The Beneficial Effect of Avocado on Skin Inflammation in a Mouse Model of AD-like Skin Lesions

명노일,김수진 한국자원식물학회 2019 한국자원식물학회지 Vol.32 No.6

Avocado, superfood, contains a variety of essential nutrients and phytochemicals. The purpose of this study was to explore whether avocado could modulate skin inflammation in vivo. We elucidated the pharmacological effects of avocado on compound 48/80- or histamine-induced scratching behaviors and 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)-like skin lesions in mice. Additionally, we investigated the anti-inflammatory activity of avocado and its underlying mechanism including its effect on the expression levels of inflammatory-related genes and nuclear factor -κB (NF-κB) in DNCB-induced AD-like skin lesions. The findings of this study demonstrate that avocado attenuated AD clinical symptoms including itching, eczematous, erythema and dryness and histamine levels in mice. Moreover, avocado suppressed both inflammatory cytokines expression as well as NF-κB and caspase-1 activation in AD-like skin lesions in mice. Taken together, these results demonstrate that avocado may be a potential candidate for treating skin inflammatory diseases like AD.

Dextran Sulfate Sodium으로 유도된 궤양성 대장염에 대한 작약의 개선 효과

명노일 한국자원식물학회 2018 한국자원식물학회지 Vol.31 No.4

Paeoniae Radix has been used as a traditional medicine for various diseases including hepatic disease. However, the inhibitory effect of Paeoniae Radix on intestinal inflammation has not been fully understood yet. The aim of this study was to evaluate the effect of Paeoniae Radix on colitis induced by dextran sulfate sodium in mice. To investigate the protective effects of Paeoniae Radix, the colitis mice were induced by drinking water containing 5% dextran sulfate sodium for 7 days. Mice were randomized into groups receiving Paeoniae Radix (100 ㎎/㎏), sulfasalazine (150 ㎎/㎏) as a positive control, or water as a negative control. We evaluated the effects of Paeoniae Radix on clinical signs induced by dextran sulfate sodium, measuring weight loss, colon length, and disease activity index. Additionally, to find a possible explanation for the anti-inflammatory effects of Paeoniae Radix, we evaluated the effects of Paeoniae Radix on the interleukin-6 and cyclooxygenase-2 levels in colitis tissue. The results indicated that mice treated with dextran sulfate sodium showed measurable clinical signs, including weight loss and reduced colon length. However, Paeoniae Radix treatment significantly improved the weight loss and disease activity index as clinical symptoms. Moreover, Paeoniae Radix inhibited the interleukin-6 and cyclooxygenase-2 expression levels in colon tissues treated with dextran sulfate sodium. Taken together, the findings of this study suggest that Paeoniae Radix may be useful for treating intestinal inflammation, including ulcerative colitis. Key words - Cyclooxygenase-2, Dextran sulfate sodium, Interleukin-6, Paeoniae Radix, Ulcerative colitis 염증성 대장질환에 대한 작약의 효능 연구가 미비하여 본연구에서는 dextran sulfate sodium로 유도된 궤양성 대장염의 임상증상인 체중감소, 결장단축, 질병활성화 정도에 대한 작약의 효과를 관찰하였다. 또한 대장 조직 내 염증매개인자인interleukin-6및 cyclooxygenase-2의 생성에 대한 작약의 효과를 측정하여 다음과 같은 결과를 얻었다. 첫째 dextran sulfate sodium로 유도된 궤양성 대장염에서 체중 감소에 대한 작약의효과를 관찰한 결과 유의적으로 억제함을 확인하였다. 둘째DSS로 유도된 궤양성 대장염에서 결장 단축에 대하여 작약의 억제 효과가 유의성 있게 나타났다. 셋째 dextran sulfate sodium 로 유도된 궤양성 대장염에서 임상증상인 설사, 잠혈 및 출혈 등의 질병활성화 정도에 대한 작약의 효과를 관찰한 결과 유의적으로 질병활성화 정도를 억제하였다. 넷째 대장 조직내 염증매개인자인 interleukin-6및 cyclooxygenase-2의 생성증가에대한 작약의 억제효과를 확인 하였다. 본 연구는 작약의 효능을과학적으로 입증한 결과로, 작약의 궤양성 대장염의 치료제 개발의 소재로서의 가능성을 시사한다.

지능형 원격검침을 이용한 전력감시·손실 시스템

명노길(NoGil Myoung),김영현(YoungHyun Kim),이상염(SangYoum Lee) 대한전기학회 2011 대한전기학회 학술대회 논문집 Vol.2011 No.7

The Ameliorative Effect of Rubi Fructus on DSS-induced Colitis in Mice

명노일(Noh-Yil Myung) 한국자원식물학회 2021 한국자원식물학회지 Vol.34 No.3

Ulcerative colitis (UC) is an inflammatory bowel disease and a chronic gastrointestinal disorder. Rubi Fructus (RF), the fruit of Rubus coreanus Miquel, is known to exert several pharmacological effects including anti-oxidative, anti-obesity and anti-inflammatory properties. However, the improving effect and mechanism of RF on intestinal inflammation is not been fully understood. The purpose of this study was to investigate the regulatory effect of RF on dextran sulfate sodium (DSS)-induced colitis in mice. We evaluated the effects of RF on DSS-induced clinical signs by analyzing weight loss and colon length. The inhibitory effects of RF on inflammatory mediators such as prostaglandin E2 (PGE2), cyclooxygenase (COX)-2, as well as the activation of nuclear factor-κB (NF-κB), were determined in colitis tissue. Our data indicated that mice treated with DSS showed clinical symptoms of colitis, including weight loss, colon length decrease and diarrhea. However, we observed that RF treatment significantly improved these clinical symptoms of weight loss, colon length decrease and diarrhea induced by DSS. RF inhibited the enhanced levels of COX-2 and PGE2 caused by DSS. We also showed that the anti-inflammatory mechanism of RF by suppressing the activation of NF-kB in DSS-treated colon tissues. Collectively, the findings of this study indicate the prospect of developing new drugs from RF for UC treatment.

Dextran sulfate sodium으로 유도된 궤양성 대장염에 대한 와송의 억제효과

명노일 ( Noh Yil Myung ) 대한본초학회 2014 大韓本草學會誌 Vol.29 No.4

Ulcerative colitis (UC) is an inflammatory bowel disease, which is one of chronic gastrointestinal disorders. Orostachys japonicus (OJ) has been used as a traditional medicine for various diseases including gastric cancer, gastric ulcers and intoxication. However, the regulatory effect of OJ on intestinal inflammation has not been fully understood, yet. The aim of this study was to investigate the effect of OJ on dextran sulfate sodium (DSS)-induced colitis in mice.Methods : To ascertain the pharmacological effects of OJ, the colitis mice were induced by drinking water containing 5% DSS for 7 days. Mice were randomized into groups receiving OJ (100 mg/kg), sulfasalazine (150 mg/kg) as a positive control, or water as a negative control. We evaluated the effects of OJ on DSS-induced the clinical signs, measuring weight loss and colon length. In addition, the inhibitory effect of OJ on the tumor necrosis factor.α (TNF-α) level was determined by enzyme-linked immunosorbent assay in colitis tissue. Results : The results indicated that mice treated with DSS showed remarkable clinical signs, including weight loss, and reduced colon length. However, treatment with OJ significantly improved the weight loss and DAI as clinical symptoms. Moreover, OJ reduced the TNF-α levels in DSS-treated colon tissues. Conclusions : Collectively, the findings of this study provide us with novel insights into the pharmacological actions of OJ as a potential medicine for use in the treatment of ulcerative colitis.

대추의 궤양성 대장염에 대한 개선 효과

명노일 ( Noh Yil Myung ) 대한본초학회 2015 大韓本草學會誌 Vol.30 No.3

Objectives : Zizyphus jujube (ZJ) has been used as a traditional medicine for various diseases. However, the inhibitory effect of ZJ on intestinal inflammation has not been fully understood, yet. The aim of this study is to investigate anti-colitis activity of ZJ in dextran sulfate sodium (DSS)-induced colitis mouse model. Methods : To investigate the protective effects of ZJ,the colitis mice were induced by drinking water containing 5% DSS for 7 days. Mice were randomized into groups receiving ZJ (500 mg/kg), sulfasalazine (SFZ) (150 mg/kg) as a positive control, or water as a negative control. We assayed the effects of ZJ on DSS-induced the clinical signs, measuring weight loss, colon length and disease activity index (DAI). Additionally, to find a possible explanation for the anti-inflammatory effects of ZJ, we evaluated the effects of ZJ on the production of prostaglandin E2 (PGE2) and expression of cyclooxygenase (COX)-2 in colitis tissue. Results : The results showed that mice treated with DSS showed considerable clinical signs, including weight loss, and reduced colon length. However, administration of ZJ significantly reduced the weight loss, shortens colon length, and improved DAI as clinical symptoms. Moreover, ZJ inhibited the PGE2 production and COX-2 expression levels in DSS-treated colon tissues. Conclusions : Collectively, the findings of this study provide us with novel insights into the pharmacological actions of ZJ as a potential molecule for use in the treatment of intestinal inflammation including ulcerative colitis.

연구논문 : 신도시 내 소각로 운영에 대한 건강영향평가 사례 연구 -중금속 흡인에 따른 인체 위해도 평가-

명노일 ( Nho Il Myung ),이영수 ( Young Soo Lee ),신대윤 ( Dae Yewn Shin ) 한국환경영향평가학회 2010 환경영향평가 Vol.19 No.3

이원자 기체 유동 해석을 위한 일반유체역학 계산모델 개발

명노신(Rho-Shin Myong),조수용(Soo-Yong Cho) 한국전산유체공학회 2001 한국전산유체공학회 학술대회논문집 Vol.2001 No.-

The study of nonlinear gas transport in rarefied condition or associated with the microscale length of the geometry has emerged as an interesting topic in recent years. Along with the DSMC method, several fluid dynamic models that come under the genera1 category of the moment method or the Chapman-Enskog method have been used for this type of problem. In the present study, on the basis of Eu's generalized hydrodynamics, a computational model for diatomic gases is proposed. The preliminary result indicates that the bulk viscosity plays a considerable role in fundamental flow problems such as the shock structure and shear flow. The general properties of the constitutive equations are obtained through a simple mathematical analysis. With an iterative computational algorithm of the constitutive equations, numerical solutions for the multi-dimensional problem can be obtained.

지능형 원격검침시스템을 이용한 전력손실 감시방법에 대한 연구

명노길(No-Gil Myoung) 한국조명·전기설비학회 2013 조명·전기설비학회논문지 Vol.27 No.8

Major utilities have been focusing on R&D and nationwide business of AMI system which plays a vital role in SmartGrid whose concept is to maximize energy efficiency and optimize electric power facility management with exchanging real time information between utilities and consumers based on ICT technologies in power grid. In this paper, we suggest a power loss monitoring method using KEPCOs AMI system which is operating in fields and with the acquisition of AMI data and analyses verify the validation of a power loss monitoring method.

CFD 응용 소프트웨어를 이용한 유동장 해석

명노신 한국항공우주학회 1991 한국항공우주학회 학술발표회 논문집 Vol.- No.-