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AMP-activated Protein Kinase 활성체인 Metformin의 모발 성장에 미치는 영향
문혜림 ( Hye-rim Moon ),박기영 ( Ki-young Park ),강현지 ( Hyun Ji Kang ),이우진 ( Woo Jin Lee ),원종현 ( Chong Hyun Won ),장성은 ( Sung Eun Chang ),이미우 ( Mi Woo Lee ),최지호 ( Jee Ho Choi ),박경훈 ( Gyeong-hun Park ) 대한피부과학회 2019 대한피부과학회지 Vol.57 No.4
Background: AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase that plays a pivotal role in the balance of cellular energy metabolism. Recent studies have reported that AMPK has numerous roles in physiological conditions, and dysregulation of AMPK induces pathological processes and diseases. However, the role of AMPK and its activators have not yet been studied in the context of hair growth regulation. Objective: To investigate the effects of metformin on dermal papilla (DP) and outer root sheath (ORS) cells, as well as the role of the AMPK pathway in hair growth. Methods: We evaluated whether metformin, a well-known AMPK activator, had any beneficial effects on hair growth. In addition, to evaluate the molecular and cellular mechanisms that were involved, protein levels of AMPK and β-catenin were analyzed. Results: Metformin increased the cellular proliferation of human DP and ORS cells. Ki-67 expression was also significantly increased after metformin treatment in the ex vivo hair follicle organ culture. Furthermore, DP and ORS cells treated with metformin had a significant increase in AMPK phosphorylation, which in turn suppressed β-catenin degradation and enhanced its nuclear accumulation. Conclusion: We demonstrated that metformin promoted hair growth via the AMPK/β-catenin signaling pathway in vitro with DP and ORS cells. The hair-promoting effects of AMPK activators may potentially be used for the treatment of alopecia, and further investigation will be needed in the future. (Korean J Dermatol 2019;57(4):175∼ 181)
문혜림 ( Hye Rim Moon ),원광희 ( Kwang Hee Won ),윤우진 ( Woo Jin Yun ),원종현 ( Chong Hyun Won ),장성은 ( Sungeun Chang ),이미우 ( Mi Woo Lee ),최지호 ( Jee Ho Choi ),문기찬 ( Kee Chan Moon ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.3
Fixed drug eruption is a pattern of a drug-induced cutaneous reaction. It is characterized by skin erythematous plaques that recur at the same site each time the drug is administered. Now, we report the case of a 26-year-old woman who presented with 2 ill-defined erythematous patches on her back with itching sensation. The patient had a history of ciprofloxacin medication. The patch test with suspected drugs showed negative reactions, but intradermal tests were positive reactions. The patient was diagnosed with fixed-drug eruption due to ciprofloxacin. (Korean J Dermatol 2013;51(3):192∼195)
문혜림 ( Hye Rim Moon ),원광희 ( Kwang Hee Won ),원종현 ( Chong Hyun Won ),장성은 ( Sung Eun Chang ),이미우 ( Mi Woo Lee ),최지호 ( Jee Ho Choi ),문기찬 ( Kee Chan Moon ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.4
Panniculitis is a rare cutaneous finding in dermatomyositis (DM), presenting as tender subcutaneous nodules. Because panniculitis may precede other symptoms of DM, and its complications, including pain, lipoatrophy and carcinosis, might be severe and irreversible, early diagnosis and treatment of panniculitis is important. We herein describe a case of dermatomyositis first presenting as panniculitis in a 45-year old man. (Korean J Dermatol 2013;51(4):284∼287).
비전형적 피부섬유종의 임상적 특징과 더모스코피 소견에 관한 연구
오하늘 ( Haneul Oh ),문혜림 ( Hye-rim Moon ),유화정 ( Hwa-jung Ryu ),김일환 ( Il-hwan Kim ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.5
Background: Dermatofibroma is a common benign skin neoplasm that is usually easy to recognize; however, in some cases, it is difficult to differentiate it from atypical dermatofibroma. Atypical dermatofibroma is a rare variant of a more aggressive nature and requires complete excision due to its tendency to recur. Objective: To describe the clinical and dermoscopic features of dermatofibromas with special emphasis on the characteristics of atypical subtypes and to differentiate them from typical subtypes on the basis of results. Methods: We retrospectively searched the databases of patients of Korea University Ansan Hospital from January 2010 to December 2019 who underwent skin biopsies or excision surgeries and had pathological reports of dermatofibroma. Analyses of the clinical characteristics (age, sex, number of lesions, anatomical site) and dermoscopic patterns were performed. Results: Dermoscopic patterns were analyzed in 148 cases of dermatofibroma; peripheral delicate pigment networks and central white scar-like patches were the most common patterns found in 45 cases (30.4%). In eight cases of atypical dermatofibroma, three cases (37.5%) showed peripheral homogenous areas and central white networks, followed by multiple white scar-like patches in 2 cases (25.0%), peripheral delicate pigment networks, and central white scar-like patches in 2 cases (25.0%). Dermoscopy revealed a statistically significant difference in the peripheral homogenous area and the central white network pattern between the two groups. Conclusion: In this study, we analyzed the dermoscopic findings of 148 patients with dermatofibroma and found that the peripheral homogenous area and central white network patterns were significantly more in atypical dermatofibroma. (Korean J Dermatol 2021;59(5):341∼347)
선상 흑조증을 주소로 내원한 소아에서 진단된 상피내의 흑색종
이상민 ( Sang Min Lee ),문혜림 ( Hye Rim Moon ),정준민 ( Joon Min Jung ),원종현 ( Chong Hyun Won ),장성은 ( Sung Eun Chang ),이미우 ( Mi Woo Lee ),최지호 ( Jee Ho Choi ),문기찬 ( Kee Chan Moon ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.3
Melanonychia is a darkening of the nails and its importance is that it may indicate the presence of a subungual malignant melanoma. Because the incidence of malignant melanoma is quite small in children, clinicians have had difficulties as to whether or not to perform a nail matrix biopsy in the children with melanonychia. Herein, we report the case of a 6-year-old boy that presented with melanonychia, which was determined to be confirmed melanoma in situ. (Korean J Dermatol 2013;51(3):211∼214)
모세혈관기형 환자에서 펄스 다이 레이저를 이용한 치료의 효과에 영향을 주는 요인에 대한 후향적 연구
박태준 ( Tae Jun Park ),문혜림 ( Hye Rim Moon ),손상욱 ( Sang Wook Son ),김일환 ( Il-hwan Kim ),유화정 ( Hwa Jung Ryu ) 대한피부과학회 2020 대한피부과학회지 Vol.58 No.3
Background: Pulsed dye laser treatment is a proven effective treatment for capillary malformation. Previous studies have shown different responses to pulsed dye laser depending on the anatomical location of the capillary malformation. Objective: This retrospective study assessed the potential differences in treatment response depending on anatomical location and the factors affecting pulsed dye laser treatment response. Methods: We retrospectively investigated 88 patients with capillary malformation (nevus flammeus or port-wine stain) in the head and neck area treated with pulsed dye laser between November 2005 and January 2019. Dermatologists evaluated the effect of treatment from photographs taken before and after treatment. The anatomical location in the head and neck, lesion size, number of treatments, and the presence of proliferative lesion were analyzed from medical records and photographs. Results: The analyzed 88 patients included 121 lesions. The lesion size and the presence of proliferative lesions significantly affected the treatment effect; however, the location of the lesion in the head and neck did not. Conclusion: Smaller lesion size and the absence of proliferative lesion showed better effects of pulsed dye laser treatment. Unlike previous studies, the lesion location did not significantly affect the treatment effect. Korean J Dermatol 2020;58(3):185∼190)
VR 기반 교통법규 변경에 따른 운전 연습 실감 콘텐츠 개발
김민선 ( Min-sun Kim ),김한서 ( Han-seo Kim ),문선경 ( Sun-kyung Moon ),신혜림 ( Hye-rim Shin ) 한국정보처리학회 2023 한국정보처리학회 학술대회논문집 Vol.30 No.2
본 연구에서는 매년 달라지는 교통법규를 바탕으로 가상현실 기술과 IoT 기술을 활용하여 게임 개발 엔진인 Unity3D를 이용한 VR 기반 교통법규 변경에 따른 운전 연습 실감 콘텐츠를 개발하고자 한다. 본 연구에서 소개하는 콘텐츠는 우회전 신호등의 유무와 좌회전 감응 신호의 상황을 학습환경으로 제공한다. 즉, 본 연구는 실제 도로에서의 교통질서를 바로잡고, 효과적인 교통안전 교육을 마련함으로써 새로운 교통법규를 정확하게 준수하도록 도움을 제공하는데 의의를 가진다.