed CRC and normal mucosa. (1) MSI-positive CRC's were noted in 12 (24.5%) CRC cases, but no MSI was detected in normal mucosal tissues. (2) MSI-positive CRC's were closed related with extracellular mucin production, plexiform pattern, and Crohns-like lymphoid reaction (p<0.05). (3) No significant relationship between MSI and age, sex, tumor size, location, grade, stage, vascular invasion and PCNA index was noted (p<0.05). (4) p53 protein expression rate of 49 CRC cases was 55.1%, and p53 expression rate of MSI-negative group was 67.6% and the rate in MSI-positive group was 16.7%. The inverse relationship between MSI and p53 expression was statistically significant (p<0.05). In summary, microsatellite instability may play an important role in colorectal carcinogenesis and morphogenesis of non-familial colorectal carcinomas, and inverse correlation between MSI phenotype and p53 expression suggests MSI and p53 mutations are independent pathway in colorectal carcinogenesis. And MSI-associated unique pathologic features may be useful for screening criteria of patients wish HNPCC.
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양영일,김찬환,강신광,주종은,Yang, Young-Il,Kim, Chan-Hwan,Khang, Shin-Kwang,Joo, Joung-Eun 대한세포병리학회 1993 대한세포병리학회지 Vol.4 No.2
Cryptococcosis is a systemic mycosis that most often involves the central nervous system, followed by subclinical or symptomatic pulmonary involvement. We describe a case of unsuspected pulmonary cryptococcosis in a 69-year-old woman, diagnosed by sputum cytology. Sputum smears revealed numerous yeast like organisms typical of Cryptococcus neoformans measuring from 7 to 17 um in diameter. Mucicarmine, PAS, and methenamine sliver stains showed positive reaction of capsule and cell wall of Cryptococcus neoformans.
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양영일 慶尙大學校 工科大學 自動化및컴퓨터應用技術硏究所 1995 自動化 및 컴퓨터應用技術 Vol.2 No.1
In this paper, we proposed new data models for the hardware implementation of Lampel-Ziv compresession algorithm. Traditional hardware implementation method based on LZ compression algorithm require three bytes for the codeword generation, called as the last symbol, the position and the matched length. MSB(Most Significant Bit) of the last symbol is used as the compression flag and the remaining seven bits represent the character. If the compression flag is one, the data is compressed and that the following two bytes have the compression information. We confined the value of the matched length to 128 instead of 256, which can be coded with seven bits only. In the proposed model, MSB is used as the compression flag. If the compression flag of the symbol is zero, the remaining seven bits of the byte represent the character with no compression. If the compression flag is one, the remaining seven bits represent length and the following byte has the information of the position. The proposed model reduces the compression ratio by 5% compared with models represented with 3 bytes. And the proposed model can be adopted to the existing hardware architectures.
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Characterization of Two-Dimensional Impurity Profile in Silicon
양영일,경종민,Yang, Yeong Yil,Kyung, Chong Min The Institute of Electronics and Information Engin 1986 전자공학회논문지 Vol.23 No.6
In this paper, we describe the physical modelling and numerical aspects of a program called PRECISE(Program for Efficient Calculation of Impurity Profile in Semiconductor by Elimination) which calcualtes a two-dimensional impurity profile in silicon due to diffusion and ion implantation steps. The PRECISE enables rapid prediction of the two-dimensional impurity profile near the mask edge-or the bird's beak during the local oxidation process. This has been developed by modifying the existing one-dimentional simulator, DIFSIM(DIFfusion SIMulator to include models for arsenic diffusion and emitter dip effect which were found out to agree fairly well with the xperimental data.
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