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문병조,김준규 ( Byung Jo Moon,Joon Kyoo Kim ) 생화학분자생물학회 1991 BMB Reports Vol.24 No.1
A rapid method for the synthesis of oligodeoxyribonucleotides by the phosphotriester approach in solution is described. This method is suitable for the preparation of relatively large quantities of pure compounds in relatively short time.
문병조,차종원,권오신,Moon Byung Jo,Cha, Jong Won,Kwon Oh Shin 대한화학회 1991 대한화학회지 Vol.35 No.1
Enkephalin의 작용을 연장하기 위한 연구이 하나로서 수개의 enkephalin aminopeptidase의 저해물을 합성하였다. 이 펩티드성 저해물은 zinc 결합자리로서 3-amino-2-hydroxy amino acid와 기질양상의 곁사슬을 가진다. 펩티드들은 용액 중에서 DCC/HOBt를 축합시약으로 사용하여 C-말단으로부터 사슬 연장법으로 합성하였다. 합성한 펩티드 저해물들은 모두 enkephalin aminopeptidase에 대하여 강한 저해 작용을 나타내었다. In an effort to increase effective action of enkephalins, several peptide inhibitors of enkephalin aminopeptidase have been synthesized. The peptides contain 3-amino-2-hydroxy amino acid as a zinc binding site and side chains of substrate pattern. The peptides were synthesized in solution by chain elongation from C-terminal end using DCC/HOBt as coupling reagent. The peptides are shown to have very strong inhibitory activity against enkephalin aminopeptidase.
문병조,정현주,김상국,김남희,Mun, Byeong Jo,Jeong, Hyeon Ju,Kim, Sang Guk,Kim, Nam Hui Korean Chemical Society 1996 Bulletin of the Korean Chemical Society Vol.17 No.1
A procedure is described for the synthesis of the title compound via phosphotriester intermediates. The preparation of $R_p$ and $S_p$ diastereomeric dinucleotide of d[Cp(S)T] was performed by the condensation of the protected deoxycytidine, the protected thymidine, 2,5-dichlorophenylphosphorodichloridothioate and 1-hydroxybenzotriazole in THF. Their designation of configuration at phosphorus as $R_p$ and $S_p$ follows from anaylsis of ${31}^P$ NMR spectroscopy and reverse-phase HPLC and the stereospecificity in the hydrolysis catalyzed by Nuclease S1 and snake venom phosphodiesterase. Diastereomerically pure $R_p$ and $S_p$ d[Cp(S)T] were utilized to synthesize oligonucleotides containing the XhoI recognition sequence with a phosphorothioate group at the cleavage site.
Rapid Synthesis of Self-Complementary Oligodeoxynucleotides
문병조,김준규,Moon, Byung-Jo,Kim, Joon-Kyoo Korean Society for Biochemistry and Molecular Biol 1991 한국생화학회지 Vol.24 No.1
용액 중에서 포스포트리에스테르 방법에 의한 올라고디옥시리보뉴크레오티드의 신속한 합성법을 개발하였다. 이 방법은 비교적 과량의 순수한 올리고뉴크레오티드를 비교적 짧은 시간에 신속히 합성하는데 적합하다. A rapid method for the synthesis of oligodeoxyribonucleotides by the phosphotriester approach in solution is described. This method is suitable for the preparation of relatively large quantities of pure compounds in relatively short time.
합성한 펩티드 저해물에 의한 엔케파린 아미노펩티다제의 저해
문병조,차종원 ( Byung Jo Moon,Jong Won Cha ) 생화학분자생물학회 1992 BMB Reports Vol.25 No.2
In an effort to increase effective action of enkephalins, several peptide inhibitors of enkephalin aminopeptidase which contain a zinc binding site at N-terminus and side chains of enkephalin were synthesized. Enkephalin aminopeptidase was purified from rat brain by (NH₄)₂SO₄ fractionation, DEAE-cellulose chromatography, gel-filtration and rechromatography on DEAE-cellulose. The enzyme hydrolyzes L-Tyr-β-naphthylamide with K_m value of 5.91 × 10^(-5) M. The peptide inhibitors are shown to be very strong competitive inhibitors of enkephalin aminopeptidase (K_i=10^(-7)M).
문병조 경북대학교 유전공학연구소 1988 遺傳工學硏究所報 Vol.3 No.1
A hypothetical ribosome binding site which contains 9-base S/D sequence, TAA termination codon, and 4-sticky end was prepared by phosphotriester approach in solution, using the rapid $quot;filtration method$quot;. Oligodeoxyribonucleotides were made in relatively large quantities and purity for structural studies by NMR and X-ray crystallography as well as molecular genetic studies.