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Overview of the Renin-Angiotensin System
류왕성,김상욱,김치정 대한심장학회 2007 Korean Circulation Journal Vol.37 No.3
Angiotensin II is an octapeptide hormone of the renin-angiotensin system (RAS), and it regulates a wide variety ofphysiological responses including salt and water balance, the blood pressure and the vascular tone. Clinical trialswith angiotensin-converting enzyme (ACE) inhibitors have demonstrated survival benefits in subjects with congestiveheart failure and myocardial infarction, and this support the importance of angiotensin II in the pathogenesisof cardiovascular diseases. Through activation of small G proteins such as Ras, Rho, and Rac, angiotensin II inducesremodeling of vascular smooth muscle cells (VSMC), including proliferation, migration, hypertrophy and inflammation.Angiotensin (1-7) appears to be the main effector peptide of ACE2 with vasodilatory, natriuretic andantiinflammatory properties. The cross-talk between the angiotensin II receptors may play an important role inmaintaining cardiovascular homeostasis. (Korean Circulation J 2007;37:91-96)
류왕성,전형식,문희범,김유영,강석영 대한천식알레르기학회 1984 천식 및 알레르기 Vol.4 No.2
Allergy to egg is thought to be an important etiologic factor in certain cases of ezcema, urticaria, asthma and gastrointestinal disturbance, particularly in children. Egg protein is at the top of the list for biological value and it is quitely capable of being a potent allergen. It has been suggested that the clinically important allergens in chicken egg are present in the white of egg rather than yolk. Ovalbumin and ovomucoid are most active components. This report is of a 29 year-old male with a life long history of severe gastrointestinal features of egg allergy. Immunological tests showed high serum IgE levels, with specific IgE antibodies to egg white, yolk and chicken meats. Provocative UGIS revealed increaaed peristaltic activity without any intrinsic pathology.