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혈변으로 내원하여 발견된 Cronkhite-Canada Syndrome 증례 1예
이현지 ( Hyun Ji Lee ),박상정 ( Sang Jung Park ),최혁순 ( Hyuk Soon Choi ),금보라 ( Bora Keum ),서연석 ( Yeon Seok Seo ),김용식 ( Yong Sik Kim ),진윤태 ( Yoon Tae Jeen ),이홍식 ( Hong Sik Lee ),전훈재 ( Hoon Jai Chun ),엄순호 ( So 대한장연구학회 2011 Intestinal Research Vol.9 No.3
Cronkhite-Canada syndrome (CCS) is a rare, non-familial hamartomatous polyposis syndrome characterized by multiple polyps in the entire gastrointestinal tract, nail dystrophy, skin pigmentation, and systemic alopecia. The clinical symptoms of this syndrome include diarrhea, abdominal pain, and alopecia often accompanied by taste disturbances, hypoalbuminemia, recurrent infections, nutritional absorption disturbances, heart failure, and gastrointestinal bleeding. We report a patient with CCS who was admitted complaining of hematochezia, melena, and a 1 month history of diarrhea, nail changes, taste disturbances, and alopecia. Upper endoscopy, colonoscopy, and capsule endoscopy were performed and showed numerous polyps in the stomach, small intestine, and large intestine. Histological sections of these polyps showed edematous stroma and cystically dilated foveolar epithelium, which was consistent with CCS. We diagnosed CCS based on the clinical symptoms and the histological findings of the polyps found via endoscopy. We report on this case and review this syndrome. (Intest Res 2011;9:238-242)
나수영,최창환,Song Eun Mi,방기배,박상형,김은수,박재준,금보라,이창균,이보인,Ryoo Seung-Bum,Koh Seong-Joon,Choi Miyoung,김주성 대한장연구학회 2023 Intestinal Research Vol.21 No.1
Ulcerative colitis (UC), a relapsing-remitting chronic inflammatory bowel disease (IBD), has a variable natural course but potentially severe disease course. Since the development of anti-tumor necrosis factor (TNF) agents has changed the natural disease course of moderate-to-severe UC, therapeutic options for patients who failed conventional treatments are expanding rapidly. IBD clinical trials have demonstrated the potential efficacy and safety of novel biologics such as anti-integrin α4β7 and anti-interleukin-12/23 monoclonal antibodies and small molecules such as a Janus kinase inhibitor. Anti-TNF biosimilars also have been approved and are widely used in IBD patients. Wise drug choices should be made considering evidence-based efficacy and safety. However, the best position of these drugs remains several questions, with limited data from direct comparative trials. In addition, there are still concerns to be elucidated on the effect of therapeutic drug monitoring and combination therapy with immunomodulators. The appropriate treatment regimens in acute severe UC and the risk of perioperative use of biologics are unclear. As novel biologics and small molecules have been approved in Korea, we present the Korean guidelines for medical management of adult outpatients with moderate-to-severe UC and adult hospitalized patients with acute severe UC, focusing on biologics and small molecules.
우리나라 대표 기상관측지점의 지리적 특성 분류에 관한 연구
민숙주,최영은,허인혜,권재일,김정용,최다솜,정현서,박금보라 건국대학교 기후연구소 2024 기후연구 Vol.19 No.1
In this study, we classified 219 representative weather stations in the Republic of Korea based on geographical features such as altitude, distance from the coastal line, total population, population density, and urban-related land cover ratios, and analyzed climate characteristics by the classified categories. The representative weather stations were categorized into six groups: mountain, plain inland city, plain inland rural, coastal city, and coastal rural stations. The most prevalent group was plain inland rural stations with 41.6%, followed by plain inland city ones with 22.8%, coastal rural ones with 21.9%, coastal city ones with 9.1%, and mountain ones with 4.6%. The climate characteristics among these geographical groups revealed significant differences (α=0.05) for annual average temperature except for coastal city and coastal rural group. However, annual precipitation was only significantly different between plain inland city and plain inland rural ones, and between coastal city and plain inland rural ones. The analyses of hot extreme climates revealed distinct differences among the six groups. At plain inland city ones, heat wave days were notably greater (15.8 days) than mountain ones (3.3 days), indicating the effect of city and elevation. Conversely, cold wave days were significantly much more in mountain stations (18.3 days) than coastal rural (1.5 days) and city (1.3 days) groups largely due to the modulation of warmer oceans in winter, elevation and city. The results of this study might be used for basic information for establishing future climate change adaptation strategies in the Republic of Korea.
Quality Indicators for Small Bowel Capsule Endoscopy
심기남,전성란,장현주,김진수,임윤정,김경옥,송현주,이현석,박재준,김지현,천재영,박수정,양동훈,민양원,금보라,이보인 대한소화기내시경학회 2017 Clinical Endoscopy Vol.50 No.2
Capsule endoscopy (CE) enables evaluation of the entire mucosal surface of the small bowel (SB), which is one of the most important steps for evaluating obscure gastrointestinal bleeding. Although the diagnostic yield of SB CE depends on many clinical factors, there are no reports on quality indicators. Thus, the Korean Gut Image Study Group (KGISG) publishes an article titled, “Quality Indicators for Small Bowel Capsule Endoscopy” under approval from the Korean Society of Gastrointestinal Endoscopy (KSGE). Herein, we initially identified process quality indicators, while the structural and outcome indicators are reserved until sufficient clinical data are accumulated. We believe that outcomes of SB CE can be improved by trying to meet our proposed quality indicators.