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쇼그렌 증후군에서 혈청 amylase 측정의 임상적 의의
남언정(Eon Jeong Nam),이난영(Nan Young Lee) 한국산학기술학회 2021 한국산학기술학회논문지 Vol.22 No.6
혈청 amylase는 침샘 및 췌장에서 주로 분비되는 대표적인 효소로 침샘의 염증으로 인한 침샘 기능 저하와 질병 활성도는 혈청 amylase에 영향을 미칠 가능성이 있어, 쇼그렌 증후군에서 이들의 상관관계를 분석함으로써 혈청 amylase 측정의 임상적 의의를 알아보고자 하였다. 쇼그렌 증후군으로 진단받았으나, 혈청 amylase치에 영향을 미치는 동반 질환이 없는 여자 환자 70명을 대상으로 하였으며, 비자극 침샘 유속(U-SFR)과 자극 침샘 유속(S-SFR), 침샘 스캔검사, 질병 활성도 표지자(ESSDAI와 ESSPRI), 혈액검사로 자가항체, 면역글로불린, amylase, 염증 표지자 검사를 시행하였다. 혈청 amylase치는 U-SFR 및 S-SFR과 유의한 양의 상관관계를 보였으며, 침샘 스캔 검사에서 귀밑샘의 분출분획이 높을수록 혈청 amylase치가 증가하였다. 그러나, 혈청 amylase와 질병 활성도 표지자 및 염증 표지자 결과는 상관관계를 보이지 않았다. 혈청 amylase 평균치를 기준으로 두 군으로 나누어 분석한 결과, 혈청 amylase치가 높은 환자 군에서 S-SFR과 귀밑샘 분출 분획이 통계적으로 유의하게 증가되어 있었다. 결론적으로, 혈청 amylase는 침 분비능과 침샘 스캔 검사에서 귀밑샘의 분출 분획과 유의한 상관관계를 보여 쇼그렌 증후군에서 침샘 기능이 이상이 없다는 것을 시사하였다. Serum amylase is a representative enzyme secreted by the salivary gland and pancreas. This study investigates the clinical significance of serum amylase levels in Sjögren’s syndrome (SS). Totally, 70 female subjects were enrolled, who were diagnosed as SS and had no accompanying afflictions that affected the serum amylase levels. Unstimulated salivary flow rate (U-SFR) and stimulated SFR (S-SFR), salivary gland scan, and disease activity markers (ESSDAI and ESSPRI), as well as blood tests including ESR, CRP, and amylase, were evaluated. Serum amylase showed significant positive correlation with the U-SFR and S-SFR, and was increased with higher ejection fraction (EF) of the parotid gland. However, there was no significant correlation with disease activity and inflammatory markers. Based on their average amylase levels, subjects were divided into two groups. The group with higher serum amylase levels showed a statistically significant increase in the S-SFR and EF of the parotid gland. Considering the results of the salivary gland scan, we conclude that serum amylase is significantly correlated with SFR and the EF of the parotid gland, thereby indicating that the salivary gland function remains intact in SS.
베체트병 환자에서 인조혈관 대치술 후 발생한 대동맥기관지루
김성욱 ( Sung Uk Kim ),김경훈 ( Kyung Hoon Kim ),조장희 ( Jang Hee Cho ),남언정 ( Eon Jeong Nam ),조준용 ( Joon Yong Cho ),이종태 ( Jong Tae Lee ),강영모 ( Young Mo Kang ) 대한내과학회 2006 대한내과학회지 Vol.71 No.5
Arterial involvement of Behcet`s disease (BD) includes arterial occlusions and aneurysms, of which aneurysms are the more common. Aortopulmonary fistula is an anomalous communication between the aorta and a segment of the tracheobronchial tree, and this may develop after thoracic vascular surgery and cause fatal hemoptysis. We experienced a case of BD in a 34-year-old man who was diagnosed as having an aortopulmonary fistula between the aortic pseudoaneurysm and the bronchus of the left upper lobe, and this developed after graft replacement surgery for aortic aneurysm.(Korean J Med 71:577-581, 2006)
테레프탈로일 염화물(terephthaloy1 chloride)에 의한 직업성천식 1례
서영익(Young Ik Seo),김건우(Gun Woo Kim),남언정(Eon Jeong Nam),현상훈(Sang Hoon Hyun),강영모(Young Mo Kang),이종명(Jong Myung Lee),김능수(Nung Soo kim) 대한천식알레르기학회 1999 천식 및 알레르기 Vol.19 No.2
Terephthaloyl chloride, a chemical of low molecular weight, is used as an intermediate by a fabric manufacturing industry. It is known to cause gastrointestinal, respiratory and skin irritation. However, it has not been reported as a cause of occupational asthma till now. We report a case of occupational asthma caused by prolonged exposure to terephthaloyl chloride in the workplace. A 38 year-old man visited at the Allergy Clinic because of cough, dyspnea and wheezing for 5 years. He had worked at a factory for 15 years where he was involved in the process of manufacturing fabrics. At presentation, he had no symptoms and showed no abnormality on physical examination. When challenged with vapor of terephthaloyl chloride, he experienced sneezing and paroxysmal cough in a couple of minutes, followed by dyspnea and wheezing at 10 min. He also experienced urticarial rashes on the face and chest. The pulmonary function tests showed an atypical prolonged immediate airway response. PC20 methacholine decreased from 5 mg/ml to 0.79 mg/ml 24 hours after the challenge. Light microscopic examination of bronchial biopsies showed loss of epithelium, thickening of basement membrane, submucosal fibrosis, and increased inflammatory cell infiltration. The immediate drop in FEV1 and urticarial rash to terephthaloyl chloride suggests the possibility of an immediate hypersensitivity immune reaction. Further studies are needed to clarify the exact mechanism of terephthaloyl chloride induced asthma.
조장희 ( Jang Hee Cho ),김성욱 ( Sung Uk Kim ),서재석 ( Jae Seok Seo ),강봉석 ( Bong Seok Kang ),남언정 ( Eon Jeong Nam ),강영모 ( Young Mo Kang ) 대한류마티스학회 2005 대한류마티스학회지 Vol.12 No.2
Objective: Behcet`s disease (BD) is a systemic vasculitis in which hyperfunction of neutrophils is one of the major pathophysiologic features. Myeloperoxidase (MPO) is an important neutrophilic lysosomal enzyme and has been implicated in tissue damage of BD. As the A allele of -463G/A polymorphism of the MPO gene is associated with diminished activity of MPO, we analyzed the association of -463G/A polymorphism of the MPO gene with BD. Methods: We analyzed -463G/A polymorphism of the MPO gene in BD patients (n=101) and controls (n=138). Genotype of the MPO gene at position -463 was determined by PCR-RFLP assay using genomic DNA. Results: The allele frequency of -463G/A polymorphism of the MPO gene did not deviate from the Hardy-Weinberg expectation in both BD patients and controls. There were no statistically significant differences in genotype distribution and allele frequency between patients and controls at position -463 (p=0.761 and p=0.549 respectively). Analysis of genotype distribution and allele frequency of the -463G/A according to sex did not show any difference between patients and controls. There were no statistically significant differences in clinical manifestations of BD among different genotypes. Conclusion: The present data indicate that the -463G/A polymorphism of the MPO gene was not associated with the susceptibility to and clinical manifestations of BD in Korea.
비후성 뇌수막염과 대동맥주위염으로 발현한 IgG4 연관 질환
은정수 ( Jung Su Eun ),권상훈 ( Sang Hoon Kwon ),이은송 ( Eun Song Lee ),강영모 ( Young Mo Kang ),남언정 ( Eon Jeong Nam ) 대한내과학회 2015 대한내과학회지 Vol.88 No.1
Immunoglobulin G4 (IgG4)-related disease (RD) is an immune-mediated, systemic fibroinflammatory condition characterizedby a lymphoplasmacytic infiltration of IgG4-positive plasma cells, storiform fibrosis, and obliterative phlebitis. IgG4-RD has becomerecognized with increasing frequency since the turn of the century and may affect almost any organ. IgG4-RD also involvesthe meninges but, to the best of our knowledge, no case of IgG4-related intracranial pachymeningitis with periaortitis has been reportedin Korea to date. Here, we report on a 65 year-old male with IgG4-RD involving the meninges and aorta. (Korean J Med 2015;88:114-119)