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여성 생식계조직의 각종 임신연관 혈장단백의 분포에 관한 면역효소조직화학적 연구
남웅수,이규완,홍성봉 고려대학교 의과대학 1986 고려대 의대 잡지 Vol.23 No.3
Pregnancy associated plasma protein-A(PAPP-A), pregnancy-specific β-1 glycoprotein (SP1) and human placental lactogen(HPL), which are specific protein, have been known to be detectable in the plasma of pregnant women, especially in mid and last trimester by radioimniunoassay. Various researches have been reported on these and the increments of them could be of value as the tumor markers and as the pregnancy related abnormalities. Surgical specimens of normal and pathologic female genital tissues were fixed in formalin and embedded in paraffin in order to detect the exact distribution of PAPP-A, SP1 and HPL in various tissue component of them. The result obtained are as follows: 1. Normal superficial and intermediate squamous epithelial cells, moderate and severe dysplasia, carcinoma in situ and keratinizing squamous cell carcinoma of uterine cervix revealed positive reaction to anti PAPP-A, SP1, and HPL antibodies. 2. Endometrium in both proliferative and secretory phase, endometrial hyperplasia, trophoblastic tumors revealed positive reaction to anti PAPP-A, SP1, and HPL antibody, hut endometrial adenocarcinoma revealed negative reaction to each of them. 3. All of the normal ovarian tissues and various epithelial ovarian tumors revealed negative reaction to PAPP-A, SP1 and HPL antibody, but stromal and germ cell ovarian tumors revealed positive reaction to each of them. 4. Reactions to each PAPP's were in uniformity among the same tissues, that is, once the reaction was positive, the reactions to the other remaining two PAPP's were positive. Similarly negative reactions appeared in the same fashion.
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남웅수(US Nam) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.9
1971년 1월 1일부터 1980년 12월 31일까지 총 10년동안 본 고려대학교 의과대학 부속병원에서 분만한 총 8020예중 조기파막 696예를 대상으로 임상적 분석 및 고찰을 하여 다음과 같은 결론을 얻었다. 1. 조기파막의 예는 분만 8020예중 696예였으며 그 빈도는 8.67%였다. 2. 조기분만 407예중 조기파막은 48예로 11.78%였다. 3. 조기파막 696예중 초산부가 486예로 69.8%, 경산부가 210예로 30.2%을 나타내어 초산부에서 약 2배 이상의 높은 빈도를 보였다. 4. 조기파막을 산모의 연령군에 따라 나누어 볼 때 26세에서 30세에 가장 많이 발생하였다. 5. 모체의 합병질환은 28.87%로서 이중 임신 중독증이 가장 많았으며 그 다음으로는 임신 빈혈의 순위였다. 6. 제왕절개술은 696예의 조기파막환자중 129예로 18.6%를 차지하였으며 그 상응증으로는 협골반 및 아두골반불균이 38예로 가장 많았으며 그 다음으로 자궁내 태아긴박증,이상태아임, 신중독증 등의 순위였다. 그 외 경관이상 및 제대탈출등이 8예 및 6예였다. 7. 태아의 이상이나 산모의 여러가지 합병증 및 조기파막의 잠재기간과 비교하여 유도분만을 시형한 총 예는 123예로 이중 15예에서 36주 이전에 실시하였으며 36주 이후는 105예였다.( 이중 3예에서 유도분만 실패로 제왕절개을 시행하였다.) 8. 조기파막 696예중 신생아 체중은 2500gm~2,999gm 사이가 428예로 61.5%였다. 9. 조기파막 712예중 ( 쌍태임신 포함) 사산이 18예로 사산율은 1000명당 25.9명이었으며 조기사망율도 14명으로 1000명당 20.1명을 차지하므로써 주산기 사망율은 평균 1000명당 46명이었다. 10. 파막후 24시간 이상을 초과한 환자는 산모의 산후 발병이 시간에 정비례하여 높았다. 11. 파막직후 또는 입원즉시 투여하기 시작한 예방적 항생제 치료는 산모의 이환률 및 재원기간을 감소시켰다. This study is the clinical analysis of 696 cases of premature rupture of membranes among 8,020 deliveries at the Department of Obstetrics and Gynecology, Korea University Hospital from January 1, 1971 to December 31, 1980. The management of membrans is still controversial problems which is concerned with an increase of prematurity, maternal morbidity and infection of infants. The results obtained were as follows: 1) The incidence of premature rupture of membranes was 8.67% (696 cases out of 8,020 deliveries). 2) The incidence of premature rupture of membranes in premature deliveries was 11.7% (48 cases out of 407 premature deliveries). 3) The incidence of premature rupture of membranes in primipara group (69.8%; 486 cases out of 696 deliveries) was higher than multipara group (30.2%; 210 cases out of 696 deliveries). 4) The age group of 26 to 30 showed highest incidence in premature rupture of membrane. 5) The most frequent coincidental diseases of P.R.O.M. were preeclampsia and anemia. 6) The Cesarean section rate was 18.6% in P.R.O.M. According to frequency, the indications for C/S were C.P.D, intrauterine fetal distress, abnormal presentation, toxemia, cervical dystocia and prolapse of cord. 7) 15 cases before 36 weeks and 105 cases after 36 weeks of gestation were induced labor due to fetal distress or maternal complications in P.R.O.M. 8) The neonatal body weight group of 2,500 to 2,999gm among 696 cases of P.R.O.M. was predominant. 9) Perinatal death rate in P.R.O.M. was 46/1,000 total births, that is, there were 32 cases of perinatal deaths (18 cases of I.U.F.D. and 14 cases of neonatal death). 10) The incidence of the puerperal morbidity showed higher in association with the length of latent period. 11) The maternal morbidity could be reduced markedly by the use of prophylactic antibiotics, and also the prophylactic antibiotic use could reduce the duration of hospitalization.
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A Case of Ovarian Pregnancy after the Previous Laparoscopic Tubal Sterilization
윤여림(YL Youn),남웅수(US Nam),정구열(KY Chung),황인규(IK Hwang),구병삼(BS Koo) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.4
A case of ovarian pregnancy after the previous laparoscopic tubal sterilization which we have experienced is reported and the literatures are briefly reviewed.
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최영송(YS Choi),이강우(KW Lee),류승일(SI Yoo),남웅수(US Nam) 대한산부인과학회 1981 Obstetrics & Gynecology Science Vol.24 No.1
저자등은 28세의 부인에서 발생한 난소미분화배세포종의 1례를 경험하였기에 이를 보고하며 이에 대한 무넌적고찰을 표기하였다. This is a case report of Dysgerminoma of ovary which is rare. A case of Dysgerminoma of left Ovary in 28 years old nulligravida presented, found postoperatively is presented with a brief review of literature concerned.
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이수종(SJ Lee),구병삼(BS Koo),신재승(JS Shin),남웅수(US Nam) 대한산부인과학회 1981 Obstetrics & Gynecology Science Vol.24 No.4
The mucocolpometra is a rare disorder usually associated with congenital malformation such as imperforated hymen, transverse vaginal septum, or other occlusion of external genitalia. The authours reports a case of mucocolpometra due to atresia of vagina in 80 years old multiparous woman . The patients had been admitted to gynecological department because of yellowish vaginal leucorrhea and left flank pain. This genital tract disorder was easily detected by means of inspection and manual examination. A transabdominal hysterectomy was performed due to above condition, and neoplastic ovaries and uterine change had to be ruled out by pathologcial studies. The mucous materila not only filled into the uterine and vaginal cavities but chronic granulomatous inflammation was noted throughout endometrium and cervix. The patients was advised to have further evaluation to rule out possible malignancy. She refused additional medical care.
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강홍영(HY Kang),유승일(SI Yoo),임태균(TK Lim),남웅수(US Nam),나종열(JY Rha) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.4
Choriocarcinoma is encountered once in every 40,000 pregnancies. The possibility of the tumor arising out side of the uterine cavity is remote, but rarely, it does occur. The chances of its arising in the ovary have been estimated to be one in 392 millions. Primary choriocarcinoma of the ovary may be gestational or non-gestational. The former type usually arises from ovarian pregnancy, and the latter arises from a teratoma or from and embryonal rest. We have experienced one case of the non-gestational choriocarcinoma of the ovary which is presented with a brief review of the literatures.
RISS
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