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Polyacryloyl- 및 Polymethacryloylcephradine의 합성과 항균작용에 관한 연구
김선일,차월석,나재운,김영호,고옥현,Kim, Sun-Il,Cha, Wol-Suk,Na, Jae-Woon,Kim, Young-Ho,Ko, Ok-Hyun 대한화학회 1992 대한화학회지 Vol.36 No.2
The reaction of N-hydroxysuccinimide with polyacrylic acid and polymethacrylic acid gave poly(N-acryloxysuccinimide)and poly(N-methacryloxysuccinimide), whose reaction with cephradine provided polyacryloylcephradine and polymethacryloylcephradine. The activities of these polymeric drugs were investigated in terms of minimum inhibitory concentration by the common twofold dilution technique. Polyacryloylcephradine revealed excellent antibacterial activity against Staphylococcus aureus ATCC 25923, Staphylococcus aureus FDA 209P, Bacillus subtilis ATCC 6633, Bacillus licheniformis ATCC 14580, Escherishia coli BE 1186 and Salmonella typhimurium TV 119. Polymethacryloylcephradine revealed excellent Staphylococcus aureus ATCC 25923, Staphylococcus aureus FDA 209P, Bacillus subtilis ATCC 6633, Escherichia coli Be 1186 and Salmonella typhimurium TV 119. Polyacrylic acid와 polymethacrylic acid를 N-hydroxysuccinimide에 반응시켜 poly(N-acryloxysuccinimide)와 poly(N-methacryloxysuccinimide)를 합성하고, 이것과 cephradine을 반응시켜 polyacryloylcephradine과 polymethacryloylcephradine을 합성하였다. 이들 중합체약의 항균성을 2단계 희석법에 의하여 최소 발육저지 농도로서 조사하였다. Polyacryloylcephradine 중합체에 대한 최소 발육저지 농도는 Staphylococcus aureus ATCC 25923, Staphylococcus aureus FDA 209P, Bacillus subtilis ATCC 6633, Bacillus licheniformis ATCC 14580, Escherichia coli BE 1186 및 Salmonella typhimurium TV 119 균주들에 항균성이 대체적으로 우수하였다. Polymethacryloylcephylococcus aureus FDA 209P, Bacillus subtilis ATCC 6633, Escherichia coli BE 1186 및 Salmonella typhimurium TV 119 균주들에 대해서 항균력을 보여주었다.
생체분해성 Poly ( DL - lactide - co - glycolide ) 랜덤공중합체 Micelle 에서 약물방출 (Ⅱ)
이동병,차월석,박영훈,김명렬,나재운,김종균 ( Dong Byung Lee,Wol Suk Cha,Yung Hoon Park,Myung Yul Kim,Jae Woon Nah,Chong Kyun Kim ) 한국공업화학회 1997 한국공업화학회 연구논문 초록집 Vol.1997 No.0
N/A The lineary release time according to the kinds of micelles prepared in the ratio 20:20 of DL-PLGA(70:30, 80:20, 90:10) and clonazepam was delayed in the order of DL-PLGA(70:30)>DL-PLGA(80:20)>DL-PLGA (90:10). Amount of drug release according to the kinds of micelles was delayed in the order of DL-PLGA(70:30)>DL-PLGA(80:20)>DL-PLEA (90:10). Homopolymers were not suited for drug carriers because drug release of poly DL-lactide was too delayed and poly glycolide shows the burst effect in early days.
포스터 발표 - 고분자공업분과 : 생체분해성 Poly ( DL - lactide - co - glycolide ) 랜덤공중합체 Micelle 에서 약물방출 (Ⅱ)
이동병,차월석,박영훈,김명렬,나재운,김종균 ( Dong Byung Lee,Wol Suk Cha,Yung Hoon Park,Myung Yul Kim,Jae Woon Nah,Chong Kyun Kim ) 한국공업화학회 1997 한국공업화학회 연구논문 초록집 Vol.1990 No.3
N/A The lineary release time according to the kinds of micelles prepared in the ratio 20:20 of DL-PLGA(70:30, 80:20, 90:10) and clonazepam was delayed in the order of DL-PLGA(70:30)>DL-PLGA(80:20)>DL-PLGA (90:10). Amount of drug release according to the kinds of micelles was delayed in the order of DL-PLGA(70:30)>DL-PLGA(80:20)>DL-PLEA (90:10). Homopolymers were not suited for drug carriers because drug release of poly DL-lactide was too delayed and poly glycolide shows the burst effect in early days.
Polyacryloylcephalexine과 Polymethacryloylcephalexine의 합성 및 그 항균작용
유의경,권규혁,차월석,나재운,Euy Kyung Yu,Gwon, Gyu Hyeok,Wol Suk Cha,Jae-Woon Na 대한화학회 1993 대한화학회지 Vol.37 No.7
방출조절성 약제를 개발하기 위한 방법으로 polyacrylic acid와 polymethacrylic acid에 thionylchloride로 chlorination하여 cephalexine을 반응시켜 Polyacryloylcephalexine 과 polymethacryloylcephalexine을 합성하였다. Polyacryloylcephalexine 중합체약에 대한 최소 발육 저지 농도로서 항균력은 Micrococcus luteus ATCC 9341과 Escherichia coli ESS이 우수하고, Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 25923, Mycobacterium phlei IFO 3158, Klebsiella pueumouiae KCTC 1560, Escherichia coli KCTC 1039, Salmonella typhimurium KCTC 1925 균주들에 대해서도 항균성이 대체적으로 우수하였다. polymethacryloylcephalexine 중합체약에 대한 최소 발육 저지 농도는 Micrococcus luteus ATCC 9341과 Klebsiella pueumouiae KCTC 1560이 우수하고, Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 25923, Mycobacterium phlei IFO 3158, Escherichia coli KCTC 1039, Escherichia coli ESS, Salmonella typhimurium KCTC 1925 균주들에 대해서는 항균력이 양호하였다. Polyacryloylcephalexine and polymethacryloylcephalexine were prepared by the reaction of polyacryloylchloride or polymethacryloyl chloride with cephalexine. The antimicrobial activities of these polymeric drugs were investigated by the common twofold dilution technique and the minimum inhibitory concentration (MIC) of polymeric durgs was also examined. Polyacryloylcephalexine revealed an excellent antibacterial activity against Micrococcus luteus ATCC 9341, Escherichia coli ESS, Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 25923, Mycobacterium phlei IFO 3158, Klebsiella pueumouiae KCTC 1560, Escherichia coli KCTC 1039, Salmonella typhimurium KCTC 1925. Polymethacryloylcephalexine revealed an excellent antibacterial activity against Micrococcus luteus ATCC 9341, Klebsiella pueumouiae KCTC 1560, Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 25923, Mycobacterium phlei IFO 3158, Escherichia coli KCTC 1039, Escherichia coli ESS, Salmonella typhimurium KCTC 1925.
차월석,김선일,이동병,나재운 ( Wol Suk Cha,Sun Il Kim,Dong Byung Lee,Jae Woon Na ) 한국공업화학회 1995 공업화학 Vol.6 No.1
약물 전달체에 prednisolone을 분산시켜 제조한 고분자 매트릭스를 pH 1.2 및 pH 7.4 완충용액에서 약물 방출실험을 하였다. 약물 방출시간은 pH 1.2보다 pH 7.4에서 더 지연되었으며 약물 전달체의 함유량이 증가함에 따라 약물 방출시간도 지연되었다. 이러한 거동은 약물 전달체가 산성에서 팽윤을 더 잘하기 때문이다. 약물 전달체의 종류에 따라 지연된 약물 방출시간은 키토산 고분자 매트릭스의 경우가 가장 길었으며, 술폰화키토산 고분자 매트릭스, 키토산·염고분자 매트릭스의 순서였다. 특히 이러한 제형들은 초기 방출속도를 억제하는 팽윤성 방출조절형 제제임을 화인할 수 있었다. The release experiments of drug were operated in the buffer solutions of pH 7.4 and pH 1.2 by using drug carriers with prednisolone for delivery drug. The release time of drug was more delayed in pH 7.4 than in pH 1.2. The reason is that drug carriers have greater swelling abilities at low pH than at high pH. The release time of drug carriers was delayed in the order of chitosan polymeric matrix, sulfonated chitosan polymeric matrix, and chitosan hydrochloride polymeric matrix. In short, the fomulation allows polymeric matrix to supress the burst effect of the drug release mechanism, which led to the controlled release pattern by swelling.