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임신중 알코올섭취가 태아발육 및 출생후 제반 생리적 신경반사에 미치는 영향
조태일,나중렬,홍승길 고려대학교 의과대학 1987 고려대 의대 잡지 Vol.24 No.1
Although liquid diets containing ethanol have been widely used in rodent models of the fetal alcohol syndrome, the nutritional adequacy of these diets and the effects of these treatment on the pregnent rat and subsequent pup development has not been sufficiently verified. Beginning on day 5 of gestation, maternal diet consumption, body weight and other physiologic parameters were monitored in rats receiving ethanol diet (Group A), paried-fed diet without ethanol (Group B) and ad libitum solid diet (Group C). The purpose of this investigation was to examine the effects of ethanol diet during pregnancy and postpartum on the developmental / reproductive parameters of pregnant rats and their offsprings. 1. Body weight of pups is suppressed by alcohol treatment - during the first 10 days postpartum, the slope of the increase in weight is significantly less than controls. - After removal of alcohol treatment, the slope of the growth curves are parallel but the ovarall weight of the alcohol treated rats is less. - The alcohol treated rats appear to be 4-6 days behind in growth when compared with controls. This appears to be true until day 8 of age. - At 80 days of age, the pre and postnatal alcohol treatment suppressed the body weight of male and female pups. 2. Duration of pregnancy is not affected by prenatal alcohol treatment, however, pellet diet rats gave birth one day earlier (p < 0.05) than alcohol treated rats. 3. Food intake was reduced (p < 0.01) in alcohol treated rats. The average was about 76 ml/day versus 119 ml/day in controls. 4. Weight gain of the mothers during pregnancy was reduced (p < 0.01) in the alcohol treated rats. The alcohol treated rats gained about 123 gm during days 5-20 of pregnancy whereas liquid and pellet controls gained 196 and 179 gm, respectively. 5. Litter size (number of pups) was not altered by alcohol treatment during pregnancy. 6. Birth weight was reduced by 18 and 10% when compared with liquid and pellet controls, however, not statistically significant. 7. Eye opening was delayed (p < 0.01) 2.4 and 1.4 days respectively, when compared with liquid and pellet diets. 8. Surface righting reflex was delayed (p < 0.01) by 3.7 days in the alcohol treated animals when compared with either controls. 9. Negative geotaxis was delayed (p < 0.01) 2.7 and 2.4 days respectively when compared with liquid and pellet diets. 10. Reflex suspension was delayed (p < 0.01) 3.3 and 3 days respectively when compared with liquid and pellet controls. It suggests that the maternal alcohol consumption plays an important role in the developmental and neurological events in the subsequent pups as described in this study.
최신임상강좌 : 상피성난소종양에서 clusterin, bax, p53, Ki-67의 발현 및 세포사멸지수에 관한 연구
이지영 ( Ji Young Lee ),나중렬 ( Jung Yeol Na ),김인선 ( In Sun Kim ),박문향 ( Moon Hyang Park ),강재성 ( Jae Seong Kang ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.9
Objective: The purpose of this study was (1) to evaluate the expressions of clusterin, bax, Ki-67, p53, and apoptotic index in epithelial ovarian tumors, borderline and malignant ovarian tumors, (2) to find out the correlation between their expressions and clinicopathological parameters, and (3) to evaluate the effect on the patient`s survival according to their expressions. Methods: The histological and clinical findings of 22 cases of ovarian cystadenomas, 44 cases of borderline tumors and 96 cases of carcinomas were evaluated. Expressions of clusterin, bax, Ki-67, p53, and apoptotic index were studied on paraffin-embedded tissue sections by immunohistochemical methods. Results: The expressions of clusterin, p53, and Ki-67 were higher in ovarian carcinomas than borderline tumors. The overexpression of p53, and Ki-67 were frequent in high stage, poorly differentiated and bilateral ovarian carcinomas. The overexpressions of clusterin, bax, p53, and Ki-67 showed a statistically significant correlation with histologic type. Apoptotic index was higher in bax overexpression group, but there was no correlation with overexpression of clusterin or p53. Ki-67 was higher in p53 overexpression group, but there was no correlation with overexpression of clusterin or p53. There was no statistically significant correlation with each other between the overexpressions of clusterin, bax, p53, and Ki-67. The overexpressions of clusterin, Ki-67, p53 was associated with overall patient`s survival in borderline significance. Conclusion: The overexpression of p53, and Ki-67 were frequent in poorly differentiated ovarian carcinomas. So the overexpression of p53, and Ki-67 can be used as prognostic factor. The overexpression of clusterin was more in epithelial ovarian carcinomas than in borderline tumors but showed no significant correlation with the overall patient`s survival. Further studies are required to clarify the possibility of using clusterin for target therapy in epithelial ovarian carcinomas.