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우리나라 만성 C형간염 환자에서 페그인터페론과 리바비린의 병합치료에 대한 효과
강명주 ( Myoung Joo Kang ),정은욱 ( Eun Uk Jung ),박상원 ( Sang Won Park ),최바울 ( Pa Ul Choi ),김지현 ( Ji Hyun Kim ),박성재 ( Sung Jae Park ),박은택 ( Eun Taek Park ),이연재 ( Youn Jae Lee ),이상혁 ( Sang Hyuk Lee ),설상영 ( Sa 대한간학회 2008 Clinical and Molecular Hepatology(대한간학회지) Vol.14 No.3
75세 이상 초고령 환자 퇴행성 척추 질환에 시행한 요추 유합술의 임상 결과
조규정(Kyu Jung Cho),박승림(Seung Rim Park),박명주(Myoung Joo Park) 대한정형외과학회 2012 대한정형외과학회지 Vol.47 No.5
목적: 75세 이상 초고령 환자에 시행한 요추 유합술 후 임상 결과가 65-75세 환자의 결과와 차이가 있는가를 알아보았다. 대상 및 방법: 퇴행성 척추 질환으로 요추 유합술을 시행하고 12개월 이상 추적 관찰된 75세 이상 27명과 65-74세 환자 98명을 대상으로 하였다. 퇴행성 척추측만증 및 재수술 환자는 제외하였다. 수술 범위는 3분절 이하 요추 유합술만 포함하였다. 환자의 술 전 American Society of Anesthesiologists (ASA) 점수, 수술 전과 최종 추시 시 시각통증등급(visual analog scale, VAS), Oswestry 장애지수(Oswestry disability index, ODI), 술 후 합병증을 비교 분석하였다. 결과: 75세 이상 환자군에서 수술 전 ASA 점수가 높고 골다공증이 심하였다. 수술 전후 통증(VAS) 및 ODI 변화는 두 군 간 통계적으로 유의한 차이가 없었다. 수술 후 발생한 조기 합병증과 후기 합병증에도 차이가 없었다. 결론: 퇴행성 요추 질환으로 요추 유합술을 시행한 75세 이상의 초고령 환자군에서 65-75세 환자군과 비교하여 수술 전 전반적인 건강상태는 좋지 않았지만, 수술 후 통증 호전과 만족도에서는 차이가 없었다. Purpose: The elderly patients have been known for high incidence of postoperative complications following a lumbar fusion surgery. This study was conducted to determine the results of clinical outcomes after a lumbar fusion surgery in patients older than 75 years and to compare with those in patients between 65 and 74 years old. Materials and Methods: One hundred twenty-five patients who underwent lumbar fusion were enrolled. The mean follow-up was 22.5±15.7 months. Preoperative diagnosis was spinal stenosis in 113 patients and degenerative spondylolisthesis in 12 patients. Revision surgery or multi-level spinal fusion (>4 segments) was excluded. There were 27 patients in group A (>75 years) and 98 patients in group B (65-74 years). Preoperative American Society of Anesthesiologists (ASA) scores, visual analog scale (VAS), Oswestry disability index (ODI), postoperative complications, and bone union rate were compared. Results: The mean age was 78.6 years and 68.8 years in Group A and Group B, respectively. The mean preoperative ASA score was statistically different between group A and group B (p=0.025). The mean bone mineral density T score in group A was higher than that in group B (p=0.002). The mean VAS did not show a difference between the groups (p=0.171). There was no difference in the mean ODI between the groups in the improvement of VAS and ODI. The major and minor complications of early complications and late complications were observed without any statistical difference. Conclusion: Although preoperative ASA score was higher and osteoporosis was severe in the elderly patients (>75 years old), the improvement of clinical outcome was satisfactory as much as younger patients (65-74 years old) following a lumbar fusion surgery for degenerative spinal disease.
GC-ECD를 이용한 배추, 사과, 감귤, 고추, 현미 중 살균제 Prochloraz의 분석법 확립
이은미 ( Eun Mi Lee ),이혜리 ( Hye Ri Lee ),류명주 ( Myoung Joo Riu ),박희원 ( Hee Won Park ),나예림 ( Ye Rim Na ),송혁환 ( Hyuk Hwan Song ),금영수 ( Young Soo Keum ),김정한 ( Jeong Han Kim ),Young Zhe Zhu 韓國環境農學會 2009 한국환경농학회지 Vol.28 No.4
Prochloraz를 2,4,6-Trichlorophenol (2,4,6-TCP)로 전환시켜 분석하는 방법을 확립하였으며, 배추, 사과, 고추. 감귤, 현미를 대사 농작물로 선정하였다. 농산물 시료를 마쇄, acetonitrile로 추출하여 dichloromethane으로 분배하고 농축액에 pyridine hydrochloride를 넣고 1시간 가열 분해를 한다. 반응액을 다시 dichloromethane으로 분배한 후 GC-ECD로 분석하였다. Prochloraz의 정량한계는 0.01 mg/kg 이었다. 회수율은 0.1 mg/kg 수준에서 105-113%, 0.5 mg/kg 수준에서 82-87% 이었고, 반복 간 분석오차는 10% 미만이었다. 이러한 분석법 개선 과정에서 기존의 soxhlet 추출과 환류장치를 쓰지 않고 용매추출법과 작은 vial을 성공적으로 적용하였고, 간편, 신속, 경제적이며 정밀한 분석법을 확립하였다. Analytical method for prochloraz in cabbage, apple, pepper, mandarin, and hulled rice was established by conversion it to 2,4,6-trichlorophenol (TCP). Crop samples were extracted with acetonitrile, and partitioned with dichloromethane. The sample extracts were hydrolyzed with pyridine hydrochloride in a vial by heating for 1 hour, and analyzed with GC-ECD after partitioning with dichloromethane. Method quantification limit (MQL) of prochloraz was 0.01 mg/kg. Recoveries at 0.1 mg/kg level was 105-113% while at 0.5 mg/kg level was 82-87%. In both of the cases CV was less than 10%. Through this procedure soxhlet extraction and refluxing apparatus of conventional method were discarded and simple solvent extraction and small vial were successfully employed, resulting in simple, rapid, economic and more precise method.
크론병과 장결핵의 감별에 있어 특징적인 대장내시경 소견
제인수 ( In Soo Je ),이상혁 ( Sang Hyuk Lee ),정은욱 ( Eun Uk Jung ),강명주 ( Myoung Joo Kang ),박상원 ( Sang Won Park ),최바울 ( Pa Ul Choi ),김지현 ( Ji Hyun Kim ),박성재 ( Sung Jae Park ),지삼룡 ( Sam Ryong Jee ),박은택 ( Eun T 대한장연구학회 2007 Intestinal Research Vol.5 No.2
Background/Aims: The incidence of Crohn``s disease (CD) is on the increase in Korea. The differentiation of Crohn``s disease from intestinal tuberculosis (IT) is difficult. The aim of this study is to determine the characteristics of colonoscopic findings and factors that differentiate CD from IT. Methods: A total of 136 patients who were diagnosed with CD or IT at the Busan Paik Hospital from January 1995 to May 2005 were included in this study. We analyzed endoscopic findings, clinical characteristics and histological findings of 75 patients with CD and 61 patients with IT retrospectively. Results: For patients with IT, 18 (58.1%) of the patients had circular ulcers. For patients with CD, 27 (42.1%) of the patients had transverse ulcers, 18 (28.1%) of the patients had longitudinal ulcer, and 19 (29.6%) of the patients had both types of ulcers. The involvement of the ileocecal valve was noted in 18 (58.0%) of the patients with CD and in 37 (57.8%) of the patients with IT. The involvement of the rectum or anus was noted in 24 (51.5%) of the patients with CD and one (3.2%) patient with IT. Conclusions: According to previous studies, the presence of an ulcer was important to differentiate CD from IT. However, the presence of an ulcer was not a significant differentiating factor in our study. On colonoscopic findings, involved segments, an aphthous ulcer, cobblestone appearance, involvement of the rectum or anus and mucosal bridge should be observed carefully. (Intest Res 2007;5:158-164)