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Cis-Diaminocyclohexane을 배위자로 하는 백금(Ⅱ)착체의 선택적 세포독성
노영수,정세영,정지창 한국환경독성학회 1998 환경독성보건학회지 Vol.13 No.2
The use of cisplatin is limited by severe side effects such as renal toxicity. Our platinum-base drug discovery is aimed at developing drugs capable of diminishing toxicity and improving antitumor activity. We synthesized new Pt (II) complex analogue [Pt (cis-DACH)(DPPP)]ㆍ2NO₂,(PC) containing cis- l,2-diaminocyclohexane as a carrier ligand and 1, 3-bis(diphenylphosphino) propane as a leaving group. Furthermore, nitrate was added to improved the solubility. In this study, its structure was determined and its antitumor activity against SKOV-3 and NIH-OVCAR-3 human ovarian adenocarcinoma, and in nitro cytotoxicity was determined against primary cultured rabbit kidney proximal tubular and renal cortical cells of human kidney using colorimetric MTT assay. PC demonstrated acceptable antitumor activity against SKOV-3 and NIH-0VCAR-3 human ovarian adenocarcinoma and significant activity as compared with that of cisplatin. The toxicity of PC was found quite less than that of cisplatin using MTT and ³H-thymidine uptake tests in rabbit proximal tubular cells and human kidney cortical cells. PC was used for human cortical tissue in 7 weeks hitoculture by the glucose-consumption tests. We determined that the new platinum drug has lower nephrotoxicity than cisplatin. Based on these results, this novel platinum (Ⅱ) complex compound (PC) represent a valuable lead in the development of a new anticancer chemotherapeutic agent capable of improving antitumor activity and low nephrotoxicity.
노영수,박일석,김정현,김성동 대한이비인후과학회 2002 대한이비인후과학회지 두경부외과학 Vol.45 No.11
Angiofibromas are rare histologicaly benign tumors that predominantly affect adolescent males and acount for approximately 0.5% of all neoplasms of the head and neck. Although angiofibromas are histologically benign, but locally invasive. These fosa, intracranium, and neck. The morbidity and mortality associated with these tumors are related to its prominent vascularity and its propensity for aggresive local growth. Pre-operative embolization is useful for reducing intraoperative blood loss and the risk of incomplete excision of the tumor. These tumors virtually arise from the nasopharynx in the region of the sphenopa-latine foramen and pterygopalatine fosa. We present a unique case of an angiofibroma limited to the left parapharyngeal space, after pre-operative embolization. (Korean J Otolaryngol 202 ;45 :1105-9)
디포스핀류 배위자를 함유한 백금(II) 착체의 합성과 항암효과
노영수,노지 마사히데,Noh, Young-Soo,Masahide, Noji 한국약제학회 1990 Journal of Pharmaceutical Investigation Vol.20 No.4
New antitumor-active pt(II) complexes of trans-l-diamine cyclohexane containing diphosphines as a leaving group were synthesized. The structures of the pt(II) complexes were determined by analyzing the infrared and $^{31}P-nuclear$ magnetic resonance spectra. Antitumor activities of the pt(II) complexes were tested against murine leukemia $L_{l210}$ according to the protocol of the National Cancer Institute. All the pt(II) complexes Synthesized were antitumor-active. In particular, water-soluble $[pt(trans-l-dach) (DPPP)](NO_3)_2$ exhibited excellent antitumor activity, giving T/C % values of 341 and 356 respectively, each with four cured mice out of six at a dose of 25 mg/kg. These pt(II) complexes are considered to be worthy of further development.
후두 전적출술 후 발생한 인두피부누공에 대한 임상적 고찰
노영수,김창훈,진재원,김진환,안회영,정철훈 대한이비인후과학회 2007 대한이비인후과학회지 두경부외과학 Vol.50 No.11
:Pharyngocutaneous fistula after total laryngectomy is one of the most comon complication in the immediate postoperative period. The objective of this study is to evaluate the variable predisposing factors after total laryngectomy and to investigate the management of pharyngocutaneous fistula. Subjects and Method:One hundred fifty cases who had been performed total laryngectomy were investigated retrospectively. Fifteen of 150 cases (10.0%) developed pha-ryngocutaneous fistula after total laryngectomy. We analyzed clinical parameters such as age, sex, smoking, alcohol intake, DM (diabetes mellitus), hypertension, liver disease, postoperative hemoglobin, albumin etc. Results:Smoking, DM, hypertension, postoperative hemoglobin, postoperative albumin were significant factors asociated with pharyngocutaneous fistula. Nine myocutaneous flap. The average duration of oral feeding was 30 postoperative days in conservative treatment group and 83 postoperative days in surgical intervention group. Conclusion:Pharyngocutaneous fistula may be preventable by correcting the predisposing factors. We must consider the initial size of fistula and the response of conservative treatment to determine me-thodology and timing of surgical management. (Korean J Otorhinolaryngol-Head Neck Surg 2007 ;50 :1023-9)
노영수,임재규,류호연,이희진,황시현,Ro, Young-Soo,Lim, Jea-Kui,Rhu, Ho-yeun,Lee, Hee-Jin,Hwang, Si-Hyon 한국금형공학회 2016 한국금형공학회지 Vol.10 No.1
Sinks occurring in the rib portion of the testing product for the unpainteds are fatal defects at surface quality. In this study, we carried out moldflow analyses for several factors that affect the sinks. The result tells us large important effective factors on sinks by analyzing sink marks estimate. We expect practical use as reference for performing analysis or manufacturing products with rib designs and injection moldings which minimize sink-marks surrounded ribs.